Facilitative glucose transporters in articular chondrocytes: expression, distribution and functional regulation of GLUT isoforms by hypoxia, hypoxia mimetics, growth factors and pro-inflammatory cytokines
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Berlin [u.a.]
Springer
2008
|
| Schriftenreihe: | Advances in anatomy, embryology and cell biology
200 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | VI, 88 S. Ill., graph. Darst. |
| ISBN: | 9783540788980 |
Internformat
MARC
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|---|---|---|---|
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| 005 | 20081117 | ||
| 007 | t | ||
| 008 | 080919s2008 ad|| |||| 00||| eng d | ||
| 020 | |a 9783540788980 |9 978-3-540-78898-0 | ||
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| 245 | 1 | 0 | |a Facilitative glucose transporters in articular chondrocytes |b expression, distribution and functional regulation of GLUT isoforms by hypoxia, hypoxia mimetics, growth factors and pro-inflammatory cytokines |c Ali Mobasheri ... |
| 264 | 1 | |a Berlin [u.a.] |b Springer |c 2008 | |
| 300 | |a VI, 88 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Advances in anatomy, embryology and cell biology |v 200 | |
| 650 | 4 | |a Arthritis |x metabolism | |
| 650 | 4 | |a Articular cartilage | |
| 650 | 4 | |a Cartilage cells | |
| 650 | 4 | |a Chondrocytes |x metabolism | |
| 650 | 4 | |a Cytokines | |
| 650 | 4 | |a Glucose | |
| 650 | 4 | |a Glucose Transport Proteins, Facilitative |x metabolism | |
| 650 | 4 | |a Glucose |x Physiological transport | |
| 650 | 0 | 7 | |a Glucosetransportproteine |0 (DE-588)4157685-8 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Gelenkknorpel |0 (DE-588)4156450-9 |2 gnd |9 rswk-swf |
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| 650 | 0 | 7 | |a Glucosetransport |0 (DE-588)4157684-6 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Glucosestoffwechsel |0 (DE-588)4129732-5 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Gelenkknorpel |0 (DE-588)4156450-9 |D s |
| 689 | 0 | 1 | |a Knorpelzelle |0 (DE-588)4208534-2 |D s |
| 689 | 0 | 2 | |a Glucosetransport |0 (DE-588)4157684-6 |D s |
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| 689 | 2 | 1 | |a Knorpelzelle |0 (DE-588)4208534-2 |D s |
| 689 | 2 | 2 | |a Glucosetransportproteine |0 (DE-588)4157685-8 |D s |
| 689 | 2 | |C b |5 DE-604 | |
| 700 | 1 | |a Mobasheri, Ali |e Sonstige |4 oth | |
| 830 | 0 | |a Advances in anatomy, embryology and cell biology |v 200 |w (DE-604)BV002528506 |9 200 | |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-016728649 | ||
Datensatz im Suchindex
| _version_ | 1804138004076298240 |
|---|---|
| adam_text | List of
Contents
1
Introduction
.......................................................... 1
1.1
Nutrient Sensing: A Fundamental Property of All Living Cells
................ 2
1.2
Glucose: The Universal Energy Currency
.................................. 3
1.3
Regulation of Glucose Metabolism by Feedback Regulation
.................. 4
1.4
Glucose Sensors: Lessons Learned from Other Organisms
.................... 5
2
Articular Cartilage: Structure, Function, and Pathophysiology
............... 5
2.1
Normal Articular Cartilage Structure and Function
......................... 6
2.2
Loss of Articular Cartilage Structure and Function in Osteoarthritis
.......... 9
3
Does Arthritis Have a Nutritional Etiology?
............................... 13
3.1
Nutrition and Osteoarthritis
............................................. 13
3.2
Nutrition and Osteochondritis Dissecans
.................................. 14
3.3
Nutrient Diffusion in the Extracellular Matrix of Articular Cartilage
.......... 15
3.4
Cartilage Canals and Vascular Supply in Subchondral Bone
.................. 16
3.5
Joint Microcirculation
.................................................. 16
3.6
Diet Influences Cartilage Canal Development
.............................. 17
4
Metabolic Dysfunction in Arthritis
....................................... 17
4.1
Regulation of Cartilage Turnover by Nutritional and Endocrine Factors
....... 17
4.2
Resistance to IGF-I Implicates Metabolic Dysfunction in OA
................. 18
5
Glucose: An Essential Metabolite and Structural Precursor
for Articular Cartilage
.................................................. 19
5.1
Glucose Metabolism in Articular Cartilage
................................. 19
5.2
Glycolysis, Glucose Metabolism, and ATP Production in Articular Cartilage
___ 19
6
Mammalian Sugar Transporter Families: GLUT and SGLT
................... 22
6.1
Physiological Roles of GLUTs
1-5......................................... 23
6.2
Physiological Roles of GLUTs
6-14........................................ 29
7
Molecular Diversity of Facultative Glucose Transporters in Articular
Chondrocytes
......................................................... 31
7.1
Functional Significance of GLUT1 and GLUT3 in Articular Chondrocytes:
The Developmental Perspective
.......................................... 32
7.2
Functional Significance of GLUT1 and GLUT3 in Articular Chondrocytes:
The Metabolic Perspective
............................................... 37
7.3
Regulation of Hypoxia and Hypoxia-Responsive Gene Expression by
the Transcription Factor HIF-la in Chondrocytes
.......................... 38
vi
List of Contents
7.4
Expression of HIF-la and GLUT1 in Normal and Osteoarthritic
Articular Cartilage
..................................................... 40
7.5
Functional Significance of ATP-Sensitive (KATP) Potassium Channels
in Articular Chondrocytes
............................................... 46
8
Regulation of Glucose
Iransport
by Nonsteroidal Anti-inflammatory Drugs
... 50
9
Glucose Transporters in the
Intervertébral Disc
............................ 53
10
Glucose Transporter Expression and Regulation in Embryonic
and Mesenchymal Stem Cells
............................................ 57
11
Concluding Remarks
................................................... 66
Acknowledgements
......................................................... 68
References
................................................................. 69
Index
..................................................................... 85
|
| adam_txt |
List of
Contents
1
Introduction
. 1
1.1
Nutrient Sensing: A Fundamental Property of All Living Cells
. 2
1.2
Glucose: The Universal Energy Currency
. 3
1.3
Regulation of Glucose Metabolism by Feedback Regulation
. 4
1.4
Glucose Sensors: Lessons Learned from Other Organisms
. 5
2
Articular Cartilage: Structure, Function, and Pathophysiology
. 5
2.1
Normal Articular Cartilage Structure and Function
. 6
2.2
Loss of Articular Cartilage Structure and Function in Osteoarthritis
. 9
3
Does Arthritis Have a Nutritional Etiology?
. 13
3.1
Nutrition and Osteoarthritis
. 13
3.2
Nutrition and Osteochondritis Dissecans
. 14
3.3
Nutrient Diffusion in the Extracellular Matrix of Articular Cartilage
. 15
3.4
Cartilage Canals and Vascular Supply in Subchondral Bone
. 16
3.5
Joint Microcirculation
. 16
3.6
Diet Influences Cartilage Canal Development
. 17
4
Metabolic Dysfunction in Arthritis
. 17
4.1
Regulation of Cartilage Turnover by Nutritional and Endocrine Factors
. 17
4.2
Resistance to IGF-I Implicates Metabolic Dysfunction in OA
. 18
5
Glucose: An Essential Metabolite and Structural Precursor
for Articular Cartilage
. 19
5.1
Glucose Metabolism in Articular Cartilage
. 19
5.2
Glycolysis, Glucose Metabolism, and ATP Production in Articular Cartilage
_ 19
6
Mammalian Sugar Transporter Families: GLUT and SGLT
. 22
6.1
Physiological Roles of GLUTs
1-5. 23
6.2
Physiological Roles of GLUTs
6-14. 29
7
Molecular Diversity of Facultative Glucose Transporters in Articular
Chondrocytes
. 31
7.1
Functional Significance of GLUT1 and GLUT3 in Articular Chondrocytes:
The Developmental Perspective
. 32
7.2
Functional Significance of GLUT1 and GLUT3 in Articular Chondrocytes:
The Metabolic Perspective
. 37
7.3
Regulation of Hypoxia and Hypoxia-Responsive Gene Expression by
the Transcription Factor HIF-la in Chondrocytes
. 38
vi
List of Contents
7.4
Expression of HIF-la and GLUT1 in Normal and Osteoarthritic
Articular Cartilage
. 40
7.5
Functional Significance of ATP-Sensitive (KATP) Potassium Channels
in Articular Chondrocytes
. 46
8
Regulation of Glucose
Iransport
by Nonsteroidal Anti-inflammatory Drugs
. 50
9
Glucose Transporters in the
Intervertébral Disc
. 53
10
Glucose Transporter Expression and Regulation in Embryonic
and Mesenchymal Stem Cells
. 57
11
Concluding Remarks
. 66
Acknowledgements
. 68
References
. 69
Index
. 85 |
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| language | English |
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| series2 | Advances in anatomy, embryology and cell biology |
| spelling | Facilitative glucose transporters in articular chondrocytes expression, distribution and functional regulation of GLUT isoforms by hypoxia, hypoxia mimetics, growth factors and pro-inflammatory cytokines Ali Mobasheri ... Berlin [u.a.] Springer 2008 VI, 88 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Advances in anatomy, embryology and cell biology 200 Arthritis metabolism Articular cartilage Cartilage cells Chondrocytes metabolism Cytokines Glucose Glucose Transport Proteins, Facilitative metabolism Glucose Physiological transport Glucosetransportproteine (DE-588)4157685-8 gnd rswk-swf Gelenkknorpel (DE-588)4156450-9 gnd rswk-swf Knorpelzelle (DE-588)4208534-2 gnd rswk-swf Arthritis (DE-588)4068867-7 gnd rswk-swf Glucosetransport (DE-588)4157684-6 gnd rswk-swf Glucosestoffwechsel (DE-588)4129732-5 gnd rswk-swf Gelenkknorpel (DE-588)4156450-9 s Knorpelzelle (DE-588)4208534-2 s Glucosetransport (DE-588)4157684-6 s DE-604 Glucosestoffwechsel (DE-588)4129732-5 s Arthritis (DE-588)4068867-7 s Glucosetransportproteine (DE-588)4157685-8 s b DE-604 Mobasheri, Ali Sonstige oth Advances in anatomy, embryology and cell biology 200 (DE-604)BV002528506 200 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016728649&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Facilitative glucose transporters in articular chondrocytes expression, distribution and functional regulation of GLUT isoforms by hypoxia, hypoxia mimetics, growth factors and pro-inflammatory cytokines Advances in anatomy, embryology and cell biology Arthritis metabolism Articular cartilage Cartilage cells Chondrocytes metabolism Cytokines Glucose Glucose Transport Proteins, Facilitative metabolism Glucose Physiological transport Glucosetransportproteine (DE-588)4157685-8 gnd Gelenkknorpel (DE-588)4156450-9 gnd Knorpelzelle (DE-588)4208534-2 gnd Arthritis (DE-588)4068867-7 gnd Glucosetransport (DE-588)4157684-6 gnd Glucosestoffwechsel (DE-588)4129732-5 gnd |
| subject_GND | (DE-588)4157685-8 (DE-588)4156450-9 (DE-588)4208534-2 (DE-588)4068867-7 (DE-588)4157684-6 (DE-588)4129732-5 |
| title | Facilitative glucose transporters in articular chondrocytes expression, distribution and functional regulation of GLUT isoforms by hypoxia, hypoxia mimetics, growth factors and pro-inflammatory cytokines |
| title_auth | Facilitative glucose transporters in articular chondrocytes expression, distribution and functional regulation of GLUT isoforms by hypoxia, hypoxia mimetics, growth factors and pro-inflammatory cytokines |
| title_exact_search | Facilitative glucose transporters in articular chondrocytes expression, distribution and functional regulation of GLUT isoforms by hypoxia, hypoxia mimetics, growth factors and pro-inflammatory cytokines |
| title_exact_search_txtP | Facilitative glucose transporters in articular chondrocytes expression, distribution and functional regulation of GLUT isoforms by hypoxia, hypoxia mimetics, growth factors and pro-inflammatory cytokines |
| title_full | Facilitative glucose transporters in articular chondrocytes expression, distribution and functional regulation of GLUT isoforms by hypoxia, hypoxia mimetics, growth factors and pro-inflammatory cytokines Ali Mobasheri ... |
| title_fullStr | Facilitative glucose transporters in articular chondrocytes expression, distribution and functional regulation of GLUT isoforms by hypoxia, hypoxia mimetics, growth factors and pro-inflammatory cytokines Ali Mobasheri ... |
| title_full_unstemmed | Facilitative glucose transporters in articular chondrocytes expression, distribution and functional regulation of GLUT isoforms by hypoxia, hypoxia mimetics, growth factors and pro-inflammatory cytokines Ali Mobasheri ... |
| title_short | Facilitative glucose transporters in articular chondrocytes |
| title_sort | facilitative glucose transporters in articular chondrocytes expression distribution and functional regulation of glut isoforms by hypoxia hypoxia mimetics growth factors and pro inflammatory cytokines |
| title_sub | expression, distribution and functional regulation of GLUT isoforms by hypoxia, hypoxia mimetics, growth factors and pro-inflammatory cytokines |
| topic | Arthritis metabolism Articular cartilage Cartilage cells Chondrocytes metabolism Cytokines Glucose Glucose Transport Proteins, Facilitative metabolism Glucose Physiological transport Glucosetransportproteine (DE-588)4157685-8 gnd Gelenkknorpel (DE-588)4156450-9 gnd Knorpelzelle (DE-588)4208534-2 gnd Arthritis (DE-588)4068867-7 gnd Glucosetransport (DE-588)4157684-6 gnd Glucosestoffwechsel (DE-588)4129732-5 gnd |
| topic_facet | Arthritis metabolism Articular cartilage Cartilage cells Chondrocytes metabolism Cytokines Glucose Glucose Transport Proteins, Facilitative metabolism Glucose Physiological transport Glucosetransportproteine Gelenkknorpel Knorpelzelle Arthritis Glucosetransport Glucosestoffwechsel |
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