Veterinary medicines in the environment: from the SETAC Pellston Workshop on Veterinary Medicines in the Environment, Pensacola, Florida, USA, 12 - 16 February 2006
Gespeichert in:
| Format: | Tagungsbericht Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Boca Raton [u.a.]
Taylor & Francis
2009
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references |
| Beschreibung: | XXV, 196 S. Ill., graph. Darst., |
| ISBN: | 9781880611944 9781420084245 |
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| 020 | |a 9781420084245 |c alk. paper |9 978-1-4200-8424-5 | ||
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| 245 | 1 | 0 | |a Veterinary medicines in the environment |b from the SETAC Pellston Workshop on Veterinary Medicines in the Environment, Pensacola, Florida, USA, 12 - 16 February 2006 |c ed. by Mark Crane ... |
| 264 | 1 | |a Boca Raton [u.a.] |b Taylor & Francis |c 2009 | |
| 300 | |a XXV, 196 S. |b Ill., graph. Darst., | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Includes bibliographical references | ||
| 650 | 7 | |a veterinary drugs |2 cabt | |
| 650 | 7 | |a drug residues |2 cabt | |
| 650 | 7 | |a veterinary products |2 cabt | |
| 650 | 7 | |a environment |2 cabt | |
| 650 | 7 | |a water pollution |2 cabt | |
| 650 | 7 | |a soil pollution |2 cabt | |
| 650 | 7 | |a risk assessment |2 cabt | |
| 650 | 7 | |a conferences |2 cabt | |
| 650 | 4 | |a Veterinary drugs - Environmental aspects | |
| 650 | 4 | |a Umwelt | |
| 650 | 4 | |a Veterinary drugs |x Environmental aspects | |
| 655 | 7 | |0 (DE-588)1071861417 |a Konferenzschrift |2 gnd-content | |
| 700 | 1 | |a Crane, Mark |e Sonstige |4 oth | |
| 711 | 2 | |a Workshop on Veterinary Medicines in the Environment |d 2006 |c Pensacola, Fla. |j Sonstige |0 (DE-588)10360216-1 |4 oth | |
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Datensatz im Suchindex
| _version_ | 1804137987876847616 |
|---|---|
| adam_text | IMAGE 1
CONTENTS LIST OF FIGURES XIII
LIST OF TAHLES XV
AHOUT THE EDITORS XVII
WORKSHOP PARTICIPANTS , XIX
FOREWORD XX I
ACKNOWLEDGMENTS XXV
CHAPTER I INTRODUCTION , ,.. , I
MARK CRANE. KATIE BARRETT, AND ALISTAIR BOXALL REFERENCES 3
CHAPTER 2 USES AND INPUTS OF VETERINARY MEDICINES IN THE ENVIRONMENT 7
ALISTAIR BOXELLL. MARK CRANE, CHRISTIAN CORSINF!.. CHARLES EIRKSON, AND
ALEX TAIT 2.1 INTRODUCTION , , , 7
2.2 VETERINARY MEDICINE USE 7
2.2.1 PARASITICIDES R
2.2.2 ANTIHACTERIALS R
2.2.3 COCCIDIOSTATS AND ANTIPROTOZOALS 10
2.2.4 ANTIFUNGALS 10
2.2.5 AQUACULTURE MEDICINES 10
2.2.6 HORMONES 10
2.2.7 GROWTH PROMOTERS 10
2.2.R OTHER MEDICINAL CLASSES II
2.3 PATHWAYS TO THE ENVIRONMENT. II
2.3.1 EMISSIONS DURING MANUFACTURING AND FORMULATION II
2.3.2 AQUACULTURE 12
2.3.3 AGRICULTURE (LIVESTOCK PRODUCTION) 13
2.3.4 COMPANION AND DOMESTIC ANIMALS 14
2.3.5 DISPOSAL OF UNWANTED DRUGS 15
2.4 SUMMARY 16
REFERENCES 17
CHAPTER 3 ENVIRONMENTAL RISK ASSESSMENT AND MANAGEMENT OF VETERINARY
MEDICINES 21
LOOP DE KNECHT, TATIANA BOUCARD, BRYAN W. BROOKS, MARK CRANE, CHARLES
EIRKSON, SAROH CEROULD, LAN KOSCHORRECK. CREGOR SCHEER. KEITH R,
SOLO/L1ON, AND ZHIXING YAN
IMAGE 2
VIII CONTENTS
3.1 INTRODUCTION 21
3.2 VETCRINARY MEDICINES IN REGULATORY PERSPECTIVE 23
3.2.1 LEGISLATION, SCOPE, AND PAST GUIDELINES FOR ENVIRONMENTAL RISK
ASSESSMENT (ERA) OF VETERINARY MCDICINES 23
3.2.1.1 UNITED STATES 24
3.2.1.2 EUROPEAN UNION 25
.L2.1.3 JAPAN 26
3.2.1.4 AUSTRAL IA 26
3.2.1.5 CANADA 26
3.2.2 CURRENT GUIDELINES: VICH AND THE VICH-EU TECHNICAL GUIDANCE
DOCUMENT (VICH-EU-TGD) 27
3.3 REFINEMENT OF VETERINARY MEDICINAL PRODUCT (VMP) RISK ASSESSMENTS 33
3.3.1 METABOLISM AND DEGRADATION 33
3.3.2 COMBINATION PRODUCTS 35
3.3.3 REFINCMENT OF ENVIRONMENTAL EXPOSURE PREDICTIONS 36
3.3.4 PROBABILISTIC RISK ASSESSMENT OF VETERINARY MEDICINES 36 3.3.4.1
CASE STUDY OF A PROBABILISTIC RISK ASSESSMENT FL)R DUNG FAUNA 37
3.4 RISK MANAGEMENT 41
3.4.1 RISK MITIGATION MEASURES WITHIN PRODUCT AUTHORIZATION OR APPROVAL
42
3.4.2 RISK ASSESSMENT AND MANAGEMENT BEYOND AUTHORIZATION OR APPROVAL 44
3.4.2.1 COMMUNICATION CHALLENGE 44
3.4.2.2 INCIDENCE REPORTING AND PHARMACOVIGILANCE 47
3.4.3 RETROSPECTIVE RISK ASSESSMENT 49
3.4.4 POSTMARKET MONITORING AND REMEDIATION 51
3.4.4.1 MONITORING ENDPOINTS 51
REFERENCES 52
CHAPTER 4 EXPOSURE ASSESSMENT OF VETERINARY MEDICINES IN AQUATIC SYSTEMS
57
CHRIS MERCA(FE. ALISTAIR BOXALL, KATHRIN FENNER, DANA KOLPIN. MARK
SERVOS, ERIC SILHERHORN. AND JANE SRAVELEY 4.1 INTRODUCTION 57
4.2 SOURCES OF VETERINARY MEDICINES IN THE AQUATIC ENVIRONMENT 58 4.2.1
TREATMENTS USED IN AGRICULTURE 58
4.2.2 TREATMENTS USED IN AQUACULTURE 61
4.3 EXPERIMENTAL STUDIES INTO THE ENTRY, FATE, AND TRANSPORT OF
VETERINARY MEDICINES IN AQUATIC SYSTEMS 62
4.3.1 AQUATIC EXPOSURE TO VETERINARY MEDICINES USED TO TREAT LIVESTOCK
62
4.3.1.1 LEACH ING TO GROUNDWATER. 63
4.3.1.2 MOVEMENT TO SURFACE WATER 63
IMAGE 3
CONTENTS IX
4.3.1.3 PREDICTING EXPOSURE 65
4.3.1.4 COMPARISON OF MODELED CONCENTRATIONS WITH MEASURED CONCENTRAT
IONS 66
4.3.2 AQUACULTURE TREATMENTS 73
4.3.2.1 INPUTS AND FATE OF MARINE AQUACULTURE TREATMENTS 75 4.3.2.2
FRESHWATER AQUACULTURE 76
4.3.2.3 MODCLING EXPOSURE FROM AQUACULTURE TREATMENTS 77 4.4 CONCLUSIONS
89
REFERENCES 91
CHAPTER 5 ASSESSING THE AQUATIC HAZARDS OF VETERINARY MEDICINES 97
BRYAN W. BROOKS. GERALD T ANKLE . JAMES F. HOBSON. JAMES M. LA::ORC!WK.
ROGER D. ALCL ERHOFF, AND KEITH R. SOLOMON 5.1 INTRODUCTION 97
5.2 PROTECTION GOALS 98
5.3 APPROACHES TO ASSESS EFFECTS OF VETERINARY MEDICI NL S 98
5.3.1 CURRENT METHODS OF ASSESSING AQUAT IC EITCCTS FOR RISK ASSCSSMENT
98
5.3.1.1 LOWER TICR APPROACHES 99
5.3.1.2 HIGHCR TIER TESTING 99
5.3. .3 LIMITATIONS 10 CURRENT APPROACHES 101
5.3.2 NOVEL APPROACHES TO AQUATIC EFFECTS ASSESSMENT 102
5.3.2.1 USC OF CHEMICAL CHARACTERISTICS. TARGET ORGANISM EFFICACY DATA.
TOXICOKINETIC DATA. AND MAMMALIAN TOXICOLOGY DATA 102
5 .. 1.2.2 USC OF ECOTOXICOGENOMICS IN ECOLOGICAL EFFECTS ASSESSMENT 108
5.4 APPLICATION FACTORS AND SPECIES SENSITIVITIES I 10
5.5 EFFECTS OF VETERINARY MEDICINES IN THE NATURAL ENVIRONMENT. L N
5.5.1 EPISODIC EXPOSURES 1 14
5.5.2 MATRIX EFFECTS 114
5.5.3 METABOLITES AND DEGRADALES 115
5.5.4 MIXTURES 116
5.5.5 ENANTIOMER-SPECI LIC HAZARD 117
5.5.6 SORPTION TO SEDI MENT 118
5.5.7 ASSESSING EFFECTS ON COMMUNITIES 119
5.6 CONCLUSIONS 121
REFERENCES 122
CHAPTER 6 EXPOSURE ASSESSMENT OF VETERINARY MEDICINES IN TERRESTRIAL
SYSTEMS 129
LOUISE POPE. ALISTAIR BOX(DL. CHRISTIAN CON ING, BENT
HALLING-SRLIRENSEN. ALEX TAIT, AND EDWARD TOPP
IMAGE 4
CONTENTS
6.1 INTRODUCTION 129
6.2 ABSORPTION AND EXCRETION BY ANIMALS 130
6.3 FATE DURING MANURE STORAGE 134
6.4 RELEASES TO THE ENVIRONMENT.. 136
6.5 FACTORS AFFECTING DISSIPATION IN THE FARM ENVIRONMENT.. 137
6.5.1 DISSIPATION AND TRANSPORT IN DUNG SYSTEMS 137
6.5.2 DISSIPATION AND TRANSPORT IN SOIL SYSTEMS 138
6.5.2.1 BIOTIC DEGRADATION PROCESSES 138
6.5.2.2 ABIOTIC DEGRADATION PROCESSES : 140
6.5.2.3 SORPTION TO SOIL... 141
6.5.3 BOUND RESIDUES 141
6.6 UPTAKE BY PLANTS 143
6.7 MODELS FOR ESTIMATING THE CONCENTRATION OF VETERINARY MEDICINE IN
SOIL 143
6.7.1 INTENSIVELY REARED ANIMALS 144
6.7.2 PASTURE ANIMALS 148
6.7.3 PEC RDINEMENT 148
6.8 RESEARCH NEEDS 149
REFERENCES 149
CHAPTER 7 ASSESSING THE EFFECTS OF VETERINARY MEDICINES ON THE
TERRESTRIAL ENVIRONMENT 155
KATIE BARRETT, KEVIN FLOATE, JOHN JENSEN, JOE ROBINSON, AND NEIL TOLSON
7.1 INTRODUCTION 155
7.2 CONSIDERATIONS UNIQUE TO VETERINARY MEDICINES 155
7.2.1 ROUTES OF ENTRY 155
7.2.2 ADDITIONAL SAFETY DATA AVAILABLE IN THE DOSSIER 156
7.2.3 RESIDUE DATA AND DETOXIFICATION BY THE TARGET ANIMAL SPECIES 156
7.3 PROTECTION GOALS 157
7.4 TIERED TESTING STRATEGY 160
7.5 JUSTIFICATION FOR EXISTING TESTING METHODS 160
7.6 USE OF INDICATOR SPECIES 160
7.7 SHORT-TERM AND SUBLETHAL EFFECTS TESTS 163
7.8 TIER A TESTING 163
7.8.1 PHYSICOCHEMICAL PROPERTIES 163
7.8.2 FATE 164
7.8.3 MICROORGANISMS 164
7.8.4 PLANTS 165
7.8.5 EARTHWORMS 165
7.8.6 COLLEMBOLANS 166
7.8.7 DUNG FAUNA 166
7.9 TIER B TESTING 168
IMAGE 5
CONTENTS XI
7.10 TIER C TESTING 169
7.10.1 MESOCOSM AND FIELD TESTING 169
7.10.2 TESTING OF ADDITIONAL SPECIES 170
7.ICU MONITORING STUDIES J70
7.11 CALCULATION OF PNEC CONCENTRATIONS AND USE OF ASSESSMENT
FACTORS J 7
7.12 METABOLITE TESTING IN TIERS A AND B 172
7. 3 SECONDARY POISONING 173
7.14 BOUND RESIDUES 174
7.15 AJTERNATIVE ENDPOI NTS 175
7.16 MODELING POPULATION AND ECOSYSTEM EFFECTS (E.G .. BIOINDICATOR
APPROACHES) 176
7.17 RESEARCH NEEDS 177
REFERENCES 177
CHAPTER 8 WORKSHOP CONCLUSIONS AND RECOMMENDATIONS IRI
MARK CRANE, KATIE BARRETT, AND ALISTAIR BOXEDL 8.1 WORKSHOP CONCLUSIONS
181
R.2 WORKSHOP RECOMMENDATIONS 184
INDEX 187
|
| adam_txt |
IMAGE 1
CONTENTS LIST OF FIGURES XIII
LIST OF TAHLES XV
AHOUT THE EDITORS XVII
WORKSHOP PARTICIPANTS , XIX
FOREWORD XX I
ACKNOWLEDGMENTS XXV
CHAPTER I INTRODUCTION , ,. , I
MARK CRANE. KATIE BARRETT, AND ALISTAIR BOXALL REFERENCES 3
CHAPTER 2 USES AND INPUTS OF VETERINARY MEDICINES IN THE ENVIRONMENT 7
ALISTAIR BOXELLL. MARK CRANE, CHRISTIAN CORSINF!. CHARLES EIRKSON, AND
ALEX TAIT 2.1 INTRODUCTION , , , 7
2.2 VETERINARY MEDICINE USE 7
2.2.1 PARASITICIDES R
2.2.2 ANTIHACTERIALS R
2.2.3 COCCIDIOSTATS AND ANTIPROTOZOALS 10
2.2.4 ANTIFUNGALS 10
2.2.5 AQUACULTURE MEDICINES 10
2.2.6 HORMONES 10
2.2.7 GROWTH PROMOTERS 10
2.2.R OTHER MEDICINAL CLASSES II
2.3 PATHWAYS TO THE ENVIRONMENT. II
2.3.1 EMISSIONS DURING MANUFACTURING AND FORMULATION II
2.3.2 AQUACULTURE 12
2.3.3 AGRICULTURE (LIVESTOCK PRODUCTION) 13
2.3.4 COMPANION AND DOMESTIC ANIMALS 14
2.3.5 DISPOSAL OF UNWANTED DRUGS 15
2.4 SUMMARY 16
REFERENCES 17
CHAPTER 3 ENVIRONMENTAL RISK ASSESSMENT AND MANAGEMENT OF VETERINARY
MEDICINES 21
LOOP DE KNECHT, TATIANA BOUCARD, BRYAN W. BROOKS, MARK CRANE, CHARLES
EIRKSON, SAROH CEROULD, LAN KOSCHORRECK. CREGOR SCHEER. KEITH R,
SOLO/L1ON, AND ZHIXING YAN
IMAGE 2
VIII CONTENTS
3.1 INTRODUCTION 21
3.2 VETCRINARY MEDICINES IN REGULATORY PERSPECTIVE 23
3.2.1 LEGISLATION, SCOPE, AND PAST GUIDELINES FOR ENVIRONMENTAL RISK
ASSESSMENT (ERA) OF VETERINARY MCDICINES 23
3.2.1.1 UNITED STATES 24
3.2.1.2 EUROPEAN UNION 25
.L2.1.3 JAPAN 26
3.2.1.4 AUSTRAL IA 26
3.2.1.5 CANADA 26
3.2.2 CURRENT GUIDELINES: VICH AND THE VICH-EU TECHNICAL GUIDANCE
DOCUMENT (VICH-EU-TGD) 27
3.3 REFINEMENT OF VETERINARY MEDICINAL PRODUCT (VMP) RISK ASSESSMENTS 33
3.3.1 METABOLISM AND DEGRADATION 33
3.3.2 COMBINATION PRODUCTS 35
3.3.3 REFINCMENT OF ENVIRONMENTAL EXPOSURE PREDICTIONS 36
3.3.4 PROBABILISTIC RISK ASSESSMENT OF VETERINARY MEDICINES 36 3.3.4.1
CASE STUDY OF A PROBABILISTIC RISK ASSESSMENT FL)R DUNG FAUNA 37
3.4 RISK MANAGEMENT 41
3.4.1 RISK MITIGATION MEASURES WITHIN PRODUCT AUTHORIZATION OR APPROVAL
42
3.4.2 RISK ASSESSMENT AND MANAGEMENT BEYOND AUTHORIZATION OR APPROVAL 44
3.4.2.1 COMMUNICATION CHALLENGE 44
3.4.2.2 INCIDENCE REPORTING AND PHARMACOVIGILANCE 47
3.4.3 RETROSPECTIVE RISK ASSESSMENT 49
3.4.4 POSTMARKET MONITORING AND REMEDIATION 51
3.4.4.1 MONITORING ENDPOINTS 51
REFERENCES 52
CHAPTER 4 EXPOSURE ASSESSMENT OF VETERINARY MEDICINES IN AQUATIC SYSTEMS
57
CHRIS MERCA(FE. ALISTAIR BOXALL, KATHRIN FENNER, DANA KOLPIN. MARK
SERVOS, ERIC SILHERHORN. AND JANE SRAVELEY 4.1 INTRODUCTION 57
4.2 SOURCES OF VETERINARY MEDICINES IN THE AQUATIC ENVIRONMENT 58 4.2.1
TREATMENTS USED IN AGRICULTURE 58
4.2.2 TREATMENTS USED IN AQUACULTURE 61
4.3 EXPERIMENTAL STUDIES INTO THE ENTRY, FATE, AND TRANSPORT OF
VETERINARY MEDICINES IN AQUATIC SYSTEMS 62
4.3.1 AQUATIC EXPOSURE TO VETERINARY MEDICINES USED TO TREAT LIVESTOCK
'" 62
4.3.1.1 LEACH ING TO GROUNDWATER. 63
4.3.1.2 MOVEMENT TO SURFACE WATER 63
IMAGE 3
CONTENTS IX
4.3.1.3 PREDICTING EXPOSURE 65
4.3.1.4 COMPARISON OF MODELED CONCENTRATIONS WITH MEASURED CONCENTRAT
IONS 66
4.3.2 AQUACULTURE TREATMENTS 73
4.3.2.1 INPUTS AND FATE OF MARINE AQUACULTURE TREATMENTS 75 4.3.2.2
FRESHWATER AQUACULTURE 76
4.3.2.3 MODCLING EXPOSURE FROM AQUACULTURE TREATMENTS 77 4.4 CONCLUSIONS
89
REFERENCES 91
CHAPTER 5 ASSESSING THE AQUATIC HAZARDS OF VETERINARY MEDICINES 97
BRYAN W. BROOKS. GERALD T ANKLE". JAMES F. HOBSON. JAMES M. LA::ORC!WK.
ROGER D. ALCL'ERHOFF, AND KEITH R. SOLOMON 5.1 INTRODUCTION 97
5.2 PROTECTION GOALS 98
5.3 APPROACHES TO ASSESS EFFECTS OF VETERINARY MEDICI NL'S 98
5.3.1 CURRENT METHODS OF ASSESSING AQUAT IC EITCCTS FOR RISK ASSCSSMENT
98
5.3.1.1 LOWER TICR APPROACHES 99
5.3.1.2 HIGHCR TIER TESTING 99
5.3.'.3 LIMITATIONS 10 CURRENT APPROACHES 101
5.3.2 NOVEL APPROACHES TO AQUATIC EFFECTS ASSESSMENT 102
5.3.2.1 USC OF CHEMICAL CHARACTERISTICS. TARGET ORGANISM EFFICACY DATA.
TOXICOKINETIC DATA. AND MAMMALIAN TOXICOLOGY DATA 102
5 . 1.2.2 USC OF ECOTOXICOGENOMICS IN ECOLOGICAL EFFECTS ASSESSMENT 108
5.4 APPLICATION FACTORS AND SPECIES SENSITIVITIES I 10
5.5 EFFECTS OF VETERINARY MEDICINES IN THE NATURAL ENVIRONMENT. L N
5.5.1 EPISODIC EXPOSURES 1 14
5.5.2 MATRIX EFFECTS 114
5.5.3 METABOLITES AND DEGRADALES 115
5.5.4 MIXTURES 116
5.5.5 ENANTIOMER-SPECI LIC HAZARD 117
5.5.6 SORPTION TO SEDI MENT 118
5.5.7 ASSESSING EFFECTS ON COMMUNITIES 119
5.6 CONCLUSIONS 121
REFERENCES 122
CHAPTER 6 EXPOSURE ASSESSMENT OF VETERINARY MEDICINES IN TERRESTRIAL
SYSTEMS 129
LOUISE POPE. ALISTAIR BOX(DL. CHRISTIAN CON'ING, BENT
HALLING-SRLIRENSEN. ALEX TAIT, AND EDWARD TOPP
IMAGE 4
CONTENTS
6.1 INTRODUCTION 129
6.2 ABSORPTION AND EXCRETION BY ANIMALS 130
6.3 FATE DURING MANURE STORAGE 134
6.4 RELEASES TO THE ENVIRONMENT. 136
6.5 FACTORS AFFECTING DISSIPATION IN THE FARM ENVIRONMENT. 137
6.5.1 DISSIPATION AND TRANSPORT IN DUNG SYSTEMS 137
6.5.2 DISSIPATION AND TRANSPORT IN SOIL SYSTEMS 138
6.5.2.1 BIOTIC DEGRADATION PROCESSES 138
6.5.2.2 ABIOTIC DEGRADATION PROCESSES : 140
6.5.2.3 SORPTION TO SOIL. 141
6.5.3 BOUND RESIDUES 141
6.6 UPTAKE BY PLANTS 143
6.7 MODELS FOR ESTIMATING THE CONCENTRATION OF VETERINARY MEDICINE IN
SOIL 143
6.7.1 INTENSIVELY REARED ANIMALS 144
6.7.2 PASTURE ANIMALS 148
6.7.3 PEC RDINEMENT 148
6.8 RESEARCH NEEDS 149
REFERENCES 149
CHAPTER 7 ASSESSING THE EFFECTS OF VETERINARY MEDICINES ON THE
TERRESTRIAL ENVIRONMENT 155
KATIE BARRETT, KEVIN FLOATE, JOHN JENSEN, JOE ROBINSON, AND NEIL TOLSON
7.1 INTRODUCTION 155
7.2 CONSIDERATIONS UNIQUE TO VETERINARY MEDICINES 155
7.2.1 ROUTES OF ENTRY 155
7.2.2 ADDITIONAL SAFETY DATA AVAILABLE IN THE DOSSIER 156
7.2.3 RESIDUE DATA AND DETOXIFICATION BY THE TARGET ANIMAL SPECIES 156
7.3 PROTECTION GOALS 157
7.4 TIERED TESTING STRATEGY 160
7.5 JUSTIFICATION FOR EXISTING TESTING METHODS 160
7.6 USE OF INDICATOR SPECIES 160
7.7 SHORT-TERM AND SUBLETHAL EFFECTS TESTS 163
7.8 TIER A TESTING 163
7.8.1 PHYSICOCHEMICAL PROPERTIES 163
7.8.2 FATE 164
7.8.3 MICROORGANISMS 164
7.8.4 PLANTS 165
7.8.5 EARTHWORMS 165
7.8.6 COLLEMBOLANS 166
7.8.7 DUNG FAUNA 166
7.9 TIER B TESTING 168
IMAGE 5
CONTENTS XI
7.10 TIER C TESTING 169
7.10.1 MESOCOSM AND FIELD TESTING 169
7.10.2 TESTING OF ADDITIONAL SPECIES 170
7.ICU MONITORING STUDIES J70
7.11 CALCULATION OF PNEC CONCENTRATIONS AND USE OF ASSESSMENT
FACTORS J 7\
7.12 METABOLITE TESTING IN TIERS A AND B 172
7.\3 SECONDARY POISONING 173
7.14 BOUND RESIDUES 174
7.15 AJTERNATIVE ENDPOI NTS 175
7.16 MODELING POPULATION AND ECOSYSTEM EFFECTS (E.G . BIOINDICATOR
APPROACHES) 176
7.17 RESEARCH NEEDS 177
REFERENCES 177
CHAPTER 8 WORKSHOP CONCLUSIONS AND RECOMMENDATIONS IRI
MARK CRANE, KATIE BARRETT, AND ALISTAIR BOXEDL 8.1 WORKSHOP CONCLUSIONS
181
R.2 WORKSHOP RECOMMENDATIONS 184
INDEX 187 |
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| discipline_str_mv | Biologie Bauingenieurwesen |
| format | Conference Proceeding Book |
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| genre | (DE-588)1071861417 Konferenzschrift gnd-content |
| genre_facet | Konferenzschrift |
| id | DE-604.BV035049217 |
| illustrated | Illustrated |
| index_date | 2024-07-02T21:55:57Z |
| indexdate | 2024-07-09T21:21:02Z |
| institution | BVB |
| institution_GND | (DE-588)10360216-1 |
| isbn | 9781880611944 9781420084245 |
| language | English |
| lccn | 2008019579 |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-016717923 |
| oclc_num | 476935088 |
| open_access_boolean | |
| owner | DE-703 DE-188 |
| owner_facet | DE-703 DE-188 |
| physical | XXV, 196 S. Ill., graph. Darst., |
| publishDate | 2009 |
| publishDateSearch | 2009 |
| publishDateSort | 2009 |
| publisher | Taylor & Francis |
| record_format | marc |
| spelling | Veterinary medicines in the environment from the SETAC Pellston Workshop on Veterinary Medicines in the Environment, Pensacola, Florida, USA, 12 - 16 February 2006 ed. by Mark Crane ... Boca Raton [u.a.] Taylor & Francis 2009 XXV, 196 S. Ill., graph. Darst., txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references veterinary drugs cabt drug residues cabt veterinary products cabt environment cabt water pollution cabt soil pollution cabt risk assessment cabt conferences cabt Veterinary drugs - Environmental aspects Umwelt Veterinary drugs Environmental aspects (DE-588)1071861417 Konferenzschrift gnd-content Crane, Mark Sonstige oth Workshop on Veterinary Medicines in the Environment 2006 Pensacola, Fla. Sonstige (DE-588)10360216-1 oth OEBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016717923&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Veterinary medicines in the environment from the SETAC Pellston Workshop on Veterinary Medicines in the Environment, Pensacola, Florida, USA, 12 - 16 February 2006 veterinary drugs cabt drug residues cabt veterinary products cabt environment cabt water pollution cabt soil pollution cabt risk assessment cabt conferences cabt Veterinary drugs - Environmental aspects Umwelt Veterinary drugs Environmental aspects |
| subject_GND | (DE-588)1071861417 |
| title | Veterinary medicines in the environment from the SETAC Pellston Workshop on Veterinary Medicines in the Environment, Pensacola, Florida, USA, 12 - 16 February 2006 |
| title_auth | Veterinary medicines in the environment from the SETAC Pellston Workshop on Veterinary Medicines in the Environment, Pensacola, Florida, USA, 12 - 16 February 2006 |
| title_exact_search | Veterinary medicines in the environment from the SETAC Pellston Workshop on Veterinary Medicines in the Environment, Pensacola, Florida, USA, 12 - 16 February 2006 |
| title_exact_search_txtP | Veterinary medicines in the environment from the SETAC Pellston Workshop on Veterinary Medicines in the Environment, Pensacola, Florida, USA, 12 - 16 February 2006 |
| title_full | Veterinary medicines in the environment from the SETAC Pellston Workshop on Veterinary Medicines in the Environment, Pensacola, Florida, USA, 12 - 16 February 2006 ed. by Mark Crane ... |
| title_fullStr | Veterinary medicines in the environment from the SETAC Pellston Workshop on Veterinary Medicines in the Environment, Pensacola, Florida, USA, 12 - 16 February 2006 ed. by Mark Crane ... |
| title_full_unstemmed | Veterinary medicines in the environment from the SETAC Pellston Workshop on Veterinary Medicines in the Environment, Pensacola, Florida, USA, 12 - 16 February 2006 ed. by Mark Crane ... |
| title_short | Veterinary medicines in the environment |
| title_sort | veterinary medicines in the environment from the setac pellston workshop on veterinary medicines in the environment pensacola florida usa 12 16 february 2006 |
| title_sub | from the SETAC Pellston Workshop on Veterinary Medicines in the Environment, Pensacola, Florida, USA, 12 - 16 February 2006 |
| topic | veterinary drugs cabt drug residues cabt veterinary products cabt environment cabt water pollution cabt soil pollution cabt risk assessment cabt conferences cabt Veterinary drugs - Environmental aspects Umwelt Veterinary drugs Environmental aspects |
| topic_facet | veterinary drugs drug residues veterinary products environment water pollution soil pollution risk assessment conferences Veterinary drugs - Environmental aspects Umwelt Veterinary drugs Environmental aspects Konferenzschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016717923&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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