Crystallization of polymorphs: a case study on astaxanthin and apocarotenoic ester
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
Aachen
Shaker
2009
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| Schriftenreihe: | Berichte aus der Verfahrenstechnik
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 98 S. Ill., graph. Darst. |
| ISBN: | 9783832287177 |
Internformat
MARC
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| 245 | 1 | 0 | |a Crystallization of polymorphs |b a case study on astaxanthin and apocarotenoic ester |c Jingfei Guo |
| 264 | 1 | |a Aachen |b Shaker |c 2009 | |
| 300 | |a 98 S. |b Ill., graph. Darst. | ||
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| 490 | 0 | |a Berichte aus der Verfahrenstechnik | |
| 502 | |a Zugl.: Halle (Saale), Univ., Diss., 2009 | ||
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Datensatz im Suchindex
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|---|---|
| adam_text | IMAGE 1
TABLE OF CONTENTS
1 INTRODUCTION 1
2 STATE OF ART 3
2.1 POLYMORPHISM 3
2.1.1 POLYMORPHS, SOLVATES AND HYDRATES 3
2.1.2 PHASE STABLILITY AND TRANSFORMATION 5
2.2 MODEL SUBSTANCE 8
2.2.1 BACKGROUND OF AXT 8
2.2.2 CHEMISTRY OF AXT - OPTICAL AND GEOMETRIC ISOMERS 9
2.2.3 CRYSTALLOGRAPHIC STUDY ON AXT 10
2.2.4 OTHER CAROTENOID - APOESTER 12
3 MOTIVATION 14
4 METHODOLOGY FOR THE STUDY OF POLYMORPHISM 15
4.1 XRAY POWDER DIFFRACTOMETER 15
4.2 THERMAL ANALYSIS 16
4.3 RAMAN SPECTROSCOPY 17
4.4 MICROSCOPY/ ESEM 19
4.5 H-NMR 20
4.6 SOLUBILITY MEASUREMENT 23
4.7 DETERMINATION OF MSZW BY TURBIDITY METER 23
4.8 EXPERIMENTAL STRATEGY 24
5 PREPARATION AND CHARACTERIZATION FOR THE NEW CRYSTALLINE FORM ON AXT
26
5.1 GENERATION OF A NEW FORM 26
5.1.1 V IA THERMAL TREATMENT 26
5.1.2 VIA EVAPORATION 28
5.1.3 A SPECIAL CASE STUDY - EVAPORATION FROM DCM 29
5.2 CHARACTERIZATION OF THE CRYSTALLINE FORMS OBTAINED 32
5.2.1 DIFFRACTION STUDIES 32
5.2.2 THERMAL ANALYSIS 36
5.2.3 OBSERVATION OF CRYSTALS BY MICROSCOPY / ESEM 38
5.2.4 RAMAN SPECTROSCOPY 41
5.3 QUANTITATIVE ANALYSIS 44
5.3.1 INVESTIGATION BY DSC 44
5.3.2 INVESTIGATION BY RAMAN SPECTROSCOPY 45
6 PHASE TRANSFORMATION OF AXT - ENANTIOTROPK OR MONOTROPIC? 48
BIBLIOGRAFISCHE INFORMATIONEN HTTP://D-NB.INFO/99883551X
DIGITALISIERT DURCH
IMAGE 2
6.1 THERMAL ANALYSIS 48
6.2 SOLUBILITY MEASUREMENTS 51
6.3 SOLVENT-MEDIATED TRANSFORMATION - SLURRY CONVERSION EXPERIMENT 54
6.4 METASTABLE ZONE MEASUREMENT 59
6.4.1 INDUCTION TIME 59
6.2.2 METASTABLE ZONE WIDTH (MSZW) 60
7 INVESTIGATION OF POLYMORPHISM ON APOESTER 63
7.1 CHARACTERIZATION OF THE STARTING CRYSTALS - SOLUBILITY TEST 63
7.2 GENERATION AND CHARACTERIZATION OF THE NEW FORM 64
8 STUDY OF CHEMICAL STABILITY AND REACTION 69
8.1 CHEMICAL STABILITY OF AXT CRYSTALS - XRPD 69
8.2 CHEMICAL STABILITY OF AXT- *-NMR SPECTROSCOPY 71
8.3 CHEMICAL STABILITY OF APOESTER - XRPDAND *-NMR SPECTROSCOPY. 76
9 DISCUSSION AND OUTLOOK 78
9.1 GENERATION AND CHARACTERIZATION OF NEW POLYMORPHIC FORMS OF AXT 78
9.2 FACTORS INFLUENCE ON THE CRYSTALLIZATION OF DESIRED FORM OF AXT 80
9.3 CHEMICAL STABILITY OF AXT 82
9.4 POSSIBLE CRYSTAL PACKING OF AXT 82
9.5 POLYMORPHISM STUDY ON APOESTER 85
10 SUMMARY 87
11 NOTATION AND ABBREVIATIONS 89
12 REFERENCES 91
|
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| author | Guo, Jingfei 1981- |
| author_GND | (DE-588)140267824 |
| author_facet | Guo, Jingfei 1981- |
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| dewey-full | 547.71 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 547 - Organic chemistry |
| dewey-raw | 547.71 |
| dewey-search | 547.71 |
| dewey-sort | 3547.71 |
| dewey-tens | 540 - Chemistry and allied sciences |
| discipline | Chemie / Pharmazie |
| format | Thesis Book |
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| genre_facet | Hochschulschrift |
| id | DE-604.BV026804800 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T23:19:20Z |
| institution | BVB |
| isbn | 9783832287177 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-022337279 |
| oclc_num | 502408699 |
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| owner_facet | DE-188 |
| physical | 98 S. Ill., graph. Darst. |
| publishDate | 2009 |
| publishDateSearch | 2009 |
| publishDateSort | 2009 |
| publisher | Shaker |
| record_format | marc |
| series2 | Berichte aus der Verfahrenstechnik |
| spelling | Guo, Jingfei 1981- Verfasser (DE-588)140267824 aut Crystallization of polymorphs a case study on astaxanthin and apocarotenoic ester Jingfei Guo Aachen Shaker 2009 98 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Berichte aus der Verfahrenstechnik Zugl.: Halle (Saale), Univ., Diss., 2009 Carotinoide (DE-588)4147357-7 gnd rswk-swf Polymorphie (DE-588)4175258-2 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Carotinoide (DE-588)4147357-7 s Polymorphie (DE-588)4175258-2 s DE-604 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=022337279&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Guo, Jingfei 1981- Crystallization of polymorphs a case study on astaxanthin and apocarotenoic ester Carotinoide (DE-588)4147357-7 gnd Polymorphie (DE-588)4175258-2 gnd |
| subject_GND | (DE-588)4147357-7 (DE-588)4175258-2 (DE-588)4113937-9 |
| title | Crystallization of polymorphs a case study on astaxanthin and apocarotenoic ester |
| title_auth | Crystallization of polymorphs a case study on astaxanthin and apocarotenoic ester |
| title_exact_search | Crystallization of polymorphs a case study on astaxanthin and apocarotenoic ester |
| title_full | Crystallization of polymorphs a case study on astaxanthin and apocarotenoic ester Jingfei Guo |
| title_fullStr | Crystallization of polymorphs a case study on astaxanthin and apocarotenoic ester Jingfei Guo |
| title_full_unstemmed | Crystallization of polymorphs a case study on astaxanthin and apocarotenoic ester Jingfei Guo |
| title_short | Crystallization of polymorphs |
| title_sort | crystallization of polymorphs a case study on astaxanthin and apocarotenoic ester |
| title_sub | a case study on astaxanthin and apocarotenoic ester |
| topic | Carotinoide (DE-588)4147357-7 gnd Polymorphie (DE-588)4175258-2 gnd |
| topic_facet | Carotinoide Polymorphie Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=022337279&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT guojingfei crystallizationofpolymorphsacasestudyonastaxanthinandapocarotenoicester |