Genetics:
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Boston [u.a.]
Jones and Bartlett Publ.
2009
|
| Ausgabe: | 7. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXVIII, 763 S. Ill., graph. Darst. |
| ISBN: | 9780763758684 |
Internformat
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV035031653 | ||
| 003 | DE-604 | ||
| 005 | 20081127 | ||
| 007 | t | ||
| 008 | 080901s2009 ad|| |||| 00||| engod | ||
| 020 | |a 9780763758684 |9 978-0-7637-5868-4 | ||
| 035 | |a (OCoLC)634904166 | ||
| 035 | |a (DE-599)BVBBV035031653 | ||
| 040 | |a DE-604 |b ger |e rakddb | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-355 | ||
| 084 | |a WG 1000 |0 (DE-625)148483: |2 rvk | ||
| 100 | 1 | |a Hartl, Daniel L. |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Genetics |c Daniel L. Hartl and Elizabeth W. Jones |
| 250 | |a 7. ed. | ||
| 264 | 1 | |a Boston [u.a.] |b Jones and Bartlett Publ. |c 2009 | |
| 300 | |a XXVIII, 763 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 0 | 7 | |a Genetik |0 (DE-588)4071711-2 |2 gnd |9 rswk-swf |
| 655 | 7 | |8 1\p |0 (DE-588)4123623-3 |a Lehrbuch |2 gnd-content | |
| 689 | 0 | 0 | |a Genetik |0 (DE-588)4071711-2 |D s |
| 689 | 0 | |5 DE-604 | |
| 700 | 1 | |a Jones, Elizabeth W. |e Verfasser |4 aut | |
| 856 | 4 | 2 | |m Digitalisierung UB Regensburg |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016700629&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-016700629 | ||
| 883 | 1 | |8 1\p |a cgwrk |d 20201028 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | |
Datensatz im Suchindex
| _version_ | 1804137962387013632 |
|---|---|
| adam_text | Preface
xv
Acknowledgments
xxiii
About the Authors
xxvi
In
Memoriam
xxvii
About the Cover
xxviii
©sm®sn
Шшт
&mâ
m ö
1.1
DNA:
The Genetic
Material
2
Experimental Proof of the Genetic
Function of
DNA 3
Genetic Role of
DNA in
Bacteriophage
4
1.2 DNA
Structure and Replication
6
An Overview of
DNA
Replication
9
1.3
Genes and Proteins
10
Inborn Errors of Metabolism as a
Cause of Hereditary Disease
10
1.4
Genetic Analysis
14
Mutant Genes and Defective Proteins
15
Complementation Test for Mutations in
the Same Gene
17
Analysis of Complementation Data
20
Other Applications of Genetic Analysis
20
1.5
Gene Expression: The Central Dogma
21
Transcription
23
Translation
24
The Genetic Code
25
1.6
Mutation
26
1.7
Genes and Environment
28
1.8
The Molecular Unity of Life
29
Prokaryotes and Eukaryotes
30
Evolutionary Relationships Among
Eukaryotes
31
Genomes and Proteomes
32
ШтшЅшшт
шшй
©шшѓШ
2.1
Genetic Differences Among
Individuals
39
DNA
Markers as Landmarks in
Chromosomes
39
2.2
The Molecular Structure of
DNA 40
Polynucleotide Chains
41
Base Pairing and Base Stacking
43
Antiparallel
Strands
45
DNA
Structure as Related to Function
46
2.3
The Separation and Identification of
Genomic
DNA
Fragments
47
Restriction Enzymes and Site-Specific
DNA
Cleavage
48
Gel Electrophoresis
50
Nucleic Acid Hybridization
52
The Southern Blot
54
2.4
Selective Replication of Genomic
DNA
Fragments
55
Constraints on
DNA
Replication: Primers
and
З -ю-З
Strand Elongation
56
The Polymerase Chain Reaction
57
2.5
The Terminology of Genetic Analysis
60
2.6
Types of
DNA
Markers Present in
Genomic
DNA 62
Single-Nucleotide Polymorphisms
(SNPs)
62
Restriction Fragment Length
Polymorphisms (RFLPs)
63
Tandem Repeat Polymorphisms
66
Copy-Number Polymorphisms (CNPs)
68
2.7
Applications of
DNA
Markers
68
Genetic Markers, Genetic Mapping, and
Disease Genes
68
Other Uses for
DNA
Markers
69
CONTENTS
vii
ШтшшЕштт
í§@glííí№si
Шт ¡Ришшшш ш
Ш®ш®Ш
sutom
3.1
Morphological
and Molecular
Phenotypes
78
3.2
Segregation of a Single Gene
80
Phenotypic Ratios in the F2 Generation
82
The Principle
oí
Segregation
83
Verification of Segregation
85
The Testcross and the Backcross
86
3.3
Segregation of Two or More Genes
87
The Principle of Independent Assortment
88
The Testcross with Unlinked Genes
88 .
Three or More Genes
89
3.4
Probability in Genetic Analysis
90
Elementary Outcomes and Events
92
Probability of the Union of Events
93
Probability of the Intersection of Events
93
Conditional Probability
94
Bayes
Theorem
96
3.5
Human Pedigree Analysis
97
Characteristics of Dominant and Recessive
Inheritance
97
Most Human Genetic Variation
is Not Bad
99
Molecular Markers in Human Pedigrees
100
3.6
Incomplete Dominance and Epistasis
101
Multiple
Alíeles
102
Human ABO Blood Groups
103
Epistasis
105
■ ii3
4.1
The Stability of Chromosome
Complements
115
4.2
Mitosis
116
4.3
Meiosis
119
The First Meiotic Division: Reduction
124
The Second Meiotic Division: Equation
128
4.4
Sex-Chromosome Inheritance
128
Chromosomal Determination of Sex
128
Х
-Linked Inheritance
129
Pedigree Characteristics of Human
Х
-linked Inheritance
133
Heterogametic Females
133
Nondisjunction as Proof of the
Chromosome Theory of Heredity
134
Sex Determination in
Drosophila
135
4.5
Probability in the Prediction of Progeny
Distributions
136
Using the Binomial Distribution in
Genetics
136
Meaning of the Binomial Coefficient
138
4.6
Testing Goodness of Fit to a Genetic
Hypothesis
139
The Chi-Square Method
139
Are Mendel s Data Too Good
to Be True?
143
Utafeag®
anod!
(Йшшшшсаш©
5.1
Linkage and Recombination of Genes in
a Chromosome
151
Coupling versus Repulsion of Syntenic
Alíeles
153
The Chi-Square Test for Linkage
153
Each Pair of linked Genes Has
a Characteristic Frequency of
Recombination
154
Recombination in Females versus Males
155
5.2
Genetic Mapping
155
Map Distance and Frequency of
Recombination
156
Crossing-over
159
Recombination Between Genes Results
from a Physical Exchange Between
Chromosomes
159
Crossing-over Takes Place at the
Pour-Strand Stage of Meiosis
161
Multiple Crossovers
164
5.3
Genetic Mapping In a Three-Point
Testcross
166
Chromosome Interference in Double
Crossovers
167
Genetic Mapping Functions
168
Genetic Map Distance and Physical
Distance
169
і
viii
CONTENTS
5.4
Genetic
Mapping in
Human
Pedigrees
170
Maximum
Likelihood and
Lod
Scores
170
5.5
Mapping by Tetrad Analysis
173
Analysis of Unordered Tetrads
173
Genetic Mapping with Unordered Tetrads
175
Analysis of Ordered Tetrads
177
5.6
Special Features of Recombination
180
Recombination Within Genes
180
Mitotic Recombination
181
ШЕшкіш
oil
ШШп Шцтсшйхж
smd]
ľMmmMmsíamiu
Ή
D©
Vd^
¡J U
6.1
Problems of Initiation, Elongation, and
Incorporation Error
191
6.2
Semiconservative Replication of
Double-Stranded
DNA 192
The Meselson-Stahl Experiment
192
Semiconservative Replication of
DNA in
Chromosomes
194
Theta Replication of Circular
DNA
Molecules
196
Rolling-Circle Replication
198
Multiple Origins and Bidirectional
Replication in Eukaryotes
198
6.3
Unwinding, Stabilization, and Stress
Relief
200
6.4
Initiation by
a Primosome
Complex
201
6.5
Chain Elongation and Proofreading
202
6.6
Discontinuous Replication of the
Lagging Strand
204
Fragments in the Replication Fork
204
The Joining of Precursor Fragments
205
6.7
Terminator Sequencing of
DNA 207
Sanger
Sequencing
208
Massively Parallel Sequencing
209
6.8
Molecular Mechanisms of
Recombination
210
Gene Conversion and Mismatch Repair
211
Double-Strand Break and Repair
Model
212
Шџшештж
©íl
ЋШ
7.1
Genome Size and Evolutionary
Complexity: The
С
-Value Paradox
222
7.2
The Supercoiling of
DNA 223
Topoisomerase Enzymes
224
7.3
The Structure of Bacterial
Chromosomes
226
7.4
The Structure of Eukaryotic
Chromosomes
226
The Nucleosome: The Structural
Unit of Chromatin
226
The Nucleosome Core Particle
226
Chromosome Territories in the Nucleus
229
Chromosome Condensation
230
7.5
Polytene Chromosomes
232
7.6
Repetitive Nucleotide Sequences in
Eukaryotic Genomes
232
Kinetics of
DNA Renaturation 233
Analysis of Genome Size and Repetitive
Sequences by Renaturation Kinetics
235
7.7
Unique and Repetitive Sequences in
Eukaryotic Genomes
237
Unique Sequences
238
Highly Repetitive Sequences
.238
Middle-Repetitive Sequences
239
7.8
Molecular Structure of the Centromere
239
7.9
Molecular Structure of the Teiomere
241
(S
8.1
Ишошѕзш
affici
Ттшшшшшѕѕ ШѕтшЕт
The Human iCaryotype
252
Standard Karyotfpes
252
The Centromere and Chromosome
Stability
255
Dosage Compensation of
Ж
-Lînked
Genes
256
The Calico Cat
259
Pseudoautosomal Inheritance
259
Active Genes in the Inactive X
Chromosome
260
Gene content and Evolution of the
Y
Chromosome
260
Tracing Human History Through the
Y
Chromosome
262
ССЖШТЅ
ix
8.2
Chromosome Abnormalities in Human
Pregnancies
264
Down Syndrome and Other Viable
Trisomie
266
Trisomie
Segregation
267
Sex-Chromosome Abnormalities
268
Environmental Effects on
Nondisjunction
269
8.3
Chromosomal Deletions and
Duplications
269
Deletions
270
Deletion Mapping
271
Duplications
273
Unequal Crossing-over in Red-Green
Color Blindness
273
8.4
Genetics of Chromosomal Inversions
275
Paracentric Inversion (Not Including the
Centromere)
275
Pericentric Inversion (Including the
Centromere)
277
8.5
Chromosomal
Translocations
277
Reciprocal
Translocations
278
Genetic Mapping of
a Translocation
Breakpoint
278
Robertsonian
Translocations
280
Translocations
and Trisomy
21 281
Translocation
Complexes in Oenothera
282
8.6
Genomic Position Effects on
Gene Expression
282
8.7
Poiyploidy in Plant Evolution
284
Sexual Versus Asexual Polyploidization
285
Autopolyploids and Allopolyploids
286
Monoploid Organisms
288
8.8
Genome Evolution in the Grass Family
(Gramineae)
289
ЇЗ
®шштт
cd?
ШтЕшш
mm
Штж
wdifüdscss
9.1 Mobile DNA 296
Plasmids 296
The
F
Plasmid:
A Conjugative
Plasmid 297
Insertion
Sequences and
Transposons
298
Mobilization of Nonconjugative Plasmids
299
Intégrons
and Antibiotic-Resistance
Cassettes
300
Pathogenicity Islands
301
Multiple-Antibiotic-Resistant Bacteria
302
9.2
Bacterial Genetics
302
Mutant Phenotypes
302
Mechanisms of Genetic Exchange
303
9.3
DNA-Mediated Transformation
303
9.4
Conjugation
305
Cointegrate Formation and Hfr Cells
305
Time-of-Entry Mapping
306
F Plasmids
311
9.5
Transduction
312
The Phage Lytic Cycle
312
Generalized Transduction
313
9.6
Bacteriophage Genetics
316
Plaque Formation and Phage Mutants
317
Genetic Recombination in the
Lytic Cycle
318
Genetic and Physical Maps of Phage T4
319
Fine Structure of the
rii Gene
in
Bacteriophage T4
321
9.7
Lysogeny and Specialized Transduction
325
Site-Specific Recombination and Lysogeny
326
Specialized Transduction
332
©mm
Шщр
é-iåi
Ü
10.1
Amino
Acids, Polypeptides, and
Proteins
342
10.2
Colinearity Between Coding Sequences
and Polypeptides
344
10.3
Transcription
344
Overview of
RNA
Synthesis
344
Types of
RNA Polymerase
346
Promoter Recognition
347
Mechanism of Transcription
348
Genetic Evidence for Promoters and
Terminators
350
10.4
Messenger
RNA
350
10.5
RNA
Processing in Eukaryotes
352
5
Capping and
3
Polyadenylation
352
Splicing of Intervening Sequences
352
Characteristics of Human Transcripts
353
Coupling of Transcription and
RNA
Processing
354
Mechanism of
RNA
Splicing
354
Effects of
Intron
Mutations
357
Exon Shuffle in the Origin of
New Genes
357
10.6
Translation
358
Nonsense-Mediated Decay
359
CONTENTS
Initiation
by mRNA Scanning
359
Elongation
361
Release
362
Protein Folding and Chaperones
364
10.7
Complex Translation Units
366
Polysomes
366
Polycistronic mRNA
366
10.8
The Standard Genetic Code
368
Genetic Evidence for a Triplet Code
368
How the Code Was Cracked
370
Features of the Standard Code
371
Transfer
RNA
and Aminoacyl-tRNA
Synthetase Enzymes
371
Redundancy and Wobble
372
Nonsense Suppression
373
MoDiKSEiiiaiJ íj1Í(í(Süíi®í!űosdí3üs
©if ©mm
11.1
Transcriptional Regulation in
Prokaryotes
381
Inducible and Repressible Systems of
Negative Regulation
381
Positive Regulation
382
11.2
The Operon System of Gene
Regulation
383
Lac Mutants
383
Inducible and Constitutive Synthesis
and Repression
384
The
Repressor
384
The Operator Region
385
The Promoter Region
385
The Operon System of Transcriptional
Regulation
386
Positive Regulation of the Lactose Operon
387
Regulation of the Tryptophan Operon
390
11.3
Regulation Through Transcription
Termination
392
Attenuation
392
Riboswitches
394
11.4
Regulation in Bacteriophage Lambda
396
11.5
Transcriptional Regulation in
Eukaryotes
398
Galactose
Metabolism in Yeast
398
Transcriptional Activator Proteins
401
Transcriptional Enhancers and
Transcriptional Silencers
401
Deletion Scanning
402
The Eukaryotic Transcription Complex
404
Chromatin-Remodeling Complexes
407
Alternative Promoters
407
11.6
Epigenetic Mechanims of Transcriptional
Regulation
409
Cytosine Methylation
411
Methylation and Transcriptional
Inactivation
411
Genomic Imprinting in the Female and
Male Germ Lines
412
11.7
Regulation Through
RNA
Processing
and Decay
413
Alternative Splicing
413
Messenger
RNA
Stability
414
11.8
RNA
Interference
414
11.9
Translationa! Control
417
Small Regulatory RNAs Controlling
Translation
417
11.10
Programmed
DNA
Rearrangements
419
Gene Amplification
419
Antibody and T-Cell Receptor Variability
419
Mating-Type
Interconversion
422
Transcriptional Control of Mating Type
423
CS@s8@aieiw
РїїтШштт,
шѕт
Wsmsęmmm
12.1
Site-Specif
ic DNA
Cleavage and
Cloning Vectors
432
Production of
DNA
Fragments with
Defined Ends
432
Recombinant
DNA
Molecules
434
Plasmad,
Lambda, and Cosmid Vectors
434
12.2
Cloning Strategies
436
Joining
DNA
Fragments
436
Insertion of a Particular
DNA
Molecule
Into a Vector
437
The Use of Reverse Transcriptase: cDNA
andRTPCR
439
12.3
Detection of
Recombinant
Molécules
440
Géne Ihactivatíon
in the Vector Molecule
440
Cloning of Large
DNA
Fragments
442
Screening for Particular
Recombinants
442
С0МТШТЅ
xli
12.4 Genormtes and
Proteomîcs
443
Genomic Sequencing
444
Genome Annotation
444
Comparative Genomics
445
Transcriptional Profiling
447
Two-Hybrid Analysis of Protein
Interactions
452
12.5
Transgenic Organisms
454
Germ-Line Transformation
m
Animals
455
Genetic Engineering in Plants
458
Transformation Rescue
459
Site-Directed Mutagenesis and Knockout
Mutations
460
12.6
Some Applications of Genetic
Engineering
46!
Giant Salmon with Engineered Growth
Hormone
461
Nutritionally Engineered Rice
462
Production of Useful Proteins
462
Genetic Engineering with Animal Viruses
463
ke
©шшпт
©íí
Lä)ciw@Dö
13.1
Genetic Determinants of
Development
472
13.2
Early Embryonic Development in
Animals
472
Autonomous Development and
Intercellular Signaling
473
Composition and Organization of Oocytes
475
Early Development and Activation of the
Zygotic Genome
476
13.3
Genetic Analysis of Development in the
Nematode
477
Analysis of Cell Lineages
478
Mutations Affecting Cell Lineages
478
Programmed Cell Death
478
Loss-of-Function and Gain-of-Punction
Alíeles
480
Epistasis in the Analysis of Developmental
Switches
483
13.4
Genetic Control of Development in
Drosophila
485
Maternal-Effect Genes and Zygotic Genes
488
Genetic Basis of Pattern Formation in
Early Development
489
Coordinate Genes
491
Gap Genes
493
Pair-Rule Genes
493
Segment-Polarity Genes
494
Interactions in the Regulatory Hierarchy
494
Metamorphosis of the Adult Fly
496
Homeotic Genes
498
HOX Genes in Evolution
498
13.5
Genetic Control of Development in
Higher Plants
500
Flower Development in Ambidopsis
500
Combinatorial Determination of
the Floral Organs
502
M®Q@(sffi]Qs]fr
Мшашошшш
®íľ
ШМштж шшй ШШЖ
íÈsmsiff
14.1
Types of Mutations
510
Germ-Line and Somatic Mutations
510
Conditional Mutations
510
Classification by Function
511
14.2
The Molecular Basis of Mutation
512
Nucleotide Substitutions
512
Missense Mutations: The Example of
Sickle-Cell Anemia
513
Insertions, Deletions, and Frameshift
Mutations
515
Dynamic Mutation of Trinucleotide
Repeats
516
Cytosine Methylation and Gene
Inactivation
518
14.3
Transposable Elements
520
Molecular Mechanisms of
Transposition
520
Transposable Elements as Agents of
Mutation
523
Transposable Elements in the Human
Genome
524
RIP: A Defense Against
Transposons
525
14.4
Spontaneous Mutation
525
The Nonadaptive Nature of Mutation
525
Estimation of Mutation Rates
527
Hot Spots of Mutation
527
14.5
Mutagens
529
Depurination
529
Oxidation
530
Base-Analog
Mutagens
531
Chemical Agents That Modify
DNA 531
Intercalating Agents
532
Ultraviolet Irradiation
532
Ionizing Radiation
533
¡xii
CONTENTS
Genetic
Effects of the Chernobyl Nuclear
Accident
536
14.6
Mechanisms of DMA Repair
537
Mismatch Repair
538
Base Excision Repair
540
AP Repair
541
Nucleotide Excision Repair
541
Photoreactivation
542
DNA
Damage Bypass
542
The SOS Repair System
543
14.7
Reverse Mutations and Suppressor
Mutations
543
Intragenic Suppression
543
Intergenic Suppression
544
The Ames Test for Mutagen/Carcinogen
Detection
545
ii Ş1
Шак&аш ШшмШт
off
Шт &М
íSwsfi© smê
(¿тшш
15.1
The Cell Cycle
552
Key Events in the Cell Cycle
552
Transcriptional Program of the Cell Cycle
553
15.2
Genetic Analysis of the Cell Cycle
554
Mutations Affecting Progression Through
the Cell Cycle
554
15.3
Progression Through the Cell Cycle
557
Cyclins and Cyclin-Dependent Protein
Kinases
557
.
Targets of the Cyclin-CDK Complexes
559
Triggers for the Gj/S and G2/M
Transitions
559
Protein Degradation Helps Regulate ihe
Cell Cycle
561
15.4
Checkpoints in the Cell Cycle
562
The
DNA
Damage Checkpoint
562
The Centrosome Duplication Checkpoint
567
The Spindle Assembly Checkpoint
567
The Spindle Position Checkpoint
568
15.5
Cancer Cells
569
Oncogenes and Proto-Oncogenes
570
Tumor-Suppressor Genes
573
15.6
Hereditary Cancer Syndromes
575
Defects in Cell-Cycle Regulation and
Checkpoints
575
Defects in
DNA
Repair
578
15.7
Genetics of the Acute
Leukémiás
578
ШЅШматтѕтѕп
©IM
smś
Шѕишшодеошо3
їт(шШш&в
ШИ
16.1
Patterns of Extranuclear Inheritance
588
Mitochondrial Genetic Diseases
588
Heteroplasmy
591
Maternal Inheritance and Maternal Effects
592
Tracing Population History Through
Mitochondrial
DNA 592
16.2 Organelle
Heredity
592
RNA
Editing
593
The Genetic Codes of Organelles
593
Leaf Variegation in Four-O Clock Plants
594
Drug Resistance in Chlamydomonas
595
Respiration-Defective Mitochondrial
Mutants
598
Cytoplasmic Male Sterility in Plants
598
16.3
The Evolutionary Origin of Organelles
600
16.4
Cytoplasmic Transmission of
Symbionts
601
16.5
Maternal Effect in Snail Shell Coiling
603
ШМШѕаш
ШтоОоойш
sradl WmmEsAm
ШшшТш %П
17.1
Molecular Evolution
612
Gene Trees
612
Bootstrapping
614
Gene Trees and Species Trees
615
Rates of Protein Evolution
615
Rates of
DNA
Evolution
616
Origins of New Genes: Orthologs and
Paralogs
617
17.2
Population Genetics
618
Altele
Frequencies and Genotype
Frequencies
619
Random Mating and the
Hardy-Weinberg Principle
620
Implications of the
Hardy-Weinberg Principle
622
A Test for Random Mating
622
ШМТШТЅ
xiii
Frequency of Heterozygous
Genotypes
623
Multiple
Alíeles
623
DNA
Typing
624
X-Linked Genes
627
17.3
inbreeding
627
The Inbreeding Coefficient
628
Allelic Identity by Descent
629
Calculation of the Inbreeding
Coefficient from Pedigrees
630
Effects of Inbreeding
632
17.4
Genetics and Evolution
632
17.5
Mutation and Migration
633
Irreversible Mutation
633
Reversible Mutation
634
17.6
Natura!
Selection
634
Selection in a Laboratory Experiment
635
Selection in Diploid Organisms
636
Components of Fitness
637
Selection-Mutation Balance
637
Hétérozygote
Superiority
638
17.7
Random Genetic Drift
639
17.8
Tracing Human History Through
Mitochondria!
DNA 643
Шш ©шттє
Шѕшш
dl
Шштѕашж
ii ű
18.1
Complex
Traits
652
Continuous, Categorical, and
Threshold Traits
652
The Normal Distribution
653
18.2
Causes of Variation
655
Genotypie
Variation
656
Environmental Variation
658
Genetics and Environment Combined
658
Genotype-by-Environment Interaction and
Association
660
18.3
Genetic Analysis of Complex Traits
660
The Number of Genes Affecting
Complex Traits
661
Broad-Sense Heritability
662
Twin Studies
663
18.4
Artificial Selection
663
Narrow-Sense Heritability
664
Phenotypic Change with Individual
Selection: A Prediction Equation
665
Long-Term
Artificial Selection
666
Inbreeding Depression and Heterosis
666
18.5
Correlation Between Relatives
667
Covariance and Correlation
667
The Geometrical Meaning of a
Corrélation
667
Estimation of Narrow-Sense
Heritability
668
18.6
Heritabilities of Threshold Traits
669
18.7
Identification of Genes Affecting
Complex Traits
670
Linkage Analysis in the Genetic Mapping
of Quantitative Trait Loci
670
The Number and Nature of QTLs
672
Candidate Genes for Complex Traits
674
Answers to Even-Numbered Problems
683
Further Reading
701
Word Roots
705
Concise Dictionary of Genetics and Genomics
Index
735
709
xiv
CONTENTS
|
| adam_txt |
Preface
xv
Acknowledgments
xxiii
About the Authors
xxvi
In
Memoriam
xxvii
About the Cover
xxviii
©sm®sn
Шшт
&mâ
m 'ö
1.1
DNA:
The Genetic
Material
2
Experimental Proof of the Genetic
Function of
DNA 3
Genetic Role of
DNA in
Bacteriophage
4
1.2 DNA
Structure and Replication
6
An Overview of
DNA
Replication
9
1.3
Genes and Proteins
10
Inborn Errors of Metabolism as a
Cause of Hereditary Disease
10
1.4
Genetic Analysis
14
Mutant Genes and Defective Proteins
15
Complementation Test for Mutations in
the Same Gene
17
Analysis of Complementation Data
20
Other Applications of Genetic Analysis
20
1.5
Gene Expression: The Central Dogma
21
Transcription
23
Translation
24
The Genetic Code
25
1.6
Mutation
26
1.7
Genes and Environment
28
1.8
The Molecular Unity of Life
29
Prokaryotes and Eukaryotes
30
Evolutionary Relationships Among
Eukaryotes
31
Genomes and Proteomes
32
ШтшЅшшт
шшй
©шшѓШ
2.1
Genetic Differences Among
Individuals
39
DNA
Markers as Landmarks in
Chromosomes
39
2.2
The Molecular Structure of
DNA 40
Polynucleotide Chains
41
Base Pairing and Base Stacking
43
Antiparallel
Strands
45
DNA
Structure as Related to Function
46
2.3
The Separation and Identification of
Genomic
DNA
Fragments
47
Restriction Enzymes and Site-Specific
DNA
Cleavage
48
Gel Electrophoresis
50
Nucleic Acid Hybridization
52
The Southern Blot
54
2.4
Selective Replication of Genomic
DNA
Fragments
55
Constraints on
DNA
Replication: Primers
and
З'-ю-З'
Strand Elongation
56
The Polymerase Chain Reaction
57
2.5
The Terminology of Genetic Analysis
60
2.6
Types of
DNA
Markers Present in
Genomic
DNA 62
Single-Nucleotide Polymorphisms
(SNPs)
62
Restriction Fragment Length
Polymorphisms (RFLPs)
63
Tandem Repeat Polymorphisms
66
Copy-Number Polymorphisms (CNPs)
68
2.7
Applications of
DNA
Markers
68
Genetic Markers, Genetic Mapping, and
"Disease Genes"
68
Other Uses for
DNA
Markers
69
CONTENTS
vii
ШтшшЕштт
í§@glííí№si
Шт ¡Ришшшш ш
Ш®ш®Ш
sutom
3.1
Morphological
and Molecular
Phenotypes
78
3.2
Segregation of a Single Gene
80
Phenotypic Ratios in the F2 Generation
82
The Principle
oí
Segregation
83
Verification of Segregation
85
The Testcross and the Backcross
86
3.3
Segregation of Two or More Genes
87
The Principle of Independent Assortment
88
The Testcross with Unlinked Genes
88 .
Three or More Genes
89
3.4
Probability in Genetic Analysis
90
Elementary Outcomes and Events
92
Probability of the Union of Events
93
Probability of the Intersection of Events
93
Conditional Probability
94
Bayes'
Theorem
96
3.5
Human Pedigree Analysis
97
Characteristics of Dominant and Recessive
Inheritance
97
Most Human Genetic Variation
is Not "Bad"
99
Molecular Markers in Human Pedigrees
100
3.6
Incomplete Dominance and Epistasis
101
Multiple
Alíeles
102
Human ABO Blood Groups
103
Epistasis
105
'■"ii3
4.1
The Stability of Chromosome
Complements
115
4.2
Mitosis
116
4.3
Meiosis
119
The First Meiotic Division: Reduction
124
The Second Meiotic Division: Equation
128
4.4
Sex-Chromosome Inheritance
128
Chromosomal Determination of Sex
128
Х
-Linked Inheritance
129
Pedigree Characteristics of Human
Х
-linked Inheritance
133
Heterogametic Females
133
Nondisjunction as Proof of the
Chromosome Theory of Heredity
134
Sex Determination in
Drosophila
135
4.5
Probability in the Prediction of Progeny
Distributions
136
Using the Binomial Distribution in
Genetics
136
Meaning of the Binomial Coefficient
138
4.6
Testing Goodness of Fit to a Genetic
Hypothesis
139
The Chi-Square Method
139
Are Mendel's Data Too Good
to Be True?
143
Utafeag®
anod!
(Йшшшшсаш©
5.1
Linkage and Recombination of Genes in
a Chromosome
151
Coupling versus Repulsion of Syntenic
Alíeles
153
The Chi-Square Test for Linkage
153
Each Pair of linked Genes Has
a Characteristic Frequency of
Recombination
154
Recombination in Females versus Males
155
5.2
Genetic Mapping
155
Map Distance and Frequency of
Recombination
156
Crossing-over
159
Recombination Between Genes Results
from a Physical Exchange Between
Chromosomes
159
Crossing-over Takes Place at the
Pour-Strand Stage of Meiosis
161
Multiple Crossovers
164
5.3
Genetic Mapping In a Three-Point
Testcross
166
Chromosome Interference in Double
Crossovers
167
Genetic Mapping Functions
168
Genetic Map Distance and Physical
Distance
169
і
viii
CONTENTS
5.4
Genetic
Mapping in
Human
Pedigrees
170
Maximum
Likelihood and
Lod
Scores
170
5.5
Mapping by Tetrad Analysis
173
Analysis of Unordered Tetrads
173
Genetic Mapping with Unordered Tetrads
175
Analysis of Ordered Tetrads
177
5.6
Special Features of Recombination
180
Recombination Within Genes
180
Mitotic Recombination
181
ШЕшкіш
oil
ШШп Шцтсшйхж
smd]
ľMmmMmsíamiu
Ή
D©
Vd^
¡J U
6.1
Problems of Initiation, Elongation, and
Incorporation Error
191
6.2
Semiconservative Replication of
Double-Stranded
DNA 192
The Meselson-Stahl Experiment
192
Semiconservative Replication of
DNA in
Chromosomes
194
Theta Replication of Circular
DNA
Molecules
196
Rolling-Circle Replication
198
Multiple Origins and Bidirectional
Replication in Eukaryotes
198
6.3
Unwinding, Stabilization, and Stress
Relief
200
6.4
Initiation by
a Primosome
Complex
201
6.5
Chain Elongation and Proofreading
202
6.6
Discontinuous Replication of the
Lagging Strand
204
Fragments in the Replication Fork
204
The Joining of Precursor Fragments
205
6.7
Terminator Sequencing of
DNA 207
Sanger
Sequencing
208
Massively Parallel Sequencing
209
6.8
Molecular Mechanisms of
Recombination
210
Gene Conversion and Mismatch Repair
211
Double-Strand Break and Repair
Model
212
Шџшештж
©íl
ЋШ
7.1
Genome Size and Evolutionary
Complexity: The
С
-Value Paradox
222
7.2
The Supercoiling of
DNA 223
Topoisomerase Enzymes
224
7.3
The Structure of Bacterial
Chromosomes
226
7.4
The Structure of Eukaryotic
Chromosomes
226
The Nucleosome: The Structural
Unit of Chromatin
226
The Nucleosome Core Particle
226
Chromosome Territories in the Nucleus
229
Chromosome Condensation
230
7.5
Polytene Chromosomes
232
7.6
Repetitive Nucleotide Sequences in
Eukaryotic Genomes
232
Kinetics of
DNA Renaturation 233
Analysis of Genome Size and Repetitive
Sequences by Renaturation Kinetics
235
7.7
Unique and Repetitive Sequences in
Eukaryotic Genomes
237
Unique Sequences
238
Highly Repetitive Sequences
.238
Middle-Repetitive Sequences
239
7.8
Molecular Structure of the Centromere
239
7.9
Molecular Structure of the Teiomere
241
(S
8.1
Ишошѕзш
affici
Ттшшшшшѕѕ ШѕтшЕт
The Human iCaryotype
252
Standard Karyotfpes
252
The Centromere and Chromosome
Stability
255
Dosage Compensation of
Ж
-Lînked
Genes
256
The Calico Cat
259
Pseudoautosomal Inheritance
259
Active Genes in the "Inactive" X
Chromosome
260
Gene content and Evolution of the
Y
Chromosome
260
Tracing Human History Through the
Y
Chromosome
262
ССЖШТЅ
ix
8.2
Chromosome Abnormalities in Human
Pregnancies
264
Down Syndrome and Other Viable
Trisomie
266
Trisomie
Segregation
267
Sex-Chromosome Abnormalities
268
Environmental Effects on
Nondisjunction
269
8.3
Chromosomal Deletions and
Duplications
269
Deletions
270
Deletion Mapping
271
Duplications
273
Unequal Crossing-over in Red-Green
Color Blindness
273
8.4
Genetics of Chromosomal Inversions
275
Paracentric Inversion (Not Including the
Centromere)
275
Pericentric Inversion (Including the
Centromere)
277
8.5
Chromosomal
Translocations
277
Reciprocal
Translocations
278
Genetic Mapping of
a Translocation
Breakpoint
278
Robertsonian
Translocations
280
Translocations
and Trisomy
21 281
Translocation
Complexes in Oenothera
282
8.6
Genomic Position Effects on
Gene Expression
282
8.7
Poiyploidy in Plant Evolution
284
Sexual Versus Asexual Polyploidization
285
Autopolyploids and Allopolyploids
286
Monoploid Organisms
288
8.8
Genome Evolution in the Grass Family
(Gramineae)
289
ЇЗ
®шштт
cd?
ШтЕшш
mm
Штж
wdifüdscss
9.1 Mobile DNA 296
Plasmids 296
The
F
Plasmid:
A Conjugative
Plasmid 297
Insertion
Sequences and
Transposons
298
Mobilization of Nonconjugative Plasmids
299
Intégrons
and Antibiotic-Resistance
Cassettes
300
Pathogenicity Islands
301
Multiple-Antibiotic-Resistant Bacteria
302
9.2
Bacterial Genetics
302
Mutant Phenotypes
302
Mechanisms of Genetic Exchange
303
9.3
DNA-Mediated Transformation
303
9.4
Conjugation
305
Cointegrate Formation and Hfr Cells
305
Time-of-Entry Mapping
306
F'Plasmids
311
9.5
Transduction
312
The Phage Lytic Cycle
312
Generalized Transduction
313
9.6
Bacteriophage Genetics
316
Plaque Formation and Phage Mutants
317
Genetic Recombination in the
Lytic Cycle
318
Genetic and Physical Maps of Phage T4
319
Fine Structure of the
rii Gene
in
Bacteriophage T4
321
9.7
Lysogeny and Specialized Transduction
325
Site-Specific Recombination and Lysogeny
326
Specialized Transduction
332
©mm
Шщр
é-iåi
Ü
10.1
Amino
Acids, Polypeptides, and
Proteins
342
10.2
Colinearity Between Coding Sequences
and Polypeptides
344
10.3
Transcription
344
Overview of
RNA
Synthesis
344
Types of
RNA Polymerase
346
Promoter Recognition
347
Mechanism of Transcription
348
Genetic Evidence for Promoters and
Terminators
350
10.4
Messenger
RNA
350
10.5
RNA
Processing in Eukaryotes
352
5'
Capping and
3'
Polyadenylation
352
Splicing of Intervening Sequences
352
Characteristics of Human Transcripts
353
Coupling of Transcription and
RNA
Processing
354
Mechanism of
RNA
Splicing
354
Effects of
Intron
Mutations
357
Exon Shuffle in the Origin of
New Genes
357
10.6
Translation
358
Nonsense-Mediated Decay
359
CONTENTS
Initiation
by mRNA Scanning
359
Elongation
361
Release
362
Protein Folding and Chaperones
364
10.7
Complex Translation Units
366
Polysomes
366
Polycistronic mRNA
366
10.8
The Standard Genetic Code
368
Genetic Evidence for a Triplet Code
368
How the Code Was Cracked
370
Features of the Standard Code
371
Transfer
RNA
and Aminoacyl-tRNA
Synthetase Enzymes
371
Redundancy and Wobble
372
Nonsense Suppression
373
MoDiKSEiiiaiJ íj1Í(í(Süíi®í!űosdí3üs
©if ©mm
11.1
Transcriptional Regulation in
Prokaryotes
381
Inducible and Repressible Systems of
Negative Regulation
381
Positive Regulation
382
11.2
The Operon System of Gene
Regulation
383
Lac" Mutants
383
Inducible and Constitutive Synthesis
and Repression
384
The
Repressor
384
The Operator Region
385
The Promoter Region
385
The Operon System of Transcriptional
Regulation
386
Positive Regulation of the Lactose Operon
387
Regulation of the Tryptophan Operon
390
11.3
Regulation Through Transcription
Termination
392
Attenuation
392
Riboswitches
394
11.4
Regulation in Bacteriophage Lambda
396
11.5
Transcriptional Regulation in
Eukaryotes
398
Galactose
Metabolism in Yeast
398
Transcriptional Activator Proteins
401
Transcriptional Enhancers and
Transcriptional Silencers
401
Deletion Scanning
402
The Eukaryotic Transcription Complex
404
Chromatin-Remodeling Complexes
407
Alternative Promoters
407
11.6
Epigenetic Mechanims of Transcriptional
Regulation
409
Cytosine Methylation
411
Methylation and Transcriptional
Inactivation
411
Genomic Imprinting in the Female and
Male Germ Lines
412
11.7
Regulation Through
RNA
Processing
and Decay
413
Alternative Splicing
413
Messenger
RNA
Stability
414
11.8
RNA
Interference
414
11.9
Translationa! Control
417
Small Regulatory RNAs Controlling
Translation
417
11.10
Programmed
DNA
Rearrangements
419
Gene Amplification
419
Antibody and T-Cell Receptor Variability
419
Mating-Type
Interconversion
422
Transcriptional Control of Mating Type
423
CS@s8@aieiw
РїїтШштт,
шѕт
Wsmsęmmm
12.1
Site-Specif
ic DNA
Cleavage and
Cloning Vectors
432
Production of
DNA
Fragments with
Defined Ends
432
Recombinant
DNA
Molecules
434
Plasmad,
Lambda, and Cosmid Vectors
434
12.2
Cloning Strategies
436
Joining
DNA
Fragments
436
Insertion of a Particular
DNA
Molecule
Into a Vector
437
The Use of Reverse Transcriptase: cDNA
andRTPCR
439
12.3
Detection of
Recombinant
Molécules
440
Géne Ihactivatíon
in the Vector Molecule
440
Cloning of Large
DNA
Fragments
442
Screening for Particular
Recombinants
442
С0МТШТЅ
xli
12.4 Genormtes and
Proteomîcs
443
Genomic Sequencing
444
Genome Annotation
444
Comparative Genomics
445
Transcriptional Profiling
447
Two-Hybrid Analysis of Protein
Interactions
452
12.5
Transgenic Organisms
454
Germ-Line Transformation
m
Animals
455
Genetic Engineering in Plants
458
Transformation Rescue
459
Site-Directed Mutagenesis and Knockout
Mutations
460
12.6
Some Applications of Genetic
Engineering
46!
Giant Salmon with Engineered Growth
Hormone
461
Nutritionally Engineered Rice
462
Production of Useful Proteins
462
Genetic Engineering with Animal Viruses
463
ke
©шшпт
©íí
Lä)ciw@Dö
13.1
Genetic Determinants of
Development
472
13.2
Early Embryonic Development in
Animals
472
Autonomous Development and
Intercellular Signaling
473
Composition and Organization of Oocytes
475
Early Development and Activation of the
Zygotic Genome
476
13.3
Genetic Analysis of Development in the
Nematode
477
Analysis of Cell Lineages
478
Mutations Affecting Cell Lineages
478
Programmed Cell Death
478
Loss-of-Function and Gain-of-Punction
Alíeles
480
Epistasis in the Analysis of Developmental
Switches
483
13.4
Genetic Control of Development in
Drosophila
485
Maternal-Effect Genes and Zygotic Genes
488
Genetic Basis of Pattern Formation in
Early Development
489
Coordinate Genes
491
Gap Genes
493
Pair-Rule Genes
493
Segment-Polarity Genes
494
Interactions in the Regulatory Hierarchy
494
Metamorphosis of the Adult Fly
496
Homeotic Genes
498
HOX Genes in Evolution
498
13.5
Genetic Control of Development in
Higher Plants
500
Flower Development in Ambidopsis
500
Combinatorial Determination of
the Floral Organs
502
M®Q@(sffi]Qs]fr
Мшашошшш
®íľ
ШМштж шшй ШШЖ
íÈsmsiff
14.1
Types of Mutations
510
Germ-Line and Somatic Mutations
510
Conditional Mutations
510
Classification by Function
511
14.2
The Molecular Basis of Mutation
512
Nucleotide Substitutions
512
Missense Mutations: The Example of
Sickle-Cell Anemia
513
Insertions, Deletions, and Frameshift
Mutations
515
Dynamic Mutation of Trinucleotide
Repeats
516
Cytosine Methylation and Gene
Inactivation
518
14.3
Transposable Elements
520
Molecular Mechanisms of
Transposition
520
Transposable Elements as Agents of
Mutation
523
Transposable Elements in the Human
Genome
524
RIP: A Defense Against
Transposons
525
14.4
Spontaneous Mutation
525
The Nonadaptive Nature of Mutation
525
Estimation of Mutation Rates
527
Hot Spots of Mutation
527
14.5
Mutagens
529
Depurination
529
Oxidation
530
Base-Analog
Mutagens
531
Chemical Agents That Modify
DNA 531
Intercalating Agents
532
Ultraviolet Irradiation
532
Ionizing Radiation
533
¡xii
CONTENTS
Genetic
Effects of the Chernobyl Nuclear
Accident
536
14.6
Mechanisms of DMA Repair
537
Mismatch Repair
538
Base Excision Repair
540
AP Repair
541
Nucleotide Excision Repair
541
Photoreactivation
542
DNA
Damage Bypass
542
The SOS Repair System
543
14.7
Reverse Mutations and Suppressor
Mutations
543
Intragenic Suppression
543
Intergenic Suppression
544
The Ames Test for Mutagen/Carcinogen
Detection
545
ii Ş1
Шак&аш ШшмШт
off
Шт &М
íSwsfi© smê
(¿тшш
15.1
The Cell Cycle
552
Key Events in the Cell Cycle
552
Transcriptional Program of the Cell Cycle
553
15.2
Genetic Analysis of the Cell Cycle
554
Mutations Affecting Progression Through
the Cell Cycle
554
15.3
Progression Through the Cell Cycle
557
Cyclins and Cyclin-Dependent Protein
Kinases
557
.
Targets of the Cyclin-CDK Complexes
559
Triggers for the Gj/S and G2/M
Transitions
559
Protein Degradation Helps Regulate ihe
Cell Cycle
561
15.4
Checkpoints in the Cell Cycle
562
The
DNA
Damage Checkpoint
562
The Centrosome Duplication Checkpoint
567
The Spindle Assembly Checkpoint
567
The Spindle Position Checkpoint
568
15.5
Cancer Cells
569
Oncogenes and Proto-Oncogenes
570
Tumor-Suppressor Genes
573
15.6
Hereditary Cancer Syndromes
575
Defects in Cell-Cycle Regulation and
Checkpoints
575
Defects in
DNA
Repair
578
15.7
Genetics of the Acute
Leukémiás
578
ШЅШматтѕтѕп
©IM
smś
Шѕишшодеошо3
\їт(шШш&в
ШИ
16.1
Patterns of Extranuclear Inheritance
588
Mitochondrial Genetic Diseases
588
Heteroplasmy
591
Maternal Inheritance and Maternal Effects
592
Tracing Population History Through
Mitochondrial
DNA 592
16.2 Organelle
Heredity
592
RNA
Editing
593
The Genetic Codes of Organelles
593
Leaf Variegation in Four-O'Clock Plants
594
Drug Resistance in Chlamydomonas
595
Respiration-Defective Mitochondrial
Mutants
598
Cytoplasmic Male Sterility in Plants
598
16.3
The Evolutionary Origin of Organelles
600
16.4
Cytoplasmic Transmission of
Symbionts
601
16.5
Maternal Effect in Snail Shell Coiling
603
ШМШѕаш
ШтоОоойш
sradl WmmEsAm
ШшшТш %П
17.1
Molecular Evolution
612
Gene Trees
612
Bootstrapping
614
Gene Trees and Species Trees
615
Rates of Protein Evolution
615
Rates of
DNA
Evolution
616
Origins of New Genes: Orthologs and
Paralogs
617
17.2
Population Genetics
618
Altele
Frequencies and Genotype
Frequencies
619
Random Mating and the
Hardy-Weinberg Principle
620
Implications of the
Hardy-Weinberg Principle
622
A Test for Random Mating
622
ШМТШТЅ
xiii
Frequency of Heterozygous
Genotypes
623
Multiple
Alíeles
623
DNA
Typing
624
X-Linked Genes
627
17.3
inbreeding
627
The Inbreeding Coefficient
628
Allelic Identity by Descent
629
Calculation of the Inbreeding
Coefficient from Pedigrees
630
Effects of Inbreeding
632
17.4
Genetics and Evolution
632
17.5
Mutation and Migration
633
Irreversible Mutation
633
Reversible Mutation
634
17.6
Natura!
Selection
634
Selection in a Laboratory Experiment
635
Selection in Diploid Organisms
636
Components of Fitness
637
Selection-Mutation Balance
637
Hétérozygote
Superiority
638
17.7
Random Genetic Drift
639
17.8
Tracing Human History Through
Mitochondria!
DNA 643
Шш ©шттє
Шѕшш
dl
Шштѕашж
ii'ű
18.1
Complex
Traits
652
Continuous, Categorical, and
Threshold Traits
652
The Normal Distribution
653
18.2
Causes of Variation
655
Genotypie
Variation
656
Environmental Variation
658
Genetics and Environment Combined
658
Genotype-by-Environment Interaction and
Association
660
18.3
Genetic Analysis of Complex Traits
660
The Number of Genes Affecting
Complex Traits
661
Broad-Sense Heritability
662
Twin Studies
663
18.4
Artificial Selection
663
Narrow-Sense Heritability
664
Phenotypic Change with Individual
Selection: A Prediction Equation
665
Long-Term
Artificial Selection
666
Inbreeding Depression and Heterosis
666
18.5
Correlation Between Relatives
667
Covariance and Correlation
667
The Geometrical Meaning of a
Corrélation
667
Estimation of Narrow-Sense
Heritability
668
18.6
Heritabilities of Threshold Traits
669
18.7
Identification of Genes Affecting
Complex Traits
670
Linkage Analysis in the Genetic Mapping
of Quantitative Trait Loci
670
The Number and Nature of QTLs
672
Candidate Genes for Complex Traits
674
Answers to Even-Numbered Problems
683
Further Reading
701
Word Roots
705
Concise Dictionary of Genetics and Genomics
Index
735
709
xiv
CONTENTS |
| any_adam_object | 1 |
| any_adam_object_boolean | 1 |
| author | Hartl, Daniel L. Jones, Elizabeth W. |
| author_facet | Hartl, Daniel L. Jones, Elizabeth W. |
| author_role | aut aut |
| author_sort | Hartl, Daniel L. |
| author_variant | d l h dl dlh e w j ew ewj |
| building | Verbundindex |
| bvnumber | BV035031653 |
| classification_rvk | WG 1000 |
| ctrlnum | (OCoLC)634904166 (DE-599)BVBBV035031653 |
| discipline | Biologie |
| discipline_str_mv | Biologie |
| edition | 7. ed. |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01389nam a2200361 c 4500</leader><controlfield tag="001">BV035031653</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20081127 </controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">080901s2009 ad|| |||| 00||| engod</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9780763758684</subfield><subfield code="9">978-0-7637-5868-4</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)634904166</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV035031653</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakddb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-355</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">WG 1000</subfield><subfield code="0">(DE-625)148483:</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Hartl, Daniel L.</subfield><subfield code="e">Verfasser</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Genetics</subfield><subfield code="c">Daniel L. Hartl and Elizabeth W. Jones</subfield></datafield><datafield tag="250" ind1=" " ind2=" "><subfield code="a">7. ed.</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Boston [u.a.]</subfield><subfield code="b">Jones and Bartlett Publ.</subfield><subfield code="c">2009</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">XXVIII, 763 S.</subfield><subfield code="b">Ill., graph. Darst.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Genetik</subfield><subfield code="0">(DE-588)4071711-2</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="655" ind1=" " ind2="7"><subfield code="8">1\p</subfield><subfield code="0">(DE-588)4123623-3</subfield><subfield code="a">Lehrbuch</subfield><subfield code="2">gnd-content</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Genetik</subfield><subfield code="0">(DE-588)4071711-2</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Jones, Elizabeth W.</subfield><subfield code="e">Verfasser</subfield><subfield code="4">aut</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">Digitalisierung UB Regensburg</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016700629&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-016700629</subfield></datafield><datafield tag="883" ind1="1" ind2=" "><subfield code="8">1\p</subfield><subfield code="a">cgwrk</subfield><subfield code="d">20201028</subfield><subfield code="q">DE-101</subfield><subfield code="u">https://d-nb.info/provenance/plan#cgwrk</subfield></datafield></record></collection> |
| genre | 1\p (DE-588)4123623-3 Lehrbuch gnd-content |
| genre_facet | Lehrbuch |
| id | DE-604.BV035031653 |
| illustrated | Illustrated |
| index_date | 2024-07-02T21:50:02Z |
| indexdate | 2024-07-09T21:20:37Z |
| institution | BVB |
| isbn | 9780763758684 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-016700629 |
| oclc_num | 634904166 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR |
| owner_facet | DE-355 DE-BY-UBR |
| physical | XXVIII, 763 S. Ill., graph. Darst. |
| publishDate | 2009 |
| publishDateSearch | 2009 |
| publishDateSort | 2009 |
| publisher | Jones and Bartlett Publ. |
| record_format | marc |
| spelling | Hartl, Daniel L. Verfasser aut Genetics Daniel L. Hartl and Elizabeth W. Jones 7. ed. Boston [u.a.] Jones and Bartlett Publ. 2009 XXVIII, 763 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Genetik (DE-588)4071711-2 gnd rswk-swf 1\p (DE-588)4123623-3 Lehrbuch gnd-content Genetik (DE-588)4071711-2 s DE-604 Jones, Elizabeth W. Verfasser aut Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016700629&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Hartl, Daniel L. Jones, Elizabeth W. Genetics Genetik (DE-588)4071711-2 gnd |
| subject_GND | (DE-588)4071711-2 (DE-588)4123623-3 |
| title | Genetics |
| title_auth | Genetics |
| title_exact_search | Genetics |
| title_exact_search_txtP | Genetics |
| title_full | Genetics Daniel L. Hartl and Elizabeth W. Jones |
| title_fullStr | Genetics Daniel L. Hartl and Elizabeth W. Jones |
| title_full_unstemmed | Genetics Daniel L. Hartl and Elizabeth W. Jones |
| title_short | Genetics |
| title_sort | genetics |
| topic | Genetik (DE-588)4071711-2 gnd |
| topic_facet | Genetik Lehrbuch |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016700629&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT hartldaniell genetics AT joneselizabethw genetics |