Cellular signal processing: an introduction to the molecular mechanisms of signal transduction
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
New York, NY [u.a.]
Garland Science
2009
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | XIII, 634 S. Ill., graph. Darst. |
| ISBN: | 9780815342151 0815342152 |
Internformat
MARC
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| 100 | 1 | |a Marks, Friedrich |d 1936- |e Verfasser |0 (DE-588)132367084 |4 aut | |
| 245 | 1 | 0 | |a Cellular signal processing |b an introduction to the molecular mechanisms of signal transduction |c Friedrich Marks ; Ursula Klingmüller ; Karin Müller-Decker |
| 264 | 1 | |a New York, NY [u.a.] |b Garland Science |c 2009 | |
| 300 | |a XIII, 634 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
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| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Includes bibliographical references and index | ||
| 650 | 4 | |a Cellular signal transduction | |
| 650 | 4 | |a Intracellular Signaling Peptides and Proteins |x physiology | |
| 650 | 4 | |a Signal Transduction |x physiology | |
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Datensatz im Suchindex
| _version_ | 1804138326453649408 |
|---|---|
| adam_text | Contents
Preface vii
Chapter 1 The Brain of the Cell : Data Processing by Protein Networks 1
Chapter 2 Supplying the Network with Energy: Basic Biochemistry of
Signal Transduction 25
Chapter 3 Evolution of Cellular Data Processing 79
Chapter 4 Basic Equipment: G-Proteins, Second Messengers, and
Protein Kinases 129
Chapter 5 Signal Transduction by Receptors with Seven
Transmembrane Domains 183
Chapter 6 Signal Transduction by Serine/Threonine Kinase-Coupled
Receptors 219
Chapter 7 Signal Transduction by Tyrosine Kinase- and Protein
Phosphatase-Coupled Receptors: A Late Invention of
Evolution 239
Chapter 8 Gene Transcription: The Ultimate Target of Signal
Transduction 283
Chapter 9 Signals Controlling mRNA Translation 325
Chapter 10 Signal Transduction by Small G-Proteins: The Art of
Molecular Targeting 353
Chapter 11 Mitogen-activated Protein Kinase and Nuclear Factor kB
Modules 389
Chapter 12 Cancer and Regulation of Cell Division 419
Chapter 13 Signal Transduction by Proteolysis and Programmed
Cell Death 455
ix
Contents
Chapter 14 Signal Transduction by Ions 477
Chapter 15 Sensory Signal Processing 535
Chapter 16 Signaling at Synapses: Neurotransmitters and their
Receptors 555
Chapter 17 Putting Together the Pieces: The Approach of Systems
Biology 599
Index 613
x
List of Headings
Chapter 1
The Brain of the Cell : Data Processing
by Protein Networks 1
1.1 Metaphors and reductionism:
temptations and limitations 1
1.2 Information and signals 3
1.3 Proteins are binary switches 6
1.4 Signal-transducing proteins are
nanoneurons 9
1.5 Signal-transducing proteins are components
of logical gates and neural networks 10
1.6 Privacy versus publicity 11
1.7 Cross talking and network formation 13
1.8 Interaction domains: how the network is
plugged together 16
1.9 Generation of signaling patterns 20
Chapter 2
Supplying the Network with Energy: Basic
Biochemistry of Signal Transduction 25
2.1 No order without work 25
2.2 Redox and nitrosylation switches:
a balance on a narrow ridge 28
2.3 Switches operated by enzymes that
hydrolyze energy-rich compounds 32
2.4 GTPase or G-protein switch 32
2.5 ATPase switches 37
2.6 Protein phosphorylation 44
2.7 Protein acetylation: a central device of
gene regulation 56
2.8 Protein ubiquitylation: more than a
signal of protein degradation 57
2.9 Mono- and poly(ADP-ribosylation) 62
2.10 Ion channel switches: how to make
use of electrical charge 64
2.11 Proteolysis switch: protein degradation
provides messenger molecules and energy 70
2.12 Receptors: how energy-supplying reactions
are combined with signal transduction 70
2.13 Brief summary of experimental standard
methods for investigation of signaling
pathways: the classical approach 74
2.14 Model organisms for investigation of
cellular signal processing 75
Chapter 3
Evolution of Cellular Data Processing 79
3.1 Evolution of biological signal processing 79
3.2 Signal-controlled transport across cell
membranes: the ancient way to communicate 82
3.3 Sensor-dependent signal processing:
two-component systems 89
3.4 From vagabonds to societies: bacterial
hormones 109
3.5 From bacteria to humans: evolution of
signaling mechanisms 113
Chapter 4
Basic Equipment: G-Proteins, Second
Messengers, and Protein Kinases 129
4.1 Stress response and vegetative nervous
system 129
4.2 Discovery of intracellular signal
transduction 133
4.3 Trimeric G-proteins: coupling of
receptors with the protein network 135
4.4 Downstream of G-proteins: enzymes
producing second messengers 141
4.5 Guanylate cyclases: not controlled by
trimeric G-proteins 166
4.6 The next level: protein kinases as
sensors of second messengers 168
Chapter 5
Signal Transduction by Receptors with
SevenTransmemhrane Domains IH A
5.1 An evolutionary model of success 183
5.2 G-protein-coupled receptors: structure
and mode of operation 184
5.3 Adrenergic receptors: sensors of stress
and sympathetic signals 193
5.4 Muscarinic acetylcholine receptors:
sensors of parasympathetic signals 199
5.5 Stress and the heart: the competition
between sympathetic and parasympathetic
signals 201
5.6 G-protein-coupled receptors activated
by proteolysis: major players in blood
clotting and inflammation 202
xi
List of Headings
5.7 Adaptation of G-protein-controlled
signaling: a matter of feedback 204
5.8 Arrestins: multifunctional adaptors for
receptor down-modulation and signaling
cross talk 206
5.9 Heptahelical receptors without G-protein
coupling: hedgehog and Wnt signaling
pathways 210
5.10 Other G-protein-independent effects of
heptahelical receptors: lessons from slime
molds and Homer 215
Chapter 6
Signal Transduction by Serine/
Threonine Kinase-Coupled Receptors 219
6.1 Protein kinase-coupled receptors: the
principle of dimerization-driven signal
transduction 219
6.2 Receptors with intrinsic serine/threonine
kinase activity: transforming growth factor
P receptor family 221
6.3 Cytokine receptors associated with
serine/threonine kinases: key players in
defense reactions 224
Chapter 7
Signal Transduction by Tyrosine Kinase-
and Protein Phosphatase-Coupled
Receptors: A Late Invention of Evolution 239
7.1 Receptor tyrosine kinases: the most
modern cellular sensors 239
7.2 Receptors associated with tyrosine
kinases 258
7.3 Signal transduction by cell adhesion
molecules 270
7.4 Protein tyrosine phosphatases and
phosphatase-coupled receptors 274
Chapter 8
Gene Transcription: The Ultimate
Target of Signal Transduction 283
8.1 Initiation of transcription 284
8.2 Histones, nucleosomes, and chromatin 287
8.3 Transcription factors as hormone receptors 298
8.4 Ligand-controlled transcription factors:
xenosensors of the toxic stress response 307
8.5 Chaperones and peptidyl-prolyl
isomerases: how signaling proteins are
prepared for work 309
8.6 Transcription factors as substrates of
protein kinases 313
8.7 Multiple post-translational modifications
of transcription factors: the hypoxic stress
response 315
8.8 Annulment of gene transcription by
RNA interference 317
8.9 Post-transcriptional splicing of
pre-mRNA: a powerful mechanism
to generate variability 318
Chapter 9
Signals Controlling mRNA Translation 325
9.1 Eukaryotic mRNA translation:
the essentials 325
9.2 Release of newly synthesized protein
by the endoplasmic reticulum: an
ancient playground of G-proteins 327
9.3 Signaling cascades controlling translation 329
9.4 Network for adjustment of cell growth
to the supply situation 335
9.5 Synopsis 349
Chapter 10
Signal Transduction by Small G-Proteins:
The Art of Molecular Targeting 353
10.1 Ras proteins: generation of order in
signal transduction 353
10.2 Other G-proteins of the Ras subfamily:
an unfinished story 363
10.3 GTPases of the Rho family: master
regulators of the actin cytoskeleton
and more 364
10.4 Arf and Rab proteins: control of vesicle
transport 377
10.5 Ran, nuclear transport, and mitosis 385
Chapter 11
Mitogen-activated Protein Kinase and
Nuclear Factor kB Modules 389
11.1 MAP kinase modules: universal relay
stations of eukaryotic signal processing 389
11.2 MAP kinases and MAP2 kinases:
the core of MAP kinase modules 390
11.3. MAP3 kinases: sensors and logical gates
of MAP kinase modules 393
11.4 MAP4 kinases and G-proteins: lessons
learned from yeast
11.5 Organization of MAP kinase modules
by scaffold proteins 400
11.6 Downstream of MAP kinase modules:
MAP kinase-activated protein kinases 401
11.7 Downstream of MAP kinase modules:
transcription factors 404
11.8 NFkB signaling pathway 408
Chapter 12
Cancer and Regulation of Cell Division 419
12.1 Cancer: a cellular psychosis 419
12.2 The cell cycle 422
12.3 Cyclins: cell cycle regulators and beyond 424
12.4 Cyclin-dependent protein kinases:
dual control by phosphorylation and
dephosphorylation 425
12.5 Cyclin-dependent kinase inhibitors:
keeping the cell cycle under control 427
12.6 GO cells, restriction points, and the
effect of mitogenic signals 428
12.7 Retinoblastoma proteins: tumor
repressors and master regulators of
the cell cycle 430
12.8 Regulation of G2 phase and G2-M
transition: precise like clockwork 432
12.9 Genotoxic stress response: a matter of
life and death 433
12.10 Phases of mitosis 439
12.11 Ubiquitin ligase APC / C: giving the beat of
mitosis 440
12.12 Mitotic protein kinases: formation of the
mitotic spindle 443
12.13 Spindle assembly checkpoint: last
chance to correct mistakes 445
12.14 Cytokinesis: how a new cell is born 446
12.15 Mitotic exit network of yeast 447
12.16 Ubiquitin ligases 449
Chapter 13
Signal Transduction by Proteolysis and
Programmed Cell Death 455
13.1 Secretase-coupled receptors: generation
of peptide second messengers 455
13.2 Apoptosis: a signal-controlled suicide of cells 464
Chapter 14
Signal Transduction by Ions 477
14.1 Cation channels: prototypical structures
and gating mechanisms 478
14.2 Voltage-gated Na+ channels: masters
of the action potential 481
14.3 Epithelial Na+ channels: regulation of
electrolyte balance and induction of
action potentials 485
List of Headings
14.4 K+-selective ion channels: regulators of
hyperpolarization and osmotic pressure 486
14.5 Calcium ions: the most versatile cellular
signals 492
14.6 Downstream of Ca2+signals 510
14.7 Anion channels 527
Chapter 15
Sensory Signal Processing 535
15.1 Taste 535
15.2 Mechanical stimuli: touch and sound 539
15.3 Temperature and pain 541
15.4 Smell 544
15.5 Vision 546
15.6 Sensory adaptation 551
Chapter 16
Signaling at Synapses: Neurotransmitters
and their Receptors 555
16.1 Neurons and synapses 555
16.2 Acetylcholine receptors 565
16.3 Y-Aminobutyric acid and
glycine receptors: mediators of
inhibitory neurotransmission 569
16.4 Glutamate receptors: favorites of
molecular brain research 573
16.5 Two gaseous signaling molecules 580
16.6 Receptors of purine and pyrimidine
nucleotides: the ATP signal 585
16.7 Cannabinoid and vanilloid receptors 586
16.8 Opioid receptors 589
16.9 Narcotics and drug addiction 590
Chapter 17
Putting Together the Pieces:
The Approach of Systems Biology 599
17.1 Systems biology: origin and focus 600
17.2 System structure: basic network
topologies and properties 600
17.3 The iterative cycle: laboratory
experiments and model building 604
17.4 Problems of quantitative data
generation and model building 605
17.5 Mathematical modeling of a signaling
pathway 606
17.6 Synthetic and predictive biology: the
improvement of biological systems 610
Index 613
xiii
|
| adam_txt |
Contents
Preface vii
Chapter 1 The "Brain of the Cell": Data Processing by Protein Networks 1
Chapter 2 Supplying the Network with Energy: Basic Biochemistry of
Signal Transduction 25
Chapter 3 Evolution of Cellular Data Processing 79
Chapter 4 Basic Equipment: G-Proteins, Second Messengers, and
Protein Kinases 129
Chapter 5 Signal Transduction by Receptors with Seven
Transmembrane Domains 183
Chapter 6 Signal Transduction by Serine/Threonine Kinase-Coupled
Receptors 219
Chapter 7 Signal Transduction by Tyrosine Kinase- and Protein
Phosphatase-Coupled Receptors: A Late Invention of
Evolution 239
Chapter 8 Gene Transcription: The Ultimate Target of Signal
Transduction 283
Chapter 9 Signals Controlling mRNA Translation 325
Chapter 10 Signal Transduction by Small G-Proteins: The Art of
Molecular Targeting 353
Chapter 11 Mitogen-activated Protein Kinase and Nuclear Factor kB
Modules 389
Chapter 12 Cancer and Regulation of Cell Division 419
Chapter 13 Signal Transduction by Proteolysis and Programmed
Cell Death 455
ix
Contents
Chapter 14 Signal Transduction by Ions 477
Chapter 15 Sensory Signal Processing 535
Chapter 16 Signaling at Synapses: Neurotransmitters and their
Receptors 555
Chapter 17 Putting Together the Pieces: The Approach of Systems
Biology 599
Index 613
x
List of Headings
Chapter 1
The "Brain of the Cell": Data Processing
by Protein Networks 1
1.1 Metaphors and reductionism:
temptations and limitations 1
1.2 Information and signals 3
1.3 Proteins are binary switches 6
1.4 Signal-transducing proteins are
"nanoneurons" 9
1.5 Signal-transducing proteins are components
of logical gates and neural networks 10
1.6 Privacy versus publicity 11
1.7 Cross talking and network formation 13
1.8 Interaction domains: how the network is
plugged together 16
1.9 Generation of signaling patterns 20
Chapter 2
Supplying the Network with Energy: Basic
Biochemistry of Signal Transduction 25
2.1 No order without work 25
2.2 Redox and nitrosylation switches:
a balance on a narrow ridge 28
2.3 Switches operated by enzymes that
hydrolyze energy-rich compounds 32
2.4 GTPase or G-protein switch 32
2.5 ATPase switches 37
2.6 Protein phosphorylation 44
2.7 Protein acetylation: a central device of
gene regulation 56
2.8 Protein ubiquitylation: more than a
signal of protein degradation 57
2.9 Mono- and poly(ADP-ribosylation) 62
2.10 Ion channel switches: how to make
use of electrical charge 64
2.11 Proteolysis switch: protein degradation
provides messenger molecules and energy 70
2.12 Receptors: how energy-supplying reactions
are combined with signal transduction 70
2.13 Brief summary of experimental standard
methods for investigation of signaling
pathways: the classical approach 74
2.14 Model organisms for investigation of
cellular signal processing 75
Chapter 3
Evolution of Cellular Data Processing 79
3.1 Evolution of biological signal processing 79
3.2 Signal-controlled transport across cell
membranes: the ancient way to communicate 82
3.3 Sensor-dependent signal processing:
two-component systems 89
3.4 From vagabonds to societies: "bacterial
hormones" 109
3.5 From bacteria to humans: evolution of
signaling mechanisms 113
Chapter 4
Basic Equipment: G-Proteins, Second
Messengers, and Protein Kinases 129
4.1 Stress response and vegetative nervous
system 129
4.2 Discovery of intracellular signal
transduction 133
4.3 Trimeric G-proteins: coupling of
receptors with the protein network 135
4.4 Downstream of G-proteins: enzymes
producing second messengers 141
4.5 Guanylate cyclases: not controlled by
trimeric G-proteins 166
4.6 The next level: protein kinases as
sensors of second messengers 168
Chapter 5
Signal Transduction by Receptors with
SevenTransmemhrane Domains IH'A
5.1 An evolutionary model of success 183
5.2 G-protein-coupled receptors: structure
and mode of operation 184
5.3 Adrenergic receptors: sensors of stress
and sympathetic signals 193
5.4 Muscarinic acetylcholine receptors:
sensors of parasympathetic signals 199
5.5 Stress and the heart: the competition
between sympathetic and parasympathetic
signals 201
5.6 G-protein-coupled receptors activated
by proteolysis: major players in blood
clotting and inflammation 202
xi
List of Headings
5.7 Adaptation of G-protein-controlled
signaling: a matter of feedback 204
5.8 Arrestins: multifunctional adaptors for
receptor down-modulation and signaling
cross talk 206
5.9 Heptahelical receptors without G-protein
coupling: hedgehog and Wnt signaling
pathways 210
5.10 Other G-protein-independent effects of
heptahelical receptors: lessons from slime
molds and Homer 215
Chapter 6
Signal Transduction by Serine/
Threonine Kinase-Coupled Receptors 219
6.1 Protein kinase-coupled receptors: the
principle of dimerization-driven signal
transduction 219
6.2 Receptors with intrinsic serine/threonine
kinase activity: transforming growth factor
P receptor family 221
6.3 Cytokine receptors associated with
serine/threonine kinases: key players in
defense reactions 224
Chapter 7
Signal Transduction by Tyrosine Kinase-
and Protein Phosphatase-Coupled
Receptors: A Late Invention of Evolution 239
7.1 Receptor tyrosine kinases: the most
modern cellular sensors 239
7.2 Receptors associated with tyrosine
kinases 258
7.3 Signal transduction by cell adhesion
molecules 270
7.4 Protein tyrosine phosphatases and
phosphatase-coupled receptors 274
Chapter 8
Gene Transcription: The Ultimate
Target of Signal Transduction 283
8.1 Initiation of transcription 284
8.2 Histones, nucleosomes, and chromatin 287
8.3 Transcription factors as hormone receptors 298
8.4 Ligand-controlled transcription factors:
xenosensors of the toxic stress response 307
8.5 Chaperones and peptidyl-prolyl
isomerases: how signaling proteins are
prepared for work 309
8.6 Transcription factors as substrates of
protein kinases 313
8.7 Multiple post-translational modifications
of transcription factors: the hypoxic stress
response 315
8.8 Annulment of gene transcription by
RNA interference 317
8.9 Post-transcriptional splicing of
pre-mRNA: a powerful mechanism
to generate variability 318
Chapter 9
Signals Controlling mRNA Translation 325
9.1 Eukaryotic mRNA translation:
the essentials 325
9.2 Release of newly synthesized protein
by the endoplasmic reticulum: an
ancient playground of G-proteins 327
9.3 Signaling cascades controlling translation 329
9.4 Network for adjustment of cell growth
to the supply situation 335
9.5 Synopsis 349
Chapter 10
Signal Transduction by Small G-Proteins:
The Art of Molecular Targeting 353
10.1 Ras proteins: generation of order in
signal transduction 353
10.2 Other G-proteins of the Ras subfamily:
an unfinished story 363
10.3 GTPases of the Rho family: master
regulators of the actin cytoskeleton
and more 364
10.4 Arf and Rab proteins: control of vesicle
transport 377
10.5 Ran, nuclear transport, and mitosis 385
Chapter 11
Mitogen-activated Protein Kinase and
Nuclear Factor kB Modules 389
11.1 MAP kinase modules: universal relay
stations of eukaryotic signal processing 389
11.2 MAP kinases and MAP2 kinases:
the core of MAP kinase modules 390
11.3. MAP3 kinases: sensors and logical gates
of MAP kinase modules 393
11.4 MAP4 kinases and G-proteins: lessons
learned from yeast
11.5 Organization of MAP kinase modules
by scaffold proteins 400
11.6 Downstream of MAP kinase modules:
MAP kinase-activated protein kinases 401
11.7 Downstream of MAP kinase modules:
transcription factors 404
11.8 NFkB signaling pathway 408
Chapter 12
Cancer and Regulation of Cell Division 419
12.1 Cancer: a "cellular psychosis" 419
12.2 The cell cycle 422
12.3 Cyclins: cell cycle regulators and beyond 424
12.4 Cyclin-dependent protein kinases:
dual control by phosphorylation and
dephosphorylation 425
12.5 Cyclin-dependent kinase inhibitors:
keeping the cell cycle under control 427
12.6 GO cells, restriction points, and the
effect of mitogenic signals 428
12.7 Retinoblastoma proteins: tumor
repressors and master regulators of
the cell cycle 430
12.8 Regulation of G2 phase and G2-M
transition: precise like clockwork 432
12.9 Genotoxic stress response: a matter of
life and death 433
12.10 Phases of mitosis 439
12.11 Ubiquitin ligase APC / C: giving the beat of
mitosis 440
12.12 Mitotic protein kinases: formation of the
mitotic spindle 443
12.13 Spindle assembly checkpoint: last
chance to correct mistakes 445
12.14 Cytokinesis: how a new cell is born 446
12.15 Mitotic exit network of yeast 447
12.16 Ubiquitin ligases 449
Chapter 13
Signal Transduction by Proteolysis and
Programmed Cell Death 455
13.1 Secretase-coupled receptors: generation
of peptide second messengers 455
13.2 Apoptosis: a signal-controlled suicide of cells 464
Chapter 14
Signal Transduction by Ions 477
14.1 Cation channels: prototypical structures
and gating mechanisms 478
14.2 Voltage-gated Na+ channels: masters
of the action potential 481
14.3 Epithelial Na+ channels: regulation of
electrolyte balance and induction of
action potentials 485
List of Headings
14.4 K+-selective ion channels: regulators of
hyperpolarization and osmotic pressure 486
14.5 Calcium ions: the most versatile cellular
signals 492
14.6 Downstream of Ca2+signals 510
14.7 Anion channels 527
Chapter 15
Sensory Signal Processing 535
15.1 Taste 535
15.2 Mechanical stimuli: touch and sound 539
15.3 Temperature and pain 541
15.4 Smell 544
15.5 Vision 546
15.6 Sensory adaptation 551
Chapter 16
Signaling at Synapses: Neurotransmitters
and their Receptors 555
16.1 Neurons and synapses 555
16.2 Acetylcholine receptors 565
16.3 Y-Aminobutyric acid and
glycine receptors: mediators of
inhibitory neurotransmission 569
16.4 Glutamate receptors: favorites of
molecular brain research 573
16.5 Two gaseous signaling molecules 580
16.6 Receptors of purine and pyrimidine
nucleotides: the ATP signal 585
16.7 Cannabinoid and vanilloid receptors 586
16.8 Opioid receptors 589
16.9 Narcotics and drug addiction 590
Chapter 17
Putting Together the Pieces:
The Approach of Systems Biology 599
17.1 Systems biology: origin and focus 600
17.2 System structure: basic network
topologies and properties 600
17.3 The iterative cycle: laboratory
experiments and model building 604
17.4 Problems of quantitative data
generation and model building 605
17.5 Mathematical modeling of a signaling
pathway 606
17.6 Synthetic and predictive biology: the
improvement of biological systems 610
Index 613
xiii |
| any_adam_object | 1 |
| any_adam_object_boolean | 1 |
| author | Marks, Friedrich 1936- Müller-Decker, Karin Klingmüller, Ursula 1964- |
| author_GND | (DE-588)132367084 (DE-588)1084651351 (DE-588)1098573455 |
| author_facet | Marks, Friedrich 1936- Müller-Decker, Karin Klingmüller, Ursula 1964- |
| author_role | aut aut aut |
| author_sort | Marks, Friedrich 1936- |
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| discipline_str_mv | Biologie |
| format | Book |
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| genre | (DE-588)4123623-3 Lehrbuch gnd-content |
| genre_facet | Lehrbuch |
| id | DE-604.BV035162404 |
| illustrated | Illustrated |
| index_date | 2024-07-02T22:51:15Z |
| indexdate | 2024-07-09T21:26:25Z |
| institution | BVB |
| isbn | 9780815342151 0815342152 |
| language | English |
| lccn | 2008029273 |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-016969493 |
| oclc_num | 228374476 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-29 DE-20 DE-11 DE-188 DE-19 DE-BY-UBM DE-B768 DE-703 DE-634 |
| owner_facet | DE-355 DE-BY-UBR DE-29 DE-20 DE-11 DE-188 DE-19 DE-BY-UBM DE-B768 DE-703 DE-634 |
| physical | XIII, 634 S. Ill., graph. Darst. |
| publishDate | 2009 |
| publishDateSearch | 2009 |
| publishDateSort | 2009 |
| publisher | Garland Science |
| record_format | marc |
| spelling | Marks, Friedrich 1936- Verfasser (DE-588)132367084 aut Cellular signal processing an introduction to the molecular mechanisms of signal transduction Friedrich Marks ; Ursula Klingmüller ; Karin Müller-Decker New York, NY [u.a.] Garland Science 2009 XIII, 634 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and index Cellular signal transduction Intracellular Signaling Peptides and Proteins physiology Signal Transduction physiology Signaltransduktion (DE-588)4318717-1 gnd rswk-swf Molekularbiologie (DE-588)4039983-7 gnd rswk-swf Cytologie (DE-588)4070177-3 gnd rswk-swf Zelle (DE-588)4067537-3 gnd rswk-swf (DE-588)4123623-3 Lehrbuch gnd-content Signaltransduktion (DE-588)4318717-1 s Cytologie (DE-588)4070177-3 s DE-604 Molekularbiologie (DE-588)4039983-7 s Zelle (DE-588)4067537-3 s DE-188 Müller-Decker, Karin Verfasser (DE-588)1084651351 aut Klingmüller, Ursula 1964- Verfasser (DE-588)1098573455 aut HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016969493&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Marks, Friedrich 1936- Müller-Decker, Karin Klingmüller, Ursula 1964- Cellular signal processing an introduction to the molecular mechanisms of signal transduction Cellular signal transduction Intracellular Signaling Peptides and Proteins physiology Signal Transduction physiology Signaltransduktion (DE-588)4318717-1 gnd Molekularbiologie (DE-588)4039983-7 gnd Cytologie (DE-588)4070177-3 gnd Zelle (DE-588)4067537-3 gnd |
| subject_GND | (DE-588)4318717-1 (DE-588)4039983-7 (DE-588)4070177-3 (DE-588)4067537-3 (DE-588)4123623-3 |
| title | Cellular signal processing an introduction to the molecular mechanisms of signal transduction |
| title_auth | Cellular signal processing an introduction to the molecular mechanisms of signal transduction |
| title_exact_search | Cellular signal processing an introduction to the molecular mechanisms of signal transduction |
| title_exact_search_txtP | Cellular signal processing an introduction to the molecular mechanisms of signal transduction |
| title_full | Cellular signal processing an introduction to the molecular mechanisms of signal transduction Friedrich Marks ; Ursula Klingmüller ; Karin Müller-Decker |
| title_fullStr | Cellular signal processing an introduction to the molecular mechanisms of signal transduction Friedrich Marks ; Ursula Klingmüller ; Karin Müller-Decker |
| title_full_unstemmed | Cellular signal processing an introduction to the molecular mechanisms of signal transduction Friedrich Marks ; Ursula Klingmüller ; Karin Müller-Decker |
| title_short | Cellular signal processing |
| title_sort | cellular signal processing an introduction to the molecular mechanisms of signal transduction |
| title_sub | an introduction to the molecular mechanisms of signal transduction |
| topic | Cellular signal transduction Intracellular Signaling Peptides and Proteins physiology Signal Transduction physiology Signaltransduktion (DE-588)4318717-1 gnd Molekularbiologie (DE-588)4039983-7 gnd Cytologie (DE-588)4070177-3 gnd Zelle (DE-588)4067537-3 gnd |
| topic_facet | Cellular signal transduction Intracellular Signaling Peptides and Proteins physiology Signal Transduction physiology Signaltransduktion Molekularbiologie Cytologie Zelle Lehrbuch |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016969493&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT marksfriedrich cellularsignalprocessinganintroductiontothemolecularmechanismsofsignaltransduction AT mullerdeckerkarin cellularsignalprocessinganintroductiontothemolecularmechanismsofsignaltransduction AT klingmullerursula cellularsignalprocessinganintroductiontothemolecularmechanismsofsignaltransduction |