Role of the autonomic renal innervation in experimental glomerulonephritis: = Bedeutung der autonomen renalen Innervation für Entzündungsvorgänge bei experimentellen Nephritiden
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2008
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| Schlagworte: | |
| Online-Zugang: | Volltext https://nbn-resolving.org/urn:nbn:de:bvb:29-opus-12165 http://d-nb.info/991986571/34 Inhaltsverzeichnis |
| Beschreibung: | III, 92 S. Ill., graph. Darst |
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Datensatz im Suchindex
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|---|---|
| adam_text | Titel: Role of the autonomic renal innervation in experimental glomerulonephritis
Autor: Vogel, Eva-Maria
Jahr: 2008
CONTENTS
Publication List 1
Abbreviations.... 2
1 Introduction 4
1.1 The Kidney 4
1.2 MesangioproliferativeGlomerulonephritis 5
1.3 Animal model of mesangioproliferative glomerulonephritis (the anti-
Thy-1.1 model) . 7
1.4 Immune cells in glomerulonephritis 9
1.5 Innervation of the kidney 10
1.6 Neuroimmunomodulation 12
1.6.1 The neuropeptide Substance P 15
1.6.2 The neuropeptide Calcitonin Gene-related peptide 16
1.7 Aim of the study 19
2 Materials and Methods 21
2.1 Animals 21
2.2 Animal treatment 21
2.2.1 Rat model of Anti-Thy-1.1 Nephritis 21
2.3 Renal denervation 21
2.3.1 Depletion of primary sensory neurons 22
2.3.2 Administration of antagonists 22
2.3.3 Blood pressure measurements 23
2.3.4 Sampling of material 23
Contents S •
2.4 Mesangial cell culture 23
2.5 Determination of urinary albumin excretion by ELISA 24
2.6 Determination of urinary protein excretion 24
2.7 CGRP Immunoassay 24
2.8 lmmunohistochernistry 25
2.9 Kidney histology 26
2.10 Immunocytochemistry 2
2.10.1 NK-1Rimmunoreactivity 26
2.10.2 CRLR immunoreactivity 27
2.11 Isolation of lymphocytes from kidneys
2.12 Flow-cytometric analysis 2°
2.13 Real Time RT-PCR 28
2.14 Sequence analysis *)
2.15 Western blot analysis 30
2.16 Statistical analysis 31
3 Results 32
3.1 Autonomic renal denervation ameliorate glomerulonephritis 32
3.2 Influence of primary sensory neurons on anti-Thy-1.1 nephritis 37
3.3 CGRP Receptor blockade influenced anti-Thy-1.1 nephritis 40
3.3.1 CGRP Receptor expression in the kidney 40
3.3.2 CGRP Receptor expression in anti-Thy-1.1 Nephritis 43
3.3.3 Blockade of CGRP receptor **
3.4 Blockade of NK-1R ameliorates glomerulonephritis 48
3.4.1 Neurokinin-1 Receptor Expression in the kidney 48
3.4.2 Neurokinin-1 receptor Expression in anti-Thy-1.1 Nephritis 50
3.4.3 Blockade of NK-1R ameliorates glomerulonephritis 53
Contents in
4 Discussion , 59
4.1 Protective role of the autonomic nervous system in glomerulonephritis 59
4.2 Depletion of primary sensory neurons influenced renal inflammation 61
4.3 CGRP in anti-Thy-1.1 nephritis - differential effects 62
4.4 Blockade of NK-1R ameliorates kidney inflammation during
glomerulonephritis 65
4.5 Perspective 67
5 Summary 68
6 References 70
7 Deutschsprachige Zusammenfassung 87
8 Danksagung .90
9 Lebenslauf 92
|
| any_adam_object | 1 |
| author | Vogel, Eva-Maria 1980- |
| author_GND | (DE-588)136969283 |
| author_facet | Vogel, Eva-Maria 1980- |
| author_role | aut |
| author_sort | Vogel, Eva-Maria 1980- |
| author_variant | e m v emv |
| building | Verbundindex |
| bvnumber | BV035223567 |
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| dewey-full | 616.6 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.6 |
| dewey-search | 616.6 |
| dewey-sort | 3616.6 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Thesis Book |
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| language | English |
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| spelling | Vogel, Eva-Maria 1980- Verfasser (DE-588)136969283 aut Role of the autonomic renal innervation in experimental glomerulonephritis = Bedeutung der autonomen renalen Innervation für Entzündungsvorgänge bei experimentellen Nephritiden von Eva-Maria Vogel Bedeutung der autonomen renalen Innervation für Entzündungsvorgänge bei experimentellen Nephritiden 2008 III, 92 S. Ill., graph. Darst txt rdacontent n rdamedia nc rdacarrier Erlangen-Nürnberg, Univ., Diss., 2008 Langzeitarchivierung Nationalbibliothek gewährleistet Immunsystem (DE-588)4026643-6 gnd rswk-swf Innervation (DE-588)4128876-2 gnd rswk-swf Niere (DE-588)4042270-7 gnd rswk-swf Wechselwirkung (DE-588)4064937-4 gnd rswk-swf Entzündung (DE-588)4014975-4 gnd rswk-swf Vegetatives Nervensystem (DE-588)4062444-4 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Niere (DE-588)4042270-7 s Entzündung (DE-588)4014975-4 s DE-604 Innervation (DE-588)4128876-2 s Vegetatives Nervensystem (DE-588)4062444-4 s Immunsystem (DE-588)4026643-6 s Wechselwirkung (DE-588)4064937-4 s Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:29-opus-12165 https://open.fau.de/handle/openfau/766 Verlag kostenfrei Volltext https://nbn-resolving.org/urn:nbn:de:bvb:29-opus-12165 Resolvingsystem http://d-nb.info/991986571/34 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017029618&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Vogel, Eva-Maria 1980- Role of the autonomic renal innervation in experimental glomerulonephritis = Bedeutung der autonomen renalen Innervation für Entzündungsvorgänge bei experimentellen Nephritiden Immunsystem (DE-588)4026643-6 gnd Innervation (DE-588)4128876-2 gnd Niere (DE-588)4042270-7 gnd Wechselwirkung (DE-588)4064937-4 gnd Entzündung (DE-588)4014975-4 gnd Vegetatives Nervensystem (DE-588)4062444-4 gnd |
| subject_GND | (DE-588)4026643-6 (DE-588)4128876-2 (DE-588)4042270-7 (DE-588)4064937-4 (DE-588)4014975-4 (DE-588)4062444-4 (DE-588)4113937-9 |
| title | Role of the autonomic renal innervation in experimental glomerulonephritis = Bedeutung der autonomen renalen Innervation für Entzündungsvorgänge bei experimentellen Nephritiden |
| title_alt | Bedeutung der autonomen renalen Innervation für Entzündungsvorgänge bei experimentellen Nephritiden |
| title_auth | Role of the autonomic renal innervation in experimental glomerulonephritis = Bedeutung der autonomen renalen Innervation für Entzündungsvorgänge bei experimentellen Nephritiden |
| title_exact_search | Role of the autonomic renal innervation in experimental glomerulonephritis = Bedeutung der autonomen renalen Innervation für Entzündungsvorgänge bei experimentellen Nephritiden |
| title_full | Role of the autonomic renal innervation in experimental glomerulonephritis = Bedeutung der autonomen renalen Innervation für Entzündungsvorgänge bei experimentellen Nephritiden von Eva-Maria Vogel |
| title_fullStr | Role of the autonomic renal innervation in experimental glomerulonephritis = Bedeutung der autonomen renalen Innervation für Entzündungsvorgänge bei experimentellen Nephritiden von Eva-Maria Vogel |
| title_full_unstemmed | Role of the autonomic renal innervation in experimental glomerulonephritis = Bedeutung der autonomen renalen Innervation für Entzündungsvorgänge bei experimentellen Nephritiden von Eva-Maria Vogel |
| title_short | Role of the autonomic renal innervation in experimental glomerulonephritis |
| title_sort | role of the autonomic renal innervation in experimental glomerulonephritis bedeutung der autonomen renalen innervation fur entzundungsvorgange bei experimentellen nephritiden |
| title_sub | = Bedeutung der autonomen renalen Innervation für Entzündungsvorgänge bei experimentellen Nephritiden |
| topic | Immunsystem (DE-588)4026643-6 gnd Innervation (DE-588)4128876-2 gnd Niere (DE-588)4042270-7 gnd Wechselwirkung (DE-588)4064937-4 gnd Entzündung (DE-588)4014975-4 gnd Vegetatives Nervensystem (DE-588)4062444-4 gnd |
| topic_facet | Immunsystem Innervation Niere Wechselwirkung Entzündung Vegetatives Nervensystem Hochschulschrift |
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