Advances in tissue engineering:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
London
Imperial College Press
2008
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | xxxviii, 908 p. ill. (some col.) 26 cm |
| ISBN: | 9781848161825 |
Internformat
MARC
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| 245 | 1 | 0 | |a Advances in tissue engineering |c editor, Julia Polak ... |
| 264 | 1 | |a London |b Imperial College Press |c 2008 | |
| 300 | |a xxxviii, 908 p. |b ill. (some col.) |c 26 cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Includes bibliographical references and index | ||
| 650 | 4 | |a Tissue engineering | |
| 650 | 4 | |a Tissue Engineering | |
| 650 | 4 | |a Tissue engineering | |
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| 943 | 1 | |a oai:aleph.bib-bvb.de:BVB01-016975687 | |
Datensatz im Suchindex
| _version_ | 1823056928283033600 |
|---|---|
| adam_text |
Contents
Contributors xix
Foreword xxxv
Introduction xxxvii
Part I: Tissue Engineering: Past, Present, and Future 1
Chapter 1: An Introduction 3
Robert M. Nerem
1. Introduction 3
2. The Early Years 4
3. The 1990s 6
4. 2000 to Present 6
5. What About the Future? 8
6. Concluding Discussion 10
Part II: Cells for Tissue Engineering 13
Chapter 2: A Brief Introduction to Different Cell Types 15
Lee Buttery and Kevin M. Shakesheff
1. Introduction 16
2. Cells and Tissue Engineering 16
3. Mature or Primary Cells 18
4. Stem Cells 19
5. Sources of Stem Cells 21
6. Immortalised Cell Lines 29
7. Reprogramming 29
8. Differentiation of Cells 30
9. Regulatory Issues 32
Chapter 3: Human Embryonic Stem Cells: International Policy 43
and Regulation
Megan Allyse and Stephen Minger
v
I Contents
1. Introduction 44
2. Controversy 45
3. International Guidelines 47
4. National Policy Systems 49
5. Conclusion 59
Chapter 4: Human Embryonic Stem Cells: Derivation and Culture 63
Emma L. Stephenson, Peter R. Braude and
Chris Mason
1. Introduction 64
2. The Emergence of Human Embryonic Stem 64
Cell Research
3. Human Embryonic Stem Cells 67
4. Culture of hESC lines 71
5. Reporting of Derivation 76
6. Concluding Remarks 77
Chapter 5: Stem Cells Differentiation 83
Pascale V. Guillot and Wei Cui
1. Introduction 83
2. Differentiation of Embryonic Stem Cells 84
3. Somatic Stem Cells 86
4. Conclusion 89
Chapter 6: Marrow Stem Cells 95
Donald G Phinney
1. Introduction 96
2. Hematopoietic Stem Cells: Discovery, 97
Phenotype, and Function
3. Mesenchymal Stem Cells: Discovery, 100
Phenotype, and Function
4. Endothelial Progenitor Cells: Discovery, 103
Phenotype, and Function 103
5. A Common Origin for Bone Marrow Stem Cells 105
6. Functional Interdependency of Bone Marrow 108
Stem Cells
7. Summary 109
vi j
!
j Contents |
; Chapter 7: Cord Blood Stem Cells — Potentials and Realities 123
| Colin P. McGuckin and Nicolas Forraz
\ 1. Introduction to the Concept of Umbilical 124
j Cord Blood Stem Cells
j 2. Cord Blood Current Clinical Uses 126
j 3. Cord Blood Processing and Cryopreservation 129
4. Cord Blood Banking 132
5. Cord Blood Research and Where the Future Lies 134
Chapter 8: Fat Stem Cells 143
Jeffrey M. Gimble, Bruce A. Bunnell and
i Farshid Guilak
1. Introduction 144
2. Types of Adipose Tissue 144
3. Isolation Procedures 145
4. Immunophenotype and Cytokine Profile 146
ofASCs
5. Immunogenicity of ASCs 147
6. Differentiation Potential 149
7. Mechanisms of Potential Utility: Genetic 158
Engineering and Gene Delivery
8. Conclusions and Future Directions 158
Chapter 9: Control of Adult Stem Cell Function in 175
Bioengineered Artificial Niches
Matthias P. Lutolf and Helen M. Blau
1. Introduction 176
2. Adult Stem Cells Reside in Niches 177
3. Common Structures and Components of 177
Stem Cell Niches
4. Key Functions of Stem Cell Niches 180
5. Niches Control the Fate of Individual Stem 181
Cells
6. The HSC Niche 183
7. Prospects for Using Engineered Artificial 185
Niches as Novel Model Systems to Probe and
Manipulate Adult Stem Cell Fate
vii
I Contents
Chapter 10: Stem Cell Immunology 199
Anthony P. Hollander and David C. Wraith
1. Why is Stem Cell Immunology Important 200
for Tissue Engineering?
2. Evolutionary Context of the Mammalian 201
Immune System
3. Materno-Foetal Tolerance as a Model for 204
Understanding Stem Cell Immune Privilege
4. Are Embryonic Stem Cells Immune 206
Privileged?
5. Are Mesenchymal Stem Cells (MSCs) 209
Immune Privileged?
6. Finding a Way Forward for the Use of 210
Allogeneic Stem Cells
Chapter 11: Development of a Design of Experiment 215
Methodology: Applications to the Design
and Analysis of Experiments
Mayasari him and Athanasios Mantalaris
1. Analysis of Factors 216
2. Design Strategy 219
3. DOE Designs 220
4. A DOE Example: Investigating the Influence of 223
Cytokines on Erythropoiesis
5. Conclusions 226
Chapter 12: Banking Stem Cell Lines for Future Therapies 229
Glyn N. Stacey and Charles J. Hunt
1. Introduction 230
2. The Rationale for Centralised Banks of Human 232
Cell Lines for Clinical Use
3. Fundamental Issues for in Vitro Cell Culture 233
4. Cell Culture Processes 234
5. Quality Assurance and Quality Control 242
6. International Perspectives 246
7. Future Developments and Expectations 247
viii
Contents |
Part III: Materials 253
Chapter 13: Synthetic Biomaterials as Cell-Responsive Artificial 255
Extracellular Matrices
Matthias P. Lutolf and Jeffrey A. Hubbell
1. Introduction 256
2. ECMs Instruct Cell Fates and Respond to 257
Cell-Secreted Signals
3. Design Principles for Cell-Responsive 259
Artificial ECMs
4. Implementation: Classes and Applications of 263
Cell-Responsive Artificial ECMs
5. Future Challenges 271
Chapter 14: Bioactive Composite Materials for Bone Tissue 279
Engineering Scaffolds
Sophie Verrier and Aldo R. Boccaccini
1. Introduction 280
2. Scaffolds Requirements 281
3. Composite Materials Approach for Tissue 283
Engineering Scaffolds
4. In Vitro and In Vivo Evaluation 288
5. Discussion 302
6. Conclusions and Future Work 303
Chapter 15: Aggregation of Cells Using Biomaterials 313
and Bioreactors
Zahia Bayoussef and Kevin M. Shakesheff
1. Introduction 314
2. Cell Adhesion and Natural Cell Aggregation 314
3. Methods of Cell Aggregation 315
4. Synthetic Cell Aggregation 316
5. Cell Aggregation on Scaffolds 323
6. Bioreactors and Cell Aggregation 325
7. Summary and Conclusion 327
Chapter 16: Nanotechnology for Tissue Engineering 333
Jean S. Stephens-Altus and Jennifer L. West
ix
I Contents
1. Introduction 334
2. Nanostructured Scaffolds 334
3. Nanoparticles for Cellular Imaging 340
4. Conclusions 343
Chapter 17: Microscale Technologies for Tissue Engineering 349
AH Khademhosseini, Yanan Du, Bimal Rajalingam,
Joseph P. Vacanti and Robert S. Langer
1. Introduction 350
2. Microscale Technologies for Controlling 351
Stem Cell Fate
3. Microscale Technologies for Engineering 357
Complex Tissues Containing Different Cell
Types and Vasculature
4. Conclusion 363
Part IV: Non-Invasive Methods to Monitor Tissue 371
Re-Modelling
Chapter 18: Biosensors 373
Tony Cass
1. Introduction to Sensor Technology 374
2. The Importance of Mass Transport in Sensor 376
Performance
3. Electrochemical Biosensors 378
4. Optical Biosensors 384
5. Mass Sensors 390
6. Cell Sensing Strategies 391
7. Tissue Sensing Strategies 393
8. Conclusions and Outlook 394
Chapter 19: Tissue-Engineering Monitoring Using 401
Microdialysis
Zhaohui Li, Olga Boubriak, Jill Urban and
Zhanfeng Cui
1. Introduction 402
2. Methodology of Microdialysis 403
x
Contents I
3. Microdialysis for Tissue Engineering 409
Monitoring — Case Studies
4. Summary 415
Chapter 20: Characterisation of Tissue Engineering Constructs 421
by Raman Spectroscopy and X-ray Micro-
Computed Tomography (fiCT)
loan Notingher and Julian R. Jones
1. Introduction 422
2. Principles and Instrumentation 426
3. Applications of Raman Micro-Spectroscopy 430
to Cells
4. Application of JJ.CT to the Quantification 435
of Scaffolds
5. Conclusions 438
Chapter 21: Role of Stem Cell Imaging in Regenerative 443
Medicine
Gabriella Passacquale and Kishore Bhakoo
1. Introduction 444
2. Ideal Imaging Technology for Non-Invasive 445
Stem Cell Tracking
3. Non-Invasive Tracking of Stem Cells Using MRI 448
4. Role of Imaging in Stem Cell-Based Therapy 453
for the Central Nervous System
5. Multimodality 456
6. Conclusions 456
Part V: Biotechnology Sector 467
Chapter 22: Lessons Learnt 469
Nancy L. Parenteau, Susan J. Sullivan, Kelvin G. M. Brockbank
and Janet Hardin Young
1. Background: The Marriage of Biology 470
and Engineering
2. The Evolving Emphasis from Engineering 471
to Biology
xi
I Contents
3. Vascular Tissue Engineering 472
4. Cartilage 475
5. Extracorporeal Devices 477
6. Skin 481
7. Conclusion 483
Chapter 23: The Promise of Stem Cells: A Venture Capital 491
Perspective
Cathy Prescott
1. Introduction 492
2. Venture Capital — Balancing Risk 492
3. The Value Proposition 494
4. "Watch and Wait" 494
5. The European Regulatory Environment 497
6. An Evolving Patent Landscape 498
7. Future Prospects? 499
Part VI: Tissue Engineering Products 501
Chapter 24: Cell Expansion, Cell Encapsulation, 3D Cultures 503
Julia M. Polak and Athanasios Mantalaris
1. Introduction 504
2. Controlled Differentiation 505
3. Generation of Clinically Relevant Number of 507
Cells in 3D Cultures as an Integrated and
Scalable Process
4. Encapsulation 508
5. Bioprocessing for Regenerative Medicine 508
6. Discussion 511
Chapter 25: Bioreactor Engineering: Regenerating the Dynamic 517
Cell Microenvironment
Tal Dvir and Smadar Cohen
1. Tissue Engineering — The Introduction of 518
3D Cell Cultures
2. Mass Transport Challenges in 3D Cell Cultures 518
3. First Generation of Tissue Engineering 520
Bioreactors
xii
Contents I
4. Perfusion Bioreactors — Theory and Practice 522
5. Examples of Perfusion Bioreactors in TE 524
6. Bioreactors Providing Physical Signals 526
7. Microfabricated Bioreactors 530
8. Concluding Remarks and Future Aspects 531
Chapter 26: UK Regulatory Issues: The View from the 537
Researcher
Caroline Munro and Neil Harris
1. Introduction 538
2. The Product Life Cycle of a Cell-Based 539
Therapeutic
3. Stage 1: Procurement — The Obtaining of 542
Cells or Tissue Components from Donors
Under cGCP
4. Stage 2: Analysis — Initial Isolation, Screening, 543
Characterisation and Manipulation of Cells/Other
Components and Storage
5. Stage 3: Confirmed Proof of Product and 544
Process — Initial to Final Screening for
Potential Use
6. Stage 4: Product Manufacturing — Production 546
of Clinical Grade Material Under cGMP
7. Stage 5: Pre-Clinical Trials — Assessment of 546
Safety and Performance for Regulatory
Submission
8. Stage 6: Clinical Trials — Clinical Assessments 549
of Product Safety and Performance
9. Stage 7: Launch — Commercially Available 551
Product
10. Stage 8: Post-Market — Ongoing Processes 552
Following Commercialisation of Product
11. Regulations, Guidelines and Codes of Practice 555
Part VII: Tissue Repair 559
Chapter 27: Stem Cell Therapy: Past, Present, and Future 561
Frederic Baron and Rainer Storb
xiii
I Contents
1. Hematopoietic Stem Cells and Hematopoietic 562
Stem Cell Transplantation
2. Plasticity of Adult Hematopoietic Stem Cells: 571
Lessons Learnt from a Canine Model of
Duchenne Muscular Dystrophy
3. Mesenchymal Stromal Cells 573
4. Embryonic Stem Cells 575
5. Future of Stem Cell Therapy 575
Chapter 28: Tissue Engineered Skin Comes of Age? 593
Sheila MacNeil
1. To What Extent can Tissue Engineered Skin 594
Deliver Normal Skin Structure and Function
for Clinical Use?
2. Which Patients can Benefit from Tissue 595
Engineered Products?
3. History of the Development of Tissue 595
Engineered Skin for Burns Injuries
4. Development of Tissue Engineered Skin 603
for Chronic Wounds
5. Development of Tissue Engineered Skin 605
for Reconstructive Surgery
6. The Design Process for Tissue Engineered 605
Products
7. Keratinocyte Stem Cells — Where are We? 606
8. Clinical and Future Development Issues 607
9. Laboratory Uses of Tissue Engineered Skin 609
10. Conclusion 612
Chapter 29: Liver Repair 619
Natasa Levicar, Madhava Pai and Nagy A. Habib
1. Introduction 620
2. Haematopoietic Stem Cells and Liver 620
Regeneration
3. Clinical Studies 622
4. Conclusions 625
xiv
Contents |
Chapter 30: Tissue Engineering for Tooth Regeneration 633
Ivan. A. Diakonov and Paul Sharpe
1. Tooth Development and Morphology 634
2. Stem Cells in the Tooth 636
3. Two Strategies for Tissue Engineering Tooth 641
Germs De Novo
4. Challenges 646
5. Conclusions 646
Chapter 31: Urogenital Repair 655
Anthony Atala
1. Introduction 656
2. Tissue Engineering Strategies for Urogenital 656
Repair
3. Tissue Engineering of Specific Urologic and 660
Genital Structures
4. Kidney 665
5. Genital Tissues 667
6. Other Applications of Genitourinary Tissue 669
Engineering
7. Conclusion 670
Part VIII: Cardiac Repair 677
Chapter 32: Basic Science 679
Sian E. Harding
1. Introduction 680
2. Conclusion 688
Chapter 33: Cardiac Repair Clinical Trials 695
Amanda Green and Eric Alton
1. Introduction 696
2. A New Treatment Option 696
3. Acute Myocardial Infarction 697
4. Chronic Ischaemic Heart Disease 715
xv
I Contents
5. Which is the Optimal Method of 719
Delivery?
6. The Future for Clinical Trials 721
Chapter 34: Myocardial Recovery Following LVAD 733
Support
Robert S. George and Emma J. Birks
1. Introduction 734
2. Overview of LVADs 735
3. LVAD and Myocardial Recovery — Clinical 741
Implications
4. Remodelling versus Reverse Remodelling 745
5. Conclusion 750
Part IX: Osteoarticular Repair 761
Chapter 35: Animal Models 763
Elizabeth A. Homer, Jennifer Kirkham and
Xuebin B. Yang
1. Introduction 764
2. The Choice of Animal 765
3. In Vivo Models for Bone and Cartilage 766
Tissue Engineering
4. Conclusion 774
Chapter 36: In Vitro 3D Human Tissue Models for Osteochondral 781
Diseases
Sourabh Ghosh and David L. Kaplan
1. Introduction 782
2. Factors Governing the Simulation of Tissue 784
Microenvironments
3. Osteochondral Tissue 792
4. Conclusions 805
Chapter 37: Application of Tissue Engineering for Craniofacial 821
Reconstruction
Deepak M. Gupta, Matthew D. Kwan, Bethany
J. Slater and Michael T. Longaker
xvi
Contents |
1. Introduction 822
2. Craniosynostosis: A Case for Mechanisms 823
Underlying Bone Formation
3. Distraction Osteogenesis: Endogenous Tissue 827
Engineering
4. Cellular-Based Tissue Engineering: Regenerative 830
Medicine
5. Conclusion 834
Chapter 38: Clinical Trials 843
Anne K. Haudenschild and Marc H. Hedrick
1. Introduction to Osteoarticular Repair 844
2. Impact 845
3. Current Medical Treatment of OA 845
4. Current Trials 848
5. Promising Future Technologies 850
6. Discussion 851
PartX: Lung Repair 859
Chapter 39: Tissue Engineering for the Respiratory Epithelium: 861
Is There a Future for Stem Cell Therapy in the Lung?
Valerie Besnard and Jeffrey A. Whitsett
1. Introduction: The Challenges Facing Cell-Based 862
Therapy for Treatment of Lung Disease
2. Lung Morphogenesis 864
3. Sources of Stem Cells 870
4. Do Bone Marrow-Derived Cells Contribute 872
to Repair?
5. Use of Intrinsic Pulmonary Progenitor Cells 875
6. The Hope of Stem Cell Therapy for Treatment 877
of Lung Disease
7. Conclusion 879
Chapter 40: The Artificial Lung 887
Andreas Nikolas Maurer and Georg Matheis
1. Introduction 888
2. Mechanical Ventilation 889
xvii
I Contents
3. Development of Membrane Ventilators 889
(Artificial Lungs, Medical Devices)
4. Near Future Tasks to Enhance Membrane 890
Ventilators
5. From Medical Devices to Biohybrid Lungs 892
6. Organoid Structures 894
7. Conclusion 895
Index 903
xviii |
| adam_txt |
Contents
Contributors xix
Foreword xxxv
Introduction xxxvii
Part I: Tissue Engineering: Past, Present, and Future 1
Chapter 1: An Introduction 3
Robert M. Nerem
1. Introduction 3
2. The Early Years 4
3. The 1990s 6
4. 2000 to Present 6
5. What About the Future? 8
6. Concluding Discussion 10
Part II: Cells for Tissue Engineering 13
Chapter 2: A Brief Introduction to Different Cell Types 15
Lee Buttery and Kevin M. Shakesheff
1. Introduction 16
2. Cells and Tissue Engineering 16
3. Mature or Primary Cells 18
4. Stem Cells 19
5. Sources of Stem Cells 21
6. Immortalised Cell Lines 29
7. Reprogramming 29
8. Differentiation of Cells 30
9. Regulatory Issues 32
Chapter 3: Human Embryonic Stem Cells: International Policy 43
and Regulation
Megan Allyse and Stephen Minger
v
I Contents
1. Introduction 44
2. Controversy 45
3. International Guidelines 47
4. National Policy Systems 49
5. Conclusion 59
Chapter 4: Human Embryonic Stem Cells: Derivation and Culture 63
Emma L. Stephenson, Peter R. Braude and
Chris Mason
1. Introduction 64
2. The Emergence of Human Embryonic Stem 64
Cell Research
3. Human Embryonic Stem Cells 67
4. Culture of hESC lines 71
5. Reporting of Derivation 76
6. Concluding Remarks 77
Chapter 5: Stem Cells Differentiation 83
Pascale V. Guillot and Wei Cui
1. Introduction 83
2. Differentiation of Embryonic Stem Cells 84
3. Somatic Stem Cells 86
4. Conclusion 89
Chapter 6: Marrow Stem Cells 95
Donald G Phinney
1. Introduction 96
2. Hematopoietic Stem Cells: Discovery, 97
Phenotype, and Function
3. Mesenchymal Stem Cells: Discovery, 100
Phenotype, and Function
4. Endothelial Progenitor Cells: Discovery, 103
Phenotype, and Function 103
5. A Common Origin for Bone Marrow Stem Cells 105
6. Functional Interdependency of Bone Marrow 108
Stem Cells
7. Summary 109
vi j
!
j Contents |
; Chapter 7: Cord Blood Stem Cells — Potentials and Realities 123
| Colin P. McGuckin and Nicolas Forraz
\ 1. Introduction to the Concept of Umbilical 124
j Cord Blood Stem Cells
j 2. Cord Blood Current Clinical Uses 126
j 3. Cord Blood Processing and Cryopreservation 129
4. Cord Blood Banking 132
5. Cord Blood Research and Where the Future Lies 134
Chapter 8: Fat Stem Cells 143
Jeffrey M. Gimble, Bruce A. Bunnell and
i Farshid Guilak
1. Introduction 144
2. Types of Adipose Tissue 144
3. Isolation Procedures 145
4. Immunophenotype and Cytokine Profile 146
ofASCs
5. Immunogenicity of ASCs 147
6. Differentiation Potential 149
7. Mechanisms of Potential Utility: Genetic 158
Engineering and Gene Delivery
8. Conclusions and Future Directions 158
Chapter 9: Control of Adult Stem Cell Function in 175
Bioengineered Artificial Niches
Matthias P. Lutolf and Helen M. Blau
1. Introduction 176
2. Adult Stem Cells Reside in Niches 177
3. Common Structures and Components of 177
Stem Cell Niches
4. Key Functions of Stem Cell Niches 180
5. Niches Control the Fate of Individual Stem 181
Cells
6. The HSC Niche 183
7. Prospects for Using Engineered Artificial 185
Niches as Novel Model Systems to Probe and
Manipulate Adult Stem Cell Fate
vii
I Contents
Chapter 10: Stem Cell Immunology 199
Anthony P. Hollander and David C. Wraith
1. Why is Stem Cell Immunology Important 200
for Tissue Engineering?
2. Evolutionary Context of the Mammalian 201
Immune System
3. Materno-Foetal Tolerance as a Model for 204
Understanding Stem Cell Immune Privilege
4. Are Embryonic Stem Cells Immune 206
Privileged?
5. Are Mesenchymal Stem Cells (MSCs) 209
Immune Privileged?
6. Finding a Way Forward for the Use of 210
Allogeneic Stem Cells
Chapter 11: Development of a Design of Experiment 215
Methodology: Applications to the Design
and Analysis of Experiments
Mayasari him and Athanasios Mantalaris
1. Analysis of Factors 216
2. Design Strategy 219
3. DOE Designs 220
4. A DOE Example: Investigating the Influence of 223
Cytokines on Erythropoiesis
5. Conclusions 226
Chapter 12: Banking Stem Cell Lines for Future Therapies 229
Glyn N. Stacey and Charles J. Hunt
1. Introduction 230
2. The Rationale for Centralised Banks of Human 232
Cell Lines for Clinical Use
3. Fundamental Issues for in Vitro Cell Culture 233
4. Cell Culture Processes 234
5. Quality Assurance and Quality Control 242
6. International Perspectives 246
7. Future Developments and Expectations 247
viii
Contents |
Part III: Materials 253
Chapter 13: Synthetic Biomaterials as Cell-Responsive Artificial 255
Extracellular Matrices
Matthias P. Lutolf and Jeffrey A. Hubbell
1. Introduction 256
2. ECMs Instruct Cell Fates and Respond to 257
Cell-Secreted Signals
3. Design Principles for Cell-Responsive 259
Artificial ECMs
4. Implementation: Classes and Applications of 263
Cell-Responsive Artificial ECMs
5. Future Challenges 271
Chapter 14: Bioactive Composite Materials for Bone Tissue 279
Engineering Scaffolds
Sophie Verrier and Aldo R. Boccaccini
1. Introduction 280
2. Scaffolds Requirements 281
3. Composite Materials Approach for Tissue 283
Engineering Scaffolds
4. In Vitro and In Vivo Evaluation 288
5. Discussion 302
6. Conclusions and Future Work 303
Chapter 15: Aggregation of Cells Using Biomaterials 313
and Bioreactors
Zahia Bayoussef and Kevin M. Shakesheff
1. Introduction 314
2. Cell Adhesion and Natural Cell Aggregation 314
3. Methods of Cell Aggregation 315
4. Synthetic Cell Aggregation 316
5. Cell Aggregation on Scaffolds 323
6. Bioreactors and Cell Aggregation 325
7. Summary and Conclusion 327
Chapter 16: Nanotechnology for Tissue Engineering 333
Jean S. Stephens-Altus and Jennifer L. West
ix
I Contents
1. Introduction 334
2. Nanostructured Scaffolds 334
3. Nanoparticles for Cellular Imaging 340
4. Conclusions 343
Chapter 17: Microscale Technologies for Tissue Engineering 349
AH Khademhosseini, Yanan Du, Bimal Rajalingam,
Joseph P. Vacanti and Robert S. Langer
1. Introduction 350
2. Microscale Technologies for Controlling 351
Stem Cell Fate
3. Microscale Technologies for Engineering 357
Complex Tissues Containing Different Cell
Types and Vasculature
4. Conclusion 363
Part IV: Non-Invasive Methods to Monitor Tissue 371
Re-Modelling
Chapter 18: Biosensors 373
Tony Cass
1. Introduction to Sensor Technology 374
2. The Importance of Mass Transport in Sensor 376
Performance
3. Electrochemical Biosensors 378
4. Optical Biosensors 384
5. Mass Sensors 390
6. Cell Sensing Strategies 391
7. Tissue Sensing Strategies 393
8. Conclusions and Outlook 394
Chapter 19: Tissue-Engineering Monitoring Using 401
Microdialysis
Zhaohui Li, Olga Boubriak, Jill Urban and
Zhanfeng Cui
1. Introduction 402
2. Methodology of Microdialysis 403
x
Contents I
3. Microdialysis for Tissue Engineering 409
Monitoring — Case Studies
4. Summary 415
Chapter 20: Characterisation of Tissue Engineering Constructs 421
by Raman Spectroscopy and X-ray Micro-
Computed Tomography (fiCT)
loan Notingher and Julian R. Jones
1. Introduction 422
2. Principles and Instrumentation 426
3. Applications of Raman Micro-Spectroscopy 430
to Cells
4. Application of JJ.CT to the Quantification 435
of Scaffolds
5. Conclusions 438
Chapter 21: Role of Stem Cell Imaging in Regenerative 443
Medicine
Gabriella Passacquale and Kishore Bhakoo
1. Introduction 444
2. Ideal Imaging Technology for Non-Invasive 445
Stem Cell Tracking
3. Non-Invasive Tracking of Stem Cells Using MRI 448
4. Role of Imaging in Stem Cell-Based Therapy 453
for the Central Nervous System
5. Multimodality 456
6. Conclusions 456
Part V: Biotechnology Sector 467
Chapter 22: Lessons Learnt 469
Nancy L. Parenteau, Susan J. Sullivan, Kelvin G. M. Brockbank
and Janet Hardin Young
1. Background: The Marriage of Biology 470
and Engineering
2. The Evolving Emphasis from Engineering 471
to Biology
xi
I Contents
3. Vascular Tissue Engineering 472
4. Cartilage 475
5. Extracorporeal Devices 477
6. Skin 481
7. Conclusion 483
Chapter 23: The Promise of Stem Cells: A Venture Capital 491
Perspective
Cathy Prescott
1. Introduction 492
2. Venture Capital — Balancing Risk 492
3. The Value Proposition 494
4. "Watch and Wait" 494
5. The European Regulatory Environment 497
6. An Evolving Patent Landscape 498
7. Future Prospects? 499
Part VI: Tissue Engineering Products 501
Chapter 24: Cell Expansion, Cell Encapsulation, 3D Cultures 503
Julia M. Polak and Athanasios Mantalaris
1. Introduction 504
2. Controlled Differentiation 505
3. Generation of Clinically Relevant Number of 507
Cells in 3D Cultures as an Integrated and
Scalable Process
4. Encapsulation 508
5. Bioprocessing for Regenerative Medicine 508
6. Discussion 511
Chapter 25: Bioreactor Engineering: Regenerating the Dynamic 517
Cell Microenvironment
Tal Dvir and Smadar Cohen
1. Tissue Engineering — The Introduction of 518
3D Cell Cultures
2. Mass Transport Challenges in 3D Cell Cultures 518
3. First Generation of Tissue Engineering 520
Bioreactors
xii
Contents I
4. Perfusion Bioreactors — Theory and Practice 522
5. Examples of Perfusion Bioreactors in TE 524
6. Bioreactors Providing Physical Signals 526
7. Microfabricated Bioreactors 530
8. Concluding Remarks and Future Aspects 531
Chapter 26: UK Regulatory Issues: The View from the 537
Researcher
Caroline Munro and Neil Harris
1. Introduction 538
2. The Product Life Cycle of a Cell-Based 539
Therapeutic
3. Stage 1: Procurement — The Obtaining of 542
Cells or Tissue Components from Donors
Under cGCP
4. Stage 2: Analysis — Initial Isolation, Screening, 543
Characterisation and Manipulation of Cells/Other
Components and Storage
5. Stage 3: Confirmed Proof of Product and 544
Process — Initial to Final Screening for
Potential Use
6. Stage 4: Product Manufacturing — Production 546
of Clinical Grade Material Under cGMP
7. Stage 5: Pre-Clinical Trials — Assessment of 546
Safety and Performance for Regulatory
Submission
8. Stage 6: Clinical Trials — Clinical Assessments 549
of Product Safety and Performance
9. Stage 7: Launch — Commercially Available 551
Product
10. Stage 8: Post-Market — Ongoing Processes 552
Following Commercialisation of Product
11. Regulations, Guidelines and Codes of Practice 555
Part VII: Tissue Repair 559
Chapter 27: Stem Cell Therapy: Past, Present, and Future 561
Frederic Baron and Rainer Storb
xiii
I Contents
1. Hematopoietic Stem Cells and Hematopoietic 562
Stem Cell Transplantation
2. Plasticity of Adult Hematopoietic Stem Cells: 571
Lessons Learnt from a Canine Model of
Duchenne Muscular Dystrophy
3. Mesenchymal Stromal Cells 573
4. Embryonic Stem Cells 575
5. Future of Stem Cell Therapy 575
Chapter 28: Tissue Engineered Skin Comes of Age? 593
Sheila MacNeil
1. To What Extent can Tissue Engineered Skin 594
Deliver Normal Skin Structure and Function
for Clinical Use?
2. Which Patients can Benefit from Tissue 595
Engineered Products?
3. History of the Development of Tissue 595
Engineered Skin for Burns Injuries
4. Development of Tissue Engineered Skin 603
for Chronic Wounds
5. Development of Tissue Engineered Skin 605
for Reconstructive Surgery
6. The Design Process for Tissue Engineered 605
Products
7. Keratinocyte Stem Cells — Where are We? 606
8. Clinical and Future Development Issues 607
9. Laboratory Uses of Tissue Engineered Skin 609
10. Conclusion 612
Chapter 29: Liver Repair 619
Natasa Levicar, Madhava Pai and Nagy A. Habib
1. Introduction 620
2. Haematopoietic Stem Cells and Liver 620
Regeneration
3. Clinical Studies 622
4. Conclusions 625
xiv
Contents |
Chapter 30: Tissue Engineering for Tooth Regeneration 633
Ivan. A. Diakonov and Paul Sharpe
1. Tooth Development and Morphology 634
2. Stem Cells in the Tooth 636
3. Two Strategies for Tissue Engineering Tooth 641
Germs De Novo
4. Challenges 646
5. Conclusions 646
Chapter 31: Urogenital Repair 655
Anthony Atala
1. Introduction 656
2. Tissue Engineering Strategies for Urogenital 656
Repair
3. Tissue Engineering of Specific Urologic and 660
Genital Structures
4. Kidney 665
5. Genital Tissues 667
6. Other Applications of Genitourinary Tissue 669
Engineering
7. Conclusion 670
Part VIII: Cardiac Repair 677
Chapter 32: Basic Science 679
Sian E. Harding
1. Introduction 680
2. Conclusion 688
Chapter 33: Cardiac Repair Clinical Trials 695
Amanda Green and Eric Alton
1. Introduction 696
2. A New Treatment Option 696
3. Acute Myocardial Infarction 697
4. Chronic Ischaemic Heart Disease 715
xv
I Contents
5. Which is the Optimal Method of 719
Delivery?
6. The Future for Clinical Trials 721
Chapter 34: Myocardial Recovery Following LVAD 733
Support
Robert S. George and Emma J. Birks
1. Introduction 734
2. Overview of LVADs 735
3. LVAD and Myocardial Recovery — Clinical 741
Implications
4. Remodelling versus Reverse Remodelling 745
5. Conclusion 750
Part IX: Osteoarticular Repair 761
Chapter 35: Animal Models 763
Elizabeth A. Homer, Jennifer Kirkham and
Xuebin B. Yang
1. Introduction 764
2. The Choice of Animal 765
3. In Vivo Models for Bone and Cartilage 766
Tissue Engineering
4. Conclusion 774
Chapter 36: In Vitro 3D Human Tissue Models for Osteochondral 781
Diseases
Sourabh Ghosh and David L. Kaplan
1. Introduction 782
2. Factors Governing the Simulation of Tissue 784
Microenvironments
3. Osteochondral Tissue 792
4. Conclusions 805
Chapter 37: Application of Tissue Engineering for Craniofacial 821
Reconstruction
Deepak M. Gupta, Matthew D. Kwan, Bethany
J. Slater and Michael T. Longaker
xvi
Contents |
1. Introduction 822
2. Craniosynostosis: A Case for Mechanisms 823
Underlying Bone Formation
3. Distraction Osteogenesis: Endogenous Tissue 827
Engineering
4. Cellular-Based Tissue Engineering: Regenerative 830
Medicine
5. Conclusion 834
Chapter 38: Clinical Trials 843
Anne K. Haudenschild and Marc H. Hedrick
1. Introduction to Osteoarticular Repair 844
2. Impact 845
3. Current Medical Treatment of OA 845
4. Current Trials 848
5. Promising Future Technologies 850
6. Discussion 851
PartX: Lung Repair 859
Chapter 39: Tissue Engineering for the Respiratory Epithelium: 861
Is There a Future for Stem Cell Therapy in the Lung?
Valerie Besnard and Jeffrey A. Whitsett
1. Introduction: The Challenges Facing Cell-Based 862
Therapy for Treatment of Lung Disease
2. Lung Morphogenesis 864
3. Sources of Stem Cells 870
4. Do Bone Marrow-Derived Cells Contribute 872
to Repair?
5. Use of Intrinsic Pulmonary Progenitor Cells 875
6. The Hope of Stem Cell Therapy for Treatment 877
of Lung Disease
7. Conclusion 879
Chapter 40: The Artificial Lung 887
Andreas Nikolas Maurer and Georg Matheis
1. Introduction 888
2. Mechanical Ventilation 889
xvii
I Contents
3. Development of Membrane Ventilators 889
(Artificial Lungs, Medical Devices)
4. Near Future Tasks to Enhance Membrane 890
Ventilators
5. From Medical Devices to Biohybrid Lungs 892
6. Organoid Structures 894
7. Conclusion 895
Index 903
xviii |
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| index_date | 2024-07-02T22:53:26Z |
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| spelling | Advances in tissue engineering editor, Julia Polak ... London Imperial College Press 2008 xxxviii, 908 p. ill. (some col.) 26 cm txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and index Tissue engineering Tissue Engineering Tissue Engineering (DE-588)4646061-5 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Tissue Engineering (DE-588)4646061-5 s DE-604 Polak, Julia M. 1939-2014 Sonstige (DE-588)121103536 oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016975687&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
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| subject_GND | (DE-588)4646061-5 (DE-588)4143413-4 |
| title | Advances in tissue engineering |
| title_auth | Advances in tissue engineering |
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| title_full | Advances in tissue engineering editor, Julia Polak ... |
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| title_full_unstemmed | Advances in tissue engineering editor, Julia Polak ... |
| title_short | Advances in tissue engineering |
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| topic | Tissue engineering Tissue Engineering Tissue Engineering (DE-588)4646061-5 gnd |
| topic_facet | Tissue engineering Tissue Engineering Aufsatzsammlung |
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