Genomic destabilization at copy number variable loci in intersubspecific hybrids of Mus musculus ssps.:
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| Format: | Thesis Book |
| Language: | English |
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Göttingen
Cuvillier
2010
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| Edition: | 1. Aufl. |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XVII, 79 S. Ill., graph. Darst., Kt. |
| ISBN: | 9783869553283 |
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| 245 | 1 | 0 | |a Genomic destabilization at copy number variable loci in intersubspecific hybrids of Mus musculus ssps. |c vorgelegt von Rick J. Scavetta |
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Titel: Genomic destabilization at copy number variable loci in intersubspecific hybrids of Mus musculus ssp
Autor: Scavetta, Rick J.
Jahr: 2010
Table of Contents
Dedication.i
Epigraph.Hi
List of Tables and Figures.vii
List of Abbreviations.ix
Acknowledgments.xi
Zusammenfassung.xiii
Abstract.xv
Declaration.xvii
1.0 Introduction. 1
1.1 Mus mutculus sips.: A Model for Evolutionary Genetics. 1
1.1.1 The Origins of Mus musculus ssps. 1
1.2 A Portrait of Copy Number Variation.3
1.2.1 The Genomic Landscape of Copy Number Variation.3
1.2.2 Consequences of Copy Number Variation. 5
1.2.3 The Origin of Copy Number Variations.7
1.3 Genetic Divergence and Reproductive Isolation.11
1.3.1 Speciation Genetics of Mus musculus ssps.,.11
1.3.2 The Xlr Superfamily.13
1.4 The Aim and Relevance of this study.15
2.0 CNV Destabilization Mus musculus ssp. Hybrids.17
2.1 The Six Gene Family.17
2.1.1 Genomic Architecture.17
2.1.2 Variation in Six cDNA.18
2.2 CNV Destabilizations in Intersubspecific Hybrids.21
2.2.1 CNVi in Wild Populations.21
2.2.2 CNVs in Wild Hybrid Populations.25
2.3 CNVs in Laboratory-Bred Hybrids.31
2.3.1 CNVs in the FI and F2 Generation.31
2.3.2 Detection of CNV Destabilization by aCGH.36
2.4 Discussion.40
3.0 DNA Repair Pathways in Hybrid Mice.43
3.1 Genome Maintenance and Instability.43
3.2 Organogenesis and Genome Maintenance.44
3-3 Experimental Outline.,.45
3.4 A Description of Embryonic DNA Repair Pathways.49
3-5 Discussion.56
4.0 Concluding Remarks.61
4.1 A General Summary.61
4.2 Novel Alleles and Hybrid Speciation.61
4.3 Outlook.62
5.0 Materials Be Methods.63
6.0 References.67
7.0 Lebenslauf.79
List of Tables and Figures
Tables
Table 1. Six, L19 and Sly copy numbers in wild pure-bred populations.23
Table 2. Mean copy numbers and independent t-test comparisons.24
Table 3. Six, L19 and Sly copy numbers in wild hybrid populations.26
Table 4. Six, L19 and Sly copy numbers in hybrid offspring families.28
Table 5. Individual copy numbers for laboratory bred animals.32
Table 6. Genes assayed in qPCR experiment and sources.47
Table 6, Continued.48
Table 7. Crosses used for obtaining E8.5 hybrid embryos.,.49
Table 8. Profiles of "developmental genes" in test populations.50
Table 9. High-Weight Genes of the first principle component axis.54
Figures
Figure 1. Geographic Distribution of M. m. muscuius ssps.2
Figure 2. The Landscape of Genetic Variation.8
Figure 3. The Genomic Architecture of the Xlr Super family.18
Figure 4. Subspecies specific Six and Six-like alleles.21
Figure 5. Copy Number Variation in Pure and Hybrid Individuals.22
Figure 6. Copy Number Distribution in Wild Hybrids.*.25
Figure 7. Copy Numbers in Hybrid Families.29
Figure 8. Polymorphisms in the Six qPCR forward primer binding site.30
Figure 9. CNV in Hybrid Crosses performed in the laboratory.33
Figure 10. S/x-like and Six Southern Blots.34
Figure 11. Southern Blot Analysis for Different Tissues.36
Figure 12. Six- and 5/x-//**-localized aCGH probes.37
Figure 13. High Confidence CNV Loci in Hybrid Individuals.39
Figure 14. PCA and Discriminant Analysis Plots.53
Figure 15. Highest- and Lowest-Weigh ted Genes on the First PCA Axis.55
Figure 16. Replication-Coupled Single-Stranded Break Repair Schema.58 |
| any_adam_object | 1 |
| author | Scavetta, Rick J. 1978- |
| author_GND | (DE-588)141628839 |
| author_facet | Scavetta, Rick J. 1978- |
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| dewey-tens | 570 - Biology |
| discipline | Biologie |
| edition | 1. Aufl. |
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| id | DE-604.BV026846699 |
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| indexdate | 2024-12-06T17:00:43Z |
| institution | BVB |
| isbn | 9783869553283 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-022375488 |
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| physical | XVII, 79 S. Ill., graph. Darst., Kt. |
| publishDate | 2010 |
| publishDateSearch | 2010 |
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| spelling | Scavetta, Rick J. 1978- Verfasser (DE-588)141628839 aut Genomic destabilization at copy number variable loci in intersubspecific hybrids of Mus musculus ssps. vorgelegt von Rick J. Scavetta 1. Aufl. Göttingen Cuvillier 2010 XVII, 79 S. Ill., graph. Darst., Kt. txt rdacontent n rdamedia nc rdacarrier Köln, Univ., Diss., 2009 Genetische Variabilität (DE-588)4264352-1 gnd rswk-swf Hausmaus (DE-588)4023784-9 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Genetische Variabilität (DE-588)4264352-1 s Hausmaus (DE-588)4023784-9 s DE-604 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=022375488&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Scavetta, Rick J. 1978- Genomic destabilization at copy number variable loci in intersubspecific hybrids of Mus musculus ssps. Genetische Variabilität (DE-588)4264352-1 gnd Hausmaus (DE-588)4023784-9 gnd |
| subject_GND | (DE-588)4264352-1 (DE-588)4023784-9 (DE-588)4113937-9 |
| title | Genomic destabilization at copy number variable loci in intersubspecific hybrids of Mus musculus ssps. |
| title_auth | Genomic destabilization at copy number variable loci in intersubspecific hybrids of Mus musculus ssps. |
| title_exact_search | Genomic destabilization at copy number variable loci in intersubspecific hybrids of Mus musculus ssps. |
| title_full | Genomic destabilization at copy number variable loci in intersubspecific hybrids of Mus musculus ssps. vorgelegt von Rick J. Scavetta |
| title_fullStr | Genomic destabilization at copy number variable loci in intersubspecific hybrids of Mus musculus ssps. vorgelegt von Rick J. Scavetta |
| title_full_unstemmed | Genomic destabilization at copy number variable loci in intersubspecific hybrids of Mus musculus ssps. vorgelegt von Rick J. Scavetta |
| title_short | Genomic destabilization at copy number variable loci in intersubspecific hybrids of Mus musculus ssps. |
| title_sort | genomic destabilization at copy number variable loci in intersubspecific hybrids of mus musculus ssps |
| topic | Genetische Variabilität (DE-588)4264352-1 gnd Hausmaus (DE-588)4023784-9 gnd |
| topic_facet | Genetische Variabilität Hausmaus Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=022375488&sequence=000004&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT scavettarickj genomicdestabilizationatcopynumbervariablelociinintersubspecifichybridsofmusmusculusssps |