Regulation of organ size by the atypical cadherins Fat and Dachsous through the hippo pathway:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2008
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Enth. 3 Sonderabdr. aus verschiedenen Zeitschr. |
| Beschreibung: | 111 S. Ill., graph. Darst. 21 cm |
Internformat
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Datensatz im Suchindex
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| adam_text | Table of Contents
Acknowledgements 4
Table of contents 6
Abstract 8
Zusammenfassung 10
Chapter 1: Background 12
1.1 Questions in growth control 13
1.2 Drosophila as a model organism 14
1.3 Regulation of Drosophila imaginal disc growth 14
1.4 Current models of organ size regulation 16
1.5 Discovery of the Hippo pathway 18
1.6 Research Significance 26
Chapter 2: The tumor suppressor genes NF2/Merlin and Expanded act 22
through Hippo signaling to regulate cell proliferation and apoptosis
2.1 Abstract 23
2.2 Publication #1 25
Chapter 3: The Fat Cadherin acts through the Hippo tumor suppressor 39
pathway to regulate tissue size
3.1 Abstract 40
3.2 Publication #2 42
Chapter 4: Boundaries of Dachsous Cadherin activity modulate Hippo 56
signaling to induce cell proliferation
4.1 Abstract 57
4.2 Manuscript #3 60
6
Chapter 5: Discussion 93
5.1 Conclusion 94
5.2 How do the properties of the Ds/Fj signaling system relate to 94
proposed models of organ size regulation?
5.3 How do cells compute Ds activity differences? 97
5.4 What is the biological significance of Ds boundaries? 97
5.5 The conservation of Mer, Ex, Ft, Ds, Fj and the Hippo pathway in 98
vertebrates
5.6 Future Directions 99
References 102
Declaration of contribution to published work 110
Curriclum Vitae 111
|
| adam_txt |
Table of Contents
Acknowledgements 4
Table of contents 6
Abstract 8
Zusammenfassung 10
Chapter 1: Background 12
1.1 Questions in growth control 13
1.2 Drosophila as a model organism 14
1.3 Regulation of Drosophila imaginal disc growth 14
1.4 Current models of organ size regulation 16
1.5 Discovery of the Hippo pathway 18
1.6 Research Significance 26
Chapter 2: The tumor suppressor genes NF2/Merlin and Expanded act 22
through Hippo signaling to regulate cell proliferation and apoptosis
2.1 Abstract 23
2.2 Publication #1 25
Chapter 3: The Fat Cadherin acts through the Hippo tumor suppressor 39
pathway to regulate tissue size
3.1 Abstract 40
3.2 Publication #2 42
Chapter 4: Boundaries of Dachsous Cadherin activity modulate Hippo 56
signaling to induce cell proliferation
4.1 Abstract 57
4.2 Manuscript #3 60
6
Chapter 5: Discussion 93
5.1 Conclusion 94
5.2 How do the properties of the Ds/Fj signaling system relate to 94
proposed models of organ size regulation?
5.3 How do cells compute Ds activity differences? 97
5.4 What is the biological significance of Ds boundaries? 97
5.5 The conservation of Mer, Ex, Ft, Ds, Fj and the Hippo pathway in 98
vertebrates
5.6 Future Directions 99
References 102
Declaration of contribution to published work 110
Curriclum Vitae 111 |
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| spelling | Willecke, Maria Verfasser (DE-588)136252214 aut Regulation of organ size by the atypical cadherins Fat and Dachsous through the hippo pathway von Maria Willecke 2008 111 S. Ill., graph. Darst. 21 cm txt rdacontent n rdamedia nc rdacarrier Enth. 3 Sonderabdr. aus verschiedenen Zeitschr. Tübingen, Univ., Diss., 2008 Hippocampus (DE-588)4642127-0 gnd rswk-swf Organgröße (DE-588)4137784-9 gnd rswk-swf Cadherine (DE-588)4314135-3 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Hippocampus (DE-588)4642127-0 s Cadherine (DE-588)4314135-3 s Organgröße (DE-588)4137784-9 s DE-604 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016768895&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Willecke, Maria Regulation of organ size by the atypical cadherins Fat and Dachsous through the hippo pathway Hippocampus (DE-588)4642127-0 gnd Organgröße (DE-588)4137784-9 gnd Cadherine (DE-588)4314135-3 gnd |
| subject_GND | (DE-588)4642127-0 (DE-588)4137784-9 (DE-588)4314135-3 (DE-588)4113937-9 |
| title | Regulation of organ size by the atypical cadherins Fat and Dachsous through the hippo pathway |
| title_auth | Regulation of organ size by the atypical cadherins Fat and Dachsous through the hippo pathway |
| title_exact_search | Regulation of organ size by the atypical cadherins Fat and Dachsous through the hippo pathway |
| title_exact_search_txtP | Regulation of organ size by the atypical cadherins Fat and Dachsous through the hippo pathway |
| title_full | Regulation of organ size by the atypical cadherins Fat and Dachsous through the hippo pathway von Maria Willecke |
| title_fullStr | Regulation of organ size by the atypical cadherins Fat and Dachsous through the hippo pathway von Maria Willecke |
| title_full_unstemmed | Regulation of organ size by the atypical cadherins Fat and Dachsous through the hippo pathway von Maria Willecke |
| title_short | Regulation of organ size by the atypical cadherins Fat and Dachsous through the hippo pathway |
| title_sort | regulation of organ size by the atypical cadherins fat and dachsous through the hippo pathway |
| topic | Hippocampus (DE-588)4642127-0 gnd Organgröße (DE-588)4137784-9 gnd Cadherine (DE-588)4314135-3 gnd |
| topic_facet | Hippocampus Organgröße Cadherine Hochschulschrift |
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