Synthesis of novel bioactive doxycycline derivatives:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2008
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| Schlagworte: | |
| Online-Zugang: | kostenfrei https://nbn-resolving.org/urn:nbn:de:bvb:29-opus-10827 http://d-nb.info/990443043/34 Inhaltsverzeichnis |
| Beschreibung: | 205 S. graph. Darst. |
Internformat
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Datensatz im Suchindex
| _version_ | 1804137983058640896 |
|---|---|
| adam_text | Table of Contents
1. Introduction 1
2. Background and aims 5
3. Synthesis of new 4-dedimethylamino doxycycline derivatives U
3.1 4-Dedimethylamino Doxycycline Derivatives 16
3.1.1 Synthesis of 4-Dedimethylamino Doxycycline 16
3.1.2 Substitutions in Position 9 17
3.1.3 Further modifications of 4-Dedimethylamino Doxycycline 19
3.1.4 Further modifications of 9-iodo-4-Dedimethylamino Doxycycline 26
3.2 Biological Investigations 35
4. Synthesis of doxycycline derivatives for SPR investigations 40
4.1 Chemistry 41
4.1.1 Synthesis of amino bearing doxycycline derivatives 41
4.2 Biological Investigations 49
5. Development of a click chemistry strategy for the
functional ization and bioconjugation of doxycycline 54
5.1 Chemistry 54
5.1.1 Alkyne / azide derivatives and reaction optimization 54
5.1.2 Functional groups tolerance studies 60
5.1.3 Amino acid conjugates 62
5.1.4 Peptide conjugates 69
5.2 Biological Investigations 78
6. Summary 81
7. Zusammenfassung 93
8. Experimental part 105
9. Abbreviations and acronyms 196
10. References 197
|
| adam_txt |
Table of Contents
1. Introduction 1
2. Background and aims 5
3. Synthesis of new 4-dedimethylamino doxycycline derivatives U
3.1 4-Dedimethylamino Doxycycline Derivatives 16
3.1.1 Synthesis of 4-Dedimethylamino Doxycycline 16
3.1.2 Substitutions in Position 9 17
3.1.3 Further modifications of 4-Dedimethylamino Doxycycline 19
3.1.4 Further modifications of 9-iodo-4-Dedimethylamino Doxycycline 26
3.2 Biological Investigations 35
4. Synthesis of doxycycline derivatives for SPR investigations 40
4.1 Chemistry 41
4.1.1 Synthesis of amino bearing doxycycline derivatives 41
4.2 Biological Investigations 49
5. Development of a click chemistry strategy for the
functional ization and bioconjugation of doxycycline 54
5.1 Chemistry 54
5.1.1 Alkyne / azide derivatives and reaction optimization 54
5.1.2 Functional groups tolerance studies 60
5.1.3 Amino acid conjugates 62
5.1.4 Peptide conjugates 69
5.2 Biological Investigations 78
6. Summary 81
7. Zusammenfassung 93
8. Experimental part 105
9. Abbreviations and acronyms 196
10. References 197 |
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| author | Usai, Igor 1979- |
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| dewey-full | 547.7 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 547 - Organic chemistry |
| dewey-raw | 547.7 |
| dewey-search | 547.7 |
| dewey-sort | 3547.7 |
| dewey-tens | 540 - Chemistry and allied sciences |
| discipline | Chemie / Pharmazie |
| discipline_str_mv | Chemie / Pharmazie |
| format | Thesis Book |
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| language | English |
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| spelling | Usai, Igor 1979- Verfasser (DE-588)136265103 aut Synthesis of novel bioactive doxycycline derivatives von Igor Usai 2008 205 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Erlangen-Nürnberg, Univ., Diss., 2008 Langzeitarchivierung Nationalbibliothek gewährleistet Derivate (DE-588)4400584-2 gnd rswk-swf Doxycyclin (DE-588)4150506-2 gnd rswk-swf Teilsynthese (DE-588)4508944-9 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Doxycyclin (DE-588)4150506-2 s Derivate (DE-588)4400584-2 s Teilsynthese (DE-588)4508944-9 s DE-604 Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:29-opus-10827 https://open.fau.de/handle/openfau/708 Verlag kostenfrei Volltext https://nbn-resolving.org/urn:nbn:de:bvb:29-opus-10827 Resolvingsystem http://d-nb.info/990443043/34 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016714884&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Usai, Igor 1979- Synthesis of novel bioactive doxycycline derivatives Derivate (DE-588)4400584-2 gnd Doxycyclin (DE-588)4150506-2 gnd Teilsynthese (DE-588)4508944-9 gnd |
| subject_GND | (DE-588)4400584-2 (DE-588)4150506-2 (DE-588)4508944-9 (DE-588)4113937-9 |
| title | Synthesis of novel bioactive doxycycline derivatives |
| title_auth | Synthesis of novel bioactive doxycycline derivatives |
| title_exact_search | Synthesis of novel bioactive doxycycline derivatives |
| title_exact_search_txtP | Synthesis of novel bioactive doxycycline derivatives |
| title_full | Synthesis of novel bioactive doxycycline derivatives von Igor Usai |
| title_fullStr | Synthesis of novel bioactive doxycycline derivatives von Igor Usai |
| title_full_unstemmed | Synthesis of novel bioactive doxycycline derivatives von Igor Usai |
| title_short | Synthesis of novel bioactive doxycycline derivatives |
| title_sort | synthesis of novel bioactive doxycycline derivatives |
| topic | Derivate (DE-588)4400584-2 gnd Doxycyclin (DE-588)4150506-2 gnd Teilsynthese (DE-588)4508944-9 gnd |
| topic_facet | Derivate Doxycyclin Teilsynthese Hochschulschrift |
| url | https://open.fau.de/handle/openfau/708 https://nbn-resolving.org/urn:nbn:de:bvb:29-opus-10827 http://d-nb.info/990443043/34 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016714884&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT usaiigor synthesisofnovelbioactivedoxycyclinederivatives |