Folic acid and folates:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Amsterdam
Elsevier
2008
|
| Schriftenreihe: | Vitamins and hormones
79 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Einzelaufn. eines Zeitschr.-Bd. |
| Beschreibung: | XVIII, 443 S. |
| ISBN: | 9780123742322 |
Internformat
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| 300 | |a XVIII, 443 S. | ||
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| 500 | |a Einzelaufn. eines Zeitschr.-Bd. | ||
| 650 | 7 | |a Folique, Acide |2 ram | |
| 650 | 4 | |a Folic acid | |
| 650 | 0 | 7 | |a Folsäure |0 (DE-588)4121288-5 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Folate |0 (DE-588)4154952-1 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Folsäure |0 (DE-588)4121288-5 |D s |
| 689 | 0 | |5 DE-604 | |
| 689 | 1 | 0 | |a Folate |0 (DE-588)4154952-1 |D s |
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Datensatz im Suchindex
| _version_ | 1804138061237321729 |
|---|---|
| adam_text | Contents
Contributors xiii
Preface xvii
1. Folate-Mediated One-Carbon Metabolism 1
Jennifer T. Fox and Patrick J. Stover
I. Overview 2
II. Introduction to Cytoplasmic One-Carbon Metabolism 4
III. Introduction to Mitochondrial One-Carbon Metabolism 24
IV. Nuclear Folate-Mediated One-Carbon Metabolism 28
Acknowledgments 29
References 29
2. Mathematical Models of Folate-Mediated One-Carbon Metabolism 45
H. F. Nijhout, M. C. Reed, and C. M. Ulrich
I. Introduction 46
II. Structure and Function of the Cycles 49
III. Why Mathematical Modeling? 51
IV. Model Development 61
V. Blood Versus Intracellular Metabolite Concentrations 66
VI. Modeling Gene-Gene and Gene-Environment Interactions 67
VII. Modeling and Simulation have Revealed Novel
Homeostatic Mechanisms 70
VIII. Steady States and Fluctuations 75
IX. Conclusions 77
Acknowledgments 78
References 78
3. Folate Deprivation, the Methionine Cycle, and Alzheimer s Disease 83
Flaubert Tchantchou and Thomas B. Shea
I. Introduction 84
II. Folate Metabolism, the Transmethylation Pathway, and AD 85
III. The Transsulfuration Pathway—Homocysteine Elimination and
Glutathione Metabolism 90
References 94
vii
viii Contents
4. Molecular Mechanisms of Adaptation to Folate Deficiency 99
llan Ifergan and Yehuda G. Assaraf
I. Folate Metabolism 101
II. Pathological States Associated with Folate Deficiency or Nutritional
Folate Insufficiency 105
III. Molecular Mechanisms of Adaptation to Folate Deprivation 108
References 131
5. Structure and Function of the Reduced Folate Carrier:
A Paradigm of a Major Facilitator Superfamily Mammalian
Nutrient Transporter 145
Larry H. Matherly and Zhanjun Hou
I. Introduction 146
II. MFS of Transporters 147
III. Folate Transport in Tissue Folate Homeostasis and Physiology:
Role of Multiple Transport Systems for Folate Uptake and Efflux 150
IV. Role of RFC in Antifolate Chemotherapy 152
V. Functional Properties of RFC 154
VI. Biochemistry of RFC 156
VII. Cloning of RFC cDNAs That Restore Transport to Transport-Impaired
Cultured Cells 158
VIII. Topological Structure of RFC 159
IX. Insights into Structural and Functional Determinants of RFC from
Studies of Mutant RFC Poteins 164
X. Conclusions 173
Acknowledgment 175
References 175
6. Renal Conservation of Folates: Role of Folate Transport Proteins 185
Vijaya L. Damaraju, Carol E. Cass, and Michael B. Sawyer
I. Introduction 186
II. Physicochemical Properties, Protein Binding, and Water Solubility 186
III. Role of Folates in Genomic Stability 188
IV. Folates and the Kidney 188
V. Folate Transport Proteins 189
VI. Localization of Putative Folate Transporters in Kidney 192
VII. Clinical Studies of Renal Handling of Folates and Antifolates 193
VIII. Role of Renal Folate Conservation in Ethanol-Related
Folate Deficiency 196
IX. Role of Folate Transport Processes in Renal Conservation of
Folates and Antifolates 197
References 198
Contents ix
7. Exploitation of the Folate Receptor in the Management of
Cancer and Inflammatory Disease 203
Christopher P. Leamon and Ann L. Jackman
I. Introduction 204
II. Aspects of the FR 205
III. Exploitation of the FR for Disease Management 208
IV. Future Prospects 225
References 226
8. Folate Receptor Expression in Pituitary Adenomas: Cellular and
Molecular Analysis 235
Chheng-Orn Evans, Congjun Yao, David LaBorde, and Nelson M. Oyesiku
I. Introduction 236
II. Methods 238
III. Result 242
IV. Discussion 259
Acknowledgments 263
References 263
9. Regulation of Human Dihydrofolate Reductase Activity
and Expression 267
Emine Ercikan Abali, Nancy E. Skacel, Hilal Celikkaya, and Yi-Ching Hsieh
I. Introduction 268
II. Structure and Binding of Dihydrofolate, MTX, and NADPH 269
III. Mechanism of DHFR Catalysis 272
IV. Alternative Substrates: Folic Acid and Dihydrobiopterin 273
V. Genomic Organization of DHFR 274
VI. Human Dihydrofolate Reductase Pseudogenes 276
VII. Transcriptional Regulation 276
VIII. Polymorphisms of DHFR 280
IX. Posttranscriptional Regulation of DHFR 283
X. Translational Regulation of DHFR 283
Acknowledgments 287
References 287
10. Catalysis of Methyl Group Transfers Involving
Tetrahydrofolate and B12 293
Stephen W. Ragsdale
I. Introduction to Methyltransferases and Their Cofactors 294
II. Three Component Systems Required for B12/THF-Dependent
Methyltransferases 296
x Contents
III. Biological Systems Impacted by B12 and Folate-Dependent
Methyltransferases 297
IV. Structure and Function of B12 in Methyltransferases 301
V. Activation of the Methyl Group Donors 307
VI. Activation of the Methyl Group Acceptors: Zn Thiolates and
NiFeS Clusters 314
Acknowledgments 317
References 317
11. Methyltetrahydrofolate in Folate-Binding Protein
Glycine /V-Methyltransferase 325
Zigmund Luka
I. Introduction 326
II. 5-Methyltetrahydrofolate in Folate Metabolism 326
III. Folate-Binding Enzymes 330
IV. Glycine A/-Methyltransferase 331
V. GNMT as Methyltetrahydrofolate-Binding Protein 335
VI. Conclusions 340
Acknowledgments 34a
References 341
12. Mechanism-Based Inhibitors of Folylpoly-, -Glutamate Synthetase
and y-Glutamyl Hydrolase: Control of Folylpoly-) -Glutamate
Homeostasis as a Drug Target 347
James K. Coward and John J. McGuire
I. Introduction 348
II. Folylpoly-y-Glutamate Homeostasis as a Drug Target 350
III. Design of Fluorogtutamate-Containing Folates and Antifolates as
FPGS or GH Alternate Substrates and/or Inhibitors 354
IV. Synthesis of Fluorine-Containing Folates and Antifolates from the
Corresponding Fluoroglutamates and Related Fluoroamino Acids 356
V. Design of Phosphorus-Containing Pseudopeptides as FPGS Inhibitors 361
VI. Design of Epoxide-Containing Peptidomimetics as GH Inhibitors 366
VII. Conclusions 366
Acknowledgment 367
References 367
13. Methylenetetrahydrofolate Reductase, Common
Polymorphisms, and Relation to Disease 375
Philip Thomas and Michael Fenech
I. Introduction 376
II. Conclusions 386
References 386
Contents xi
14. Mitochondrial Methylenetetrahydrofolate Dehydrogenase,
Methenyltetrahydrofolate Cyclohydrolase, and
Formyltetrahydrofolate Synthetases 393
Karen E. Christensen and Robert E. MacKenzie
I. Introduction 394
II. Yeast Mitochondria Contain a Trifunctional
Dehydrogenase-Cydohydrolase-Synthetase 395
III. Mammalian Mitochondrial Methylenetetrahydrofolate
Dehydrogenase 395
IV. Mitochondrial Formyltetrahydrofolate Synthetase 403
V. Conclusion 405
References 408
15. The Structure and Mechanism of 6-Hydroxymethyl-7,
8-Dihydropterin Pyrophosphokinase 411
Jeremy P. Derrick
I. Introduction 412
II. Structural and Mechanistic Studies on EcoHPPK 413
III. Structures of HPPKs from Other Organisms 421
IV. Kinetics 424
V. Relationship of HPPK to Other Pyrophosphoryl Transfer Enzymes 426
VI. Concluding Remarks 429
References 430
Index 435
|
| adam_txt |
Contents
Contributors xiii
Preface xvii
1. Folate-Mediated One-Carbon Metabolism 1
Jennifer T. Fox and Patrick J. Stover
I. Overview 2
II. Introduction to Cytoplasmic One-Carbon Metabolism 4
III. Introduction to Mitochondrial One-Carbon Metabolism 24
IV. Nuclear Folate-Mediated One-Carbon Metabolism 28
Acknowledgments 29
References 29
2. Mathematical Models of Folate-Mediated One-Carbon Metabolism 45
H. F. Nijhout, M. C. Reed, and C. M. Ulrich
I. Introduction 46
II. Structure and Function of the Cycles 49
III. Why Mathematical Modeling? 51
IV. Model Development 61
V. Blood Versus Intracellular Metabolite Concentrations 66
VI. Modeling Gene-Gene and Gene-Environment Interactions 67
VII. Modeling and Simulation have Revealed Novel
Homeostatic Mechanisms 70
VIII. Steady States and Fluctuations 75
IX. Conclusions 77
Acknowledgments 78
References 78
3. Folate Deprivation, the Methionine Cycle, and Alzheimer's Disease 83
Flaubert Tchantchou and Thomas B. Shea
I. Introduction 84
II. Folate Metabolism, the Transmethylation Pathway, and AD 85
III. The Transsulfuration Pathway—Homocysteine Elimination and
Glutathione Metabolism 90
References 94
vii
viii Contents
4. Molecular Mechanisms of Adaptation to Folate Deficiency 99
llan Ifergan and Yehuda G. Assaraf
I. Folate Metabolism 101
II. Pathological States Associated with Folate Deficiency or Nutritional
Folate Insufficiency 105
III. Molecular Mechanisms of Adaptation to Folate Deprivation 108
References 131
5. Structure and Function of the Reduced Folate Carrier:
A Paradigm of a Major Facilitator Superfamily Mammalian
Nutrient Transporter 145
Larry H. Matherly and Zhanjun Hou
I. Introduction 146
II. MFS of Transporters 147
III. Folate Transport in Tissue Folate Homeostasis and Physiology:
Role of Multiple Transport Systems for Folate Uptake and Efflux 150
IV. Role of RFC in Antifolate Chemotherapy 152
V. Functional Properties of RFC 154
VI. Biochemistry of RFC 156
VII. Cloning of RFC cDNAs That Restore Transport to Transport-Impaired
Cultured Cells 158
VIII. Topological Structure of RFC 159
IX. Insights into Structural and Functional Determinants of RFC from
Studies of Mutant RFC Poteins 164
X. Conclusions 173
Acknowledgment 175
References 175
6. Renal Conservation of Folates: Role of Folate Transport Proteins 185
Vijaya L. Damaraju, Carol E. Cass, and Michael B. Sawyer
I. Introduction 186
II. Physicochemical Properties, Protein Binding, and Water Solubility 186
III. Role of Folates in Genomic Stability 188
IV. Folates and the Kidney 188
V. Folate Transport Proteins 189
VI. Localization of Putative Folate Transporters in Kidney 192
VII. Clinical Studies of Renal Handling of Folates and Antifolates 193
VIII. Role of Renal Folate Conservation in Ethanol-Related
Folate Deficiency 196
IX. Role of Folate Transport Processes in Renal Conservation of
Folates and Antifolates 197
References 198
Contents ix
7. Exploitation of the Folate Receptor in the Management of
Cancer and Inflammatory Disease 203
Christopher P. Leamon and Ann L. Jackman
I. Introduction 204
II. Aspects of the FR 205
III. Exploitation of the FR for Disease Management 208
IV. Future Prospects 225
References 226
8. Folate Receptor Expression in Pituitary Adenomas: Cellular and
Molecular Analysis 235
Chheng-Orn Evans, Congjun Yao, David LaBorde, and Nelson M. Oyesiku
I. Introduction 236
II. Methods 238
III. Result 242
IV. Discussion 259
Acknowledgments 263
References 263
9. Regulation of Human Dihydrofolate Reductase Activity
and Expression 267
Emine Ercikan Abali, Nancy E. Skacel, Hilal Celikkaya, and Yi-Ching Hsieh
I. Introduction 268
II. Structure and Binding of Dihydrofolate, MTX, and NADPH 269
III. Mechanism of DHFR Catalysis 272
IV. Alternative Substrates: Folic Acid and Dihydrobiopterin 273
V. Genomic Organization of DHFR 274
VI. Human Dihydrofolate Reductase Pseudogenes 276
VII. Transcriptional Regulation 276
VIII. Polymorphisms of DHFR 280
IX. Posttranscriptional Regulation of DHFR 283
X. Translational Regulation of DHFR 283
Acknowledgments 287
References 287
10. Catalysis of Methyl Group Transfers Involving
Tetrahydrofolate and B12 293
Stephen W. Ragsdale
I. Introduction to Methyltransferases and Their Cofactors 294
II. Three Component Systems Required for B12/THF-Dependent
Methyltransferases 296
x Contents
III. Biological Systems Impacted by B12 and Folate-Dependent
Methyltransferases 297
IV. Structure and Function of B12 in Methyltransferases 301
V. Activation of the Methyl Group Donors 307
VI. Activation of the Methyl Group Acceptors: Zn Thiolates and
NiFeS Clusters 314
Acknowledgments 317
References 317
11. Methyltetrahydrofolate in Folate-Binding Protein
Glycine /V-Methyltransferase 325
Zigmund Luka
I. Introduction 326
II. 5-Methyltetrahydrofolate in Folate Metabolism 326
III. Folate-Binding Enzymes 330
IV. Glycine A/-Methyltransferase 331
V. GNMT as Methyltetrahydrofolate-Binding Protein 335
VI. Conclusions 340
Acknowledgments 34a
References 341
12. Mechanism-Based Inhibitors of Folylpoly-, -Glutamate Synthetase
and y-Glutamyl Hydrolase: Control of Folylpoly-) -Glutamate
Homeostasis as a Drug Target 347
James K. Coward and John J. McGuire
I. Introduction 348
II. Folylpoly-y-Glutamate Homeostasis as a Drug Target 350
III. Design of Fluorogtutamate-Containing Folates and Antifolates as
FPGS or GH Alternate Substrates and/or Inhibitors 354
IV. Synthesis of Fluorine-Containing Folates and Antifolates from the
Corresponding Fluoroglutamates and Related Fluoroamino Acids 356
V. Design of Phosphorus-Containing Pseudopeptides as FPGS Inhibitors 361
VI. Design of Epoxide-Containing Peptidomimetics as GH Inhibitors 366
VII. Conclusions 366
Acknowledgment 367
References 367
13. Methylenetetrahydrofolate Reductase, Common
Polymorphisms, and Relation to Disease 375
Philip Thomas and Michael Fenech
I. Introduction 376
II. Conclusions 386
References 386
Contents xi
14. Mitochondrial Methylenetetrahydrofolate Dehydrogenase,
Methenyltetrahydrofolate Cyclohydrolase, and
Formyltetrahydrofolate Synthetases 393
Karen E. Christensen and Robert E. MacKenzie
I. Introduction 394
II. Yeast Mitochondria Contain a Trifunctional
Dehydrogenase-Cydohydrolase-Synthetase 395
III. Mammalian Mitochondrial Methylenetetrahydrofolate
Dehydrogenase 395
IV. Mitochondrial Formyltetrahydrofolate Synthetase 403
V. Conclusion 405
References 408
15. The Structure and Mechanism of 6-Hydroxymethyl-7,
8-Dihydropterin Pyrophosphokinase 411
Jeremy P. Derrick
I. Introduction 412
II. Structural and Mechanistic Studies on EcoHPPK 413
III. Structures of HPPKs from Other Organisms 421
IV. Kinetics 424
V. Relationship of HPPK to Other Pyrophosphoryl Transfer Enzymes 426
VI. Concluding Remarks 429
References 430
Index 435 |
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| index_date | 2024-07-02T22:13:43Z |
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| spelling | Folic acid and folates editor-in-chief, Gerald Litwack Amsterdam Elsevier 2008 XVIII, 443 S. txt rdacontent n rdamedia nc rdacarrier Vitamins and hormones 79 Einzelaufn. eines Zeitschr.-Bd. Folique, Acide ram Folic acid Folsäure (DE-588)4121288-5 gnd rswk-swf Folate (DE-588)4154952-1 gnd rswk-swf Folsäure (DE-588)4121288-5 s DE-604 Folate (DE-588)4154952-1 s Litwack, Gerald Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016767640&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Folic acid and folates Folique, Acide ram Folic acid Folsäure (DE-588)4121288-5 gnd Folate (DE-588)4154952-1 gnd |
| subject_GND | (DE-588)4121288-5 (DE-588)4154952-1 |
| title | Folic acid and folates |
| title_auth | Folic acid and folates |
| title_exact_search | Folic acid and folates |
| title_exact_search_txtP | Folic acid and folates |
| title_full | Folic acid and folates editor-in-chief, Gerald Litwack |
| title_fullStr | Folic acid and folates editor-in-chief, Gerald Litwack |
| title_full_unstemmed | Folic acid and folates editor-in-chief, Gerald Litwack |
| title_short | Folic acid and folates |
| title_sort | folic acid and folates |
| topic | Folique, Acide ram Folic acid Folsäure (DE-588)4121288-5 gnd Folate (DE-588)4154952-1 gnd |
| topic_facet | Folique, Acide Folic acid Folsäure Folate |
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