Physical activity and type 2 diabetes: therapeutic effects and mechanisms of action
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Champaign, IL
Human Kinetics
2008
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | xii, 219 p. ill. 29 cm |
| ISBN: | 9780736064798 0736064796 |
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| 245 | 1 | 0 | |a Physical activity and type 2 diabetes |b therapeutic effects and mechanisms of action |c John A. Hawley, Juleen R. Zierath, editors |
| 264 | 1 | |a Champaign, IL |b Human Kinetics |c 2008 | |
| 300 | |a xii, 219 p. |b ill. |c 29 cm | ||
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| 500 | |a Includes bibliographical references and index | ||
| 650 | 4 | |a Diabetes |x Exercise therapy | |
| 650 | 4 | |a Insulin resistance |x Exercise therapy | |
| 650 | 4 | |a Diabetes |x Prevention | |
| 650 | 4 | |a Diabetes Mellitus, Type 2 |x prevention & control | |
| 650 | 4 | |a Exercise | |
| 650 | 4 | |a Insulin Resistance |x physiology | |
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Datensatz im Suchindex
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| adam_text | Contents
Contributors ix
Preface xi
Part I Aetiology of Insulin Resistance and Type 2 Diabetes
Prevalence and Consequences of the Diabesity Epidemic
Chapter 1 The Increasing Burden of Type 2 Diabetes: Magnitude,
Causes, and Implications of the Epidemic 3
Edward W. Gregg, PhD; and Andrea K. Kriska, PhD
Diabetes Prevalence and Incidence in Adults 3
Type 2 Diabetes in Youths and Adolescents 7
Risk Factors for Diabetes and Causes of the Epidemic 7
Determinants of Recent Diabetes Trends 9
Anticipated Consequences of Diabetes
and the Outlook for Prevention 10
Concluding Remarks 11
References 11
Chapter 2 Waging War on Type 2 Diabetes: Primary Prevention
Through Exercise Biology 15
Frank W. Booth, PhD; Manu V. Chakravarthy, MD, PhD;
and Matthew J. Laye, BS
Scope of the Problem 15
Rationale for Action 16
Role of Physical Inactivity in Diabetes 18
New Ammunitions 19
Future Battle Plans 20
Concluding Remarks 21
References 21
Part II Defects in Metabolism and Insulin Resistance
Chapter 3 Fatty Acid Uptake and Insulin Resistance 25
Arend Bonen, PhD; Adrian Chabowski, MD, PhD;
Jan F.C. Glatz, PhD; andJoostJ.F.P. Luiken, PhD
Long-Chain Fatty Acids and Their Uptake Across the Sarcolemma 26
Fatty Acid Transporters 27
LCFA Transport and Transporters in Obesity and Type 2 Diabetes 32
iii
iv Contents ____. ...
Concluding Remarks 37
References 38
Chapter 4 Lipid Metabolism and Insulin Signaling 43
Jason R. Berggren, PhD; Leslie A. Consitt, PhD;
and Joseph A. Houmard, PhD
Lipid Metabolism in Skeletal Muscle 43
Insulin Signaling 46
Does Lipid Exposure Impair Insulin Action? 48
Perturbations in Substrate Utilization With Type 2 Diabetes
and Obesity 50
The Exercise Paradox 51
Effect of Weight Loss on Muscle Lipid Accumulation
and Insulin Signaling 52
Concluding Remarks 53
References 53
Chapter 5 Metabolic Inflexibility and Insulin Resistance
in Skeletal Muscle 59
Bret H. Goodpaster, PhD; and David E. Kelley, MD
Substrate Utilization During Rest in Individuals Who Are Lean
and Healthy 59
Substrate Utilization in Individuals Who Are Insulin Resistant 60
Effects of Weight Loss on Metabolic Flexibility in Obesity
and Type 2 Diabetes 63
Effects of Exercise Training on Metabolic Flexibility in Obesity
and Type 2 Diabetes 64
Concluding Remarks 66
References 66
Chapter 6 Nutrient Sensing Links Obesity With Diabetes Risk 71
Sarah Crunkhorn, PhD; and Mary Elizabeth Patti, MD
Nutrient Sensing and Control of Food Intake 71
Cellular Nutrient Sensing 73
PGC-1 as a Key Effector Responsive to Nutrition in Muscle 78
Concluding Remarks 79
References 79
Chapter 7 Inflammation-Induced Insulin Resistance in Obesity:
When Immunity Affects Metabolic Control 83
Phillip James White, MS; and Andre Marette, PhD
Obesity: A Chronic Low-Grade Inflammatory State 83
Evolution of Inflammation in Obesity 85
Contents v
Mechanisms Linking Inflammation to Insulin Resistance in Obesity 89
AMPK: From a Gauge of Energy Status to a Novel Target
for Alleviating Inflammation in Obesity 96
Concluding Remarks 97
References 98
Part III Prevention of Type 2 Diabetes Through Exercise Training
Chapter 8 Transcription Factors Regulating Exercise Adaptation 107
David Kitz Kramer, PhD; and Anna Krook, PhD
Activation of MAPK Signaling 107
Nuclear Factor of Activated T Cells 110
Regulation of GLUT4 Expression 110
Myocyte Enhancer Factor 2 and GLUT4 Enhancer Factor 111
Mitochondria Biogenesis and Increased Lipid Oxidation 111
Exercise-Mediated Regulation of PPARs 112
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1 113
Myogenic Development and Adaptation 113
Concluding Remarks 114
References 115
Chapter 9 Exercise and Calorie Restriction Use Different
Mechanisms to Improve Insulin Sensitivity 119
Gregory D. Cartee, PhD
Effects of Exercise and Calorie Restriction on
Skeletal Muscle Energy Status 119
Insulin Signaling for Glucose Transport 120
Exercise- and Contraction-Stimulated Signaling Pathway
for Glucose Transport 120
Insulin Signaling and Action After Acute Exercise 121
Effects of Exercise Training on Insulin Sensitivity and Signaling 124
Effects of Calorie Restriction Distinct From Weight Loss 127
Effects of Calorie Restriction on Insulin Signaling in Skeletal Muscle 127
Combined Effects of Exercise and Calorie Restriction 129
Concluding Remarks 130
References 131
Chapter 10 Mitochondrial Oxidative Capacity and Insulin Resistance 135
Kevin R. Short, PhD
Mitochondrial Structure and Function 135
Evidence of a Role for Mitochondria in Insulin Resistance
and Diabetes 135
vi Contents
Evidence That Mitochondria Are Not Responsible for
Insulin Resistance 138
Concluding Remarks 142
References 142
Chapter 11 Effects of Acute Exercise and Exercise Training
on Insulin Action in Skeletal Muscle 147
Erik A. Richter, MD, DMSci; and Jorgen F.P. Wojtaszewski, PhD
Exercise and Contraction Signaling in Muscle 147
Insulin Signaling: A Web 150
Effects of a Single Exercise Bout on Insulin Sensitivity 152
Effects of Exercise Training on Insulin Action 153
Concluding Remarks 156
References 156
Chapter 12 Resistance Exercise Training and
the Management of Diabetes 161
J0rgen F.P Wojtaszewski, PhD; Henriette Pilegaard, PhD;
and Flemming Dela, MD
Resistance Training and Insulin Sensitivity 162
Mechanisms Behind Resistance Training-Induced Improvements
in Insulin Sensitivity 166
Training-Induced Gene Expression 169
Concluding Remarks 170
References 170
Part IV Prevention of Type 2 Diabetes
Identification of Novel Molecular Targets and Pathways
Chapter 13 AMPK: The Master Switch for Type 2 Diabetes? 177
W.W. Winder, PhD; and DM. Thomson, PhD
Discoveries Suggesting AMPK Could Be Important for Prevention
and Treatment of Type 2 Diabetes 177
Could Type 2 Diabetes Result From a Deficiency
in AMPK Signaling? 178
How Can AMPK Activation Help Prevent Type 2 Diabetes? 179
Can Chemical AMPK Activation Prevent Diabetes? 181
Feasibility of Using AMPK Activators 181
Future Directions 182
Concluding Remarks 182
References 183
Contents vii
Chapter 14 Protein Kinase C and Insulin Resistance 187
Carsten Schmitz-Peiffer, PhD
PKC Family of Serine and Threonine Kinases 187
Roles for PKC in Normal Glucose Homeostasis 189
PKC and Defective Glucose Disposal 190
Concluding Remarks 195
References 196
Chapter 15 Evidence for Prescribing Exercise as a Therapy for
Treating Patients With Type 2 Diabetes 203
Sarah }. Lessard, PhD; and John A. Hawley, PhD, FACSM
Options for Treating Insulin Resistance and Type 2 Diabetes 203
Molecular Evidence for Prescribing Exercise Training 204
Exercise and Drug Combination Therapy 207
Exercise-Like Effects of Current Antihyperglycemic Drugs 209
Prescribing Exercise Training: Practical Considerations 209
Concluding Remarks 210
References 211
Index 215
About the Editors 219
|
| adam_txt |
Contents
Contributors ix
Preface xi
Part I Aetiology of Insulin Resistance and Type 2 Diabetes
Prevalence and Consequences of the "Diabesity" Epidemic
Chapter 1 The Increasing Burden of Type 2 Diabetes: Magnitude,
Causes, and Implications of the Epidemic 3
Edward W. Gregg, PhD; and Andrea K. Kriska, PhD
Diabetes Prevalence and Incidence in Adults 3
Type 2 Diabetes in Youths and Adolescents 7
Risk Factors for Diabetes and Causes of the Epidemic 7
Determinants of Recent Diabetes Trends 9
Anticipated Consequences of Diabetes
and the Outlook for Prevention 10
Concluding Remarks 11
References 11
Chapter 2 Waging War on Type 2 Diabetes: Primary Prevention
Through Exercise Biology 15
Frank W. Booth, PhD; Manu V. Chakravarthy, MD, PhD;
and Matthew J. Laye, BS
Scope of the Problem 15
Rationale for Action 16
Role of Physical Inactivity in Diabetes 18
New Ammunitions 19
Future Battle Plans 20
Concluding Remarks 21
References 21
Part II Defects in Metabolism and Insulin Resistance
Chapter 3 Fatty Acid Uptake and Insulin Resistance 25
Arend Bonen, PhD; Adrian Chabowski, MD, PhD;
Jan F.C. Glatz, PhD; andJoostJ.F.P. Luiken, PhD
Long-Chain Fatty Acids and Their Uptake Across the Sarcolemma 26
Fatty Acid Transporters 27
LCFA Transport and Transporters in Obesity and Type 2 Diabetes 32
iii
iv Contents _. .
Concluding Remarks 37
References 38
Chapter 4 Lipid Metabolism and Insulin Signaling 43
Jason R. Berggren, PhD; Leslie A. Consitt, PhD;
and Joseph A. Houmard, PhD
Lipid Metabolism in Skeletal Muscle 43
Insulin Signaling 46
Does Lipid Exposure Impair Insulin Action? 48
Perturbations in Substrate Utilization With Type 2 Diabetes
and Obesity 50
The Exercise Paradox 51
Effect of Weight Loss on Muscle Lipid Accumulation
and Insulin Signaling 52
Concluding Remarks 53
References 53
Chapter 5 Metabolic Inflexibility and Insulin Resistance
in Skeletal Muscle 59
Bret H. Goodpaster, PhD; and David E. Kelley, MD
Substrate Utilization During Rest in Individuals Who Are Lean
and Healthy 59
Substrate Utilization in Individuals Who Are Insulin Resistant 60
Effects of Weight Loss on Metabolic Flexibility in Obesity
and Type 2 Diabetes 63
Effects of Exercise Training on Metabolic Flexibility in Obesity
and Type 2 Diabetes 64
Concluding Remarks 66
References 66
Chapter 6 Nutrient Sensing Links Obesity With Diabetes Risk 71
Sarah Crunkhorn, PhD; and Mary Elizabeth Patti, MD
Nutrient Sensing and Control of Food Intake 71
Cellular Nutrient Sensing 73
PGC-1 as a Key Effector Responsive to Nutrition in Muscle 78
Concluding Remarks 79
References 79
Chapter 7 Inflammation-Induced Insulin Resistance in Obesity:
When Immunity Affects Metabolic Control 83
Phillip James White, MS; and Andre Marette, PhD
Obesity: A Chronic Low-Grade Inflammatory State 83
Evolution of Inflammation in Obesity 85
Contents v
Mechanisms Linking Inflammation to Insulin Resistance in Obesity 89
AMPK: From a Gauge of Energy Status to a Novel Target
for Alleviating Inflammation in Obesity 96
Concluding Remarks 97
References 98
Part III Prevention of Type 2 Diabetes Through Exercise Training
Chapter 8 Transcription Factors Regulating Exercise Adaptation 107
David Kitz Kramer, PhD; and Anna Krook, PhD
Activation of MAPK Signaling 107
Nuclear Factor of Activated T Cells 110
Regulation of GLUT4 Expression 110
Myocyte Enhancer Factor 2 and GLUT4 Enhancer Factor 111
Mitochondria Biogenesis and Increased Lipid Oxidation 111
Exercise-Mediated Regulation of PPARs 112
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1 113
Myogenic Development and Adaptation 113
Concluding Remarks 114
References 115
Chapter 9 Exercise and Calorie Restriction Use Different
Mechanisms to Improve Insulin Sensitivity 119
Gregory D. Cartee, PhD
Effects of Exercise and Calorie Restriction on
Skeletal Muscle Energy Status 119
Insulin Signaling for Glucose Transport 120
Exercise- and Contraction-Stimulated Signaling Pathway
for Glucose Transport 120
Insulin Signaling and Action After Acute Exercise 121
Effects of Exercise Training on Insulin Sensitivity and Signaling 124
Effects of Calorie Restriction Distinct From Weight Loss 127
Effects of Calorie Restriction on Insulin Signaling in Skeletal Muscle 127
Combined Effects of Exercise and Calorie Restriction 129
Concluding Remarks 130
References 131
Chapter 10 Mitochondrial Oxidative Capacity and Insulin Resistance 135
Kevin R. Short, PhD
Mitochondrial Structure and Function 135
Evidence of a Role for Mitochondria in Insulin Resistance
and Diabetes 135
vi Contents
Evidence That Mitochondria Are Not Responsible for
Insulin Resistance 138
Concluding Remarks 142
References 142
Chapter 11 Effects of Acute Exercise and Exercise Training
on Insulin Action in Skeletal Muscle 147
Erik A. Richter, MD, DMSci; and Jorgen F.P. Wojtaszewski, PhD
Exercise and Contraction Signaling in Muscle 147
Insulin Signaling: A Web 150
Effects of a Single Exercise Bout on Insulin Sensitivity 152
Effects of Exercise Training on Insulin Action 153
Concluding Remarks 156
References 156
Chapter 12 Resistance Exercise Training and
the Management of Diabetes 161
J0rgen F.P Wojtaszewski, PhD; Henriette Pilegaard, PhD;
and Flemming Dela, MD
Resistance Training and Insulin Sensitivity 162
Mechanisms Behind Resistance Training-Induced Improvements
in Insulin Sensitivity 166
Training-Induced Gene Expression 169
Concluding Remarks 170
References 170
Part IV Prevention of Type 2 Diabetes
Identification of Novel Molecular Targets and Pathways
Chapter 13 AMPK: The Master Switch for Type 2 Diabetes? 177
W.W. Winder, PhD; and DM. Thomson, PhD
Discoveries Suggesting AMPK Could Be Important for Prevention
and Treatment of Type 2 Diabetes 177
Could Type 2 Diabetes Result From a Deficiency
in AMPK Signaling? 178
How Can AMPK Activation Help Prevent Type 2 Diabetes? 179
Can Chemical AMPK Activation Prevent Diabetes? 181
Feasibility of Using AMPK Activators 181
Future Directions 182
Concluding Remarks 182
References 183
Contents vii
Chapter 14 Protein Kinase C and Insulin Resistance 187
Carsten Schmitz-Peiffer, PhD
PKC Family of Serine and Threonine Kinases 187
Roles for PKC in Normal Glucose Homeostasis 189
PKC and Defective Glucose Disposal 190
Concluding Remarks 195
References 196
Chapter 15 Evidence for Prescribing Exercise as a Therapy for
Treating Patients With Type 2 Diabetes 203
Sarah }. Lessard, PhD; and John A. Hawley, PhD, FACSM
Options for Treating Insulin Resistance and Type 2 Diabetes 203
Molecular Evidence for Prescribing Exercise Training 204
Exercise and Drug Combination Therapy 207
Exercise-Like Effects of Current Antihyperglycemic Drugs 209
Prescribing Exercise Training: Practical Considerations 209
Concluding Remarks 210
References 211
Index 215
About the Editors 219 |
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| spelling | Physical activity and type 2 diabetes therapeutic effects and mechanisms of action John A. Hawley, Juleen R. Zierath, editors Champaign, IL Human Kinetics 2008 xii, 219 p. ill. 29 cm txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and index Diabetes Exercise therapy Insulin resistance Exercise therapy Diabetes Prevention Diabetes Mellitus, Type 2 prevention & control Exercise Insulin Resistance physiology Sport (DE-588)4056366-2 gnd rswk-swf Diabetes mellitus Typ 2 (DE-588)1194598587 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Diabetes mellitus Typ 2 (DE-588)1194598587 s Sport (DE-588)4056366-2 s DE-604 Hawley, John A. 1932- Sonstige (DE-588)136021743 oth Zierath, Juleen R. Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016963242&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
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| subject_GND | (DE-588)4056366-2 (DE-588)1194598587 (DE-588)4143413-4 |
| title | Physical activity and type 2 diabetes therapeutic effects and mechanisms of action |
| title_auth | Physical activity and type 2 diabetes therapeutic effects and mechanisms of action |
| title_exact_search | Physical activity and type 2 diabetes therapeutic effects and mechanisms of action |
| title_exact_search_txtP | Physical activity and type 2 diabetes therapeutic effects and mechanisms of action |
| title_full | Physical activity and type 2 diabetes therapeutic effects and mechanisms of action John A. Hawley, Juleen R. Zierath, editors |
| title_fullStr | Physical activity and type 2 diabetes therapeutic effects and mechanisms of action John A. Hawley, Juleen R. Zierath, editors |
| title_full_unstemmed | Physical activity and type 2 diabetes therapeutic effects and mechanisms of action John A. Hawley, Juleen R. Zierath, editors |
| title_short | Physical activity and type 2 diabetes |
| title_sort | physical activity and type 2 diabetes therapeutic effects and mechanisms of action |
| title_sub | therapeutic effects and mechanisms of action |
| topic | Diabetes Exercise therapy Insulin resistance Exercise therapy Diabetes Prevention Diabetes Mellitus, Type 2 prevention & control Exercise Insulin Resistance physiology Sport (DE-588)4056366-2 gnd Diabetes mellitus Typ 2 (DE-588)1194598587 gnd |
| topic_facet | Diabetes Exercise therapy Insulin resistance Exercise therapy Diabetes Prevention Diabetes Mellitus, Type 2 prevention & control Exercise Insulin Resistance physiology Sport Diabetes mellitus Typ 2 Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016963242&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT hawleyjohna physicalactivityandtype2diabetestherapeuticeffectsandmechanismsofaction AT zierathjuleenr physicalactivityandtype2diabetestherapeuticeffectsandmechanismsofaction |