Detailed analysis of immunoprivileged tissues in skin appendages:
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
Gießen
DVG-Service
2008
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| Ausgabe: | 1. Aufl. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Nebentitel: Detaillierte Analyse von immunpriviligierten Geweben in Hautanhangsorganen |
| Beschreibung: | 262 S. Ill., graph. Darst. 21 cm |
| ISBN: | 9783939902843 |
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| 245 | 1 | 0 | |a Detailed analysis of immunoprivileged tissues in skin appendages |c vorgelegt von Katja Christina Meyer |
| 250 | |a 1. Aufl. | ||
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| 500 | |a Nebentitel: Detaillierte Analyse von immunpriviligierten Geweben in Hautanhangsorganen | ||
| 502 | |a Zugl.: Hannover, Tierärztliche Hochsch., Diss., 2008 | ||
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| 650 | 7 | |a immune response |2 cabt | |
| 650 | 7 | |a skin |2 cabt | |
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| 650 | 7 | |a immun system |2 cabt | |
| 650 | 7 | |a hair |2 cabt | |
| 650 | 7 | |a immunohistochemistry |2 cabt | |
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Datensatz im Suchindex
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| adam_text | TIERARZTLICHE HOCHSCHULE HANNOVER ANATOMISCHES INSTITUT DETAILED
ANALYSIS OF IMMUNOPRIVILEGED TISSUES IN SKIN APPENDAGES
INAUGURAL-DISSERTATION ZUR ERIANGUNG DES GRADES EINER DOKTORIN DER
VETERINARMEDIZIN - DOCTOR MEDICINAE VETERINARIAE - (DR. MED..VET.).---*
*** * VORGELEGT VON KATJA CHRISTINA MEYER (HAMBURG) HANNOVER 2008
TABLE OF CONTENTS TABLE OF CONTENTS TABLE OF CONTENTS 5 ABBREVIATIONS 9
FIGURES 12 TABLES 16 1 INTRODUCTION 17 2 LITERATURE 20 2.1 A SHORT
SYNTHESIS OF HAIR FOLLICLE BIOLOGY 20 2.1.1 HAIR FOLLICLE MORPHOGENESIS
22 2.1.2 FUNCTIONAL ANATOMY OF THE HAIR FOLLICLE 24 2.1.3 HAIR FOLLICLE
CYCLE 31 2.2 SINUS HAIR FOLLICLE BIOLOGY: OVERVIEW 35 2.2.1 SINUS HAIR
FOLLICLE MORPHOGENESIS 36 2.2.2 FUNCTIONAL ANATOMY OF THE SINUS HAIR
FOLLICLE . 38 1.1.1 SINUS HAIR FOLLICLE CYCLE 42 2.3 MURINE NAIL
APPARATUS: OVERVIEW 44 2.3.1 NAIL MORPHOGENESIS 45 2.3.2 FUNCTIONAL
ANATOMY OF THE NAIL __; 46 2.3.3 GROWTH OF THE NAIL 50 2.4
IMMUNE-LOGICAL BACKGROUND FOR THE CURRENT STUDY 51 2.4.1 INNATE IMMUNE
SYSTEM ; 51 2.4.2 ACQUIRED IMMUNE SYSTEM 52 2.4.3 IMMUNE PRIVILEGE:
DEFINITION AND BASIC CHARACTERISTICS 53 2.5 IMMUNE PRIVILEGE IN SKIN
APPENDAGES 56 2.5.1 THE ANAGEN HAIR BULB AS AN IMMUNOPRIVILEGED SITE *__
59 2.5.2 DOWNREGULATION OF MHC CLASS LA AND NK CELLS 61 2.5.3 INFANTILE
HUMAN NAIL MATRIX IS A SITE OF RELATIVE IMMUNE PRIVILEGE 64 2.6 THE
IMMUNE PRIVILEGE COLLAPSE MODEL OF AA PATHOGENESIS 67 COLLAPSE AND
RESTORATION OF IP IN THE ANAGEN HAIR BULB IN VITRO 69 2.7 THE HUMAN
BULGE REGION AS A SITE OF RELATIVE IMMUNE PRIVILEGE? . 71 TABLE OF
CONTENTS 2.8 BULGE IP COLLAPSE AND THE PATHOGENESIS OF PCA 73 2.9
FUNCTION OF IMMUNOPRIVILEGED SITES ; 75 2.10 IMMUNE PRIVILEGE MARKERS 77
2.10.1 MHC CLASS I MOLECULES 78 2.10.2 P2-MICROGLOBULIN 81 2.10.3 MHC
CLASS II MOLECULES 82 2.10.4 MHC CLASS IB MOLECULES 84 2.10.5 CD4+ AND
CD8+ T CELLS 85 2.10.6 A-MSH AND ACTH 86 2.10.7 TGF-P 89 2.10.8 MIF 91
2.10.9 IDO 92 2.10.10 CD200 95 2.10.11 MASTCELLS 96 2.10.12 ICAM-1 100
2.10.13 P-DEFENSIN2 101 2.11 K(D)PT - A CANDIDATE AS HAIR GROWTH
MODULATOR AND IP RESTORER IN ANAGEN HAIR BULBS? 103 2.12 QUESTIONS
ADDRESSED IN THIS STUDY 105 2.13 EXPERIMENTAL DESIGN 105 3 MATERIALS AND
METHODS 707 3.1 TISSUE COLLECTION 107 3.1.1 HUMAN TISSUE COLLECTION 107
3.1.2 MURINE TISSUE COLLECTION 108 3.2 HUMAN HAIR FOLLICLE ISOLATION 110
3.3 HUMAN HF ORGAN CULTURE 111 3.4 FULL THICKNESS HUMAN SCALP SKIN ORGAN
CULTURE 114 3.5 HISTOLOGICAL STAININGS 115 3.5.1 HEMATOXYLIN-EOSIN
STAINING 115 3.5.2 TRICHROMATIC STAINING 116 3.5.3 TOLUIDINE BLUE
STAINING 116 3.5.4 LEDER S ESTERASE STAINING 117 TABLE OF CONTENTS 3.5.5
3.6 3.6.1 3.6.2 3.6.3 3.6.4 3.6.5 3.7 3.7.1 3.7.2 3.7.3 3.7.4 3.7.5
3.7.6 3.7.7 3.7.8 KI-67/TUNEL IMMUNOHISTOCHEMISTRY PRIMARY ANTIBODIES
AVIDIN BIOTIN COMPLEX-PEROXIDASE ENVISION-ALKALINE PHOSPHATASE
IMMUNOFLUORESCENCE TYRAMIRIE SIQNAL AMPLIFICATION (TSA) HISTOMORPHOMETRY
ASSESSMENT OF HAIR CYCLE STAQES ASSESSMENT OF PROLIFERATINA MATRIX
KERATINOCYTES ASSESSMENT OF IMMUNOSTAININQ INTENSITY ASSESSMENT OF MHC
CLASS I IR IN ISOLATED HFS ASSESSMENT OF MAST CELLS ASSESSMENT OF MHC
CLASS II, CD4, CD54, CD11 B, MAST CELLS AND C-KIT POSITIVE CELLS
MICROSCOPICAL EQUIPMENT STATISTICAL ANALVSIS 4 RESULTS 4.1 4.1.1 4.1.2
4.1.3 4.1.4 4.1.5 IMMUNE PRIVILEQE AND THE HUMAN HAIR FOLLICLE BULQE
DEMONSTRATION OF MHC CLASS LA AND P 2 -MICROGLOBULIN EXPRESSION ON
CD200+ CELLS _ DEMONSTRATION OF MHC CLASS II+ CELLS IN THE BULQE
DEMONSTRATION OF HLA-E EXPRESSION IN CD200+ BULAE CELLS LOCALLY
GENERATED IMMUNOSUPPRESSANTS COMPLEMENT THE BULQE IP DEMONSTRATION OF
MACROPHAGE MIGRATION INHIBITORY FACTOR AND INDOLEAMINE-2,3- RIIOXYAENASE
4.1.6 4.2 INFLUENCE OF IFN-Y ON ECTOPIC MHC CLASS I PROTEIN EXPRESSION
IN THE BULGE ORS INFLUENCE OF THE A-MSH RELATED TRIPEPTIDE K(D)PT ON
HUMAN HAIR FOLLICLE BIOLOGV IN SITU UNDER DRO-INFLAMMATORV CONDITIONS
4.2.1 4.2.2 INFLUENCE OF K(D)PT ON IFN-V INDUCED MHC CLASS I AND II
PROTEIN EXPRESSION 118 120 120 121 123 123 124 125 125 125 126 127 128
128 L?9 129 131 131 _ 131 137 140 141 144 _ 149 151 IS1 REACTION OF
K(D)PT ON THE IFN-Y INDUCED UPREGULATION OF TOTAL MAST CELL NUMBERS AND
MAST CELL DEARANULATION 4.2.3 4.2.4 4.3 4.3.1 4.3.2 INFLUENCE OF K(D)PT
ON THE HAIR CYCLE INFLUENCE OF K(D)PT ON HAIR MATRIX KERATINOCYTE
PROLIFERATION AND APOPTOSIS IMMUNE PRIVILEGE AND MURINE SINUS HAIR
FOLLICLES DEMONSTRATION OF MHC CLASS I MOLECULES DEMONSTRATION OF MHC
CLASS II MOLECULES 155 157 158 159 159 161 TABLE OF CONTENTS 4.3.3
DEMONSTRATION OF CD4+T CELLS 163 4.3.4 DEMONSTRATION OF CD11B MOLECULES
165 4.3.5 DEMONSTRATION OF TGF-PI MOLECULES 167 4.3.6 DEMONSTRATION OF
MAST CELLS 169 4.4 IMMUNE PRIVILEGE AND THE MURINE MOUSE NAIL APPARATUS
171 4.4.1 DEMONSTRATION OF MHC CLASS I MOLECULES : 171 4.4.2
DEMONSTRATION OF MHC CLASS II MOLECULES 173 4.4.3 DEMONSTRATION OF CD4+
T CELLS 175 4.4.4 DEMONSTRATION OF TGF-P1 MOLECULES 176 4.4.5
DEMONSTRATION OF CD54 MOLECULES 177 4.4.6 DEMONSTRATION OF MAST CELLS
178 4.4.7 DEMONSTRATION OF P-DEFENSIN 2 180 5 DISCUSSION 181 5.1
INTRODUCTORY REMARKS 181 5.2 METHODS EMPLOYED 182 5.3 IMMUNE PRIVILEGE
IN THE HUMAN HAIR FOLLICLE BULGE, MURINE NAIL AND SINUS HAIR FOLLICLE
186 5.3.1 THE HUMAN HF BULGE 186 5.3.2 THE MURINE SINUS HAIR FOLLICLE
AND NAIL APPARATUS 193 5.3.3 COMPARISON OF THE HUMAN HF BULGE, MURINE
SINUS HAIR FOLLICLE AND NAIL APPARATUS 200 5.4 EFFECTS OF K(D)PT ON THE
HAIR FOLLICLE IMMUNE SYSTEM 202 5.5 CONCLUSIONS 204 5.6 PERSPECTIVES 205
6 SUMMARY ; 207 7 ZUSAMMENFASSUNG 209 8 REFERENCES 212 9 ANNEX 257
|
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| author | Meyer, Katja Christina 1979- |
| author_GND | (DE-588)136919863 |
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| dewey-ones | 612 - Human physiology |
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| dewey-sort | 3612.799 |
| dewey-tens | 610 - Medicine and health |
| discipline | Agrar-/Forst-/Ernährungs-/Haushaltswissenschaft / Gartenbau Medizin |
| edition | 1. Aufl. |
| format | Thesis Book |
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| spelling | Meyer, Katja Christina 1979- Verfasser (DE-588)136919863 aut Detailed analysis of immunoprivileged tissues in skin appendages vorgelegt von Katja Christina Meyer 1. Aufl. Gießen DVG-Service 2008 262 S. Ill., graph. Darst. 21 cm txt rdacontent n rdamedia nc rdacarrier Nebentitel: Detaillierte Analyse von immunpriviligierten Geweben in Hautanhangsorganen Zugl.: Hannover, Tierärztliche Hochsch., Diss., 2008 analysis cabt immune response cabt skin cabt tissues cabt immun system cabt hair cabt immunohistochemistry cabt hair follicles cabt Haut swd Hautanhangsgebilde swd (DE-588)4113937-9 Hochschulschrift gnd-content HEBIS Datenaustausch Darmstadt application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017064067&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Meyer, Katja Christina 1979- Detailed analysis of immunoprivileged tissues in skin appendages analysis cabt immune response cabt skin cabt tissues cabt immun system cabt hair cabt immunohistochemistry cabt hair follicles cabt Haut swd Hautanhangsgebilde swd |
| subject_GND | (DE-588)4113937-9 |
| title | Detailed analysis of immunoprivileged tissues in skin appendages |
| title_auth | Detailed analysis of immunoprivileged tissues in skin appendages |
| title_exact_search | Detailed analysis of immunoprivileged tissues in skin appendages |
| title_full | Detailed analysis of immunoprivileged tissues in skin appendages vorgelegt von Katja Christina Meyer |
| title_fullStr | Detailed analysis of immunoprivileged tissues in skin appendages vorgelegt von Katja Christina Meyer |
| title_full_unstemmed | Detailed analysis of immunoprivileged tissues in skin appendages vorgelegt von Katja Christina Meyer |
| title_short | Detailed analysis of immunoprivileged tissues in skin appendages |
| title_sort | detailed analysis of immunoprivileged tissues in skin appendages |
| topic | analysis cabt immune response cabt skin cabt tissues cabt immun system cabt hair cabt immunohistochemistry cabt hair follicles cabt Haut swd Hautanhangsgebilde swd |
| topic_facet | analysis immune response skin tissues immun system hair immunohistochemistry hair follicles Haut Hautanhangsgebilde Hochschulschrift |
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