Genetics primer for exercise science and health:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Champaign, IL [u.a.]
Human Kinetics
2007
|
| Schriftenreihe: | Primers for exercise science series
|
| Schlagworte: | |
| Online-Zugang: | Table of contents only Inhaltsverzeichnis |
| Beschreibung: | XIII, 177 S. Ill., graph. Darst. 28 cm |
| ISBN: | 0736063439 9780736063432 |
Internformat
MARC
| LEADER | 00000nam a2200000zc 4500 | ||
|---|---|---|---|
| 001 | BV035156212 | ||
| 003 | DE-604 | ||
| 005 | 20081209 | ||
| 007 | t | ||
| 008 | 081112s2007 xxuad|| |||| 00||| eng d | ||
| 010 | |a 2007004421 | ||
| 020 | |a 0736063439 |c soft cover |9 0-7360-6343-9 | ||
| 020 | |a 9780736063432 |9 978-0-7360-6343-2 | ||
| 035 | |a (OCoLC)84730104 | ||
| 035 | |a (DE-599)BVBBV035156212 | ||
| 040 | |a DE-604 |b ger |e aacr | ||
| 041 | 0 | |a eng | |
| 044 | |a xxu |c US | ||
| 049 | |a DE-703 | ||
| 050 | 0 | |a QH431 | |
| 082 | 0 | |a 612/.044 | |
| 084 | |a WG 7000 |0 (DE-625)148612: |2 rvk | ||
| 100 | 1 | |a Roth, Stephen M. |d 1973- |e Verfasser |0 (DE-588)135699215 |4 aut | |
| 245 | 1 | 0 | |a Genetics primer for exercise science and health |c Stephen M. Roth |
| 264 | 1 | |a Champaign, IL [u.a.] |b Human Kinetics |c 2007 | |
| 300 | |a XIII, 177 S. |b Ill., graph. Darst. |c 28 cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 0 | |a Primers for exercise science series | |
| 650 | 7 | |a Genetik |2 swd | |
| 650 | 7 | |a Gesundheit |2 swd | |
| 650 | 7 | |a Sportliche Aktivität |2 swd | |
| 650 | 7 | |a Sportwissenschaft |2 swd | |
| 650 | 4 | |a Human genetics | |
| 650 | 4 | |a Exercise |x Physiological aspects | |
| 650 | 4 | |a Sports |x Physiological aspects | |
| 650 | 4 | |a Genetics | |
| 650 | 4 | |a Physical Fitness |x physiology | |
| 650 | 4 | |a Exercise |x physiology | |
| 650 | 4 | |a Genetic Techniques | |
| 650 | 4 | |a Variation (Genetics) | |
| 856 | 4 | |u http://www.loc.gov/catdir/toc/ecip0711/2007004421.html |3 Table of contents only | |
| 856 | 4 | 2 | |m HBZ Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016963392&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-016963392 | ||
Datensatz im Suchindex
| _version_ | 1804138317039534080 |
|---|---|
| adam_text | Contents
Preface xi
Acknowledgments xiii
Part I Basics of Genetics 1
chapter 1 Individual Differences: The Role of
Genetics in Exercise Science and Health 3
Hidden Aspect of Average Values 3
Why Do We See Variation in a Physical Trait? 6
Summary 7
Learning Aids 7
chapter 2 DNA, RNA, and Protein 9
Basic Cell Biology 9
DNA 10
Our Genetic Material as Chromosomes 11
Special Focus: The Human Genome Project 12
RNA 13
Amino Acids and Proteins 14
Structure of Genes 15
Summary 17
Learning Aids 18
chapter 3 Transcription, Translation,
and the Genetic Code 19
Moving from DNA to RNA: Transcription 19
Posttranscriptional Modifications of RNA 20
Moving from RNA to Protein: Translation 21
Posttranslational Modifications of Proteins 22
Genetic Code 22
Summary 23
Learning Aids 23
v
Vi CONTENTS
c h a p t e r 4 Moving Genetic Material
to the Next Generation 25
Basic Reproduction 25
Sex Cell Production and Meiosis 26
Special Focus: Mitosis Versus Meiosis 26
Chromosomal Recombination 28
Mendelian Inheritance Patterns 30
Summary 32
Learning Aids 33
chapter 5 Heritability and the Basics
of Genetic Variation 35
Familial Resemblance: Genes and Environment 35
Heritability as a Measure of Genetic Contribution 36
Genetic Variation 38
Special Focus: Twin and Family Studies 39
Types of Genetic Variation 40
Special Focus: Labeling Polymorphisms 42
How Genetic Variation Can Influence Physical Traits 44
How Do Polymorphisms Arise?
Genetic Variation and Evolution 47
Summary 48
Learning Aids 49
chapter 6 Genetic Variation and Disease 51
Mendelian Disease Genetics 51
Special Focus: Muscular Dystrophy 53
Complex Disease 54
Gene x Environment Interactions 56
Special Focus: Obesity as a Complex Trait 57
Gene x Gene Interactions 58
Summary 59
Learning Aids 59
CONTENTS Vii
chapter 7 Linkage Disequilibrium, Haplotype,
and Environmental Interaction 61
Recombination Revisited 61
Linkage Disequilibrium 63
Linkage Analysis in Families 65
Haplotype: Combinations of Neighboring Alleles 67
Special Focus: The International HapMap Project 69
Diplotype: Combinations of Haplotypes 70
Gene x Environment Interaction Revisited 72
An Introduction to Epigenetics 72
Summary 74
Learning Aids 74
Part II Research Design and Methods ... 75
chapter 8 Getting Started:
Basic Skills for Genetics Research 77
Is Genetic Variation Important for My Trait of Interest? 77
Using PubMed 79
Interpreting Existing Literature 79
Identifying and Selecting Candidate Genes
and Polymorphisms 80
Using Genome Databases 82
Summary 84
Learning Aids 84
chapter 9 Issues in Study Design and Analysis 85
How Genetics Necessarily Alters Study Design 85
Typical Study Designs 87
Subject Recruitment 89
Geographic Ancestry 90
Special Focus: Race in Genetics 92
Prospective Versus Retrospective 93
Statistical Approaches 94
Interpretation of Results:
Association Versus Cause and Effect 95
Viii CONTENTS
Summary 96
Learning Aids 96
chapter 10 Basic Laboratory Methods in Genetics 99
DNA From Blood or Cheek Cells 99
Polymerase Chain Reaction (PCR) 100
Genotyping With Restriction Enzymes 103
Genotyping With Fluorescent Tags 105
DNA Sequencing 106
Special Focus: DNA Microarrays 107
Summary 110
Learning Aids 110
Part III Current Findings and Extensions
of Genetics Research Ill
chapter 11 Current Research Findings in the
Genetics of Exercise Science and Health ... 113
Overview of Current Findings 113
Special Focus: The Human Gene Map for Performance
and Health-Related Fitness Phenotypes 114
ACTN3 and Muscle Performance 116
ApoE and Cognitive Impairment 118
ACE and Sport Performance 121
Myostatin and Muscle Mass 124
Summary 127
Learning Aids 128
chapter 12 Personalized Medicine 129
Genetics and Complex Disease Revisited 129
Promise and Limitations of Personalized Medicine 130
Special Focus: Pharmacogenomics 131
Genetics in Nutrition and Exercise Prescription 132
Genetics in Disease Prevention 134
Summary 135
Learning Aids 135
CONTENTS ix
chapter 13 Ethical Challenges in Genetics and Society .. 137
Ethical, Legal, and Social Implications of Genomics 137
Gene Therapy for Disease Treatment 140
Special Focus: Stem Cells 142
Genetics in Sport: Genetic Testing and Gene Doping
for Performance 143
Summary 145
Learnings Aids 145
Appendix A Answers to Review Questions 147
Appendix B Evolution and Hardy-Weinberg Equilibrium 153
Glossary 157
Bibliography 165
Index 169
About the Author 177
|
| adam_txt |
Contents
Preface xi
Acknowledgments xiii
Part I Basics of Genetics 1
chapter 1 Individual Differences: The Role of
Genetics in Exercise Science and Health 3
Hidden Aspect of Average Values 3
Why Do We See Variation in a Physical Trait? 6
Summary 7
Learning Aids 7
chapter 2 DNA, RNA, and Protein 9
Basic Cell Biology 9
DNA 10
Our Genetic Material as Chromosomes 11
Special Focus: The Human Genome Project 12
RNA 13
Amino Acids and Proteins 14
Structure of Genes 15
Summary 17
Learning Aids 18
chapter 3 Transcription, Translation,
and the Genetic Code 19
Moving from DNA to RNA: Transcription 19
Posttranscriptional Modifications of RNA 20
Moving from RNA to Protein: Translation 21
Posttranslational Modifications of Proteins 22
Genetic Code 22
Summary 23
Learning Aids 23
v
Vi CONTENTS
c h a p t e r 4 Moving Genetic Material
to the Next Generation 25
Basic Reproduction 25
Sex Cell Production and Meiosis 26
Special Focus: Mitosis Versus Meiosis 26
Chromosomal Recombination 28
Mendelian Inheritance Patterns 30
Summary 32
Learning Aids 33
chapter 5 Heritability and the Basics
of Genetic Variation 35
Familial Resemblance: Genes and Environment 35
Heritability as a Measure of Genetic Contribution 36
Genetic Variation 38
Special Focus: Twin and Family Studies 39
Types of Genetic Variation 40
Special Focus: Labeling Polymorphisms 42
How Genetic Variation Can Influence Physical Traits 44
How Do Polymorphisms Arise?
Genetic Variation and Evolution 47
Summary 48
Learning Aids 49
chapter 6 Genetic Variation and Disease 51
Mendelian Disease Genetics 51
Special Focus: Muscular Dystrophy 53
Complex Disease 54
Gene x Environment Interactions 56
Special Focus: Obesity as a Complex Trait 57
Gene x Gene Interactions 58
Summary 59
Learning Aids 59
CONTENTS Vii
chapter 7 Linkage Disequilibrium, Haplotype,
and Environmental Interaction 61
Recombination Revisited 61
Linkage Disequilibrium 63
Linkage Analysis in Families 65
Haplotype: Combinations of Neighboring Alleles 67
Special Focus: The International HapMap Project 69
Diplotype: Combinations of Haplotypes 70
Gene x Environment Interaction Revisited 72
An Introduction to Epigenetics 72
Summary 74
Learning Aids 74
Part II Research Design and Methods . 75
chapter 8 Getting Started:
Basic Skills for Genetics Research 77
Is Genetic Variation Important for My Trait of Interest? 77
Using PubMed 79
Interpreting Existing Literature 79
Identifying and Selecting Candidate Genes
and Polymorphisms 80
Using Genome Databases 82
Summary 84
Learning Aids 84
chapter 9 Issues in Study Design and Analysis 85
How Genetics Necessarily Alters Study Design 85
Typical Study Designs 87
Subject Recruitment 89
Geographic Ancestry 90
Special Focus: Race in Genetics 92
Prospective Versus Retrospective 93
Statistical Approaches 94
Interpretation of Results:
Association Versus Cause and Effect 95
Viii CONTENTS
Summary 96
Learning Aids 96
chapter 10 Basic Laboratory Methods in Genetics 99
DNA From Blood or Cheek Cells 99
Polymerase Chain Reaction (PCR) 100
Genotyping With Restriction Enzymes 103
Genotyping With Fluorescent Tags 105
DNA Sequencing 106
Special Focus: DNA Microarrays 107
Summary 110
Learning Aids 110
Part III Current Findings and Extensions
of Genetics Research Ill
chapter 11 Current Research Findings in the
Genetics of Exercise Science and Health . 113
Overview of Current Findings 113
Special Focus: The Human Gene Map for Performance
and Health-Related Fitness Phenotypes 114
ACTN3 and Muscle Performance 116
ApoE and Cognitive Impairment 118
ACE and Sport Performance 121
Myostatin and Muscle Mass 124
Summary 127
Learning Aids 128
chapter 12 Personalized Medicine 129
Genetics and Complex Disease Revisited 129
Promise and Limitations of Personalized Medicine 130
Special Focus: Pharmacogenomics 131
Genetics in Nutrition and Exercise Prescription 132
Genetics in Disease Prevention 134
Summary 135
Learning Aids 135
CONTENTS ix
chapter 13 Ethical Challenges in Genetics and Society . 137
Ethical, Legal, and Social Implications of Genomics 137
Gene Therapy for Disease Treatment 140
Special Focus: Stem Cells 142
Genetics in Sport: Genetic Testing and Gene Doping
for Performance 143
Summary 145
Learnings Aids 145
Appendix A Answers to Review Questions 147
Appendix B Evolution and Hardy-Weinberg Equilibrium 153
Glossary 157
Bibliography 165
Index 169
About the Author 177 |
| any_adam_object | 1 |
| any_adam_object_boolean | 1 |
| author | Roth, Stephen M. 1973- |
| author_GND | (DE-588)135699215 |
| author_facet | Roth, Stephen M. 1973- |
| author_role | aut |
| author_sort | Roth, Stephen M. 1973- |
| author_variant | s m r sm smr |
| building | Verbundindex |
| bvnumber | BV035156212 |
| callnumber-first | Q - Science |
| callnumber-label | QH431 |
| callnumber-raw | QH431 |
| callnumber-search | QH431 |
| callnumber-sort | QH 3431 |
| callnumber-subject | QH - Natural History and Biology |
| classification_rvk | WG 7000 |
| ctrlnum | (OCoLC)84730104 (DE-599)BVBBV035156212 |
| dewey-full | 612/.044 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 612 - Human physiology |
| dewey-raw | 612/.044 |
| dewey-search | 612/.044 |
| dewey-sort | 3612 244 |
| dewey-tens | 610 - Medicine and health |
| discipline | Biologie Medizin |
| discipline_str_mv | Biologie Medizin |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01815nam a2200505zc 4500</leader><controlfield tag="001">BV035156212</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20081209 </controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">081112s2007 xxuad|| |||| 00||| eng d</controlfield><datafield tag="010" ind1=" " ind2=" "><subfield code="a">2007004421</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">0736063439</subfield><subfield code="c">soft cover</subfield><subfield code="9">0-7360-6343-9</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9780736063432</subfield><subfield code="9">978-0-7360-6343-2</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)84730104</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV035156212</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">aacr</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="044" ind1=" " ind2=" "><subfield code="a">xxu</subfield><subfield code="c">US</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-703</subfield></datafield><datafield tag="050" ind1=" " ind2="0"><subfield code="a">QH431</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">612/.044</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">WG 7000</subfield><subfield code="0">(DE-625)148612:</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Roth, Stephen M.</subfield><subfield code="d">1973-</subfield><subfield code="e">Verfasser</subfield><subfield code="0">(DE-588)135699215</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Genetics primer for exercise science and health</subfield><subfield code="c">Stephen M. Roth</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Champaign, IL [u.a.]</subfield><subfield code="b">Human Kinetics</subfield><subfield code="c">2007</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">XIII, 177 S.</subfield><subfield code="b">Ill., graph. Darst.</subfield><subfield code="c">28 cm</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="0" ind2=" "><subfield code="a">Primers for exercise science series</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Genetik</subfield><subfield code="2">swd</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Gesundheit</subfield><subfield code="2">swd</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Sportliche Aktivität</subfield><subfield code="2">swd</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Sportwissenschaft</subfield><subfield code="2">swd</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Human genetics</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Exercise</subfield><subfield code="x">Physiological aspects</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Sports</subfield><subfield code="x">Physiological aspects</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Genetics</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Physical Fitness</subfield><subfield code="x">physiology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Exercise</subfield><subfield code="x">physiology</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Genetic Techniques</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Variation (Genetics)</subfield></datafield><datafield tag="856" ind1="4" ind2=" "><subfield code="u">http://www.loc.gov/catdir/toc/ecip0711/2007004421.html</subfield><subfield code="3">Table of contents only</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">HBZ Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016963392&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-016963392</subfield></datafield></record></collection> |
| id | DE-604.BV035156212 |
| illustrated | Illustrated |
| index_date | 2024-07-02T22:48:49Z |
| indexdate | 2024-07-09T21:26:16Z |
| institution | BVB |
| isbn | 0736063439 9780736063432 |
| language | English |
| lccn | 2007004421 |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-016963392 |
| oclc_num | 84730104 |
| open_access_boolean | |
| owner | DE-703 |
| owner_facet | DE-703 |
| physical | XIII, 177 S. Ill., graph. Darst. 28 cm |
| publishDate | 2007 |
| publishDateSearch | 2007 |
| publishDateSort | 2007 |
| publisher | Human Kinetics |
| record_format | marc |
| series2 | Primers for exercise science series |
| spelling | Roth, Stephen M. 1973- Verfasser (DE-588)135699215 aut Genetics primer for exercise science and health Stephen M. Roth Champaign, IL [u.a.] Human Kinetics 2007 XIII, 177 S. Ill., graph. Darst. 28 cm txt rdacontent n rdamedia nc rdacarrier Primers for exercise science series Genetik swd Gesundheit swd Sportliche Aktivität swd Sportwissenschaft swd Human genetics Exercise Physiological aspects Sports Physiological aspects Genetics Physical Fitness physiology Exercise physiology Genetic Techniques Variation (Genetics) http://www.loc.gov/catdir/toc/ecip0711/2007004421.html Table of contents only HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016963392&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Roth, Stephen M. 1973- Genetics primer for exercise science and health Genetik swd Gesundheit swd Sportliche Aktivität swd Sportwissenschaft swd Human genetics Exercise Physiological aspects Sports Physiological aspects Genetics Physical Fitness physiology Exercise physiology Genetic Techniques Variation (Genetics) |
| title | Genetics primer for exercise science and health |
| title_auth | Genetics primer for exercise science and health |
| title_exact_search | Genetics primer for exercise science and health |
| title_exact_search_txtP | Genetics primer for exercise science and health |
| title_full | Genetics primer for exercise science and health Stephen M. Roth |
| title_fullStr | Genetics primer for exercise science and health Stephen M. Roth |
| title_full_unstemmed | Genetics primer for exercise science and health Stephen M. Roth |
| title_short | Genetics primer for exercise science and health |
| title_sort | genetics primer for exercise science and health |
| topic | Genetik swd Gesundheit swd Sportliche Aktivität swd Sportwissenschaft swd Human genetics Exercise Physiological aspects Sports Physiological aspects Genetics Physical Fitness physiology Exercise physiology Genetic Techniques Variation (Genetics) |
| topic_facet | Genetik Gesundheit Sportliche Aktivität Sportwissenschaft Human genetics Exercise Physiological aspects Sports Physiological aspects Genetics Physical Fitness physiology Exercise physiology Genetic Techniques Variation (Genetics) |
| url | http://www.loc.gov/catdir/toc/ecip0711/2007004421.html http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016963392&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT rothstephenm geneticsprimerforexercisescienceandhealth |