Verfügbarkeit: The laboratory rat

The laboratory rat: 1 Biology and diseases

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Bibliographische Detailangaben
Format:	Buch
Sprache:	English
Veröffentlicht:	New York Acad. Pr. 1979
Schriftenreihe:	American College of Laboratory Animal Medicine series
Schlagworte:	Laboratory animals Rats
Online-Zugang:	Inhaltsverzeichnis
Beschreibung:	XIII, 435 S. Ill.
ISBN:	0120749017

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Datensatz im Suchindex

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adam_text	Titel: Bd. 1. The laboratory rat. Biology and diseases Autor: Jahr: 1979 The Laboratory Rat Volume I Biology and Diseases EDITED BY Henry J. Baker Department of Comparative Medicine Schools of Medicine and Dentistry University of Alabama in Birmingham Birmingham, Alabama /. Russell Lindsey Department of Comparative Medicine Schools of Medicine and Dentistry University of Alabama in Birmingham and the Veterans Administration Hospital Birmingham, Alabama Steven H. Weisbroth AnMed Laboratories, Inc. New Hyde Park, New York ACADEMIC PRESS 1979 A SUBSIDIARY OF HARCOURT BRACE JOVANOVICH, PUBLISHERS New York London Toronto Sydney San Francisco Contents List of Contributors ix Chapter 4 Morphophysiology W. Sheldon Bivin, M. Pat Crawford, and Preface xi N. R. Brewer I. Introduction 74 Contents Of Volume II XÜi D- General Appearance 74 Hl. The Digestive System 77 IV. Respiratory System 83 Chapter 1 Historical Foundations V. Cardiovascular System 86 J. Russell Lindsey VI. Urinary and Reproductive Systems 88 I. Origin of the Laboratory Rat 2 Vn. Endocrine System 93 II. The Wistar Institute 3 VIII. Nervous System 95 III. Nutrition and Biochemistry 11 IX. Special Sense Organs 98 IV. Endocrinology and Reproductive Physiology 16 References 100 V. Cancer Research Institutes 19 VI. Behavioral Research 23 Vn. Genetics 25 Other Stocks of Rats 29 Daniel H. Ringler and Lyubica Dabich Chapter 5 Hematology and Clinical Biochemistry VIII IX. Genealogy of Major Rat Stocks and Strains 30 I. Introduction 105 X. Some Key Events after World War II 31 n Sources of Variation 105 XI. Information Requested 32 m Microtechniques 107 References 33 Iv- Quantities and Units 107 V. Hematology 108 _, _ _ , y-, VI. Clinical Biochemistry 113 Chapter 2 Taxonomy and Genetics References 118 Roy Robinson I. Introduction 37 H. Taxonomy and Geographical Distribution 38 Chapter 6 Nutrition DI. Adaptation to the Laboratory 38 Adrianne E. Rogers IV. Genetics 39 I. Introduction 123 V. Chromosome Mapping 47 O. Dietary Considerations in Experimental Studies 124 VI. Cytogenetics 47 HI. Nutrient Requirements 128 VH. Inbred Strains 50 References 146 Reference£ 50 Chapter 7 Reproduction and Breeding Chapter 3 Inbred Strains Dennis E j Baker Michael F. W. Festing I. introduction 154 I. Introduction 55 II. Biotic Aspects 154 n. Nomenclature Rules 56 in. Nutrition 158 References 69 IV. Spatial Aspects 160 »• TABLE OF CONTENTS V. Climatic Aspects 160 Chapter 13 Neoplastic Diseases VI. Temporal Aspects 162 Norman H. Altman and DawnG. Goodman VH. Management 163 _ Introduction 334 References 166 H. Integumentary System 336 m. Musculoskeletal System 340 Chapter 8 Housing to Control Research Variables IV- Respiratory System 341 Henry J. Baker, J. Russell Lindsey, and 1 Cardiovascular System 342 ,. , . . VI. Digestive System 343 Steven H. Weisbroth vn Endocrine System 347 I. Introduction 169 ym Hematopoietic System 352 H. Physical Factors Affecting Biological Response 170 K ijrinary System 355 m. Chemical Factors Affecting Biologie Response 180 x^ Female Reproductive System 358 IV. Microbial Factors Affecting Biologie Response 183 XI Mammary Gland 361 V. Ethical and Legal Considerations 186 xn Male Reproductive System 362 Xm. Nervous System 365 References 371 References 186 Chapter 9 Bacterial and Mycotic Diseases Steven H. Weisbroth Chapter 14 Lesions Associated with Aging I. Introduction 193 II. Bacterial Diseases 194 HI. Mycotic Diseases 228 References 230 Miriam R. Anver and Bennett J. Cohen I. Introduction 378 H. Major Age-Associated Lesions 378 HI. Influence of Diet on Longevity and Age-Associated Lesions 384 Chapter 10 Mycoplasma! and Rickettsia! Diseases IV. other Age-Associated Lesions 387 Gail H. Cassell, J. Russell Lindsey, References 396 Henry J. Baker, and Jerry K. Davis Chapter 15 Health Hazards for Man I. Introduction 243 II. Mycoplasmal Diseases 243 UI. Rickettsial Diseases 259 References 265 Estelle Hecht Geller I. Introduction 402 H. Allergy 402 HI. Bites 402 Chapter 11 Viral Diseases IV. Bacterial Diseases 402 Robert O. Jacoby, Pravin N. Bhatt, and V. Rickettsial Diseases 405 Albert M. Jonas VI. Viral Diseases 405 I. Introduction 272 VH. Protozoan Diseases 406 D. DNA Viruses 273 VBI. Helminth Infections 406 HI. RNA Viruses 284 K- Arthropod Infestations 407 IV. Unclassified Viruses or Viruslike Agents 297 x- Mycoses 407 V. Experimental Viral Infections 298 XI. Conclusion 407 VI. CollectionofSamples for Serological Tests and Virus References 407 Isolation 299 Vn. General Comments on the Detection, Diagnosis, and Control of Viral Infections 300 Appendix 1 Selected Normative Data 411 References 302 Henry J. Baker, J. Russell Lindsey, and Steven H. Weisbroth Chapter 12 Parasitic Diseases Chao-Kuang Hsu I. Introduction 307 Appendix 2 Drugs and Dosages 413 II. Parasites of Parenteral Systems 308 Sam M. Kruckenberg DI. Parasites of the Alimentary System 317 IV. Parasites of the Integument 326 References 328 Subject Index 423 The Laboratory Rat Volume II Research Applications EDITED BY Henry J. Baker Department of Comparative Medicine Schools of Medicine and Dentistry University of Alabama in Birmingham Birmingham, Alabama /. Russell Lindsey Department of Comparative Medicine Schools of Medicine and Dentistry University of Alabama in Birmingham and the Veterans Administration Hospital Birmingham, Alabama Steven H. Weisbroth An Med Laboratories, Inc. New Hyde Park, New York ACADEM1C PRESS 1980 A SUBSIDIARY OF HARCOURT BRACE JOVANOVICH, PUBLISHERS New York London Toronto Sydney San Francisco Contents List of Contributors ix Chapter 4 Embryology and Teratology Allan R. Beaudoin Preface xi I- Introduction 75 n. Embryology 76 _ ,. , . •:; HI. Experimental Teratology 85 Contents of Volume I xm J^ ^ Chapter 1 Research Methodology Chapter 5 Toxicology Alan L. Kraus G Bmce Briggs and I. Introduction 2 II. Handling and Restraint 2 III. Identification Methods 4 TV. _r______________ V. Substance Administration 19 m Toxicological Research ..... _ 104 VI Frederick W. Oehme I. Introduction 104 . ,,.. c II. General Considerations in Selecting Animals for Specimen Couecüon - . ° A rtvt T hn ues 22 • Considerations for Selecting the Laboratory Rat for Toxicological Research 104 IV. Variables to Be Controlled 106 Vn. Euthanasia 24 Vm. Specialized Research Techniques 26 .,»,,,.,, . . . .^ . .-,,._.. 10 V. Use of the Laboratory Rat in Pharmaceuücal Testing 108 IX. Necropsy Techniques 28 . ,..,..., . . , _ , 28 VI. Studies Usmg the Laboratory Rat in Evaluating the Safety and Efficacy of New Drugs 111 Vn. Use of the Laboratory Rat for Safety and Efficacy Chapter 2 Gnotobiology . Testing of Nondrug Chemicals 116 Henry L. Foster Vin. Good Laboratory Practices in Conducting Toxicity I. Introduction 43 Studies 117 H. The Germfree and Gnotobiotic Laboratory Rat 44 IX. Conclusion 117 in. Research Applications of Gnotobiotic Rats 51 References 117 IV. Conclusions 52 References 54 Chapter 6 Experimental Oncology John C. Peckham Chapter 3 Dental Research I. introduction 119 Juan M. Navia and Annie Jo Narkates U. Rats as Research Animals in Oncology 120 I. Introduction 59 III. Rat Tumors as Models of Human Neoplastic Disease 122 H. Oral Characteristics of the Rat 60 IV. Use in Carcinogenesis 133 HI. The Rat as an Animal Model for the Study of Oral V. Use in Cancer Therapy 136 Disease 64 VI. Use in Cancer Prevention 136 IV. Conclusion 72 vn. Conclusions 137 References 72 References 137 v,7i CONTENTS Chapter 7 Experimental Gerontology Chapter 10 Immunogenetics Joe D. Burek and Carel F. Hollander Donald V. Cramer, Heinz W. Kunz, I. Introduction 149 and Thomas J. GUI, HI n. Some Factors That Influence Longevity and the I. Definitions 213 Interpretation of Results from Life Span Studies n. Cell Surface Alloantigens 214 Using Rats 150 rrj. Genetically Controlled Immune Responses 217 m. How Old Is an Old Rat? 154 iv. Allogeneic Reactions 220 IV. Cost of Old Rats 155 v. Immunogenetics of Wild Populations of Rats 221 V. Models of Aging Using the Rat 155 VI. Conclusions 221 VI. Sources of Old Rats 157 References 222 Vn. Summary 157 References 158 Chapter 11 Experimental Parasitology Chapter 8 Cardiovascular Research Dickson D. Despommier Sanford P. Bishop l- introduction 225 I. Introduction 162 H. Survey of Parasites Which Have Been Used H. Macroscopic Anatomy 162 Experimentally in Rattus norvegicus 225 m. Microscopic Anatomy 164 DI. Rattus norvegicus as a Model for Human Parasitic IV. Methods for in Vivo Evaluation of the Cardiovascular Diseases 235 System 165 References 240 V. Methods for in Vitro Study of Myocardium 166 VI. Spontaneous Models of Human Cardiovascular Disease 168 Chapter 12 Wild Rats in Research VH. Experimentally Induced Models for Cardiovascular Christine S. F. Williams Research 172 I. Introduction 245 Vm. Use of the Rat for Miscellaneous Studies 174 n. Laboratory Management of Captive Wild Rats 246 IX. Special Considerations for Use of the Rat in m. Wild Rats Used in Research 247 Cardiovascular Research 175 References 253 X. Conclusions 175 References 176 Appendix 1 Selected Normative Data 257 Chapter 9 Immunology Henry J. Baker, J. Russell Lindsey, Philip B. Carter and Herve Bazin and Steven H. Weisbroth I. Introduction 181 n. Humoral Aspects 181 in. Celiular Aspects 192 Appendix 2 Drugs and Dosages 259 IV. Autoimmune Disease 204 Sam M. Kruckenberg V. Infection and Tumor Immunity 204 VI. Conclusion 205 References 205 Subject Index 269
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