Evaluating clinical research: all that glitters is not gold
The objective of this book is to make its readers better informed and more critical consumers of clinical research to help them recognize the strengths and the weaknesses of scientific publications. In doing so, the reader will be able to distinguish patient-important and methodologically sound stud...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
New York, NY
Springer
2007
|
| Ausgabe: | 2. ed. |
| Schlagworte: | |
| Online-Zugang: | Publisher description Inhaltsverzeichnis Inhaltsverzeichnis |
| Zusammenfassung: | The objective of this book is to make its readers better informed and more critical consumers of clinical research to help them recognize the strengths and the weaknesses of scientific publications. In doing so, the reader will be able to distinguish patient-important and methodologically sound studies from those having limitations in design, conduct and interpretation. There are no prerequisites for reading this book. The text is basic and has no statistical formulas. Key take-home messages are listed at the end of each chapter. The large number of cartoons has two purposes: First, to make the text easier to read and generate a few laughs and, second, to underscore specific points, sometimes in a provocative way. Bengt D. Furberg, MD, PhD is board-certified in internal medicine. After spending a decade as medical director in the pharmaceutical industry, he now serves as medical consultant, evaluating the safety and efficacy of pharmaceutical products and medical devices and promoting evidence-based medicine. His brother, Curt D. Furberg, MD, PhD, is Professor in the Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA. After arriving in the United States from Sweden, he worked at the National Heart, Lung, and Blood Institute of the National Institutes of Health for 12 years. He is co-author of Fundamentals of Clinical Trials with Lawrence M. Friedman and David L. DeMets. His areas of interest are clinical trials, evidence-based medicine and drug safety. The authors have acquired much of their knowledge about clinical studies through the "trial and error" method. Thus, they have personal experience with many of the problems they describe. |
| Beschreibung: | VII, 161 S. Ill. |
| ISBN: | 9780387728988 0387728988 9780387728995 |
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| 520 | 3 | |a The objective of this book is to make its readers better informed and more critical consumers of clinical research to help them recognize the strengths and the weaknesses of scientific publications. In doing so, the reader will be able to distinguish patient-important and methodologically sound studies from those having limitations in design, conduct and interpretation. There are no prerequisites for reading this book. The text is basic and has no statistical formulas. Key take-home messages are listed at the end of each chapter. The large number of cartoons has two purposes: First, to make the text easier to read and generate a few laughs and, second, to underscore specific points, sometimes in a provocative way. Bengt D. Furberg, MD, PhD is board-certified in internal medicine. After spending a decade as medical director in the pharmaceutical industry, he now serves as medical consultant, evaluating the safety and efficacy of pharmaceutical products and medical devices and promoting evidence-based medicine. His brother, Curt D. Furberg, MD, PhD, is Professor in the Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA. After arriving in the United States from Sweden, he worked at the National Heart, Lung, and Blood Institute of the National Institutes of Health for 12 years. He is co-author of Fundamentals of Clinical Trials with Lawrence M. Friedman and David L. DeMets. His areas of interest are clinical trials, evidence-based medicine and drug safety. The authors have acquired much of their knowledge about clinical studies through the "trial and error" method. Thus, they have personal experience with many of the problems they describe. | |
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Datensatz im Suchindex
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|---|---|
| adam_text | Contents
Chapter 1 What is the purpose of this book? 1
Chapter 2 Why is benefit-to-harm balance essential to treatment decisions? 5
Chapter 3 What are the strengths of randomized controlled clinical trials? 11
Chapter 4 What are the weaknesses of randomized controlled clinical trials? 17
Chapter 5 Do meta-analyses provide the ultimate truth? 23
Chapter 6 What are the strengths of observational studies? 29
Chapter 7 What are the weaknesses of observational studies? 35
Chapter 8 Were the scientific questions stated in advance? 39
Chapter 9 Were the treatment groups comparable initially? 45
Chapter 10 Why is blinding/masking so important? 49
Chapter 11 How is symptomatic improvement measured? 53
Chapter 12 Is it really possible to assess quality of life? 57
Chapter 13 What is the value of biologic markers in drug evaluation? 61
Chapter 14 How are adverse drug reactions measured? 67
Chapter 15 How representative are study subjects in clinical trials? 73
Chapter 16 What happened to the study subjects who disappeared from
the analysis? 77
Chapter 17 How reliable are active-control trials? 83
Chapter 18 How informative are composite outcomes? 89
Chapter 19 Do changes in biologic markers predict clinical benefit? 95
Chapter 20 How trustworthy are the authors? 99
Chapter 21 Does publication in a reputable scientific journal guarantee
quality? 103
Chapter 22 Is it necessary to be a biostatistician to interpret scientific data? 107
Chapter 23 Are all drugs of a class interchangeable? 115
Chapter 24 How much confidence can be placed on economic analysis? 121
Chapter 25 How should I handle the massive flow of information? 125
Chapter 26 How well is research translated into clinical care? 131
Appendix A Glossary 137
Appendix B Explanations for checklist questions 143
References 149
Index 159
About the Authors 163
|
| adam_txt |
Contents
Chapter 1 What is the purpose of this book? 1
Chapter 2 Why is benefit-to-harm balance essential to treatment decisions? 5
Chapter 3 What are the strengths of randomized controlled clinical trials? 11
Chapter 4 What are the weaknesses of randomized controlled clinical trials? 17
Chapter 5 Do meta-analyses provide the ultimate truth? 23
Chapter 6 What are the strengths of observational studies? 29
Chapter 7 What are the weaknesses of observational studies? 35
Chapter 8 Were the scientific questions stated in advance? 39
Chapter 9 Were the treatment groups comparable initially? 45
Chapter 10 Why is blinding/masking so important? 49
Chapter 11 How is symptomatic improvement measured? 53
Chapter 12 Is it really possible to assess quality of life? 57
Chapter 13 What is the value of biologic markers in drug evaluation? 61
Chapter 14 How are adverse drug reactions measured? 67
Chapter 15 How representative are study subjects in clinical trials? 73
Chapter 16 What happened to the study subjects who disappeared from
the analysis? 77
Chapter 17 How reliable are active-control trials? 83
Chapter 18 How informative are composite outcomes? 89
Chapter 19 Do changes in biologic markers predict clinical benefit? 95
Chapter 20 How trustworthy are the authors? 99
Chapter 21 Does publication in a reputable scientific journal guarantee
quality? 103
Chapter 22 Is it necessary to be a biostatistician to interpret scientific data? 107
Chapter 23 Are all drugs of a class interchangeable? 115
Chapter 24 How much confidence can be placed on economic analysis? 121
Chapter 25 How should I handle the massive flow of information? 125
Chapter 26 How well is research translated into clinical care? 131
Appendix A Glossary 137
Appendix B Explanations for checklist questions 143
References 149
Index 159
About the Authors 163 |
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| spelling | Furberg, Bengt Verfasser aut Evaluating clinical research all that glitters is not gold Bengt D. Furberg ; Curt D. Furberg 2. ed. New York, NY Springer 2007 VII, 161 S. Ill. txt rdacontent n rdamedia nc rdacarrier The objective of this book is to make its readers better informed and more critical consumers of clinical research to help them recognize the strengths and the weaknesses of scientific publications. In doing so, the reader will be able to distinguish patient-important and methodologically sound studies from those having limitations in design, conduct and interpretation. There are no prerequisites for reading this book. The text is basic and has no statistical formulas. Key take-home messages are listed at the end of each chapter. The large number of cartoons has two purposes: First, to make the text easier to read and generate a few laughs and, second, to underscore specific points, sometimes in a provocative way. Bengt D. Furberg, MD, PhD is board-certified in internal medicine. After spending a decade as medical director in the pharmaceutical industry, he now serves as medical consultant, evaluating the safety and efficacy of pharmaceutical products and medical devices and promoting evidence-based medicine. His brother, Curt D. Furberg, MD, PhD, is Professor in the Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA. After arriving in the United States from Sweden, he worked at the National Heart, Lung, and Blood Institute of the National Institutes of Health for 12 years. He is co-author of Fundamentals of Clinical Trials with Lawrence M. Friedman and David L. DeMets. His areas of interest are clinical trials, evidence-based medicine and drug safety. The authors have acquired much of their knowledge about clinical studies through the "trial and error" method. Thus, they have personal experience with many of the problems they describe. Clinical medicine / Research Clinical trials Medicine / Research Medizin Biomedical Research methods Clinical Trials as Topic Clinical medicine Research Drug Evaluation Medicine Research Research Design Furberg, Curt 1936- Verfasser (DE-588)131121049 aut http://www.loc.gov/catdir/enhancements/fy0826/2007930204-d.htmlTest Publisher description lizenzfrei http://www.loc.gov/catdir/enhancements/fy0826/2007930204-t.htmlTest lizenzfrei Inhaltsverzeichnis HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016784466&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Furberg, Bengt Furberg, Curt 1936- Evaluating clinical research all that glitters is not gold Clinical medicine / Research Clinical trials Medicine / Research Medizin Biomedical Research methods Clinical Trials as Topic Clinical medicine Research Drug Evaluation Medicine Research Research Design |
| title | Evaluating clinical research all that glitters is not gold |
| title_auth | Evaluating clinical research all that glitters is not gold |
| title_exact_search | Evaluating clinical research all that glitters is not gold |
| title_exact_search_txtP | Evaluating clinical research all that glitters is not gold |
| title_full | Evaluating clinical research all that glitters is not gold Bengt D. Furberg ; Curt D. Furberg |
| title_fullStr | Evaluating clinical research all that glitters is not gold Bengt D. Furberg ; Curt D. Furberg |
| title_full_unstemmed | Evaluating clinical research all that glitters is not gold Bengt D. Furberg ; Curt D. Furberg |
| title_short | Evaluating clinical research |
| title_sort | evaluating clinical research all that glitters is not gold |
| title_sub | all that glitters is not gold |
| topic | Clinical medicine / Research Clinical trials Medicine / Research Medizin Biomedical Research methods Clinical Trials as Topic Clinical medicine Research Drug Evaluation Medicine Research Research Design |
| topic_facet | Clinical medicine / Research Clinical trials Medicine / Research Medizin Biomedical Research methods Clinical Trials as Topic Clinical medicine Research Drug Evaluation Medicine Research Research Design |
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