Treatment of bone and soft tissue sarcomas:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Berlin [u.a.]
Springer
2009
|
| Schriftenreihe: | Recent results in cancer research
179 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXII, 361 S. zahlr. Ill., graph. Darst. |
| ISBN: | 9783540779599 |
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| 490 | 1 | |a Recent results in cancer research |v 179 | |
| 650 | 4 | |a Osteosarcoma / Treatment | |
| 650 | 4 | |a Soft tissue tumors / Treatment | |
| 650 | 4 | |a Osteosarcoma |x Treatment | |
| 650 | 4 | |a Soft tissue tumors |x Treatment | |
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Datensatz im Suchindex
| _version_ | 1804138489691766784 |
|---|---|
| adam_text | Part I Diagnostics
1 Biopsy of Bone and Soft Tissue Tumours:
Hints and Hazards 3
Andreas Lcithner, Werner Maurer-F.rtl, and Reinhard Windhager
1.1 Introduction 3
1.2 Diagnostic Algorithm 3
1.3 Biopsy 5
1.3.1 Biopsy Technique 6
1.4 Hints 7
1.5 Hazards 7
1.6 Definitive Diagnosis 9
References 10
2 The Role of Intra-operative Pathological Evaluation
in the Management of Musculoskeletal Tumours 11
Robert U. Ashford, Richard A. Scolyer, Stanley W. McCarthy,
S. Fiona Bonar, Rooshdiya Z. Karim, and Paul D. Stalley
2.1 Introduction: Indications for Intra-operative Pathological
Evaluation in Musculoskeletal Surgical Oncology I 1
2.2 Pathological Options for Intra-operative Evaluation 12
2.2.1 Frozen Section 12
2.2.2 Fine Needle Aspiration Cytology 14
2.2.3 Touch Imprint Cytology 16
2.3 Uses of Frozen Section in Musculoskeletal Tumours 16
2.3.1 Operative Core Biopsy of Presumed Sarcoma 17
2.3.2 Surgical Margin Biopsy Imprint 18
2.3.3 Confirmation of Diagnosis Prior to Definitive Treatment 19
2.3.4 Evaluation of Tumour Spread 20
2.3.5 Intramedullary Nailing of Presumed Metastasis 20
v
vi Contents
2.3.6 Frozen Section for Everyone? 20
2.3.7 Beware the Pitfalls of Frozen Section 20
2.4 Cost-Effectiveness 21
2.5 Discussion 22
References 23
3 Sentinel Node Biopsy in Soft Tissue Sarcoma 25
Dimosthenis Andreou and Per-Ulf Tunn
3.1 Introduction 25
3.2 Technique of Lymphatic Mapping and Sentinel Lymph
Node Biopsy 26
3.2.1 Preoperative Lymphoscintigraphy 26
3.2.2 Intraoperative Lymphatic Mapping 28
3.2.3 Histopathological Examination 30
3.3 Sentinel Node Biopsy in the Management of Soft
Tissue Sarcoma 31
3.3.1 Clear Cell Sarcoma 31
3.3.2 Synovial Sarcoma 31
3.3.3 Rhabdomyosarcoma 32
3.3.4 Epithelioid Sarcoma 32
3.4 Discussion 33
References 34
Part II Bone Sarcomas
4 Modular Endoprosthetic Reconstruction in Malignant
Bone Tumors: Indications and Limits 39
Maurice Balke, Helmut Ahrens, Arne Streitbiirger, Georg Gosheger,
and Jendrik Hardes
4.1 Introduction 39
4.2 Surgical Technique 40
4.3 Postoperative Management 42
4.4 Complications 42
4.5 Indications and Limits 44
4.5.1 Tumor Prostheses in Children 45
4.6 Functional Results 46
Summary 47
References 48
Contents vii
5 Allograft Reconstruction in Malignant Bone Tumors:
Indications and Limits 51
Kevin A. Raskin and Francis Hornicek
5.1 Introduction 51
5.1.1 Biology 52
5.2 Indications and Types 52
5.2.1 Intercalary Allografts 52
5.2.2 Ostcoarticular Allografts 53
5.2.3 Allograft Arthrodesis 53
5.2.4 Allograft-Prosthetic Composites 55
5.3 Limits 55
Summary 57
References 57
6 Expandable Endoprostheses in Malignant Bone Tumors in Children:
Indications and Limitations 59
Rainer Baumgart and Ulrieh Lenze
6.1 Introduction 59
6.2 Principles of Expandable Tumor Hndoprosthesis 60
6.3 The Expandable Tumor Endoprosthesis MUTARS Xpand 61
6.4 The Bioexpandable Tumor Endoprosthesis MUTARS
Bio-Xpand 62
6.5 Indications 64
6.5.1 Step 1 64
6.5.2 Step 2 64
6.6 Limitations 65
6.7 Clinical Cases 66
6.8 Conclusion 6S
References 72
7 The Long-Term Risks of Infection and Amputation
with Limb Salvage Surgery Using Endoprostheses 75
Lee Jeys and Robert Grimer
7.1 Introduction 75
7.2 Long-Term Limb Salvage 76
7.3 Infection and Lndoprostheses 77
7.4 New Techniques to Combat Infection SI
7.4.1 Surface Treatments XI
7.4.2 Antibiotic Prophylaxis S2
7.5 Conclusions S2
References X2
viii Contents
8 Reconstruction of the Pelvis After Resection of Malignant
Bone Tumours in Children and Adolescents 85
Martin Dominkus, Eslam Darwish, and Philipp Funovics
8.1 Introduction 85
8.2 Diagnosis 86
8.3 Biopsy 86
8.4 Preoperative Staging and Therapy 86
8.5 Resection Type I: Os Ilium 88
8.5.1 Partial Resection of the Ilium Without Discontinuity
of the Pelvic Ring 88
8.5.2 Complete Resection of the Os Ilium with Discontinuity
of the Pelvic Ring 88
8.6 Resection Type II: Acetabulum 89
8.6.1 Biological Reconstruction Methods 92
8.6.2 Endoprosthetic Reconstruction Methods 96
8.7 Resection Type III +/- IV 101
8.7.1 Allograft 101
8.7.2 Autograft 102
8.7.3 Flail Hip 102
8.7.4 Hip Transpositionplasty 102
8.8 Resection Type III 103
8.9 Resection Type II, III 104
8.10 Resection Type I-III/IV 104
8.10.1 Flail Hip: No Reconstruction 105
8.10.2 Hemipelvis Allograft 106
8.11 Future Aspects 108
Summary 108
References 109
9 Methods of Biological Reconstruction for Bone Sarcoma:
Indications and Limits 113
Pierre Kunz and Ludger Bernd
9.1 Introduction 113
9.2 Biological Reconstruction Procedures and Outcome 114
9.2.1 Transplantation of Vital Autografts 114
9.2.2 Implantation of Avital Bone: Extracorporeal Devitalized
Autografts 119
9.2.3 De Novo Bone Formation: Distraction Osteogenesis 123
9.3 Discussion 127
9.3.1 Vital Bone Grafts: Vascularization 128
9.3.2 Biomechanical Aspects in Free Bone Grafts: Union,
Hypertrophy, Fracture 130
9.3.3 Complications and Functional Outcome in Vital Grafts 131
9.3.4 Extracorporeal Devitalized Grafts 131
Contents ix
9.3.5 Distraction Osteogenesis 132
9.3.6 Indications and Limitations 133
9.4 Conclusion 134
References 135
10 Bone Sarcoma of the Spine 141
Klaus-Dieter Schaser, 1. Melcher, A. Luzzati,
and A. C. Disch
10.1 Introduction and Epidemiology 141
10.2 Clinical Presentation 142
10.3 Diagnostics and Radiographic Imaging 143
10.4 Role and Technique of Biopsy 143
10.5 Oncosurgical Staging Systems of Primary Vertebral Tumors 144
10.6 Surgical Approaches 146
10.6.1 Posterior/Posterolateral Approach 146
10.6.2 Anterior Approaches 146
10.7 Surgical Strategies, Patient Selection, Treatment Decisions
and Surgical Techniques 149
10.8 Surgical Technique of En Bloc Spondyleetomy/Total
En Bloc Vertebrectomy 150
10.8.1 Resection Technique 151
10.8.2 Technique: Spinal Reconstruction 152
10.9 Current Management of Individual Primary Malignant
Vertebral Column Tumors 152
10.9.1 Osteosarcoma 152
10.9.2 Ewing Sarcoma 155
10.9.3 Chondrosarcoma 158
10.9.4 Chordoma 158
10.10 Nonsurgical Treatment Options 159
10.10.1 Radiation 159
10.10.2 Chemotherapy 161
10.10.3 Embolization 161
10.10.4 Pain Management 161
10.11 Complications 161
10.12 Prognosis 162
References 162
11 Computer-Assisted Pelvic Tumor Resection: Fields of Application.
Limits, and Perspectives 169
Sebastian Fehlberg. Sebastian Eulenstein, Thomas Lange.
Dimosthenis Andreou, and Per-Ulf Tunn
11.1 Introduction 169
11.2 Navigation Procedures 1 71
11.2.1 Preoperative Imaging and Segmentation 171
x Contents
11.2.2 Tracking Systems 172
11.2.3 Intraoperative Patient-to-image Registration 173
11.2.4 Intraoperative Visualization 176
11.3 Fields of Application 176
11.4 Clinical Results 178
11.5 Limits and Perspectives 179
Summary 180
References 180
12 Pulmonary Metastasectomy for Osteosarcoma: Is It Justified? 183
Klaus-Dieter Diemel, Heinz-Jiirgen Klippe, and Detlev Branscheid
12.1 History of Osteosarcoma and Pulmonary Metastasectomy 183
12.2 Thoracic Surgery Becomes Important Part of Interdisciplinary
Concepts 185
12.2.1 From Single-Centre Experience to Large Databases 187
12.3 Evaluating the Patient with Pulmonary Metastases 187
12.3.1 Computed Tomography of the Lung 188
12.3.2 SPECT and PET Scans 188
12.4 Prognostic Factors and Their Impact for Pulmonary
Metastasectomy 189
12.4.1 Factors Correlating to Modalities and Therapies
of the Primary Tumour 189
12.4.2 Factors Concerning the Time of Presentation of Metastases 190
12.4.3 Factors Concerning Properties of Metastases
and Surgical Remission 190
12.5 Techniques in Pulmonary Metastasectomy 190
12.5.1 Operative Approach to the Metastatic Lung 190
12.5.2 Techniques in Pulmonary Resection 193
12.6 Our Own Results 196
12.7 Discussion 200
12.7.1 The Reviewed Studies 200
12.7.2 Risk Factors Affecting Survival After Pulmonary
Metastasectomy 202
12.7.3 Surgical Approach for Pulmonary Metastasectomy 203
12.7.4 A Place for Minimally Invasive Surgery (VATS)? 204
12.8 Conclusions 204
References 205
Contents xi
Part III Soft Tissue Sarcomas
13 Standardized Approach to the Treatment
ofAdult Soft Tissue Sarcoma of the Extremities 211
Per-Ulf Turin, Christoph Kettelhack, and Hans Roland Diirr
Abbreviations 21 1
13.1 Introduction 212
13.2 Biopsy Techniques 212
13.3 Surgical Therapy in Soft Tissue Sarcoma: General Principles 213
13.3.1 The Influence of Surgical Margins 215
13.3.2 The Influence of an Unplanned Excision 216
13.3.3 The Influence of Local Recurrence 218
13.4 Neoadjuvant and Adjuvant Treatment Modalities
in Soft Tissue Sarcoma 218
13.4.1 The Role of Systemic Chemotherapy 219
13.4.2 The Role of Isolated Limb Perfusion 220
13.4.3 The Role of Radiotherapy 220
13.4.4 Response Assessment After Neoadjuvant Treatment
in Soft Tissue Sarcoma 222
Summary 224
References 224
14 Evaluating Surgery Quality in Soft Tissue Sarcoma 229
Eberhard Stoeckle, Jean-Michel Coindre, Michele Kind,
Guy (Cantor, and Binh N. Bui
14.1 Introduction 229
14.2 What End-Points for Assessing Local Tumour Control? 230
14.3 Local Recurrence Rates 231
14.4 Margins and Their Impact on Local Control 232
14.4.1 Margin Determination and Local Outcome 232
14.4.2 Co-factors Influencing Margin Quality 235
14.4.3 Impact of Margin and Other Factors on Local Recurrence 237
14.5 Long-Term Follow-Up with Actuarial Estimates
in Homogeneous Patient Groups 238
14.6 Recapitulation: Criteria for Evaluating Surgery Quality with STS 238
References 238
15 Peripheral Nerve Considerations in the Management
of Extremity Soft Tissue Sarcomas 243
Peter C. Ferguson. Anna A. Kulidjian. Kevin B. Jones.
Benjamin M. Deheshi. and Jay S. Wunder
15.1 Introduction 243
15.2 Diagnosis of Peripheral Nerve Involvement 244
xii Contents
15.2.1 History and Physical Examination 244
15.2.2 Imaging 245
15.2.3 Other Diagnostic Considerations 246
15.3 Management of Peripheral Nerve Involvement 246
15.3.1 General Approach 246
15.3.2 Epineural Dissection 246
15.3.3 Nerve Resection Without Reconstruction 249
15.3.4 Nerve Resection and Reconstruction 252
15.3.5 Distal Functional Restoration: Tendon Transfers 253
15.3.6 Distal Functional Restoration: Distal Nerve Transfers 254
15.3.7 Amputation 254
15.4 Conclusions 255
References 255
16 Isolated Limb Perfusion with TNF-oc and Melphalan
in Locally Advanced Soft Tissue Sarcomas of the Extremities 257
Dirk J. Grunhagen, Johannes H.W. de Wilt, Albertus N. Van Geel,
Cornelis Verhoef, and Alexander M.M. Eggermont
16.1 Introduction 257
16.2 Isolated Limb Perfusion 258
16.3 The Rationale for Using Tumour Necrosis Factor-a in ILP 259
16.4 TNF-Based Isolated Limb Perfusion for STS 261
16.5 Results with TNFPlus Doxorubicin 262
16.6 Toxicityofa TNF-Based ILP 262
16.7 Special Patient Categories 265
16.7.1 Patients with Overt Metastatic Disease 265
16.7.2 Patients with Multiple Tumours in the Extremity 265
16.7.3 Patients with Recurrent Tumours in an Irradiated Field 265
16.7.4 Elderly Patients ( 75 Years Old) 265
16.7.5 TNF-Based ILP Activity in Other Histologies 265
16.8 Future Perspectives 266
16.9 Conclusions 266
References 266
17 Management of Locally Recurrent Soft Tissue Sarcoma
after Prior Surgery and Radiation Therapy 271
Peter Hohenberger and Matthias H.M. Schwarzbach
17.1 Introduction 271
17.2 Treatment Options 272
17.3 Problems for Surgery Encountered with Previous Radiotherapy 273
17.4 Practical Management of In-Field Sarcoma Recurrence 275
17.5 Treatment Decisions in Surgical Re-intervention 276
17.6 Indication for Multimodal Re-treatment 277
17.7 Conclusion 281
References 281
Contents xiii
18 Management of Vascular Involvement
in Extremity Soft Tissue Sarcoma 285
Ashish Mahendra, Yair Gortzak, Peter C. Ferguson,
Benjamin M. Deheshi, Thomas F. Lindsay, and Jay S. Wunder
18.1 Introduction 285
18.2 Indications for Vascular Resection and Reconstruction
in Extremity Soft Tissue Sarcoma 286
18.3 Patient Workup 287
18.4 Surgical and Functional Outcome 289
18.4.1 Amputation Risk 290
18.4.2 Use of Muscle Flaps 290
18.4.3 Wound Complications 290
18.4.4 Postoperative Limb Edema and DVT 290
18.4.5 Risk of Local Recurrence 291
18.4.6 Risk of Systemic Disease 291
18.4.7 Functional Outcome 291
18.5 Vascular Outcome 293
18.5.1 Arterial Reconstruction 293
18.5.2 Venous Reconstruction 293
18.5.3 Type of Vascular Graft 294
18.6 Effects of Radiotherapy 296
Summary 298
References 298
19 Current Concepts in the Management of Retroperitoneal
Soft Tissue Sarcoma 301
Matthias H.M. Schwarzbach and Peter Hohenberger
19.1 Introduction 301
19.2 Definitions Referring to Retroperitoneal Sarcomas 302
19.3 Diagnostic Requirements in Retroperitoneal Sarcomas 302
19.4 Vascular Involvement 303
19.5 Surgical Therapy in Localized Soft Tissue Sarcomas
of the Retroperitoncum 305
19.6 Surgical Therapy in Metastasi/ed Soft Tissue Sarcomas
of the Retroperitoneum 314
19.7 Prognosis 315
19.8 Chemotherapy and Radiation Therapy 315
Summary 317
References 317
xiv Contents
20 Pulmonary Metastasectomy for Soft Tissue Sarcomas: Is It Justified? 321
Joachim Pfannschmidt, Hans Hoffmann, Thomas Schneider,
and Hendrik Dienemann
20.1 Introduction 321
20.2 Clinical Features 323
20.3 Radiology 323
20.4 Patient Selection 324
20.5 Surgery 325
20.6 Video-Assisted Thoracic Surgery 326
20.7 Prognostic Factors 327
20.7.1 Overall Survival 327
20.7.2 Recurrent Pulmonary Metastases 331
20.7.3 Perioperative Chemotherapy 331
20.8 Future Directions 332
20.9 Conclusions 333
References 333
Part IV Quality of Life Assessment
21 Quality of Life (QOL) in Patients with Osteosarcoma 339
Rajaram Nagarajan
21.1 Osteosarcoma 339
21.2 Treatment and Survival 340
21.3 Quality of Life 340
21.4 Outcomes Model 341
References 343
22 Clinical Trials in Osteosarcoma Treatment:
Patients Perspective Through Art 345
Lizzie Burns and Martha Perisoglou
22.! Introduction 345
22.2 Patients with Osteosarcoma and the EURAMOS 1 Clinical Trial 346
22.3 Bringing Medicine to Life 346
22.4 The Patients Perspective 347
22.4.1 Syed 347
22.4.2 Omar 350
22.4.3 Shane 350
22.4.4 Laura 351
22.4.5 Meg 352
22.4.6 Simon 353
Contents xv
22.4.7 Bhavin 355
22.4.8 Sam 357
22.4.9 Charlie 357
22.5 Art and Cancer 359
22.6 Conclusion 360
Acknowledgements 360
References 360
|
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV035224786 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T21:29:00Z |
| institution | BVB |
| isbn | 9783540779599 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-017030822 |
| oclc_num | 227917040 |
| open_access_boolean | |
| owner | DE-29 DE-19 DE-BY-UBM DE-12 |
| owner_facet | DE-29 DE-19 DE-BY-UBM DE-12 |
| physical | XXII, 361 S. zahlr. Ill., graph. Darst. |
| publishDate | 2009 |
| publishDateSearch | 2009 |
| publishDateSort | 2009 |
| publisher | Springer |
| record_format | marc |
| series | Recent results in cancer research |
| series2 | Recent results in cancer research |
| spelling | Treatment of bone and soft tissue sarcomas Per-Ulf Tunn (ed.) Berlin [u.a.] Springer 2009 XXII, 361 S. zahlr. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Recent results in cancer research 179 Osteosarcoma / Treatment Soft tissue tumors / Treatment Osteosarcoma Treatment Soft tissue tumors Treatment Osteosarkom (DE-588)4172929-8 gnd rswk-swf Therapie (DE-588)4059798-2 gnd rswk-swf Weichteilsarkom (DE-588)4189415-7 gnd rswk-swf Knochenkrebs (DE-588)4031331-1 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Osteosarkom (DE-588)4172929-8 s Therapie (DE-588)4059798-2 s DE-604 Weichteilsarkom (DE-588)4189415-7 s Knochenkrebs (DE-588)4031331-1 s 1\p DE-604 Tunn, Per-Ulf Sonstige oth Erscheint auch als Online-Ausgabe 978-3-540-77960-5 Recent results in cancer research 179 (DE-604)BV000000043 179 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017030822&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Treatment of bone and soft tissue sarcomas Recent results in cancer research Osteosarcoma / Treatment Soft tissue tumors / Treatment Osteosarcoma Treatment Soft tissue tumors Treatment Osteosarkom (DE-588)4172929-8 gnd Therapie (DE-588)4059798-2 gnd Weichteilsarkom (DE-588)4189415-7 gnd Knochenkrebs (DE-588)4031331-1 gnd |
| subject_GND | (DE-588)4172929-8 (DE-588)4059798-2 (DE-588)4189415-7 (DE-588)4031331-1 (DE-588)4143413-4 |
| title | Treatment of bone and soft tissue sarcomas |
| title_auth | Treatment of bone and soft tissue sarcomas |
| title_exact_search | Treatment of bone and soft tissue sarcomas |
| title_full | Treatment of bone and soft tissue sarcomas Per-Ulf Tunn (ed.) |
| title_fullStr | Treatment of bone and soft tissue sarcomas Per-Ulf Tunn (ed.) |
| title_full_unstemmed | Treatment of bone and soft tissue sarcomas Per-Ulf Tunn (ed.) |
| title_short | Treatment of bone and soft tissue sarcomas |
| title_sort | treatment of bone and soft tissue sarcomas |
| topic | Osteosarcoma / Treatment Soft tissue tumors / Treatment Osteosarcoma Treatment Soft tissue tumors Treatment Osteosarkom (DE-588)4172929-8 gnd Therapie (DE-588)4059798-2 gnd Weichteilsarkom (DE-588)4189415-7 gnd Knochenkrebs (DE-588)4031331-1 gnd |
| topic_facet | Osteosarcoma / Treatment Soft tissue tumors / Treatment Osteosarcoma Treatment Soft tissue tumors Treatment Osteosarkom Therapie Weichteilsarkom Knochenkrebs Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017030822&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000000043 |
| work_keys_str_mv | AT tunnperulf treatmentofboneandsofttissuesarcomas |