The eye's aqueous humor:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
Elsevier, Acad. Press
2008
|
| Ausgabe: | ed. 2 |
| Schriftenreihe: | Current topics in membranes
62 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XX, 483 S., [8] Bl. Ill., graph. Darst. |
| ISBN: | 9780123738943 |
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| 245 | 1 | 0 | |a The eye's aqueous humor |c ed. by Mortimer M. Civan |
| 250 | |a ed. 2 | ||
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| 300 | |a XX, 483 S., [8] Bl. |b Ill., graph. Darst. | ||
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Datensatz im Suchindex
| _version_ | 1804138371283419136 |
|---|---|
| adam_text | Contents
Contributors
xiii
Preface
xv
Previous Volumes in Series
xvii
CHAPTER
1
Formation of the Aqueous Humor: Transport
Components and Their Integration
Mortimer M. Civan
I. Overview
2
II. Introduction
2
III. Structure of Ciliary Epithelium
6
IV. Unidirectional Secretion of Aqueous Humor
(
V. Potential Unidirectional
Reabsorption
of
Aqueous Humor
18
VI. Regulation of Net Aqueous
Humor Secretion
19
VII.
Summary of Current Views, Recent Advances,
and Future Directions
30
References
33
CHAPTER
2
Ocular Aquaporins and Aqueous Humor Dynamics
W. Daniel Stamer, Nicholas W. Baetz, and Andrea J. Yool
I. Overview
47
II. Introduction
48
III. Aquaporins: Discovery, Structure, and Func¬
tion
48
IV. Ocular Distribution of Aquaporins
50
V. Aquaporins and Aqueous Humor Dynamics
54
VI. Ion Channel Activity of AQP1
60
VII. Aquaporin
and Ion Channel Interactions
61
VIII.
Future Directions
64
References
65
УІІ
VUl
Contents
CHAPTER
3
The Role of Gap Junction Channels in the Ciliary
Body Secretory Epithelium
Richard T.
Mathias,
Thomas W. White, and Peter R. Brink
I. Overview
71
II. Introduction
72
III. General Properties of Connexins Including Those
Composing the Ciliary Body Epithelium
Gap Junctions
75
IV. Modeling of Fluid Transport by the Ciliary
Epithelium
79
V. Animal Models Support a Role for Gap
Junctions in Fluid Transport by Ocular
Epithelia
92
References
93
CHAPTER
4
Regional Dependence of Inflow: Lessons from
Electron Probe X-ray Microanalysis
Anthony D. C. Macknight and Mortimer M. Civan
I. Overview
98
II. Introduction
98
III. Review of Electron-probe X-ray
Microanalysis
99
IV. Total Inflow
103
V. Topography of Inflow
110
VI. A
New Model for Aqueous Humor
Production
114
VII.
Effect of Timolol on Inflow
117
VIII.
Future Directions
119
References
119
CHAPTER
5
Functional Modulators Linking Inflow with
Outflow of Aqueous Humor
Miguel Coca-Prados
and Sikha Ghosh
I. Overview
123
II. Introduction
124
III. Sources of Neuropeptides and
Peptide
Hormones
in the AqH
125
IV. Neuroendocrine Characteristics of the
Biiayered
CE
128
V. Neuroendocrine Phenotype of the TM
137
Contents
VI.
Regulation
of
Neuroendocrine
Signals: The
Potential Role of Neutral Endopeptidase
24.11
(Neprelysin)
138
VII.
Neuroendocrine
Signaling in the
CE
and TM
140
VIII.
Putative Glutamatergic System in the
Inflow-Outflow Axis:
Glutamate
as a
Functional Endocrine/Paracrine Signal
Between
CE
and TM Cells
141
IX. Implications of
a Neuroendocrine
Signaling in
the Anterior Segment of the Eye
X. Summary
150
References
151
145
CHAPTER
6
Aqueous Humor Outflow Resistance
Thomas F.
Freddo
and Mark Johnson
I. Overview
161
II. Introduction
162
III. The Aqueous Humor
165
IV. Regions of Low Outflow Resistance
165
V. Regions of Potential Significant Outflow
Resistance
171
VI. Endothelial Lining of
Schlemm s
Canal
178
VII.
Summary
186
References
186
CHAPTER
7
Aqueous Humor Dynamics
ł
Carol
В.
Toris
I. Overview
193
II. Components of Aqueous Humor Dynamics
and Measurement Techniques
194
III. Aqueous Humor Dynamics in Research
Animals
218
IV. Summary
222
References
222
CHAPTER
8
Aqueous Humor Dynamics
ÍÍ
Carol B. Tons and Carl B. Camras
I. Overview
232
II. Introduction
232
Contents
III.
Normal
Values
of Aqueous Humor Dynamics
in Humans
233
IV. Clinical Syndromes
237
V. Drugs Affecting Aqueous Humor Dynamics
246
VI. Summary
259
References
259
CHAPTER
9
Effects of Circulatory Events on Aqueous
Humor Inflow and Intraocular Pressure
Herbert A. Reitsamer and Jeffrey W. Kiel
I. Overview
273
II. Introduction
274
III. lop Effects on Ocular Blood Flow
274
IV. Ocular Blood Flow Effects on IOP
275
V. Ciliary Blood Flow and Aqueous Production
281
VI. Episcleral Venous Pressure and IOP
295
VII.
Conclusion
296
References
297
CHAPTER
10
Retinal Ganglion Cells and Glaucoma: Traditional
Patterns and New Possibilities
Claire H. Mitchell and Wennan
Lu
I. Overview
301
II. Introduction
302
III. Influences on Glaucomatous Damage to Ganglion
Cells
303
IV. Mechanisms of Ganglion Cell Death
307
V. Conclusion
315
References
316
CHAPTER
11
What is Functional Genomics Teaching us about
Intraocular Pressure Regulation and Glaucoma
Teresa
Borras
I. Overview
324
II. Introduction
324
III. Functional Genomics: Microarrays, Proteomics
and Protein Modification
326
IV. Tissues Involved in the Development of
Glaucoma. Survey of Microarray Studies
329
Contents
V. The Trabecular Meshwork Tissue: Expressed
Genes (CDNA) and Proteins Obtained by
Direct Sequencing and Mass Spectrometry
335
VI. The Trabecular Meshwork Tissue: In Search of
Genes Responding to Glaucomatous Insults
348
VII.
Proposed Molecular Signature of Human
Glaucoma
361
References
365
CHAPTER
12
Molecular Approaches to Glaucoma:
Intriguing Clues for Pathology
Ernst R. Tamm
I. Overview
379
II. Transforming Growth Factor-B
380
III. Thrombospondin-l
383
IV. Connective Tissue Growth Factor
384
V. Bone Morphogenetic Protein-7
388
VI. Myocilin
389
VII. Optineurin
403
VIII.
WD Repeat Domain
36 410
IX. Conclusion
411
References
411
CHAPTER
13
Outflow Signaling Mechanisms and New
Therapeutic Strategies for the Control of
Intraocular Pressure
lok
-Нои
Pang and Abbot F. Clark
I. Overview
428
II. Introduction
428
III. New Approaches for IOP Lowering
439
IV. Future Therapeutic Opportunities
455
References
457
Index
471
|
| adam_txt |
Contents
Contributors
xiii
Preface
xv
Previous Volumes in Series
xvii
CHAPTER
1
Formation of the Aqueous Humor: Transport
Components and Their Integration
Mortimer M. Civan
I. Overview
2
II. Introduction
2
III. Structure of Ciliary Epithelium
6
IV. Unidirectional Secretion of Aqueous Humor
(
V. Potential Unidirectional
Reabsorption
of
Aqueous Humor
18
VI. Regulation of Net Aqueous
Humor Secretion
19
VII.
Summary of Current Views, Recent Advances,
and Future Directions
30
References
33
CHAPTER
2
Ocular Aquaporins and Aqueous Humor Dynamics
W. Daniel Stamer, Nicholas W. Baetz, and Andrea J. Yool
I. Overview
47
II. Introduction
48
III. Aquaporins: Discovery, Structure, and Func¬
tion
48
IV. Ocular Distribution of Aquaporins
50
V. Aquaporins and Aqueous Humor Dynamics
54
VI. Ion Channel Activity of AQP1
60
VII. Aquaporin
and Ion Channel Interactions
61
VIII.
Future Directions
64
References
65
УІІ
VUl
Contents
CHAPTER
3
The Role of Gap Junction Channels in the Ciliary
Body Secretory Epithelium
Richard T.
Mathias,
Thomas W. White, and Peter R. Brink
I. Overview
71
II. Introduction
72
III. General Properties of Connexins Including Those
Composing the Ciliary Body Epithelium
Gap Junctions
75
IV. Modeling of Fluid Transport by the Ciliary
Epithelium
79
V. Animal Models Support a Role for Gap
Junctions in Fluid Transport by Ocular
Epithelia
92
References
93
CHAPTER
4
Regional Dependence of Inflow: Lessons from
Electron Probe X-ray Microanalysis
Anthony D. C. Macknight and Mortimer M. Civan
I. Overview
98
II. Introduction
98
III. Review of Electron-probe X-ray
Microanalysis
99
IV. Total Inflow
103
V. Topography of Inflow
110
VI. A
New Model for Aqueous Humor
Production
114
VII.
Effect of Timolol on Inflow
117
VIII.
Future Directions
119
References
119
CHAPTER
5
Functional Modulators Linking Inflow with
Outflow of Aqueous Humor
Miguel Coca-Prados
and Sikha Ghosh
I. Overview
123
II. Introduction
124
III. Sources of Neuropeptides and
Peptide
Hormones
in the AqH
125
IV. Neuroendocrine Characteristics of the
Biiayered
CE
128
V. Neuroendocrine Phenotype of the TM
137
Contents
VI.
Regulation
of
Neuroendocrine
Signals: The
Potential Role of Neutral Endopeptidase
24.11
(Neprelysin)
138
VII.
Neuroendocrine
Signaling in the
CE
and TM
140
VIII.
Putative Glutamatergic System in the
Inflow-Outflow Axis:
Glutamate
as a
Functional Endocrine/Paracrine Signal
Between
CE
and TM Cells
141
IX. Implications of
a Neuroendocrine
Signaling in
the Anterior Segment of the Eye
X. Summary
150
References
151
145
CHAPTER
6
Aqueous Humor Outflow Resistance
Thomas F.
Freddo
and Mark Johnson
I. Overview
161
II. Introduction
162
III. The Aqueous Humor
165
IV. Regions of Low Outflow Resistance
165
V. Regions of Potential Significant Outflow
Resistance
171
VI. Endothelial Lining of
Schlemm 's
Canal
178
VII.
Summary
186
References
186
CHAPTER
7
Aqueous Humor Dynamics
ł
Carol
В.
Toris
I. Overview
193
II. Components of Aqueous Humor Dynamics
and Measurement Techniques
194
III. Aqueous Humor Dynamics in Research
Animals
218
IV. Summary
222
References
222
CHAPTER
8
Aqueous Humor Dynamics
ÍÍ
Carol B. Tons and Carl B. Camras
I. Overview
232
II. Introduction
232
Contents
III.
Normal
Values
of Aqueous Humor Dynamics
in Humans
233
IV. Clinical Syndromes
237
V. Drugs Affecting Aqueous Humor Dynamics
246
VI. Summary
259
References
259
CHAPTER
9
Effects of Circulatory Events on Aqueous
Humor Inflow and Intraocular Pressure
Herbert A. Reitsamer and Jeffrey W. Kiel
I. Overview
273
II. Introduction
274
III. lop Effects on Ocular Blood Flow
274
IV. Ocular Blood Flow Effects on IOP
275
V. Ciliary Blood Flow and Aqueous Production
281
VI. Episcleral Venous Pressure and IOP
295
VII.
Conclusion
296
References
297
CHAPTER
10
Retinal Ganglion Cells and Glaucoma: Traditional
Patterns and New Possibilities
Claire H. Mitchell and Wennan
Lu
I. Overview
301
II. Introduction
302
III. Influences on Glaucomatous Damage to Ganglion
Cells
303
IV. Mechanisms of Ganglion Cell Death
307
V. Conclusion
315
References
316
CHAPTER
11
What is Functional Genomics Teaching us about
Intraocular Pressure Regulation and Glaucoma
Teresa
Borras
I. Overview
324
II. Introduction
324
III. Functional Genomics: Microarrays, Proteomics
and Protein Modification
326
IV. Tissues Involved in the Development of
Glaucoma. Survey of Microarray Studies
329
Contents
V. The Trabecular Meshwork Tissue: Expressed
Genes (CDNA) and Proteins Obtained by
Direct Sequencing and Mass Spectrometry
335
VI. The Trabecular Meshwork Tissue: In Search of
Genes Responding to Glaucomatous Insults
348
VII.
Proposed Molecular Signature of Human
Glaucoma
361
References
365
CHAPTER
12
Molecular Approaches to Glaucoma:
Intriguing Clues for Pathology
Ernst R. Tamm
I. Overview
379
II. Transforming Growth Factor-B
380
III. Thrombospondin-l
383
IV. Connective Tissue Growth Factor
384
V. Bone Morphogenetic Protein-7
388
VI. Myocilin
389
VII. Optineurin
403
VIII.
WD Repeat Domain
36 410
IX. Conclusion
411
References
411
CHAPTER
13
Outflow Signaling Mechanisms and New
Therapeutic Strategies for the Control of
Intraocular Pressure
lok
-Нои
Pang and Abbot F. Clark
I. Overview
428
II. Introduction
428
III. New Approaches for IOP Lowering
439
IV. Future Therapeutic Opportunities
455
References
457
Index
471 |
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| index_date | 2024-07-02T23:02:02Z |
| indexdate | 2024-07-09T21:27:07Z |
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| spelling | The eye's aqueous humor ed. by Mortimer M. Civan ed. 2 Amsterdam [u.a.] Elsevier, Acad. Press 2008 XX, 483 S., [8] Bl. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Current topics in membranes 62 Glaukom (DE-588)4021210-5 gnd rswk-swf Kammerwasser (DE-588)4163161-4 gnd rswk-swf Sekretion (DE-588)4124179-4 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Kammerwasser (DE-588)4163161-4 s DE-604 Glaukom (DE-588)4021210-5 s Sekretion (DE-588)4124179-4 s Civan, Mortimer M. Sonstige oth Current topics in membranes 62 (DE-604)BV036839511 62 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016998947&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | The eye's aqueous humor Current topics in membranes Glaukom (DE-588)4021210-5 gnd Kammerwasser (DE-588)4163161-4 gnd Sekretion (DE-588)4124179-4 gnd |
| subject_GND | (DE-588)4021210-5 (DE-588)4163161-4 (DE-588)4124179-4 (DE-588)4143413-4 |
| title | The eye's aqueous humor |
| title_auth | The eye's aqueous humor |
| title_exact_search | The eye's aqueous humor |
| title_exact_search_txtP | The eye's aqueous humor |
| title_full | The eye's aqueous humor ed. by Mortimer M. Civan |
| title_fullStr | The eye's aqueous humor ed. by Mortimer M. Civan |
| title_full_unstemmed | The eye's aqueous humor ed. by Mortimer M. Civan |
| title_short | The eye's aqueous humor |
| title_sort | the eye s aqueous humor |
| topic | Glaukom (DE-588)4021210-5 gnd Kammerwasser (DE-588)4163161-4 gnd Sekretion (DE-588)4124179-4 gnd |
| topic_facet | Glaukom Kammerwasser Sekretion Aufsatzsammlung |
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