Polychlorinated biphenyls: Human Health Aspects:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | Undetermined |
| Veröffentlicht: |
Geneva
World Health Organization
2003
|
| Schriftenreihe: | Concise international chemical assessment document
55 |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | IV , 58 S. |
| ISBN: | 9241530553 |
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| 245 | 1 | 0 | |a Polychlorinated biphenyls: Human Health Aspects |c 1. draft prepared by Dr Obaid M. Faroon |
| 264 | 1 | |a Geneva |b World Health Organization |c 2003 | |
| 300 | |a IV , 58 S. | ||
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| 490 | 1 | |a Concise international chemical assessment document |v 55 | |
| 700 | 1 | |a Faroon, Obaid M. |e Sonstige |4 oth | |
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Datensatz im Suchindex
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| adam_text | TABLE OF CONTENTS
FOREWORD 1
1. EXECUTIVE SUMMARY 4
2. IDENTITY AND PHYSICAL/CHEMICAL PROPERTIES 5
3. ANALYTICAL METHODS 7
3.1 Biological samples 7
3.2 Environmental samples 10
4. SOURCES OF HUMAN AND ENVIRONMENTAL EXPOSURE 11
5. ENVIRONMENTAL TRANSPORT, DISTRIBUTION, AND TRANSFORMATION 11
5.1 Transport and partitioning 11
5.2 Transformation and degradation 13
5.2.1 Air 13
5.2.2 Water 13
5.2.3 Sediment and soil 14
6. ENVIRONMENTAL LEVELS AND HUMAN EXPOSURE 14
6.1 Environmental levels 14
6.2 Human exposure 15
6.3 Tissue concentrations 16
7. COMPARATIVE KINETICS AND METABOLISM IN LABORATORY ANIMALS AND
HUMANS 16
8. EFFECTS ON LABORATORY MAMMALS AND/JV VITROTEST SYSTEMS 18
8.1 Single exposure 18
8.2 Short-term exposure 19
8.3 Long-term exposure and carcinogenicity 19
8.4 Genotoxicity and related end-points 21
8.5 Reproductive toxicity 22
8.5.1 Effects on fertility 22
8.5.2 Estrogen-related effects 22
8.5.3 Developmental effects 23
8.6 Immunotoxicity 25
8.7 Neurochemical effects 26
8.8 Mode of action 26
9. EFFECTS ON HUMANS 27
9.1 Carcinogenicity 28
9.2 Genotoxicity 30
9.3 Reproductive toxicity 31
9.3.1 Fertility 31
9.3.2 Growth and development 31
iii
Concise International Chemical Assessment Document 55 9.4 Immunological effects 33
9.5 Neurological effects 33
9.6 Irritation and sensitization 34
10. EVALUATION OF HEALTH EFFECTS 34
10.1 Hazard identification and dose-response assessment 35
10.2 Criteria for setting tolerable intakes and tolerable concentrations for PCB mixtures 36
10.3 Sample risk characterization 36
10.4 Uncertainties in the health risk assessment 36
11. PREVIOUS EVALUATIONS BY INTERNATIONAL BODIES 37
REFERENCES 38
APPENDIX 1 — SOURCE DOCUMENT 48
APPENDIX 2 — CICAD PEER REVIEW 50
APPENDIX 3 — CICAD FINAL REVIEW BOARD 51
APPENDIX 4 — ABBREVIATIONS AND ACRONYMS 52
INTERNATIONAL CHEMICAL SAFETY CARD 53
RESUME D ORIENTATION 55
RESUMEN DE ORIENTACION 57
iv
|
| adam_txt |
TABLE OF CONTENTS
FOREWORD 1
1. EXECUTIVE SUMMARY 4
2. IDENTITY AND PHYSICAL/CHEMICAL PROPERTIES 5
3. ANALYTICAL METHODS 7
3.1 Biological samples 7
3.2 Environmental samples 10
4. SOURCES OF HUMAN AND ENVIRONMENTAL EXPOSURE 11
5. ENVIRONMENTAL TRANSPORT, DISTRIBUTION, AND TRANSFORMATION 11
5.1 Transport and partitioning 11
5.2 Transformation and degradation 13
5.2.1 Air 13
5.2.2 Water 13
5.2.3 Sediment and soil 14
6. ENVIRONMENTAL LEVELS AND HUMAN EXPOSURE 14
6.1 Environmental levels 14
6.2 Human exposure 15
6.3 Tissue concentrations 16
7. COMPARATIVE KINETICS AND METABOLISM IN LABORATORY ANIMALS AND
HUMANS 16
8. EFFECTS ON LABORATORY MAMMALS AND/JV VITROTEST SYSTEMS 18
8.1 Single exposure 18
8.2 Short-term exposure 19
8.3 Long-term exposure and carcinogenicity 19
8.4 Genotoxicity and related end-points 21
8.5 Reproductive toxicity 22
8.5.1 Effects on fertility 22
8.5.2 Estrogen-related effects 22
8.5.3 Developmental effects 23
8.6 Immunotoxicity 25
8.7 Neurochemical effects 26
8.8 Mode of action 26
9. EFFECTS ON HUMANS 27
9.1 Carcinogenicity 28
9.2 Genotoxicity 30
9.3 Reproductive toxicity 31
9.3.1 Fertility 31
9.3.2 Growth and development 31
iii
Concise International Chemical Assessment Document 55 9.4 Immunological effects 33
9.5 Neurological effects 33
9.6 Irritation and sensitization 34
10. EVALUATION OF HEALTH EFFECTS 34
10.1 Hazard identification and dose-response assessment 35
10.2 Criteria for setting tolerable intakes and tolerable concentrations for PCB mixtures 36
10.3 Sample risk characterization 36
10.4 Uncertainties in the health risk assessment 36
11. PREVIOUS EVALUATIONS BY INTERNATIONAL BODIES 37
REFERENCES 38
APPENDIX 1 — SOURCE DOCUMENT 48
APPENDIX 2 — CICAD PEER REVIEW 50
APPENDIX 3 — CICAD FINAL REVIEW BOARD 51
APPENDIX 4 — ABBREVIATIONS AND ACRONYMS 52
INTERNATIONAL CHEMICAL SAFETY CARD 53
RESUME D'ORIENTATION 55
RESUMEN DE ORIENTACION 57
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| id | DE-604.BV035171965 |
| illustrated | Not Illustrated |
| index_date | 2024-07-02T22:54:40Z |
| indexdate | 2024-07-09T21:26:38Z |
| institution | BVB |
| isbn | 9241530553 |
| language | Undetermined |
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| physical | IV , 58 S. |
| publishDate | 2003 |
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| series | Concise international chemical assessment document |
| series2 | Concise international chemical assessment document |
| spelling | Polychlorinated biphenyls: Human Health Aspects 1. draft prepared by Dr Obaid M. Faroon Geneva World Health Organization 2003 IV , 58 S. txt rdacontent n rdamedia nc rdacarrier Concise international chemical assessment document 55 Faroon, Obaid M. Sonstige oth Concise international chemical assessment document 55 (DE-604)BV021595306 55 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016978884&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Polychlorinated biphenyls: Human Health Aspects Concise international chemical assessment document |
| title | Polychlorinated biphenyls: Human Health Aspects |
| title_auth | Polychlorinated biphenyls: Human Health Aspects |
| title_exact_search | Polychlorinated biphenyls: Human Health Aspects |
| title_exact_search_txtP | Polychlorinated biphenyls: Human Health Aspects |
| title_full | Polychlorinated biphenyls: Human Health Aspects 1. draft prepared by Dr Obaid M. Faroon |
| title_fullStr | Polychlorinated biphenyls: Human Health Aspects 1. draft prepared by Dr Obaid M. Faroon |
| title_full_unstemmed | Polychlorinated biphenyls: Human Health Aspects 1. draft prepared by Dr Obaid M. Faroon |
| title_short | Polychlorinated biphenyls: Human Health Aspects |
| title_sort | polychlorinated biphenyls human health aspects |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016978884&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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