The influence of cell mechanics, cell-cell interactions, and proliferation on epithelial packing:
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2009
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 148 S. Ill., graph. Darst. 1 CD-ROM (12 cm) |
Internformat
MARC
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| 003 | DE-604 | ||
| 005 | 20110228 | ||
| 007 | t | ||
| 008 | 110326s2009 ad|| m||| 00||| eng d | ||
| 015 | |a 10,H03 |2 dnb | ||
| 016 | 7 | |a 1000125645 |2 DE-101 | |
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| 100 | 1 | |a Röper, Jens-Christian |d 1977- |e Verfasser |0 (DE-588)140037667 |4 aut | |
| 245 | 1 | 0 | |a The influence of cell mechanics, cell-cell interactions, and proliferation on epithelial packing |c von Jens-Christian Röper |
| 264 | 1 | |c 2009 | |
| 300 | |a 148 S. |b Ill., graph. Darst. |e 1 CD-ROM (12 cm) | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 502 | |a Dresden, Techn. Univ., Diss., 2009 | ||
| 655 | 7 | |0 (DE-588)4113937-9 |a Hochschulschrift |2 gnd-content | |
| 856 | 4 | 2 | |m DNB Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=022326969&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-022326969 | ||
Datensatz im Suchindex
| _version_ | 1804145417707847680 |
|---|---|
| adam_text | TABLE
OF
CONTENTS
DECLARATION
5
SUMMARY
6
ABBREVIATIONS
8
TABLE
OF
CONTENTS
10
TABLE
OF
FIGURES
13
1.
INTRODUCTION
16
1.1.
EPITHELIAL
TISSUE
GEOMETRY
AND
FUNCTION
16
1.2.
DROSOPHILA
WING
DEVELOPMENT
18
1.2.1.
LARVAL
STAGE
20
1.2.2.
PREPUPAL
AND
PUPAL
STAGE
20
1.3.
EPITHELIA
STRUCTURE
AND
CELLULAR
REARRANGEMENTS
DURING
MORPHOGENESIS
22
1.3.1.
EPITHELIAL
STRUCTURE
AND
FUNCTION
23
1.3.2.
INTERCELLULAR
JUNCTIONS
24
1.3.3.
ADHESION
AND
CYTOSKELETAL
ORGANISATION
AT
ADHERENS
JUNCTIONS
26
1.3.4.
CORTICAL
CYTOSKELETON
27
1.3.5.
NON-MUSCLE
MYOSIN
II
28
1.4.
CELL
PROLIFERATION
AND
GEOMETRIC
DISORDER
29
1.5.
CELL
MECHANICS
31
1.5.1.
CELL
PACKING,
CELL
SORTING
AND
SURFACE
TENSION
31
1.5.2.
ADHESION
AND
THE
DIFFERENTIAL
ADHESION
HYPOTHESIS
(DAH)
32
1.5.3.
INTERCELLULAR
SURFACE
TENSION
35
1.5.4.
VISCOELASTICITY
OF
CELLS
36
1.6.
LASER
ABLATION
37
1.6.1.
LASER
TISSUE
INTERACTIONS
37
1.6.2.
BIOLOGICAL
APPLICATIONS
39
1.6.3.
LASER
ABLATION
AS
A
TOOL
TO
ANALYSE
CELL
MECHANICS
39
2.
SCOPE
OF
THIS
THESIS
43
10
3.
RESULTS
44
3.1.
WING
DISC
44
3.1.1.
PHYSICAL
DESCRIPTION
OF
CELL
PACKING
IN
EPITHELIA:
A
VERTEX
MODEL
44
3.1.2.
PACKING
IRREGULARITY
INDUCED
BY
CELL
DIVISIONS
49
3.1.3.
PACKING
GEOMETRY
IN
THE
THIRD
INSTAR
WING
IMAGINAL
DISC
54
3.1.4.
PROBING
MECHANICAL
PROPERTIES
OF
THE
JUNCTIONAL
NETWORK
BY
LASER
ABLATION
58
3.1.5.
SHORT
BOUNDARIES
ARE
UNDER
H
IGHER
TENS
ION
5
9
3.1.6.
CHANGING
PARAMETERS
WITHIN
THE
WING
EPITHELIAL
TISSUE
60
3.1.7.
LOCAL
DEFORMATIONS
ARE
STRONGLY
ANISOTROPIC
61
3.1.8.
SIMULATING
CELL-SHAPE
CHANGES
AFTER
LASER
ABLATION
62
3.1.9.
THE
DISPLACEMENT
FIELD
OF
VERTICES
IS
ANISOTROPIC
65
3.1.10.
COMPARING
DISPLACEMENT
FIELDS
FROM
EXPERIMENTS
AND
SIMULATIONS
69
3.2.
PUPAL
WING
69
3.2.1.
TOPOLOGY
AND
MORPHOLOGY
CHANGES
DURING
WING
DEVELOPMENT
69
3.2.2.
TISSUE
STRETCHES
ANISOTROPICALLY
DURING
DEVELOPMENT
73
3.2.3.
BOND
ORIENTATION
CORRELATES
WITH
STRETCHING
AND
HEXAGONAL
REPACKING
76
3.2.4.
BOND
LENGTH
CHANGES
DURING
DEVELOPMENT
76
3.2.5.
AMOUNT
OF
FOUR-FOLD
VERTICES
77
3.2.6.
LASER
ABLATION
DURING
DEVELOPMENT:
SUBCELLULAR
ANISOTROPIC
TENSION
78
3.2.7.
HINGE
CONTRACTION
IS
RESPONSIBLE
FOR TISSUE
STRETCHING
82
4.
DISCUSSION
84
4.1.
WING
DISC
84
4.1.1.
PHYSICAL
MODEL
AND
WING
DISC
PACKING
GEOMETRY
84
4.1.2.
DISORDER
GENERATED
BY
PROLIFERATION
85
4.1.3.
CUTOFF
86
4.1.4.
LASER
AB
LATION
86
4.1.5.
ADDITIONAL
FEATURES
88
4.1.6.
ANISOTROPIC
SUBCELLULAR
TENSION
90
4.1.7.
HEXAGONAL
PACKING
DURING
PUPAL
STAGES:
AN
ANNEALING
PROCESS?
91
4.2.
PUPAL
WING
93
4.2.1.
HEXAGONAL
PACKING
DURING
PUPAL
STAGES:
PASSIVE
CELL
REARRANGEMENT
93
4.2.2.
ORDERING
AND
DISORDERING
INFLUENCE
OF
CELLULAR
REARRANGEMENTS
95
4.2.3.
THE
FORCES
THAT
ACT
DURING
PUPAL
DEVELOPMENT,
PHYSICAL
PARAMETERS
95
4.2.4.
CELL
DIVISION
99
4.2.5.
PLANAR
CELL
POLARITY
PROTEINS
101
5.
CONCLUSION
104
11
6.
MATERIAL
AND
METHODS
107
6.1.
EXPERIMENTAL
PROCEDURES
107
6.1.1.
FLY
STRAINS
107
6.1.2.
IMMUNOHISTOCHEMISTRY
107
6.1.3.
THIRD
INSTAR
WING
IMAGINAL
DISC
PREPARATION
108
6.1.4.
PUPAL
WING
PREPARATION
108
6.1.5.
LASER-ABLATION
EXPERIMENTS
108
6.1.6.
HINGE
CUTS
109
6.1.7.
DRUG
TREATMENT
109
6.2.
SIMULATIONS
AND
DATA
ANALYSIS
109
6.2.1.
SIMULATIONS
109
6.2.2.
COMPARISON
OF
EXPERIMENT
AND
SIMULATION
110
6.2.3.
AUTOMATED
IMAGE
ANALYSIS
111
6.2.4.
BOND
LENGTH,
AREA
AND
PERIMETER
CHANGES
111
6.2.5.
DISPLACEMENT
FIELD
112
6.2.6.
CELL
STRETCH
112
6.2.7.
PERCENTAGE
OF
FOUR-FOLD
VERTICES
112
6.2.8.
FIGURE
PREPARATION
113
7.
REFERENCES
114
8.
APPENDIX
134
8.1.
MOVIES
134
8.2.
ADDITIONAL
FIGURES
137
8.3.
DATA
AND
STATISTICS
142
9.
ACKNOWLEDGEMENTS
146
10.
PUBLICATIONS
148
12
|
| any_adam_object | 1 |
| author | Röper, Jens-Christian 1977- |
| author_GND | (DE-588)140037667 |
| author_facet | Röper, Jens-Christian 1977- |
| author_role | aut |
| author_sort | Röper, Jens-Christian 1977- |
| author_variant | j c r jcr |
| building | Verbundindex |
| bvnumber | BV026793457 |
| ctrlnum | (OCoLC)560566110 (DE-599)DNB1000125645 |
| dewey-full | 573.7983835515774 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 573 - Specific physiological systems in animals |
| dewey-raw | 573.7983835515774 |
| dewey-search | 573.7983835515774 |
| dewey-sort | 3573.7983835515774 |
| dewey-tens | 570 - Biology |
| discipline | Biologie |
| format | Thesis Book |
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| genre | (DE-588)4113937-9 Hochschulschrift gnd-content |
| genre_facet | Hochschulschrift |
| id | DE-604.BV026793457 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T23:19:07Z |
| institution | BVB |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-022326969 |
| oclc_num | 560566110 |
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| owner | DE-188 |
| owner_facet | DE-188 |
| physical | 148 S. Ill., graph. Darst. 1 CD-ROM (12 cm) |
| publishDate | 2009 |
| publishDateSearch | 2009 |
| publishDateSort | 2009 |
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| spelling | Röper, Jens-Christian 1977- Verfasser (DE-588)140037667 aut The influence of cell mechanics, cell-cell interactions, and proliferation on epithelial packing von Jens-Christian Röper 2009 148 S. Ill., graph. Darst. 1 CD-ROM (12 cm) txt rdacontent n rdamedia nc rdacarrier Dresden, Techn. Univ., Diss., 2009 (DE-588)4113937-9 Hochschulschrift gnd-content DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=022326969&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Röper, Jens-Christian 1977- The influence of cell mechanics, cell-cell interactions, and proliferation on epithelial packing |
| subject_GND | (DE-588)4113937-9 |
| title | The influence of cell mechanics, cell-cell interactions, and proliferation on epithelial packing |
| title_auth | The influence of cell mechanics, cell-cell interactions, and proliferation on epithelial packing |
| title_exact_search | The influence of cell mechanics, cell-cell interactions, and proliferation on epithelial packing |
| title_full | The influence of cell mechanics, cell-cell interactions, and proliferation on epithelial packing von Jens-Christian Röper |
| title_fullStr | The influence of cell mechanics, cell-cell interactions, and proliferation on epithelial packing von Jens-Christian Röper |
| title_full_unstemmed | The influence of cell mechanics, cell-cell interactions, and proliferation on epithelial packing von Jens-Christian Röper |
| title_short | The influence of cell mechanics, cell-cell interactions, and proliferation on epithelial packing |
| title_sort | the influence of cell mechanics cell cell interactions and proliferation on epithelial packing |
| topic_facet | Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=022326969&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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