Cancer stem cells: identification and targets
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Hoboken, NJ
Wiley
2009
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIV, 245 S., [6 Bl.] Ill., graph. Darst. |
| ISBN: | 9780470122013 0470122013 |
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| 245 | 1 | 0 | |a Cancer stem cells |b identification and targets |c ed. by Sharmila Bapat |
| 264 | 1 | |a Hoboken, NJ |b Wiley |c 2009 | |
| 300 | |a XIV, 245 S., [6 Bl.] |b Ill., graph. Darst. | ||
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| 338 | |b nc |2 rdacarrier | ||
| 650 | 4 | |a Cancer cells | |
| 650 | 4 | |a Stem cells | |
| 650 | 4 | |a Neoplastic Stem Cells | |
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Datensatz im Suchindex
| _version_ | 1804138325917827072 |
|---|---|
| adam_text | CONTENTS
Contributors
xi
Preface
xiii
1
Cancer Stem Cells: Similarities and Variations in the Theme
of Normal Stem Cells
1
Sharmila Bapat, Anne Collins, Michael Dean,
Kenneth Nephew, and Suraiya Rasheed
1.1
Introduction,
1
1.2
Stem Cells in the Life of an Organism,
2
1.2.1
Stem Cells in Early Development and Fetal Life,
3
1.2.2
Stem Cells in the Adult Organism,
4
1.3
Cancer Stem Cells,
7
1.3.1
Activation of Stem Cells and Cancer,
7
1.3.2
Isolation and Identification of Cancer Stem Cells,
10
1.3.3
De Novo
Generation of a New Organ (Tumor) by
Transformed Stem Cells,
12
1.4
Self-Renewal and Differentiation in CSCs,
13
1.5
CSC Plasticity as Regulated by Intrinsic and Extrinsic Stem
Cell Factors,
14
1.5.1
Stem Cell Intrinsic Factors: Genetic and Epigenetic
Effects,
14
1.5.2
Stem Cell Extrinsic Effects: Niche Effects and
Microenvironmental Signaling,
16
1.6
Conclusions and Future Perspectives,
18
References,
20
2
Leukemie
Stem Cells
27
Sharmila Bapat
2.1
Introduction,
27
2.2
Dysregulation of Hematopoiesis in Leukemia,
28
2.2.1
Normal Hematopoietic Stem Cell Hierarchies,
28
2.2.2
Understanding Aberrant Hierarchies in Leukemia,
30
2.2.3
Types of Leukemia,
31
vi
CONTENTS
2.3
Identification and isolation of Cancer-Initiating
Cells in Leukemia,
35
2.4
Molecular Regulation of Aberrant Hierarchies,
36
2.4.1
Signaling Pathways Deregulated in Leukemia,
37
2.4.2
Self-Renewal of Normal and
Leukemie
Stem Cells,
39
2.4.3
Epigenetic Effects,
40
2.4.4
MicroRNA in Leukemia Development,
42
2.5
Conclusions and Future Perspectives,
44
References,
45
3
Isolation and Characterization of Breast and Brain Cancer
Stem Cells
57
Meera Saxena and Annapoorni Rangarajan
3.1
Introduction,
57
3.2
Breast Cancer Stem Cells,
58
3.2.1
Mammary Gland Architecture and Cell Types,
58
3.2.2
Breast Cancer,
59
3.2.3
Identification of Breast Cancer Stem Cells,
59
3.2.4
Putative Breast Cancer Stem Cells that Exhibit
theCD44+ CD24-/l0WLin- Marker Profile,
61
3.2.5 ES A+
Subpopulation
of CD24~lowLin- Cells Enriched
by Tumorigenicity,
61
3.2.6
Tumorigenic Breast Cells Displaying Properties of Stem
Cells,
61
3.2.7
In Vitro Propagation of Breast Cancer Stem Cells as
Mammospheres,
62
3.3
Brain Cancer Stem Cells,
64
3.3.1
Brain Architecture and Cell Types,
64
3.3.2
Brain Cancers,
65
3.3.3
Brain Stem Cells,
66
3.3.4
Brain Cancer Stem Cells,
66
3.3.5
Brain Cancer-Derived Cells that Generate Tumor
Spheres,
67
3.4
Conclusions and Future Perspectives,
69
References,
70
4
Cancer Stem Cell Side Populations
73
Danuta
Baììcki
and Raymond Beaulieu
4.1
Introduction,
73
4.2
Stem Cell Side Populations,
75
4.3
Side Populations in Normal Tissue,
78
4.4
Side Populations in Tumors,
79
CONTENTS
vii
4.5
Overcoming Side Population Limitations,
80
4.6
Conclusions and Future Perspectives,
81
References,
82
5
Evidence for Cancer Stem Cells in Retinoblastoma
87
GailM.Seigel
5.1
Introduction,
87
5.2
Elusive Origins of Retinoblastoma,
87
5.3
Sources of Retinoblastoma Cells for Study,
88
5.4
Precedent for Cancer Stem Cells,
88
5.5
Side Populations in Retinoblastoma,
89
5.6
Immunoreactivity to Stem Cell Markers in Retinoblastoma,
89
5.7
Conclusions and Future Perspectives,
91
References,
92
6
Ovarian Stem Cell Biology and the Emergence of Ovarian Cancer
Stem Cells
95
Anjali Kusumbe and Sharmila Bapat
6.1
Introduction,
95
6.2
Overview of the Human Ovary,
95
6.2.1
Histological Landmarks,
95
6.2.2
Ovarian Development: The Story Before Birth,
96
6.2.3
The Mammalian
Oogénesis
Dogma,
98
6.3
Stem/Progenitor Cells in the Adult Mammalian Ovary,
98
6.3.1
Historical Perspective,
98
6.3.2
The
Oogénesis
Dogma Revisited,
99
6.4
Is Ovarian Cancer a Stem Cell Disease?,
104
6.4.1
Putative Role of Stem/Progenitor Cells in Ovarian
Cancer,
104
6.4.2
Tumor as an Aberrant Organ Initiated by Cancer
Stem Cells,
105
6.4.3
Ovarian Cancer Stem Cells Isolated as a Side
Population,
106
6.4.4
New Challenge: Targeting Ovarian Cancer
Stem Cells,
106
References,
107
7
Prostate Cancer Stem Cells 111
Stefanie Hager,
Norman
J. Maitland,
and Anne Collins
7.1
Introduction, 111
7.2
Human Prostate Biology, Gland Architecture,
and Pathological Alterations,
1
1
1
viii CONTENTS
7.3
Prostate
Epithelial Stem Cells,
113
7.3.1
Evidence for Prostate Epithelial Stem Cells,
113
7.3.2
Isolation of Human Prostate Epithelial Stem Cells
and Demonstration of Their Stem Cell Character,
116
7.3.3
Epithelial Stem Cells in the
Murine
Prostate,
118
7.3.4
Other Markers of Prostate Epithelial Stem Cells,
119
7.4
Prostate Cancer Stem Cells,
120
7.4.1
Role of Stem Cells in Prostate Cancer,
120
7.4.2
Prospective Isolation of Prostate Cancer Stem Cells
from Human Tissue Samples,
122
7.4.3
Role of the Stem Cell Niche in Prostate Cancer,
124
7.4.4
Putative Markers of Prostate Cancer Stem Cells,
124
7.5
Stem Cell Tracking in the Prostate,
125
7.6
Conclusions and Future Perspectives,
127
References,
127
8
Molecular Signatures of Highly Malignant Melanoma Stem Cells
135
Suraiya Rasheed
8.1
General Properties of Human Melanomas,
135
8.2
Characteristics of Stem Cell-Derived Melanomas,
136
8.3
The Cat Model System for Stem Cell Melanomas,
137
8.3.1
Biological Characteristics of Highly Malignant Stem
Cell Melanomas,
138
8.3.2
Trans-differentiation of the Malignant Cat Melanoma
into
Neuronal
Cells,
139
8.3.3
Proteins Associated with
Neuronal
Cell
Differentiation,
140
8.3.4
Cell Cycle Dysregulation and Antitumorigenic Effects
During Cell Differentiation,
144
8.3.5
Molecular Signatures of Self Renewal and
Long-Term
Proliferation of Tumor Cells,
145
8.3.6
Proteins Involved in Tumorigenesis and Metastasis,
147
8.3.7
Expression of Germline and Embryonic Proteins in Cat
Melanomas,
149
8.3.8
Naturally Occurring Protein-Protein Interaction
Complexes in Melanomas,
149
8.3.9
Networks of Protein Interaction Pathways,
152
8.4
Challenges of Research in Cancer Stem Cells
and Therapeutics,
152
8.5
Conclusions and Future Perspectives,
154
References,
156
CONTENTS ix
9 Invasion Program
of
Normal
and Cancer Stem Cells
167
David
Olmeda,
Gema
Moreno-Bueno,
David
Samó,
José Palacios, and Amparo Cano
9.1
Introduction,
167
9.2
Basics of
Tumor
Progression: Invasion and Metastasis,
168
9.3
Epitheliał-to-Mesenchymal
Transition in Development and Its
Relation to The Invasive Process,
169
9.4
Regulation of EMT: From Signals to Molecular Pathways,
172
9.5
EMT and Cancer Stem Cells,
176
9.6
Can Stem Cell Properties Be Extensive to Invasive
Tumor Cells?,
177
9.7
Is There a Unique EMT Program Linked to Invasion?,
178
9.8
Evidence of EMT in Human Clinical Tumors,
180
9.9
Expression of Mesenchymal Markers and Cadherin Switching in
Carcinomas,
181
9.10
Expression of EMT Inducers in Human Tumors,
183
9.11
Occurrence of EMT in a Specific Subset of Breast
Carcinomas,
185
9.12
Conclusions and Future Perspectives,
186
References,
187
10
Epigenetics in Cancer Stem Cell Development
197
Kenneth Nephew, Curt Balch, Tim H.-M. Huang, Zhang Shu,
Michael Chan, and Pearlly Yan
10.1
Introduction,
197
10.2
Characterization of Candidate Cancer Stem Cells,
198
10.3
Possible Origins of Cancer Stem Cells,
198
10.4
Epigenetics in Normal Development,
199
10.5
Epigenetic Regulation of the Cancer Stem Cell Phenotype,
200
10.6
Contributions of Epigenetics to Drug Resistance in Cancer Stem
Cells,
204
10.7
Genome-Wide Interrogation of Epigenetic Modifications
in Cancer Stem Cells,
206
10.8
Epigenetic Therapies Against Poorly Differentiated
CancerCells,
207
10.9
Conclusions and Future Perspectives,
208
References,
209
11
Cancer Stem Cells and New Therapeutic Approaches
217
Michael Dean
11.1
Cancer Stem Cells,
217
χ
CONTENTS
11.2
Activation of Stem Cells and
Cancer,
218
11.2.1
Initiation and Promotion Revised,
219
11.2.2
Stem Cell Activation and Specific Cancers,
221
11.3
Major Cancers and Risk Factors,
223
11.3.1
Liver Cancer,
223
11.3.2
Lung Cancer,
224
11.3.3
Gastric Cancer,
224
11.3.4
Pancreatic Cancer,
224
11.3.5
Cervical Cancer,
225
11.4
Treatment Implications,
225
11.5
Future Perspectives,
227
11.6
Conclusions,
228
References,
243
12
Immunobiology of Cancer Stem Cells
233
Shubhada V. Chiplunkar
12.1
Cancer Stem Cells,
233
12.2
Cancer Stem Cells and Lymphocytes,
234
12.3
Trafficking of Normal Stem Cells and Metastasis
of Cancer Stem Cells,
236
References,
238
Index
243
|
| adam_txt |
CONTENTS
Contributors
xi
Preface
xiii
1
Cancer Stem Cells: Similarities and Variations in the Theme
of Normal Stem Cells
1
Sharmila Bapat, Anne Collins, Michael Dean,
Kenneth Nephew, and Suraiya Rasheed
1.1
Introduction,
1
1.2
Stem Cells in the Life of an Organism,
2
1.2.1
Stem Cells in Early Development and Fetal Life,
3
1.2.2
Stem Cells in the Adult Organism,
4
1.3
Cancer Stem Cells,
7
1.3.1
Activation of Stem Cells and Cancer,
7
1.3.2
Isolation and Identification of Cancer Stem Cells,
10
1.3.3
De Novo
Generation of a New Organ (Tumor) by
Transformed Stem Cells,
12
1.4
Self-Renewal and Differentiation in CSCs,
13
1.5
CSC Plasticity as Regulated by Intrinsic and Extrinsic Stem
Cell Factors,
14
1.5.1
Stem Cell Intrinsic Factors: Genetic and Epigenetic
Effects,
14
1.5.2
Stem Cell Extrinsic Effects: Niche Effects and
Microenvironmental Signaling,
16
1.6
Conclusions and Future Perspectives,
18
References,
20
2
Leukemie
Stem Cells
27
Sharmila Bapat
2.1
Introduction,
27
2.2
Dysregulation of Hematopoiesis in Leukemia,
28
2.2.1
Normal Hematopoietic Stem Cell Hierarchies,
28
2.2.2
Understanding Aberrant Hierarchies in Leukemia,
30
2.2.3
Types of Leukemia,
31
vi
CONTENTS
2.3
Identification and isolation of Cancer-Initiating
Cells in Leukemia,
35
2.4
Molecular Regulation of Aberrant Hierarchies,
36
2.4.1
Signaling Pathways Deregulated in Leukemia,
37
2.4.2
Self-Renewal of Normal and
Leukemie
Stem Cells,
39
2.4.3
Epigenetic Effects,
40
2.4.4
MicroRNA in Leukemia Development,
42
2.5
Conclusions and Future Perspectives,
44
References,
45
3
Isolation and Characterization of Breast and Brain Cancer
Stem Cells
57
Meera Saxena and Annapoorni Rangarajan
3.1
Introduction,
57
3.2
Breast Cancer Stem Cells,
58
3.2.1
Mammary Gland Architecture and Cell Types,
58
3.2.2
Breast Cancer,
59
3.2.3
Identification of Breast Cancer Stem Cells,
59
3.2.4
Putative Breast Cancer Stem Cells that Exhibit
theCD44+ CD24-/l0WLin- Marker Profile,
61
3.2.5 ES A+
Subpopulation
of CD24~lowLin- Cells Enriched
by Tumorigenicity,
61
3.2.6
Tumorigenic Breast Cells Displaying Properties of Stem
Cells,
61
3.2.7
In Vitro Propagation of Breast Cancer Stem Cells as
Mammospheres,
62
3.3
Brain Cancer Stem Cells,
64
3.3.1
Brain Architecture and Cell Types,
64
3.3.2
Brain Cancers,
65
3.3.3
Brain Stem Cells,
66
3.3.4
Brain Cancer Stem Cells,
66
3.3.5
Brain Cancer-Derived Cells that Generate Tumor
Spheres,
67
3.4
Conclusions and Future Perspectives,
69
References,
70
4
Cancer Stem Cell Side Populations
73
Danuta
Baììcki
and Raymond Beaulieu
4.1
Introduction,
73
4.2
Stem Cell Side Populations,
75
4.3
Side Populations in Normal Tissue,
78
4.4
Side Populations in Tumors,
79
CONTENTS
vii
4.5
Overcoming Side Population Limitations,
80
4.6
Conclusions and Future Perspectives,
81
References,
82
5
Evidence for Cancer Stem Cells in Retinoblastoma
87
GailM.Seigel
5.1
Introduction,
87
5.2
Elusive Origins of Retinoblastoma,
87
5.3
Sources of Retinoblastoma Cells for Study,
88
5.4
Precedent for Cancer Stem Cells,
88
5.5
Side Populations in Retinoblastoma,
89
5.6
Immunoreactivity to Stem Cell Markers in Retinoblastoma,
89
5.7
Conclusions and Future Perspectives,
91
References,
92
6
Ovarian Stem Cell Biology and the Emergence of Ovarian Cancer
Stem Cells
95
Anjali Kusumbe and Sharmila Bapat
6.1
Introduction,
95
6.2
Overview of the Human Ovary,
95
6.2.1
Histological Landmarks,
95
6.2.2
Ovarian Development: The Story Before Birth,
96
6.2.3
The Mammalian
Oogénesis
Dogma,
98
6.3
Stem/Progenitor Cells in the Adult Mammalian Ovary,
98
6.3.1
Historical Perspective,
98
6.3.2
The
Oogénesis
Dogma Revisited,
99
6.4
Is Ovarian Cancer a Stem Cell Disease?,
104
6.4.1
Putative Role of Stem/Progenitor Cells in Ovarian
Cancer,
104
6.4.2
Tumor as an Aberrant Organ Initiated by Cancer
Stem Cells,
105
6.4.3
Ovarian Cancer Stem Cells Isolated as a Side
Population,
106
6.4.4
New Challenge: Targeting Ovarian Cancer
Stem Cells,
106
References,
107
7
Prostate Cancer Stem Cells 111
Stefanie Hager,
Norman
J. Maitland,
and Anne Collins
7.1
Introduction, 111
7.2
Human Prostate Biology, Gland Architecture,
and Pathological Alterations,
1
1
1
viii CONTENTS
7.3
Prostate
Epithelial Stem Cells,
113
7.3.1
Evidence for Prostate Epithelial Stem Cells,
113
7.3.2
Isolation of Human Prostate Epithelial Stem Cells
and Demonstration of Their Stem Cell Character,
116
7.3.3
Epithelial Stem Cells in the
Murine
Prostate,
118
7.3.4
Other Markers of Prostate Epithelial Stem Cells,
119
7.4
Prostate Cancer Stem Cells,
120
7.4.1
Role of Stem Cells in Prostate Cancer,
120
7.4.2
Prospective Isolation of Prostate Cancer Stem Cells
from Human Tissue Samples,
122
7.4.3
Role of the Stem Cell Niche in Prostate Cancer,
124
7.4.4
Putative Markers of Prostate Cancer Stem Cells,
124
7.5
Stem Cell Tracking in the Prostate,
125
7.6
Conclusions and Future Perspectives,
127
References,
127
8
Molecular Signatures of Highly Malignant Melanoma Stem Cells
135
Suraiya Rasheed
8.1
General Properties of Human Melanomas,
135
8.2
Characteristics of Stem Cell-Derived Melanomas,
136
8.3
The Cat Model System for Stem Cell Melanomas,
137
8.3.1
Biological Characteristics of Highly Malignant Stem
Cell Melanomas,
138
8.3.2
Trans-differentiation of the Malignant Cat Melanoma
into
Neuronal
Cells,
139
8.3.3
Proteins Associated with
Neuronal
Cell
Differentiation,
140
8.3.4
Cell Cycle Dysregulation and Antitumorigenic Effects
During Cell Differentiation,
144
8.3.5
Molecular Signatures of Self Renewal and
Long-Term
Proliferation of Tumor Cells,
145
8.3.6
Proteins Involved in Tumorigenesis and Metastasis,
147
8.3.7
Expression of Germline and Embryonic Proteins in Cat
Melanomas,
149
8.3.8
Naturally Occurring Protein-Protein Interaction
Complexes in Melanomas,
149
8.3.9
Networks of Protein Interaction Pathways,
152
8.4
Challenges of Research in Cancer Stem Cells
and Therapeutics,
152
8.5
Conclusions and Future Perspectives,
154
References,
156
CONTENTS ix
9 Invasion Program
of
Normal
and Cancer Stem Cells
167
David
Olmeda,
Gema
Moreno-Bueno,
David
Samó,
José Palacios, and Amparo Cano
9.1
Introduction,
167
9.2
Basics of
Tumor
Progression: Invasion and Metastasis,
168
9.3
Epitheliał-to-Mesenchymal
Transition in Development and Its
Relation to The Invasive Process,
169
9.4
Regulation of EMT: From Signals to Molecular Pathways,
172
9.5
EMT and Cancer Stem Cells,
176
9.6
Can Stem Cell Properties Be Extensive to Invasive
Tumor Cells?,
177
9.7
Is There a Unique EMT Program Linked to Invasion?,
178
9.8
Evidence of EMT in Human Clinical Tumors,
180
9.9
Expression of Mesenchymal Markers and Cadherin Switching in
Carcinomas,
181
9.10
Expression of EMT Inducers in Human Tumors,
183
9.11
Occurrence of EMT in a Specific Subset of Breast
Carcinomas,
185
9.12
Conclusions and Future Perspectives,
186
References,
187
10
Epigenetics in Cancer Stem Cell Development
197
Kenneth Nephew, Curt Balch, Tim H.-M. Huang, Zhang Shu,
Michael Chan, and Pearlly Yan
10.1
Introduction,
197
10.2
Characterization of Candidate Cancer Stem Cells,
198
10.3
Possible Origins of Cancer Stem Cells,
198
10.4
Epigenetics in Normal Development,
199
10.5
Epigenetic Regulation of the Cancer Stem Cell Phenotype,
200
10.6
Contributions of Epigenetics to Drug Resistance in Cancer Stem
Cells,
204
10.7
Genome-Wide Interrogation of Epigenetic Modifications
in Cancer Stem Cells,
206
10.8
Epigenetic Therapies Against Poorly Differentiated
CancerCells,
207
10.9
Conclusions and Future Perspectives,
208
References,
209
11
Cancer Stem Cells and New Therapeutic Approaches
217
Michael Dean
11.1
Cancer Stem Cells,
217
χ
CONTENTS
11.2
Activation of Stem Cells and
Cancer,
218
11.2.1
Initiation and Promotion Revised,
219
11.2.2
Stem Cell Activation and Specific Cancers,
221
11.3
Major Cancers and Risk Factors,
223
11.3.1
Liver Cancer,
223
11.3.2
Lung Cancer,
224
11.3.3
Gastric Cancer,
224
11.3.4
Pancreatic Cancer,
224
11.3.5
Cervical Cancer,
225
11.4
Treatment Implications,
225
11.5
Future Perspectives,
227
11.6
Conclusions,
228
References,
243
12
Immunobiology of Cancer Stem Cells
233
Shubhada V. Chiplunkar
12.1
Cancer Stem Cells,
233
12.2
Cancer Stem Cells and Lymphocytes,
234
12.3
Trafficking of Normal Stem Cells and Metastasis
of Cancer Stem Cells,
236
References,
238
Index
243 |
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| callnumber-sort | RC 3269 |
| callnumber-subject | RC - Internal Medicine |
| classification_rvk | XH 2700 XH 3000 XH 3105 |
| ctrlnum | (OCoLC)230180377 (DE-599)BVBBV035162076 |
| dewey-full | 616.99406 362.196/994 |
| dewey-hundreds | 600 - Technology (Applied sciences) 300 - Social sciences |
| dewey-ones | 616 - Diseases 362 - Social problems and services to groups |
| dewey-raw | 616.99406 362.196/994 |
| dewey-search | 616.99406 362.196/994 |
| dewey-sort | 3616.99406 |
| dewey-tens | 610 - Medicine and health 360 - Social problems and services; associations |
| discipline | Soziologie Medizin |
| discipline_str_mv | Soziologie Medizin |
| format | Book |
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| id | DE-604.BV035162076 |
| illustrated | Illustrated |
| index_date | 2024-07-02T22:51:07Z |
| indexdate | 2024-07-09T21:26:24Z |
| institution | BVB |
| isbn | 9780470122013 0470122013 |
| language | English |
| lccn | 2008035481 |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-016969168 |
| oclc_num | 230180377 |
| open_access_boolean | |
| owner | DE-20 DE-355 DE-BY-UBR DE-11 |
| owner_facet | DE-20 DE-355 DE-BY-UBR DE-11 |
| physical | XIV, 245 S., [6 Bl.] Ill., graph. Darst. |
| publishDate | 2009 |
| publishDateSearch | 2009 |
| publishDateSort | 2009 |
| publisher | Wiley |
| record_format | marc |
| spelling | Cancer stem cells identification and targets ed. by Sharmila Bapat Hoboken, NJ Wiley 2009 XIV, 245 S., [6 Bl.] Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Cancer cells Stem cells Neoplastic Stem Cells Krebszelle (DE-588)4128704-6 gnd rswk-swf Stammzelle (DE-588)4665329-6 gnd rswk-swf Krebszelle (DE-588)4128704-6 s Stammzelle (DE-588)4665329-6 s DE-604 Bapat, Sharmila Sonstige oth Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016969168&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Cancer stem cells identification and targets Cancer cells Stem cells Neoplastic Stem Cells Krebszelle (DE-588)4128704-6 gnd Stammzelle (DE-588)4665329-6 gnd |
| subject_GND | (DE-588)4128704-6 (DE-588)4665329-6 |
| title | Cancer stem cells identification and targets |
| title_auth | Cancer stem cells identification and targets |
| title_exact_search | Cancer stem cells identification and targets |
| title_exact_search_txtP | Cancer stem cells identification and targets |
| title_full | Cancer stem cells identification and targets ed. by Sharmila Bapat |
| title_fullStr | Cancer stem cells identification and targets ed. by Sharmila Bapat |
| title_full_unstemmed | Cancer stem cells identification and targets ed. by Sharmila Bapat |
| title_short | Cancer stem cells |
| title_sort | cancer stem cells identification and targets |
| title_sub | identification and targets |
| topic | Cancer cells Stem cells Neoplastic Stem Cells Krebszelle (DE-588)4128704-6 gnd Stammzelle (DE-588)4665329-6 gnd |
| topic_facet | Cancer cells Stem cells Neoplastic Stem Cells Krebszelle Stammzelle |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016969168&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT bapatsharmila cancerstemcellsidentificationandtargets |