Analysis of the anti-tumor immune response against sporadic cancers in LoxP-Tag transgenic mice:
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2008
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 93 Bl. Ill., graph. Darst. |
Internformat
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| 245 | 1 | 0 | |a Analysis of the anti-tumor immune response against sporadic cancers in LoxP-Tag transgenic mice |c by Melinda Czéh |
| 264 | 1 | |c 2008 | |
| 300 | |a 93 Bl. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
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| 502 | |a Berlin, Freie Univ., Diss., 2008 | ||
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Datensatz im Suchindex
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|---|---|
| adam_text | 1 Directory
2 Introduction 4
2.1 Mouse Models 4
2.2 Simian Virus 40 (SV40) 4
2.3 SV40 Tag and Transgenic Mouse Models 6
2.4 Turning on Tumors / The Inducible System 6
2.5 The Cre/loxP Recombination System 7
2.6 Immune Response against SV40 Tag Induced Tumors 8
2.7 Colon Carcinoma 10
2.8 Pathways to Colorectal Cancers 10
2.8.1 The Gatekeepers 11
2.8.2 The Caretakers 12
2.8.3 The Landscapes 13
2.9 The Gastrointestinal Stem Cell Niche 13
2.10 Mouse Models of Colon Carcinoma 13
2.11 SV40 Tag and Transgenic Mouse Models of Colon Carcinoma 14
2.12 New Trials Using Tissue-specific Cre-mediated Recombination in the Epithelium of
Gastrointestinal Tract 15
2.13 The Vil-Cre Transgenic Mouse Model 16
2.14 Vil-Cre-ERT2 Transgenic Mouse Model 17
2.15 Polyomaviruses and Colon Carcinoma 17
2.16 Unspecific CTL Unresponsiveness 18
2.17 The Contribution of CD4+ T Lymphocytes to Antitumor Immune Response and to
Tolerance during Tumor Development 19
2.18 The LoxP-Tag Transgenic Mice 20
3 The Aim of the Work 22
4 Materials and Methods 24
4.1 Mice 24
4.2 Genotyping of Mice 24
4.3 Investigation of Spontaneous Tumor Development in the LoxP-Tag and the CD4 x
LoxP-Tag Transgenic Mice 24
4.4 Histology and Immunohistochemistry 24
4.5 Adenoviral Gene Transfer into Colon Epithelial Cells in C57BL/6 and LoxP-Tag
Transgenic Mice 25
4.6 Investigation of Spontaneous Colon Carcinoma Development in the Fabpl x LoxP-
Tag, Vil-Cre x LoxP-Tag and Vil-Cre-ERT2 x LoxP-Tag Transgenic Mice 26
4.7 Immunofluorescence Staining for SV40 Tag and P-catenin 26
4.8 Detection of the Cre/LoxP Recombination in Tumor Tissue 26
4.9 Detection of anti-SV40 Tag Specific Antibody with ELISA 27
4.10 Isotyping of anti- SV40 Tag Specific Antibodies with ELISA 27
4.11 Preparation of Single Cell Suspension from Spleen 27
4.12 In Vivo Kill Assay against the Tumor-Specific Antigen SV40 Tag and against the
Unrelated Tumor-Specific Antigen, gp33 28
4.13 Allogeneic In Vivo Kill Assay 28
4.14 Tumor Transplantation Experiments 29
4.15 Depletion of CD3+ T Lymphocytes During Tumor Development 30
4.16 In Vitro Depletion of CD4+ T Lymphocyte from Spleen of Tumor-bearing and Control
Mice 30
4.17 Adoptive Transfer of Splenocytes / T Lymphocytes into Rag2 ~ Mice 30
5 Results 32
5.1 LoxP-Tag Transgenic Mice Spontaneously Developed Solid Tumors in Different
Organs 32
5.2 The Local Application of the P-Galactosidase-Expressing Adenovirus (Ad-P-Gal)
into the Colon Led to an Infrequent Gene Transfer Predominantly in the Superficial Layer
of the Colon Epithelium 35
5.3 The Local Application of the Cre-Expressing Adenovirus (Ad-Cre) into the Colon of
LoxP-Tag Transgenic Mice Did Not Induce Colon Carcinoma 37
5.4 Fabpl-Cre x LoxP-Tag Transgenic Mice Did Not Express SV40 Tag in the Epithelial
Cells of Colon and Did Not Develop Colon Carcinoma 37
5.5 Expression of SV40 Tag in Vil-Cre x LoxP-Tag and Vil-Cre-ERT2 x LoxP-Tag
Transgenic Mice 38
5.6 Vil-Cre x LoxP-Tag Transgenic Mice Developed Carcinoma of the Intestine/Colon 41
5.7 Vil-Cre x LoxP-Tag Transgenic Mice Were Tolerant for SV40 Tag 44
5.8 Vil-Cre-ERT2 x LoxP-Tag Transgenic Mice Developed Cre-Recombinase Mediated,
Sporadic Colon Carcinomas without Induction by Tamoxifen 46
5.9 Colon Carcinomas of the Vil-Cre-ERT2 x LoxP-Tag Transgenic Mice Are Invasive,
Frequently Metastasize and Show Both Epithelial and Neuroendocrine Markers 47
5.10 Vil-Cre-ERT2 x LoxP-Tag Transgenic Mice Were Not Tolerant For the SV40 Tag ...49
5.11 Tumor-bearing LoxP-Tag Transgenic Mice Had Diminished In Vivo Kill Against an
Unrelated Antigen 52
5.12 Tumor-Bearing LoxP-Tag Transgenic Mice Had Normal NK cell Reactivity against
Allogeneic Target 53
5.13 Tumor-bearing LoxP-Tag Transgenic Mice Had Diminished CTL Responsiveness
against the Allogeneic Targets 55
5.14 Regressor Tumor Cells Derived from Syngeneic C57BL/6 Mice Did Not Grow in
Tumor-Bearing LoxP-Tag Transgenic Mice 56
5.15 MHC Allogeneic Tumor Cells Did Not Grow in Tumor-Bearing LoxP-Tag Transgenic
Mice 58
5.16 MHC Allogeneic Tumor Did Grow in Tumor-Bearing LoxP-Tag Transgenic Mice
after T Lymphocytes Depletion 59
5.17 CD4 x LoxP-Tag Transgenic Mice Developed Spontaneous Tumors Comparable
to the Littermate CD4+/ x LoxP-Tag Transgenic Mice 61
5.18 CD4+ T lymphocytes Were Not Responsible for the Development of CTL Tolerance
in the LoxP-Tag Transgenic Mice 64
6 Discussion 68
7 Summary 80
8 Zusammenfassung 81
9 Literature 83
|
| adam_txt |
1 Directory
2 Introduction 4
2.1 Mouse Models 4
2.2 Simian Virus 40 (SV40) 4
2.3 SV40 Tag and Transgenic Mouse Models 6
2.4 "Turning on Tumors"/ The Inducible System 6
2.5 The Cre/loxP Recombination System 7
2.6 Immune Response against SV40 Tag Induced Tumors 8
2.7 Colon Carcinoma 10
2.8 Pathways to Colorectal Cancers 10
2.8.1 The "Gatekeepers" 11
2.8.2 The "Caretakers" 12
2.8.3 The "Landscapes" 13
2.9 The Gastrointestinal Stem Cell Niche 13
2.10 Mouse Models of Colon Carcinoma 13
2.11 SV40 Tag and Transgenic Mouse Models of Colon Carcinoma 14
2.12 New Trials Using Tissue-specific Cre-mediated Recombination in the Epithelium of
Gastrointestinal Tract 15
2.13 The Vil-Cre Transgenic Mouse Model 16
2.14 Vil-Cre-ERT2 Transgenic Mouse Model 17
2.15 Polyomaviruses and Colon Carcinoma 17
2.16 Unspecific CTL Unresponsiveness 18
2.17 The Contribution of CD4+ T Lymphocytes to Antitumor Immune Response and to
Tolerance during Tumor Development 19
2.18 The LoxP-Tag Transgenic Mice 20
3 The Aim of the Work 22
4 Materials and Methods 24
4.1 Mice 24
4.2 Genotyping of Mice 24
4.3 Investigation of Spontaneous Tumor Development in the LoxP-Tag and the CD4 x
LoxP-Tag Transgenic Mice 24
4.4 Histology and Immunohistochemistry 24
4.5 Adenoviral Gene Transfer into Colon Epithelial Cells in C57BL/6 and LoxP-Tag
Transgenic Mice 25
4.6 Investigation of Spontaneous Colon Carcinoma Development in the Fabpl x LoxP-
Tag, Vil-Cre x LoxP-Tag and Vil-Cre-ERT2 x LoxP-Tag Transgenic Mice 26
4.7 Immunofluorescence Staining for SV40 Tag and P-catenin 26
4.8 Detection of the Cre/LoxP Recombination in Tumor Tissue 26
4.9 Detection of anti-SV40 Tag Specific Antibody with ELISA 27
4.10 Isotyping of anti- SV40 Tag Specific Antibodies with ELISA 27
4.11 Preparation of Single Cell Suspension from Spleen 27
4.12 In Vivo Kill Assay against the Tumor-Specific Antigen SV40 Tag and against the
Unrelated Tumor-Specific Antigen, gp33 28
4.13 Allogeneic In Vivo Kill Assay 28
4.14 Tumor Transplantation Experiments 29
4.15 Depletion of CD3+ T Lymphocytes During Tumor Development 30
4.16 In Vitro Depletion of CD4+ T Lymphocyte from Spleen of Tumor-bearing and Control
Mice 30
4.17 Adoptive Transfer of Splenocytes / T Lymphocytes into Rag2'~ Mice 30
5 Results 32
5.1 LoxP-Tag Transgenic Mice Spontaneously Developed Solid Tumors in Different
Organs 32
5.2 The Local Application of the P-Galactosidase-Expressing Adenovirus (Ad-P-Gal)
into the Colon Led to an Infrequent Gene Transfer Predominantly in the Superficial Layer
of the Colon Epithelium 35
5.3 The Local Application of the Cre-Expressing Adenovirus (Ad-Cre) into the Colon of
LoxP-Tag Transgenic Mice Did Not Induce Colon Carcinoma 37
5.4 Fabpl-Cre x LoxP-Tag Transgenic Mice Did Not Express SV40 Tag in the Epithelial
Cells of Colon and Did Not Develop Colon Carcinoma 37
5.5 Expression of SV40 Tag in Vil-Cre x LoxP-Tag and Vil-Cre-ERT2 x LoxP-Tag
Transgenic Mice 38
5.6 Vil-Cre x LoxP-Tag Transgenic Mice Developed Carcinoma of the Intestine/Colon 41
5.7 Vil-Cre x LoxP-Tag Transgenic Mice Were Tolerant for SV40 Tag 44
5.8 Vil-Cre-ERT2 x LoxP-Tag Transgenic Mice Developed Cre-Recombinase Mediated,
Sporadic Colon Carcinomas without Induction by Tamoxifen 46
5.9 Colon Carcinomas of the Vil-Cre-ERT2 x LoxP-Tag Transgenic Mice Are Invasive,
Frequently Metastasize and Show Both Epithelial and Neuroendocrine Markers 47
5.10 Vil-Cre-ERT2 x LoxP-Tag Transgenic Mice Were Not Tolerant For the SV40 Tag .49
5.11 Tumor-bearing LoxP-Tag Transgenic Mice Had Diminished In Vivo Kill Against an
Unrelated Antigen 52
5.12 Tumor-Bearing LoxP-Tag Transgenic Mice Had Normal NK cell Reactivity against
Allogeneic Target 53
5.13 Tumor-bearing LoxP-Tag Transgenic Mice Had Diminished CTL Responsiveness
against the Allogeneic Targets 55
5.14 Regressor Tumor Cells Derived from Syngeneic C57BL/6 Mice Did Not Grow in
Tumor-Bearing LoxP-Tag Transgenic Mice 56
5.15 MHC Allogeneic Tumor Cells Did Not Grow in Tumor-Bearing LoxP-Tag Transgenic
Mice 58
5.16 MHC Allogeneic Tumor Did Grow in Tumor-Bearing LoxP-Tag Transgenic Mice
after T Lymphocytes Depletion 59
5.17 CD4"'" x LoxP-Tag Transgenic Mice Developed Spontaneous Tumors Comparable
to the Littermate CD4+/" x LoxP-Tag Transgenic Mice 61
5.18 CD4+ T lymphocytes Were Not Responsible for the Development of CTL Tolerance
in the LoxP-Tag Transgenic Mice 64
6 Discussion 68
7 Summary 80
8 Zusammenfassung 81
9 Literature 83 |
| any_adam_object | 1 |
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| author | Czéh, Melinda |
| author_facet | Czéh, Melinda |
| author_role | aut |
| author_sort | Czéh, Melinda |
| author_variant | m c mc |
| building | Verbundindex |
| bvnumber | BV035045094 |
| ctrlnum | (OCoLC)260074903 (DE-599)BVBBV035045094 |
| dewey-full | 616.994 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.994 |
| dewey-search | 616.994 |
| dewey-sort | 3616.994 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| discipline_str_mv | Medizin |
| format | Thesis Book |
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| index_date | 2024-07-02T21:54:28Z |
| indexdate | 2024-07-09T21:20:56Z |
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| language | English |
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| spelling | Czéh, Melinda Verfasser aut Analysis of the anti-tumor immune response against sporadic cancers in LoxP-Tag transgenic mice by Melinda Czéh 2008 93 Bl. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Berlin, Freie Univ., Diss., 2008 Tumor (DE-588)4078460-5 gnd rswk-swf Tumorimmunologie (DE-588)4128018-0 gnd rswk-swf Immunreaktion (DE-588)4133841-8 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Tumor (DE-588)4078460-5 s Immunreaktion (DE-588)4133841-8 s DE-604 Tumorimmunologie (DE-588)4128018-0 s DE-188 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016713870&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Czéh, Melinda Analysis of the anti-tumor immune response against sporadic cancers in LoxP-Tag transgenic mice Tumor (DE-588)4078460-5 gnd Tumorimmunologie (DE-588)4128018-0 gnd Immunreaktion (DE-588)4133841-8 gnd |
| subject_GND | (DE-588)4078460-5 (DE-588)4128018-0 (DE-588)4133841-8 (DE-588)4113937-9 |
| title | Analysis of the anti-tumor immune response against sporadic cancers in LoxP-Tag transgenic mice |
| title_auth | Analysis of the anti-tumor immune response against sporadic cancers in LoxP-Tag transgenic mice |
| title_exact_search | Analysis of the anti-tumor immune response against sporadic cancers in LoxP-Tag transgenic mice |
| title_exact_search_txtP | Analysis of the anti-tumor immune response against sporadic cancers in LoxP-Tag transgenic mice |
| title_full | Analysis of the anti-tumor immune response against sporadic cancers in LoxP-Tag transgenic mice by Melinda Czéh |
| title_fullStr | Analysis of the anti-tumor immune response against sporadic cancers in LoxP-Tag transgenic mice by Melinda Czéh |
| title_full_unstemmed | Analysis of the anti-tumor immune response against sporadic cancers in LoxP-Tag transgenic mice by Melinda Czéh |
| title_short | Analysis of the anti-tumor immune response against sporadic cancers in LoxP-Tag transgenic mice |
| title_sort | analysis of the anti tumor immune response against sporadic cancers in loxp tag transgenic mice |
| topic | Tumor (DE-588)4078460-5 gnd Tumorimmunologie (DE-588)4128018-0 gnd Immunreaktion (DE-588)4133841-8 gnd |
| topic_facet | Tumor Tumorimmunologie Immunreaktion Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016713870&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT czehmelinda analysisoftheantitumorimmuneresponseagainstsporadiccancersinloxptagtransgenicmice |