Verfügbarkeit: Chlorinated Naphthalenes

Chlorinated Naphthalenes:

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Bibliographische Detailangaben
Format:	Buch
Sprache:	Undetermined
Veröffentlicht:	Geneva World Health Organization 2001
Schriftenreihe:	Concise international chemical assessment document 34
Online-Zugang:	Inhaltsverzeichnis
Beschreibung:	IV, 57 S.
ISBN:	9241530340

Internformat

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Datensatz im Suchindex

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adam_text	TABLE OF CONTENTS FOREWORD 1 1. EXECUTIVE SUMMARY 4 2. IDENTITY AND PHYSICAL/CHEMICAL PROPERTIES 6 3. ANALYTICAL METHODS 6 4. SOURCES OF HUMAN AND ENVIRONMENTAL EXPOSURE 10 5. ENVIRONMENTAL TRANSPORT, DISTRIBUTION, AND TRANSFORMATION 11 6. ENVIRONMENTAL LEVELS AND HUMAN EXPOSURE 13 6.1 Environmental levels 13 6.2 Human exposure 17 7. COMPARATIVE KINETICS AND METABOLISM IN LABORATORY ANIMALS AND HUMANS 20 8. , EFFECTS ON LABORATORY MAMMALS AND IN VITRO TEST SYSTEMS 21 8.1 Single exposure 21 1,8.? .Short-term exposure 22 ^ %% Medium-term exposure 22 . ... 8.4.... Long-term exposure and carcinogenicity 24 8.5 Genotoxicity and related end-points 24 8.6 Reproductive toxicity 24 8.6.1 Effects on fertility 24 8.6.2 Developmental toxicity 24 8.6.3 Endocrine disruption 24 8.7 Other toxicity/mode of action 24 8.7.1 Induction of microsomal enzymes and related effects 24 8.7.2 Effects on lipid peroxidation and antioxidant enzyme activities 25 8.7.3 Skin irritation, dermal lesions, and acne (including bovine hyperkeratosis) 25 8.7.4 Toxic equivalency factor (TEF) and relative potency (REP) concept 26 9. EFFECTS ON HUMANS 27 9.1 Occupational exposure 27 9.2 General population exposure 29 10. EFFECTS ON OTHER ORGANISMS IN THE LABORATORY AND FIELD 29 10.1 Aquatic environment 29 10.2 Terrestrial environment 29 11. EFFECTS EVALUATION 29 11.1 Evaluation of health effects 29 iii Concise International Chemical Assessment Document 34 11.1.1 Hazard identification and dose-response assessment 29 11.1.2 Criteria for setting tolerable intakes/concentrations or guidance values for chlorinated naphthalenes 31 11.1.3 Sample risk characterization 31 11.2 Evaluation of environmental effects 32 11.3 Uncertainties in the evaluation 33 12. PREVIOUS EVALUATIONS BY INTERNATIONAL BODIES 33 REFERENCES 34 APPENDIX 1 — SOURCE DOCUMENTS 41 APPENDIX 2 — CICAD PEER REVIEW 41 APPENDIX 3 — CICAD FINAL REVIEW BOARD 42 INTERNATIONAL CHEMICAL SAFETY CARDS 43 RESUME D ORIENTATION 53 RESUMEN DE ORIENTACI6N 55
adam_txt	TABLE OF CONTENTS FOREWORD 1 1. EXECUTIVE SUMMARY 4 2. IDENTITY AND PHYSICAL/CHEMICAL PROPERTIES 6 3. ANALYTICAL METHODS 6 4. SOURCES OF HUMAN AND ENVIRONMENTAL EXPOSURE 10 5. ENVIRONMENTAL TRANSPORT, DISTRIBUTION, AND TRANSFORMATION 11 6. ENVIRONMENTAL LEVELS AND HUMAN EXPOSURE 13 6.1 Environmental levels 13 6.2 Human exposure 17 7. COMPARATIVE KINETICS AND METABOLISM IN LABORATORY ANIMALS AND HUMANS 20 8. , EFFECTS ON LABORATORY MAMMALS AND IN VITRO TEST SYSTEMS 21 8.1 Single exposure 21 1,8.? .Short-term exposure 22 ^'%% 'Medium-term exposure 22 . . 8.4. Long-term exposure and carcinogenicity 24 8.5 Genotoxicity and related end-points 24 8.6 Reproductive toxicity 24 8.6.1 Effects on fertility 24 8.6.2 Developmental toxicity 24 8.6.3 Endocrine disruption 24 8.7 Other toxicity/mode of action 24 8.7.1 Induction of microsomal enzymes and related effects 24 8.7.2 Effects on lipid peroxidation and antioxidant enzyme activities 25 8.7.3 Skin irritation, dermal lesions, and acne (including bovine hyperkeratosis) 25 8.7.4 Toxic equivalency factor (TEF) and relative potency (REP) concept 26 9. EFFECTS ON HUMANS 27 9.1 Occupational exposure 27 9.2 General population exposure 29 10. EFFECTS ON OTHER ORGANISMS IN THE LABORATORY AND FIELD 29 10.1 Aquatic environment 29 10.2 Terrestrial environment 29 11. EFFECTS EVALUATION 29 11.1 Evaluation of health effects 29 iii Concise International Chemical Assessment Document 34 11.1.1 Hazard identification and dose-response assessment 29 11.1.2 Criteria for setting tolerable intakes/concentrations or guidance values for chlorinated naphthalenes 31 11.1.3 Sample risk characterization 31 11.2 Evaluation of environmental effects 32 11.3 Uncertainties in the evaluation 33 12. PREVIOUS EVALUATIONS BY INTERNATIONAL BODIES 33 REFERENCES 34 APPENDIX 1 — SOURCE DOCUMENTS 41 APPENDIX 2 — CICAD PEER REVIEW 41 APPENDIX 3 — CICAD FINAL REVIEW BOARD 42 INTERNATIONAL CHEMICAL SAFETY CARDS 43 RESUME D'ORIENTATION 53 RESUMEN DE ORIENTACI6N 55
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isbn	9241530340
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spelling	Chlorinated Naphthalenes 1. draft prepared by P. D. Howe... Geneva World Health Organization 2001 IV, 57 S. txt rdacontent n rdamedia nc rdacarrier Concise international chemical assessment document 34 Howe, P. D. Sonstige oth Concise international chemical assessment document 34 (DE-604)BV021595306 34 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016974245&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle	Chlorinated Naphthalenes Concise international chemical assessment document
title	Chlorinated Naphthalenes
title_auth	Chlorinated Naphthalenes
title_exact_search	Chlorinated Naphthalenes
title_exact_search_txtP	Chlorinated Naphthalenes
title_full	Chlorinated Naphthalenes 1. draft prepared by P. D. Howe...
title_fullStr	Chlorinated Naphthalenes 1. draft prepared by P. D. Howe...
title_full_unstemmed	Chlorinated Naphthalenes 1. draft prepared by P. D. Howe...
title_short	Chlorinated Naphthalenes
title_sort	chlorinated naphthalenes
url	http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016974245&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
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