Current topics in complement II: [4th Aegean Conferences Workshop on Complement Associated Diseases, Animal Models, and Therapeutics (June 10 - 17, 2007) in Porto Heli, Greece]
Gespeichert in:
| Format: | Tagungsbericht Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York, NY
Springer
2008
|
| Schriftenreihe: | Advances in experimental medicine and biology
632 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXX, 316 S. Ill., graph. Darst. 235 mm x 155 mm |
| ISBN: | 9780387789514 0387789510 9780387789521 |
Internformat
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| 245 | 1 | 0 | |a Current topics in complement II |b [4th Aegean Conferences Workshop on Complement Associated Diseases, Animal Models, and Therapeutics (June 10 - 17, 2007) in Porto Heli, Greece] |c John D. Lambris, ed. |
| 264 | 1 | |a New York, NY |b Springer |c 2008 | |
| 300 | |a XXX, 316 S. |b Ill., graph. Darst. |c 235 mm x 155 mm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
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| 490 | 1 | |a Advances in experimental medicine and biology |v 632 | |
| 650 | 2 | |a Complement System Proteins |a immunology | |
| 650 | 2 | |a Protéines du système du complément - immunologie | |
| 650 | 4 | |a Complement (Immunology) |v Congresses | |
| 650 | 4 | |a Complement System Proteins |x immunology |v Congresses | |
| 650 | 0 | 7 | |a Komplement |g Immunologie |0 (DE-588)4120589-3 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)1071861417 |a Konferenzschrift |y 2007 |z Porto Heli |2 gnd-content | |
| 655 | 2 | |a Congresses | |
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| 700 | 1 | |a Lambris, John D. |e Sonstige |4 oth | |
| 711 | 2 | |a Workshop on Complement Associated Diseases, Animal Models, and Therapeutics |n 4 |d 2007 |c Porto Cheli |j Sonstige |0 (DE-588)6522991-5 |4 oth | |
| 830 | 0 | |a Advances in experimental medicine and biology |v 632 |w (DE-604)BV000003102 |9 632 | |
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Datensatz im Suchindex
| _version_ | 1804138511774777344 |
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| adam_text | Contents
Preface v
Contributors xvii
1. Adipokines and the Immune System: An Adipocentric
View 1
Robin MacLaren, Wei Cui and Katherine Cianflone
1 Introduction 1
2 Endocrine Functions of Adipose Tissue in the Immune System 2
3 Adipose Tissue Crosstalk: Adipocytes and Macrophages 3
4 Adipose Tissue Micro-Environment 5
4.1 Adipocyte-Mediated Recruitment, Differentiation and Macrophage
Differentiation 5
4.2 Effects of Macrophages on Adipocyte Function 6
4.3 Effects of Adipocytes on Macrophage Function 7
4.4 Contribution of Preadipocytes to Altered Adipocyte and Macrophage
Function 7
4.5 Pros and Cons of Macrophage Infiltration 7
4.6 Effect of Weight Loss on Adipose Tissue Function 8
5 The Role of C5L2: Adipose vs. Immune 9
5.1 Metabolism, C3, and Acylation Stimulating Protein (ASP) 9
5.2 Identification of C5L2 and Ligand Binding in Transfected Cells 10
5.3 Signalling of C5L2 in Transfected Cells 12
5.4 A DRY Motif is not Required for Signalling 12
5.5 Endogenous Expression of C5L2 and Functionality 13
5.6 In vivo Role of C5L2 in Mice and Humans 15
6 Summary 15
References 16
2. The Role of Complement in Stroke Therapy 23
Ricardo J. Komotar, Grace H. Kim, Marc L. Otten, Benjamin Hassid,
J. Mocco, Michael E. Sughrue, Robert M. Starke, William J. Mack,
Andrew F. Ducruet, Maxwell B. Merkow, Matthew C. Garrett, and
E. Sander Connolly
1 Introduction 23
2 Inflammation Following Cerebral Ischemia 24
viii Contents
3 Complement Mediated Ischemia/Reprefusion Injury 24
4 Complement Mediated Cell Clearance 25
5 Implications of Complement Inhibition 26
6 Complement and Neurogenesis/Neurorecovery 26
7 Steps Towards Clinical Translation 27
8 Conclusion 28
References 28
3. Food Intake Regulation by Central Complement System 35
Kousaku Ohinata and Masaaki Yoshikawa
1 Introduction 35
2 C3a Effect on Food Intake 36
2.1 Anorexigenic Action of Central C3a 36
2.2 C3a Agonist Peptides Derived from Natural Proteins 37
2.3 Involvement of the PGE2-EP4 Receptor Pathway 38
3 C5a Effect on Food Intake 41
3.1 Orexigenic Action of Central C5a 41
3.2 Involvement of PGD2-DP, Receptor 41
References 42
4. A Pivotal Role of Activation of Complement Cascade
(CC) in Mobilization of Hematopoietic Stem/Progenitor
Cells (HSPC) 47
Mariusz Z. Ratajczak, Marcin Wysoczynski, Ryan Reca, Wu Wan, Ewa
K. Zuba-Surma, Magda Kucia, and Janina Ratajczak
1 Introduction 47
2 Mobilization of HSPC and Problem of Poor Mobilizers 48
3 G-CSF-Induced Mobilization Triggers Activation of CC 50
4 Experimental Evidence that Ig-Deficient RAG2, SCID and Jh Mice, but not
T-Cell-Depleted Mice, Respond Poorly to G-CSF Induced Mobilization 52
5 Defective Mobilization in RAG2, SCID and Jh Mice is Restored by
Purified Immunoglobulins Supports Further a Pivotal Role of Ig in this
Process 54
6 Evidence that CC Activation and C3a Generation in Serum Correlate
with G-CSF Induced HSPC Mobilization 54
7 In Contrast to G-CSF-Mobilization, RAG2, SCID and Jh Mice Display
Normal Zymosan-Induced Mobilization 56
8 Impaired Mobilization in C5-Deficient Mice Supports a Pivotal Role
for CC in Egress of HSPC from BM and their Mobilization into PB 56
9 Conclusions 58
References 59
Contents ix
5. Regulation of Tissue Inflammation by Thrombin-
Activatable Carboxypeptidase B (or TAFI) 61
Lawrence L.K. Leung, Toshihiko Nishimura, and Timothy Myles
1 Introduction 61
2 Procoagulant and Anticoagulant Properties of Thrombin 62
3 Dissociation of Thrombin s Procoagulant and Anticoagulant Properties 62
4 Thrombin-Activatable Procarboxypeptidase B as a Physiological
Substrate for the Thrombin/Thrombomodulin Complex 63
5 Thrombin-Activatable Carboxypeptidase B as an Anti-inflammatory
Molecule 64
6 Carboxypeptidase B Reduces Bradykinin-Induced Hypotension In Vivo 66
7 Carboxypeptidase B Ameliorates C5a-Induced Alveolitis In Vivo 66
8 ProCPB-Deficient Mice Are Predisposed to Abdominal Aneurysm
Formation and Arthritis In Vivo 67
9 Regulation of Thrombin s Inflammatory Properties by Thrombin-
Activatable Procarboxypeptidase B 67
References 68
6. Interaction between the Coagulation and Complement
System 71
Umme Amara, Daniel Rittirsch, Michael Flierl, Uwe Bruckner,
Andreas Klos, Florian Gebhard, John D. Lambris, and Markus Huber-Lang
1 Introduction 71
2 Serine Protease Systems 72
2.1 Coagulation System 72
2.2 Fibrinolytic System 74
2.3 Complement System 74
3 C3a and C5a Generation by Coagulation Factors 75
4 Complement: New Activation Paths 76
5 Interaction between the Coagulation and Complement Cascade After
Trauma 76
6 Conclusion 77
References 77
7. Platelet Mediated Complement Activation 81
Ellinor I.B. Peerschke, Wei Yin, Berhane Ghebrehiwet
1 Complement Activation on Platelets 81
2 Complement Activation on Platelet Microparticles (PMP) 83
x Contents
3 Pathophysiology of Platelet Mediated Complement Activation 84
4 Regulation of complement Activity on Platelets 86
5 Summary and Conclusion 87
References 88
8. Adrenergic Regulation of Complement-Induced Acute
Lung Injury 93
Michael A. Flierl, Daniel Rittirsch, J. Vidya Sarma,
Markus Huber-Lang, and Peter A. Ward
1 Introduction 93
2 Phagocytes: A New Adrenergic Organ 94
2.1 Evidence for de novo-Synthesis, Release and Inactivation
ofCatecholamines by Phagocytes 94
2.2 Modulation of Phagocyte Functions by Catecholamines 96
3 Phagocyte-Derived Catecholamines Regulate Complement-Dependent
Acute Lung Injury 96
4 Outlook 98
5 Conclusion 100
References 100
9. Ficolins: Stucture, Function and Associated Diseases 105
Xiao-Lian Zhang, Mohammed A.M. AH
1 Introduction 105
2 Structures of Ficolins 107
3 Ficolin Genetics 108
4 Ficolin and Infectious Diseases 109
5 Single nucleotide Polymorphisms in Ficolins 110
6 Ficolins and Apoptosis 110
7 Ficolins and Systemic Lupus Erythematosus 110
8 Ficolins and IgA nephropathy (IgAN) 110
9 Ficolins andPreeclampsia Ill
10 Ficolin and C-Reactive Protein 111
11 Concluding Remarks Ill
References 112
10. Complement Factor H: Using Atomic Resolution
Structure to Illuminate Disease Mechanisms 117
Paul N. Barlow, Gregory S. Hageman, and Susan M. Lea
1 Introduction 117
2 Involvement of Factor H in Human Disease 119
3 CFH Binding Sites 121
Contents xi
4 The Structure of Factor H 122
4.1 Low Resolution Structural Information on CFH 123
4.2 Atomic Structure of the CFH Carboxy-terminus 123
4.3 Atomic Structures for Both Tyr and His variants of CCP 7 125
4.5 Atomic Structure for CFH-678 125
4.6 Sulfated Sugar Recognition at the Polymorphic residue 127
4.7 Additional Binding Sites for Sulfated-Sugar Within CFH-6,7,8 128
5 Structure: Insights into Disease Mechanism 129
6 Options for Therapy 130
References 133
11. Role of Complement in Motor Neuron Disease: Animal
Models and Therapeutic Potential of Complement
Inhibitors 143
Trent M. Woodruff, Kerina J. Costantini, Steve M. Taylor, and
Peter G. Noakes
1 Background 143
2 Animal Models of Motor Neuron Disease 144
2.1 Early Models of Motor Neuron Disease 144
2.2 SOD1 Transgenic Model of Amyotrophic Lateral Sclerosis 144
3 Clinical Evidence for Complement Involvement 146
4 Experimental Evidence for Complement Involvement 149
5 Therapeutic Possibilities 151
6 Summary 153
References 153
12. The Role of Membrane Complement Regulatory
Proteins in Cancer Immunotherapy 159
Jun Yan, Daniel J. Allendorf, Bing Li, Ruowan Yan, Richard Hansen,
and Rossen Donev
1 Complement System and its Activation 159
2 Membrane-Bound Complement Regulatory Proteins and their Expression
on Tumors 161
3 Antitumor mAb Therapy and mCRPs on Tumors 162
4 mCRPs and Adaptive T-Cell Responses 163
5 Modulation of mCRPs for Immunotherapy 164
5.1 Neutralizing mAbs 164
5.2 Small Interfering RNAs or Anti-sense Oligos 165
5.3 Chemotherapeutic Drugs 166
5.4 Peptide Inhibitors of mCR Gene Expression 166
6 Concluding Remarks 167
References 167
xii Contents
13. Role of Complement in Ethanol-Induced Liver Injury 175
Michele T. Pritchard, Megan R. McMullen, M. Edward Medof,
Abram Stavitsky, and Laura E. Nagy
1 Alcoholic liver Disease 175
1.1 Innate and Adaptive Immunity in Ethanol-Induced Liver Injury 176
2 Complement and Ethanol-Induced Liver Injury 176
2.1 Ethanol and Complement Activation 178
2.2 Role of Complement in Ethanol-Induced Liver Injury 178
3 C3 in the Development of Hepatic Steatosis 179
4 Complement and Inflammatory Cytokines in Ethanol-Induced Liver Injury 179
5 Complement Regulatory Proteins in Ethanol-Induced Liver Injury 180
6 Membrane Attack Complex (MAC) and Ethanol-Induced Liver Injury 181
7 Complement in Hepatocellular Proliferation 181
8 Complement and Waste Disposal : Complement and Ethanol-Induced
Apoptosis 182
9. Conclusions 182
References 183
14. Immune Complex-Mediated Cytokine Production is
Regulated by Classical Complement Activation both
In Vivo and In Vitro 187
Johan Ronnelid, Erik Ahlin, Bo Nilsson, Kristina Nilsson-Ekdahl, and
Linda Mathsson
1 Introduction 187
2 Down-Regulation of IC-Induced IL-12 Production by the Classical
Complement Pathway 188
3 Complement Blockade Induce Inverse Regulation of Cryoglobulin-
Stimulated TNF-a and IL-10 Production 192
4 In Vivo Complement Activation and Anti-SSA in SLE 195
5 Discussion 197
6 Concluding Remarks 198
References 198
15. Subversion of Innate Immunity by Periodontopathic
Bacteria via Exploitation of Complement Receptor-3 203
George Hajishengallis, Min Wang, Shuang Liang, Muhamad-Ali K.
Shakhatreh, Deanna James, So-ichiro Nishiyama, Fuminobu
Yoshimura, and Donald R. Demuth
1 Introduction 203
2 CR3 in Innate Immunity 204
3 P. gingivalis interacts with CR3 Through its Cell Surface Fimbriae 205
Contents xiii
4 Biological Significance of CR3-P. gingivalis Interactions: In Vitro
Mechanistic Studies 205
4.1 P. gingivalis Stimulates CR3-Dependent Transendothelial Migration
of Monocytes 207
4.2 P. gingivalis Enters Macrophages via CR3 and Resists Intracellular
Killing 208
4.3 P. gingivalis Interaction with CR3 Downregulates IL-12 Induction 210
5 In vivo Evidence for CR3 exploitation by P. gingivalis and Implications
in Periodontitis 211
6 CR3 exploitation by P. gingivalis depends on TLR2 214
7 Conclusion 214
References 215
16. Staphyloccocal Complement Inhibitors:
Biological Functions, Recognition of
Complement Components, and Potential
Therapeutic Implications 221
Brian V. Geisbrecht
1 S. aureus as a Model System for Immune Evasion 221
2 The Anti-Complement Activities ofX aureus 222
2.1 Inhibitors of Complement Activation and Amplification 222
2.2 Inhibitors of Complement-induced Inflammatory Responses 225
2.3 Remaining Questions 225
3 Toward a Molecular Understanding of Complement Evasion 226
3.1 Recognition of C3 by S. aureus Efb 226
3.2 Recognition of C3 by S. aureus Ehp 228
3.3 Inhibitory Mechanisms of the Efb Family 230
4 Potential Therapeutic Applications of the Efb Family 231
5 Conclusions 233
6 References 233
17. Human Astrovirus Coat Protein: A Novel Cl Inhibitor 237
Neel K. Krishna and Kenji M. Cunnion
1 Introduction 237
2 Cl, the First Complement Component 239
3 Cl Inhibitors 240
3.1 Cl-Inhibitor 240
3.2 Decorin and Biglycan 240
3.3 Neutrophil Defensins 240
3.4 Clq Receptor Proteins 241
4 The Astroviruses 241
xiv Contents
5 Inhibition of Complement Activity By Human Astrovirus Coat Protein
(HAstVCP) 242
5.1 HAstV CP Suppresses Classical Pathway Activity 243
5.2 HAstV CP Binds to the A-chain of Clq 244
5.3 HAstV CP Specifically Targets the Cl Complex 245
5.4 HAstV CP Suppresses Complement Activation via an Inhibitory
Mechanism 246
5.5 Hypothetical Mechanism of Cl Inhibition by HAstV CP 247
6 Human Astrovirus Coat Protein: Potential as a Therapeutic for Complement-
Mediated Diseases 247
7 Conclusions 248
8 References 248
18. Hypothesis: Combined Inhibition of Complement and
CD14 as Treatment Regimen to Attenuate the
Inflammatory Response 253
Tom Eirik Mollnes, Dorte Christiansen, Ole-Lars Brekke, and
Terje Espevik
1 Introduction 253
2 Complement 255
3 CD14 and Toll-Like Receptors 256
3.1 Toll-like Receptors are Essential Membrane Receptors in the
Inflammatory Response 256
3.2 TLR Signaling 257
4 Rational for Combined Complement and CD14 Inhibition 257
4.1 Escherichia Coli Bacteria 257
4.2 Endotoxin (LPS) 259
4.3 Gram Negative Sepsis 259
4.4 General Principles for the Inflammatory Reaction: Role of
Endogenous Ligands 259
5 Conclusion 261
References 261
19. Targeting Classical Complement Pathway to Treat
Complement Mediated Autoimmune Diseases 265
Erdem Tiiziin, Jing Li, Shamsher S. Saini, Huan Yang, and Premkumar
Christadoss
1 Complement System in Myasthenia Gravis 265
2 Classical Complement Pathway in EAMG 268
3 Anti-Clq Antibody Prevents and Treats EAMG 268
Contents xv
4 Conclusion 270
References 271
20. Compstatin: A Complement Inhibitor on its Way
to Clinical Application 273
Daniel Ricklin and John D. Lambris
1 Tackling Complement at its Core 273
2 Discovery and Initial Characterization 275
3 Tuning the Structure 278
4 Exploring the Binding Site and Mode 280
5 First Steps Towards Therapeutic Applications 283
6 From Bench to Bedside: Clinical Development 285
7 Conclusions and Perspectives 286
References 288
21. Derivatives of Human Complement Component C3 for
Therapeutic Complement Depletion: A Novel Class of
Therapeutic Agents 293
David C. Fritzinger, Brian E. Hew, June Q. Lee, James Newhouse,
Maqsudul Alam, John R. Ciallella, Mallory Bowers, William B. Gorsuch,
Benjamin J. Guikema, Gregory L. Stahl, and Carl-Wilhelm Vogel
1 Background and Concept 293
2 Development of C3 Derivatives for Therapeutic Complement Depletion 296
3 Discussion and Outlook 301
References 304
Index 309
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| genre | (DE-588)1071861417 Konferenzschrift 2007 Porto Heli gnd-content Congresses |
| genre_facet | Konferenzschrift 2007 Porto Heli Congresses |
| id | DE-604.BV035239921 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T21:29:21Z |
| institution | BVB |
| institution_GND | (DE-588)6522991-5 |
| isbn | 9780387789514 0387789510 9780387789521 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-017045733 |
| oclc_num | 494148788 |
| open_access_boolean | |
| owner | DE-12 DE-355 DE-BY-UBR |
| owner_facet | DE-12 DE-355 DE-BY-UBR |
| physical | XXX, 316 S. Ill., graph. Darst. 235 mm x 155 mm |
| publishDate | 2008 |
| publishDateSearch | 2008 |
| publishDateSort | 2008 |
| publisher | Springer |
| record_format | marc |
| series | Advances in experimental medicine and biology |
| series2 | Advances in experimental medicine and biology |
| spelling | Current topics in complement II [4th Aegean Conferences Workshop on Complement Associated Diseases, Animal Models, and Therapeutics (June 10 - 17, 2007) in Porto Heli, Greece] John D. Lambris, ed. New York, NY Springer 2008 XXX, 316 S. Ill., graph. Darst. 235 mm x 155 mm txt rdacontent n rdamedia nc rdacarrier Advances in experimental medicine and biology 632 Complement System Proteins immunology Protéines du système du complément - immunologie Complement (Immunology) Congresses Complement System Proteins immunology Congresses Komplement Immunologie (DE-588)4120589-3 gnd rswk-swf (DE-588)1071861417 Konferenzschrift 2007 Porto Heli gnd-content Congresses Komplement Immunologie (DE-588)4120589-3 s b DE-604 Lambris, John D. Sonstige oth Workshop on Complement Associated Diseases, Animal Models, and Therapeutics 4 2007 Porto Cheli Sonstige (DE-588)6522991-5 oth Advances in experimental medicine and biology 632 (DE-604)BV000003102 632 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017045733&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Current topics in complement II [4th Aegean Conferences Workshop on Complement Associated Diseases, Animal Models, and Therapeutics (June 10 - 17, 2007) in Porto Heli, Greece] Advances in experimental medicine and biology Complement System Proteins immunology Protéines du système du complément - immunologie Complement (Immunology) Congresses Complement System Proteins immunology Congresses Komplement Immunologie (DE-588)4120589-3 gnd |
| subject_GND | (DE-588)4120589-3 (DE-588)1071861417 |
| title | Current topics in complement II [4th Aegean Conferences Workshop on Complement Associated Diseases, Animal Models, and Therapeutics (June 10 - 17, 2007) in Porto Heli, Greece] |
| title_auth | Current topics in complement II [4th Aegean Conferences Workshop on Complement Associated Diseases, Animal Models, and Therapeutics (June 10 - 17, 2007) in Porto Heli, Greece] |
| title_exact_search | Current topics in complement II [4th Aegean Conferences Workshop on Complement Associated Diseases, Animal Models, and Therapeutics (June 10 - 17, 2007) in Porto Heli, Greece] |
| title_full | Current topics in complement II [4th Aegean Conferences Workshop on Complement Associated Diseases, Animal Models, and Therapeutics (June 10 - 17, 2007) in Porto Heli, Greece] John D. Lambris, ed. |
| title_fullStr | Current topics in complement II [4th Aegean Conferences Workshop on Complement Associated Diseases, Animal Models, and Therapeutics (June 10 - 17, 2007) in Porto Heli, Greece] John D. Lambris, ed. |
| title_full_unstemmed | Current topics in complement II [4th Aegean Conferences Workshop on Complement Associated Diseases, Animal Models, and Therapeutics (June 10 - 17, 2007) in Porto Heli, Greece] John D. Lambris, ed. |
| title_short | Current topics in complement II |
| title_sort | current topics in complement ii 4th aegean conferences workshop on complement associated diseases animal models and therapeutics june 10 17 2007 in porto heli greece |
| title_sub | [4th Aegean Conferences Workshop on Complement Associated Diseases, Animal Models, and Therapeutics (June 10 - 17, 2007) in Porto Heli, Greece] |
| topic | Complement System Proteins immunology Protéines du système du complément - immunologie Complement (Immunology) Congresses Complement System Proteins immunology Congresses Komplement Immunologie (DE-588)4120589-3 gnd |
| topic_facet | Complement System Proteins immunology Protéines du système du complément - immunologie Complement (Immunology) Congresses Complement System Proteins immunology Congresses Komplement Immunologie Konferenzschrift 2007 Porto Heli Congresses |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017045733&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000003102 |
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