Pharmacogenetics:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Oxford [u.a.]
Oxford Univ. Press
2008
|
| Ausgabe: | 2. ed. |
| Schriftenreihe: | Oxford monographs on medical genetics
55 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | XIV, 433 S. graph. Darst. |
| ISBN: | 9780195341515 0195341511 |
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| 250 | |a 2. ed. | ||
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Datensatz im Suchindex
| _version_ | 1804138088556920832 |
|---|---|
| adam_text | Contents
I. FOUNDATIONS
1.
Beginnings
3
Cellular foundations of early pharmacology and genetics
4
Molecular foundations of early pharmacology and genetics
5
Emergence of modern genetics and experimental pharmacogenetics
8
Informational foundations of modern genetics
10
The genomics era
13
The effect of molecular biology on pharmacogenetics
13
2.
Defining Pharmacogenetics
18
The genetic profile of human drug response
19
Evidence for individual variation in drug response
24
Evidence that variation in drug response is inherited
25
Interaction with other fields empowers pharmacogenetics
27
Pharmacogenetics is a component of ecogenetics
27
The scope of pharmacogenetics
27
Strategies for gene identification
37
Linking pharmacogenetics to clinical applications
45
Summary
48
II. FUNDAMENTALS
3.
Pharmacology of Human Drag Response
53
Pharmacology and genetics of human drug response
are complementary
53
Dose-response relationships
54
xü CONTENTS
Pharmacokinetics
in pharmacogenetics 60
Pharmacogenetic
mechanisms of human drug response
64
Testing pharmacogenetic hypotheses
64
Summary
70
4.
Age-Related Pharmacology
72
Age-related physiological variation
73
Pharmacokinetic variation
74
Pharmacodynamic variation
89
Summary
95
5.
Genetics in Pharmacology
99
The fine structure of genetic profiling human drug response
99
Some elementary features of the human genome
101
Framework for dissecting genetic variation in human drug response
104
Twin studies
105
Inheritance patterns of
monogenie
traits
110
Mathematical treatment of heterogeneity in human drug response
116
Molecular pharmacogenetics
130
Impediments to pharmacogenetic investigation
134
Summary
137
6.
Epigenetics
142
The emergence of epigenetics
143
The foundations of epigenetics
145
The effect of molecular biology on epigenetics
148
Epigenetics in health and disease
159
Therapeutic potential for epigenetic disease
172
Summary
176
7.
Genomic Tools
184
Charting the evolution of genomic tools
185
Conventional analytical techniques
188
Conventional analysis of genetic variants
189
Advances in genomic technology
199
Emerging technologies
211
Summary
218
8.
Ethnic Pharmacogenetics
231
Marrying race and ethnicity to genetic variation
231
Grappling with race and ethnicity during the twentieth century
232
CONTENTS
xiii
Ethnie
specificity in drug response
236
Frequency of pharmacogenetic ethnic specificities
237
Ethnicity as a starting point for pharmacogenetic
investigation
245
Ethnic specificity in drug development
249
Culturally specific risks of ethnic research
249
Summary
252
9.
Modeling Human Drag Response
258
Mouse models of pharmacogenetic traits
259
Constructing inbred mouse models
260
Mouse models of the arylhydrocarbon receptor
and N-acetyltransferase polymorphisms
269
Creating mouse models by gene targeting
216
Mouse models of human disorders created by gene targeting
279
Quantitative trait locus (QTL) analysis
279
Modeling with simple eukaryotic organisms
289
Summary
290
III. FUTURES
10.
Drag Discovery
297
Changing pharmaceutical perspectives
297
Human drug efficacy targets
299
Applying genomics to drug discovery
302
Small molecule drug discovery
302
Protein therapeutics
308
Genetic pathways to improved drug therapy
323
Summary
334
11.
Predictive Biology
338
Indexing pharmacogenetic knowledge
339
Edging toward personalized medicine
340
Digging deeper into human genetic variation
359
New dimensions in drug discovery
370
When good drugs go bad, what to do?
Ъ11
Summary
379
XIV
CONTENTS
Synthesis 3gp
Appendix A
393
Appendix
В
422
Appendix
С
414
Index 417
|
| adam_txt |
Contents
I. FOUNDATIONS
1.
Beginnings
3
Cellular foundations of early pharmacology and genetics
4
Molecular foundations of early pharmacology and genetics
5
Emergence of modern genetics and experimental pharmacogenetics
8
Informational foundations of modern genetics
10
The genomics era
13
The effect of molecular biology on pharmacogenetics
13
2.
Defining Pharmacogenetics
18
The genetic profile of human drug response
19
Evidence for individual variation in drug response
24
Evidence that variation in drug response is inherited
25
Interaction with other fields empowers pharmacogenetics
27
Pharmacogenetics is a component of ecogenetics
27
The scope of pharmacogenetics
27
Strategies for gene identification
37
Linking pharmacogenetics to clinical applications
45
Summary
48
II. FUNDAMENTALS
3.
Pharmacology of Human Drag Response
53
Pharmacology and genetics of human drug response
are complementary
53
Dose-response relationships
54
xü CONTENTS
Pharmacokinetics
in pharmacogenetics 60
Pharmacogenetic
mechanisms of human drug response
64
Testing pharmacogenetic hypotheses
64
Summary
70
4.
Age-Related Pharmacology
72
Age-related physiological variation
73
Pharmacokinetic variation
74
Pharmacodynamic variation
89
Summary
95
5.
Genetics in Pharmacology
99
The fine structure of genetic profiling human drug response
99
Some elementary features of the human genome
101
Framework for dissecting genetic variation in human drug response
104
Twin studies
105
Inheritance patterns of
monogenie
traits
110
Mathematical treatment of heterogeneity in human drug response
116
Molecular pharmacogenetics
130
Impediments to pharmacogenetic investigation
134
Summary
137
6.
Epigenetics
142
The emergence of epigenetics
143
The foundations of epigenetics
145
The effect of molecular biology on epigenetics
148
Epigenetics in health and disease
159
Therapeutic potential for epigenetic disease
172
Summary
176
7.
Genomic Tools
184
Charting the evolution of genomic tools
185
Conventional analytical techniques
188
Conventional analysis of genetic variants
189
Advances in genomic technology
199
Emerging technologies
211
Summary
218
8.
Ethnic Pharmacogenetics
231
Marrying race and ethnicity to genetic variation
231
Grappling with race and ethnicity during the twentieth century
232
CONTENTS
xiii
Ethnie
specificity in drug response
236
Frequency of pharmacogenetic ethnic specificities
237
Ethnicity as a starting point for pharmacogenetic
investigation
245
Ethnic specificity in drug development
249
Culturally specific risks of ethnic research
249
Summary
252
9.
Modeling Human Drag Response
258
Mouse models of pharmacogenetic traits
259
Constructing inbred mouse models
260
Mouse models of the arylhydrocarbon receptor
and N-acetyltransferase polymorphisms
269
Creating mouse models by gene targeting
216
Mouse models of human disorders created by gene targeting
279
Quantitative trait locus (QTL) analysis
279
Modeling with simple eukaryotic organisms
289
Summary
290
III. FUTURES
10.
Drag Discovery
297
Changing pharmaceutical perspectives
297
Human drug efficacy targets
299
Applying genomics to drug discovery
302
Small molecule drug discovery
302
Protein therapeutics
308
Genetic pathways to improved drug therapy
323
Summary
334
11.
Predictive Biology
338
Indexing pharmacogenetic knowledge
339
Edging toward personalized medicine
340
Digging deeper into human genetic variation
359
New dimensions in drug discovery
370
When good drugs go bad, what to do?
Ъ11
Summary
379
XIV
CONTENTS
Synthesis 3gp
Appendix A
393
Appendix
В
422
Appendix
С
414
Index 417 |
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| isbn | 9780195341515 0195341511 |
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| spelling | Weber, Wendell W. Verfasser (DE-588)136203647 aut Pharmacogenetics Wendell W. Weber 2. ed. Oxford [u.a.] Oxford Univ. Press 2008 XIV, 433 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Oxford monographs on medical genetics 55 Includes bibliographical references and index Pharmacogenetics Pharmakogenetik (DE-588)4271255-5 gnd rswk-swf Pharmakogenetik (DE-588)4271255-5 s DE-604 Oxford monographs on medical genetics 55 (DE-604)BV000008339 55 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016782083&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
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| subject_GND | (DE-588)4271255-5 |
| title | Pharmacogenetics |
| title_auth | Pharmacogenetics |
| title_exact_search | Pharmacogenetics |
| title_exact_search_txtP | Pharmacogenetics |
| title_full | Pharmacogenetics Wendell W. Weber |
| title_fullStr | Pharmacogenetics Wendell W. Weber |
| title_full_unstemmed | Pharmacogenetics Wendell W. Weber |
| title_short | Pharmacogenetics |
| title_sort | pharmacogenetics |
| topic | Pharmacogenetics Pharmakogenetik (DE-588)4271255-5 gnd |
| topic_facet | Pharmacogenetics Pharmakogenetik |
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