Verfügbarkeit: Carbohydrates

Carbohydrates: the essential molecules of life

This book provides the "nuts and bolts" background for a successful study of carbohydrates - the essential molecules that not only give you energy, but are an integral part of many biological processes. A question often asked is 'Why do carbohydrate chemistry?' The answer is simp...

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Bibliographische Detailangaben
Hauptverfasser:	Stick, Robert V. (VerfasserIn), Williams, Spencer J. (VerfasserIn)
Format:	Buch
Sprache:	English
Veröffentlicht:	Amsterdam [u.a.] Elsevier Science 2009
Ausgabe:	2. ed.
Schlagworte:	Carbohydrates Chemie Kohlenhydratstoffwechsel Kohlenhydrate
Online-Zugang:	Inhaltsverzeichnis
Zusammenfassung:	This book provides the "nuts and bolts" background for a successful study of carbohydrates - the essential molecules that not only give you energy, but are an integral part of many biological processes. A question often asked is 'Why do carbohydrate chemistry?' The answer is simple: It is fundamental to a study of biology. Carbohydrates are the building blocks of life and enable biological processes to take place. Therefore the book will provide a taste for the subject of glycobiology.
Beschreibung:	Previous ed.: San Diego, Calif.; London: Academic, 2001
Beschreibung:	XXI, 474 S. 24cm
ISBN:	0240521188 9780240521183

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Datensatz im Suchindex

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adam_text	Contents Preface and Acknowledgements xvii Abbreviations xix CHAPTER 1: The Nuts and Bolts of Carbohydrates 1 The Early Years 1 The Constitution of Glucose and Other Sugars 7 The Cyclic Forms of Sugars, and Mutarotation 15 The Shape (Conformation) of Cyclic Sugars, and the Anomeric Effect 23 References 32 CHAPTER 2: Synthesis and Protecting Groups 35 Esters 36 Acetates 36 Benzoates 38 Chloroacetates 39 Pivalates 39 Levulinates 39 Carbonates, borates, phosphates, sulfates and nitrates 40 Sulfonates 41 Ethers 42 Methyl ethers 42 Benzyl ethers 43 4-Methoxybenzyl ethers 44 Allyl ethers 45 Trityl ethers 45 Silyl ethers 45 Acetáis 47 Cyclic acetáis 49 viii Contents Benzylidene acetáis 50 4-Methoxybenzylidene acetáis 53 Isopropylidene acetáis 54 Diacetals 57 Cyclohexylidene acetáis 58 Dithioacetals 58 Thioacetals 58 Stannylene acetáis 59 The Protection of Amines 61 Orthogonality 66 References 67 CHAPTER 3: The Reactions of Monosaccharides 75 Oxidation 75 Reduction 80 Halogenation 84 Non-anomeric halogenation 85 Anomeric halogenation 89 Alkenes and Carbocycles 93 Non-anomeric alkenes 93 Anomeric alkenes 94 Carbocycles 96 Anhydro Sugars 98 Non-anomeric anhydro sugars 99 Anomeric anhydro sugars 101 Deoxy, Amino Deoxy and Branched-chain Sugars 105 Deoxy sugars 105 Amino deoxy sugars 107 Branched-chain sugars 111 Miscellaneous Reactions 112 Wittig reaction 112 Thiazole-based homologation 113 Mitsunobu reaction 114 Orthoesters 115 Contents ix Industrially Important Ketoses 117 D-Fructose 117 L-Sorbose 119 Isomaltulose 119 Lactulose 120 Aza and Imino Sugars 121 References 124 CHAPTER 4: Formation of the Glycosidic Linkage 133 General 135 The different glycosidic linkages 135 The mechanism of glycosidation 136 Ion pairs and the solvent 136 The substituent at C2 137 The armed/disarmed concept 137 The torsionai control concept 138 The latent/active concept 139 Activation of the glycosyl acceptor 139 The concept of orthogonality 140 Reciprocal donor/acceptor selectivity 140 Hemiacetals 141 Glycosyl Esters 144 Glycosyl Halides and Orthoesters 145 The Koenigs-Knorr reaction (1,2-trans) 146 The orthoester procedure (1,2-trans) 148 Halide catalysis (1,2-cis) 150 Glycosyl fluorides (1,2-cis and 1,2-trans) 152 Glycosyl Imidates (1,2-cis and 1,2-trans) 153 Thioglycosides (1,2475 and 1,2-trans) 156 Seleno- and Telluroglycosides 160 Glycosyl Sulfoxides (sulfinyl glycosides; 1,2-cis and 1,2-trans) 162 Glycals 164 4-Pentenyl Activation (1,2-cis and 1,2-trans) 166 χ Contents ß-D-Mannopyranosides (1,2-cií) 169 Glycosyl halides 169 Glycosyl sulf oxides (and thioglycosides) 170 ß-D-Glucopyranoside to ß-D-mannopyranoside 171 Intramolecular aglycon delivery 172 Other methods 173 ß-Rhamnopyranosides (1,2-rá) 174 г-Асеіатіао^^еоху Glycosides 174 2-Deoxy Glycosides 178 Sialosides 180 Furanosides 181 Miscellaneous Methods 182 Alkenyl glycosides 182 Remote activation 183 C-Glycosides 186 The addition of carbanions to anomeric electrophiles 187 The addition of electrophiles to anomeric carbanions 188 Glycosyl radicals 190 Miscellaneous 191 References 191 CHAPTER 5: Oligosaccharide Synthesis 203 Strategies in Oligosaccharide Synthesis 203 Linear syntheses 204 Convergent syntheses 206 Two-directional syntheses 206 One-pot syntheses 207 Polymer-supported Synthesis 210 Types of polymers 211 Linkers 212 Attachment of the sugar to the linker/polymer 213 The glycosyl donors used 213 Insoluble versus soluble polymers 213 Trichloroacetimidates 214 Pentenyl glycosides 215 Contents xi Glycosyl sulfoxides 215 Thioglycosides 216 Glycals 216 Automated oligosaccharide synthesis 217 Combinatorial synthesis and the generation of libraries 217 References 219 CHAPTER 6: Monosaccharide Metabolism 225 The Role of Charged Intermediates in Basic Metabolism 225 Glucose-ó-phosphate: a Central Molecule in Carbohydrate Metabolism 226 Glycolysis 227 The Fate of Pyruvate in Primary Metabolism 230 Under aerobic conditions 230 Under anaerobic conditions 230 Gluconeogenesis 231 The Pentose Phosphate Pathway 232 The Glyoxylate Cycle 234 Biosynthesis of Sugar Nucleoside Diphosphates 235 Nucleotidylyltransferases 235 Biosynthesis of UDP-glucose, UDP-galactose and galactose 236 Biosynthesis of UDP-glucuronic acid and UDP-xylose 238 Biosynthesis of GDP-mannose 239 Biosynthesis of UDP-TV-acetylglucosamine and UDP-N-acetylgalactosamine 240 Biosynthesis of UDP-N-acetylmuramic acid 242 Biosynthesis of GDP-fucose 242 Biosynthesis of furanosyl nucleoside diphosphates: UDP-galactofuranose and UDP-arabinofuranose 243 Biosynthesis of Sialic Acids and CMP-Sialic Acids 244 Biosynthesis of »ryo-Inositol 246 Biosynthesis of L-Ascorbic Acid 247 References 249 xii Contents CHAPTER 7: Enzymatic Cleavage of Glycosides: Mechanism, Inhibition and Synthetic Applications 253 Glycoside Hydrolases 253 Retaining and Inverting Mechanisms 255 Sequence-based classification of glycoside hydrolases 255 Mechanism of inverting glycoside hydrolases 256 Mechanism of retaining glycoside hydrolases that use carboxylic acids as nucleophiles 256 Mechanism of retaining glycoside hydrolases that use tyrosine as a catalytic nucleophile 258 Mechanism of retaining glycoside hydrolases that use substrate-assisted catalysis 258 Unusual Enzymes that Catalyse Glycoside Cleavage 259 Transglycosidases 262 Structure-based Studies of Glycoside Hydrolases 263 Reagents and Tools for the Study of Glycoside Hydrolases 265 Non-covalent Glycoside Hydrolase Inhibitors 268 Exploitation of Glycoside Hydrolases in Synthesis 272 Thermodynamic control (reversed hydrolysis) 273 Kinetic control (transglycosidation) 273 Glycosynthases: Mutant Glycosidases for Glycoside Synthesis 276 Thioglycoligases: Mutant Glycosidases for Thioglycoside Synthesis 278 Hehre Resynthesis/Hydrolysis Mechanism 279 References 280 CHAPTER 8: Glycosyltransferases 285 Classification and Mechanism 285 Classification 286 Mechanism 286 Glycosyltransferases and the One-enzyme One-linkage Hypothesis 291 Sequence-based Classification and Structure 292 Reversibility of Glycosyl Transfer by Glycosyltransferases 293 Contents xiii Inhibitors of Glycosyltransferases 294 Direct inhibition of glycosyltransferases 294 Therapeutically-useful glycosyltransferase inhibitors 299 Indirect inhibition of glycosyltransferases by metabolic interference 301 Chemical Modification of Glycoconjugates Using Metabolic Pathway Promiscuity 303 Use of Glycosyltransferases in Synthesis 305 Enzymatic synthesis using glycosyltransferases and sugar (di)phosphonucleoside donors 306 Multienzyme systems including sugar (di)phosphonucleoside generation and recycling 311 Synthesis using glycosyltransferases in engineered whole cell systems 314 References 316 CHAPTER 9: Disaccharides, Oligosaccharides and Polysaccharides 321 Cellulose and Cellobiose 321 Starch, Amylopectin, Amylose and Maltose 324 Glycogen 326 Cyclodextrins 327 Sucrose, Sucrose Analogues and Sucrose Oligosaccharides 328 Lactose and Milk Oligosaccharides 331 Fructans 333 Chitin and Chitosan 334 Trehalose and Trehalose Oligosaccharides 335 1,3-ß-Glucans 337 Mannans 338 References 339 CHAPTER 10: Modifications of Glycans and Glycoconjugates 343 Epimerization 344 Sulfation 345 xiv Contents Sulfotransferases 345 Sulfatases 345 Sulfated glycosaminoglycans 346 Heparin 347 Nodulation factors 349 Sulfated carbohydrates from halophilic bacteria 349 Mycobacterial sulfoglycolipids 350 Sulfated nucleosides 351 Sulfation in inflammation 351 Sulfatide and seminolipid 352 Phosphorylation 353 Mannose-6-phosphate 353 Phosphoglycosylation in Leishmania and other protists 354 Teichoic acids 355 Other phosphoglycans 356 Carboxylic Acid Esters 357 Acylated bacterial antigens 357 Mycobacterial fatty acid esters 359 Carboxylic acid esters in hemicelluloses 360 Modifications of Sialic Acids 362 Other Carbohydrate Modifications 363 References 364 CHAPTER 11: Glycoproteins and Proteoglycans 369 N-Linked Glycosylation 370 Biosynthesis of the lipid-linked oligosaccharide 371 Transfer of the lipid-linked oligosaccharide 372 N-Glycan trimming and the calnexin/calreticulin cycle 373 Golgi processing of N-linked glycans 374 ER-associated protein degradation 375 Diversity of N-linked glycans 376 Inhibitors of N-linked glycoprotein biosynthesis 377 Modification of N-Linked Glycans for Lysosomal Targeting 378 О -Linked Mucins/Proteoglycans, Blood Group Antigens and Xenorejection 379 Mucin-type О -linked glycosylation 379 Contents xv The blood group antigens 382 Xenotransplantation and the a-l^-Gal epitope 386 О -Linked N-Acetyl-ß-D-glucosamine 387 Glycosylphosphatidylinositol Membrane Anchors 389 Other Types of Protein Glycosylation 392 O-Fucose 392 C-Mannose 393 O-Mannose glycans 393 Rare protein modifications 394 Proteoglycans and Glycosaminoglycans 395 Hyaluronan 396 Chondroitin sulfate/dermatan sulfate 397 Keratan sulfate 398 Heparin and neparan sulfate 399 Lysosomal Degradation of Glycoconjugates 402 N-Linked glycoprotein degradation 403 Glycosaminoglycan degradation 404 Treatment of lysosomal storage disorders with imino sugar inhibitors 408 References 410 CHAPTER 12: Classics in Carbohydrate Chemistry and Glycobiology 413 The Immucillins: Transition-state Analogue Inhibitors of Enzymie N-Ribosyl Transfer Reactions 413 Development of a Candidate Anti-toxic Malarial Vaccine 422 Synthetic Carbohydrate Anti-tumour Vaccines 428 New and Improved Anticoagulant Therapeutics Based on Heparin 435 References 442 APPENDIX I 445 Reagents for O-Protecting Group Removal 445 Reagents for N-Protecting Group Removal 446 xvi Contents APPENDIX Π 447 Carbohydrate Nomenclature 447 The Literature of Carbohydrates 447 Reference literature 447 Primary literature 448 Monographs and related works 448 Recent edited works 449 Recent textbooks 450 Miscellaneous 451 EPILOGUE 453 INDEX 461
adam_txt	Contents Preface and Acknowledgements xvii Abbreviations xix CHAPTER 1: The 'Nuts and Bolts' of Carbohydrates 1 The Early Years 1 The Constitution of Glucose and Other Sugars 7 The Cyclic Forms of Sugars, and Mutarotation 15 The Shape (Conformation) of Cyclic Sugars, and the Anomeric Effect 23 References 32 CHAPTER 2: Synthesis and Protecting Groups 35 Esters 36 Acetates 36 Benzoates 38 Chloroacetates 39 Pivalates 39 Levulinates 39 Carbonates, borates, phosphates, sulfates and nitrates 40 Sulfonates 41 Ethers 42 Methyl ethers 42 Benzyl ethers 43 4-Methoxybenzyl ethers 44 Allyl ethers 45 Trityl ethers 45 Silyl ethers 45 Acetáis 47 Cyclic acetáis 49 viii Contents Benzylidene acetáis 50 4-Methoxybenzylidene acetáis 53 Isopropylidene acetáis 54 Diacetals 57 Cyclohexylidene acetáis 58 Dithioacetals 58 Thioacetals 58 Stannylene acetáis 59 The Protection of Amines 61 Orthogonality 66 References 67 CHAPTER 3: The Reactions of Monosaccharides 75 Oxidation 75 Reduction 80 Halogenation 84 Non-anomeric halogenation 85 Anomeric halogenation 89 Alkenes and Carbocycles 93 Non-anomeric alkenes 93 Anomeric alkenes 94 Carbocycles 96 Anhydro Sugars 98 Non-anomeric anhydro sugars 99 Anomeric anhydro sugars 101 Deoxy, Amino Deoxy and Branched-chain Sugars 105 Deoxy sugars 105 Amino deoxy sugars 107 Branched-chain sugars 111 Miscellaneous Reactions 112 Wittig reaction 112 Thiazole-based homologation 113 Mitsunobu reaction 114 Orthoesters 115 Contents ix Industrially Important Ketoses 117 D-Fructose 117 L-Sorbose 119 Isomaltulose 119 Lactulose 120 Aza and Imino Sugars 121 References 124 CHAPTER 4: Formation of the Glycosidic Linkage 133 General 135 The different glycosidic linkages 135 The mechanism of glycosidation 136 Ion pairs and the solvent 136 The substituent at C2 137 The 'armed/disarmed' concept 137 The 'torsionai control' concept 138 The 'latent/active' concept 139 Activation of the glycosyl acceptor 139 The concept of 'orthogonality' 140 'Reciprocal donor/acceptor selectivity' 140 Hemiacetals 141 Glycosyl Esters 144 Glycosyl Halides and Orthoesters 145 The Koenigs-Knorr reaction (1,2-trans) 146 The orthoester procedure (1,2-trans) 148 Halide catalysis (1,2-cis) 150 Glycosyl fluorides (1,2-cis and 1,2-trans) 152 Glycosyl Imidates (1,2-cis and 1,2-trans) 153 Thioglycosides (1,2475 and 1,2-trans) 156 Seleno- and Telluroglycosides 160 Glycosyl Sulfoxides (sulfinyl glycosides; 1,2-cis and 1,2-trans) 162 Glycals 164 4-Pentenyl Activation (1,2-cis and 1,2-trans) 166 χ Contents ß-D-Mannopyranosides (1,2-cií) 169 Glycosyl halides 169 Glycosyl sulf oxides (and thioglycosides) 170 ß-D-Glucopyranoside to ß-D-mannopyranoside 171 Intramolecular aglycon delivery 172 Other methods 173 ß-Rhamnopyranosides (1,2-rá) 174 г-Асеіатіао^^еоху Glycosides 174 2-Deoxy Glycosides 178 Sialosides 180 Furanosides 181 Miscellaneous Methods 182 Alkenyl glycosides 182 Remote activation 183 C-Glycosides 186 The addition of carbanions to anomeric electrophiles 187 The addition of electrophiles to anomeric carbanions 188 Glycosyl radicals 190 Miscellaneous 191 References 191 CHAPTER 5: Oligosaccharide Synthesis 203 Strategies in Oligosaccharide Synthesis 203 Linear syntheses 204 Convergent syntheses 206 Two-directional syntheses 206 'One-pot' syntheses 207 Polymer-supported Synthesis 210 Types of polymers 211 Linkers 212 Attachment of the sugar to the linker/polymer 213 The glycosyl donors used 213 Insoluble versus soluble polymers 213 Trichloroacetimidates 214 Pentenyl glycosides 215 Contents xi Glycosyl sulfoxides 215 Thioglycosides 216 Glycals 216 Automated oligosaccharide synthesis 217 Combinatorial synthesis and the generation of 'libraries' 217 References 219 CHAPTER 6: Monosaccharide Metabolism 225 The Role of Charged Intermediates in Basic Metabolism 225 Glucose-ó-phosphate: a Central Molecule in Carbohydrate Metabolism 226 Glycolysis 227 The Fate of Pyruvate in Primary Metabolism 230 Under aerobic conditions 230 Under anaerobic conditions 230 Gluconeogenesis 231 The Pentose Phosphate Pathway 232 The Glyoxylate Cycle 234 Biosynthesis of Sugar Nucleoside Diphosphates 235 Nucleotidylyltransferases 235 Biosynthesis of UDP-glucose, UDP-galactose and galactose 236 Biosynthesis of UDP-glucuronic acid and UDP-xylose 238 Biosynthesis of GDP-mannose 239 Biosynthesis of UDP-TV-acetylglucosamine and UDP-N-acetylgalactosamine 240 Biosynthesis of UDP-N-acetylmuramic acid 242 Biosynthesis of GDP-fucose 242 Biosynthesis of furanosyl nucleoside diphosphates: UDP-galactofuranose and UDP-arabinofuranose 243 Biosynthesis of Sialic Acids and CMP-Sialic Acids 244 Biosynthesis of »ryo-Inositol 246 Biosynthesis of L-Ascorbic Acid 247 References 249 xii Contents CHAPTER 7: Enzymatic Cleavage of Glycosides: Mechanism, Inhibition and Synthetic Applications 253 Glycoside Hydrolases 253 Retaining and Inverting Mechanisms 255 Sequence-based classification of glycoside hydrolases 255 Mechanism of inverting glycoside hydrolases 256 Mechanism of retaining glycoside hydrolases that use carboxylic acids as nucleophiles 256 Mechanism of retaining glycoside hydrolases that use tyrosine as a catalytic nucleophile 258 Mechanism of retaining glycoside hydrolases that use substrate-assisted catalysis 258 Unusual Enzymes that Catalyse Glycoside Cleavage 259 Transglycosidases 262 Structure-based Studies of Glycoside Hydrolases 263 Reagents and Tools for the Study of Glycoside Hydrolases 265 Non-covalent Glycoside Hydrolase Inhibitors 268 Exploitation of Glycoside Hydrolases in Synthesis 272 Thermodynamic control (reversed hydrolysis) 273 Kinetic control (transglycosidation) 273 Glycosynthases: Mutant Glycosidases for Glycoside Synthesis 276 Thioglycoligases: Mutant Glycosidases for Thioglycoside Synthesis 278 Hehre Resynthesis/Hydrolysis Mechanism 279 References 280 CHAPTER 8: Glycosyltransferases 285 Classification and Mechanism 285 Classification 286 Mechanism 286 Glycosyltransferases and the 'One-enzyme One-linkage' Hypothesis 291 Sequence-based Classification and Structure 292 Reversibility of Glycosyl Transfer by Glycosyltransferases 293 Contents xiii Inhibitors of Glycosyltransferases 294 'Direct' inhibition of glycosyltransferases 294 Therapeutically-useful glycosyltransferase inhibitors 299 'Indirect' inhibition of glycosyltransferases by metabolic interference 301 Chemical Modification of Glycoconjugates Using Metabolic Pathway Promiscuity 303 Use of Glycosyltransferases in Synthesis 305 Enzymatic synthesis using glycosyltransferases and sugar (di)phosphonucleoside donors 306 Multienzyme systems including sugar (di)phosphonucleoside generation and recycling 311 Synthesis using glycosyltransferases in engineered whole cell systems 314 References 316 CHAPTER 9: Disaccharides, Oligosaccharides and Polysaccharides 321 Cellulose and Cellobiose 321 Starch, Amylopectin, Amylose and Maltose 324 Glycogen 326 Cyclodextrins 327 Sucrose, Sucrose Analogues and Sucrose Oligosaccharides 328 Lactose and Milk Oligosaccharides 331 Fructans 333 Chitin and Chitosan 334 Trehalose and Trehalose Oligosaccharides 335 1,3-ß-Glucans 337 Mannans 338 References 339 CHAPTER 10: Modifications of Glycans and Glycoconjugates 343 Epimerization 344 Sulfation 345 xiv Contents Sulfotransferases 345 Sulfatases 345 Sulfated glycosaminoglycans 346 Heparin 347 Nodulation factors 349 Sulfated carbohydrates from halophilic bacteria 349 Mycobacterial sulfoglycolipids 350 Sulfated nucleosides 351 Sulfation in inflammation 351 Sulfatide and seminolipid 352 Phosphorylation 353 Mannose-6-phosphate 353 Phosphoglycosylation in Leishmania and other protists 354 Teichoic acids 355 Other phosphoglycans 356 Carboxylic Acid Esters 357 Acylated bacterial antigens 357 Mycobacterial fatty acid esters 359 Carboxylic acid esters in hemicelluloses 360 Modifications of Sialic Acids 362 Other Carbohydrate Modifications 363 References 364 CHAPTER 11: Glycoproteins and Proteoglycans 369 N-Linked Glycosylation 370 Biosynthesis of the lipid-linked oligosaccharide 371 Transfer of the lipid-linked oligosaccharide 372 N-Glycan trimming and the calnexin/calreticulin cycle 373 Golgi processing of N-linked glycans 374 ER-associated protein degradation 375 Diversity of N-linked glycans 376 Inhibitors of N-linked glycoprotein biosynthesis 377 Modification of N-Linked Glycans for Lysosomal Targeting 378 О -Linked Mucins/Proteoglycans, Blood Group Antigens and Xenorejection 379 'Mucin-type' О -linked glycosylation 379 Contents xv The blood group antigens 382 Xenotransplantation and the a-l^-Gal epitope 386 О -Linked N-Acetyl-ß-D-glucosamine 387 Glycosylphosphatidylinositol Membrane Anchors 389 Other Types of Protein Glycosylation 392 O-Fucose 392 C-Mannose 393 O-Mannose glycans 393 Rare protein modifications 394 Proteoglycans and Glycosaminoglycans 395 Hyaluronan 396 Chondroitin sulfate/dermatan sulfate 397 Keratan sulfate 398 Heparin and neparan sulfate 399 Lysosomal Degradation of Glycoconjugates 402 N-Linked glycoprotein degradation 403 Glycosaminoglycan degradation 404 Treatment of lysosomal storage disorders with imino sugar inhibitors 408 References 410 CHAPTER 12: Classics in Carbohydrate Chemistry and Glycobiology 413 The Immucillins: Transition-state Analogue Inhibitors of Enzymie N-Ribosyl Transfer Reactions 413 Development of a Candidate Anti-toxic Malarial Vaccine 422 Synthetic Carbohydrate Anti-tumour Vaccines 428 New and Improved Anticoagulant Therapeutics Based on Heparin 435 References 442 APPENDIX I 445 Reagents for O-Protecting Group Removal 445 Reagents for N-Protecting Group Removal 446 xvi Contents APPENDIX Π 447 Carbohydrate Nomenclature 447 The Literature of Carbohydrates 447 Reference literature 447 Primary literature 448 Monographs and related works 448 Recent edited works 449 Recent textbooks 450 Miscellaneous 451 EPILOGUE 453 INDEX 461
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id	DE-604.BV035101170
illustrated	Not Illustrated
index_date	2024-07-02T22:14:16Z
indexdate	2024-07-09T21:22:14Z
institution	BVB
isbn	0240521188 9780240521183
language	English
oai_aleph_id	oai:aleph.bib-bvb.de:BVB01-016769146
oclc_num	243820615
open_access_boolean
owner	DE-703 DE-19 DE-BY-UBM DE-91G DE-BY-TUM DE-355 DE-BY-UBR
owner_facet	DE-703 DE-19 DE-BY-UBM DE-91G DE-BY-TUM DE-355 DE-BY-UBR
physical	XXI, 474 S. 24cm
publishDate	2009
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publisher	Elsevier Science
record_format	marc
spelling	Stick, Robert V. Verfasser aut Carbohydrates the essential molecules of life Robert V. Stick ; Spencer J. Williams 2. ed. Amsterdam [u.a.] Elsevier Science 2009 XXI, 474 S. 24cm txt rdacontent n rdamedia nc rdacarrier Previous ed.: San Diego, Calif.; London: Academic, 2001 This book provides the "nuts and bolts" background for a successful study of carbohydrates - the essential molecules that not only give you energy, but are an integral part of many biological processes. A question often asked is 'Why do carbohydrate chemistry?' The answer is simple: It is fundamental to a study of biology. Carbohydrates are the building blocks of life and enable biological processes to take place. Therefore the book will provide a taste for the subject of glycobiology. Carbohydrates Chemie (DE-588)4009816-3 gnd rswk-swf Kohlenhydratstoffwechsel (DE-588)4031656-7 gnd rswk-swf Kohlenhydrate (DE-588)4164517-0 gnd rswk-swf Kohlenhydratstoffwechsel (DE-588)4031656-7 s DE-604 Kohlenhydrate (DE-588)4164517-0 s Chemie (DE-588)4009816-3 s Williams, Spencer J. Verfasser aut Digitalisierung UB Bayreuth application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016769146&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle	Stick, Robert V. Williams, Spencer J. Carbohydrates the essential molecules of life Carbohydrates Chemie (DE-588)4009816-3 gnd Kohlenhydratstoffwechsel (DE-588)4031656-7 gnd Kohlenhydrate (DE-588)4164517-0 gnd
subject_GND	(DE-588)4009816-3 (DE-588)4031656-7 (DE-588)4164517-0
title	Carbohydrates the essential molecules of life
title_auth	Carbohydrates the essential molecules of life
title_exact_search	Carbohydrates the essential molecules of life
title_exact_search_txtP	Carbohydrates the essential molecules of life
title_full	Carbohydrates the essential molecules of life Robert V. Stick ; Spencer J. Williams
title_fullStr	Carbohydrates the essential molecules of life Robert V. Stick ; Spencer J. Williams
title_full_unstemmed	Carbohydrates the essential molecules of life Robert V. Stick ; Spencer J. Williams
title_short	Carbohydrates
title_sort	carbohydrates the essential molecules of life
title_sub	the essential molecules of life
topic	Carbohydrates Chemie (DE-588)4009816-3 gnd Kohlenhydratstoffwechsel (DE-588)4031656-7 gnd Kohlenhydrate (DE-588)4164517-0 gnd
topic_facet	Carbohydrates Chemie Kohlenhydratstoffwechsel Kohlenhydrate
url	http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016769146&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
work_keys_str_mv	AT stickrobertv carbohydratestheessentialmoleculesoflife AT williamsspencerj carbohydratestheessentialmoleculesoflife

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