Recognition and alleviation of pain in laboratory animals:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Washington, Wash.
National Academy Press
2009
|
| Schlagworte: | |
| Online-Zugang: | Inhalt Inhaltsverzeichnis |
| Beschreibung: | 177 S. |
| ISBN: | 9780309128346 030912834X |
Internformat
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Datensatz im Suchindex
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|---|---|
| adam_text | Recognition and
Alleviation of Pain
in Laboratory Animals
Committee on Recognition and Alleviation of Pain in Laboratory Animals
Institute for Laboratory Animal Research
Division on Earth and Life Studies
NATIONAL RESEARCH COUNCIL
OF THE NATIONAL ACADEMIES
THE NATIONAL ACADEMIES PRESS
Washington, D.C.
www.nap.edu
Contents
GLOSSARY xi
SUMMARY 1
Approach to This Study, 2
Pain in Animal Research, 3
Recommendations, 4
References, 5
INTRODUCTION 7
Organization of the Report, 8
References, 9
1 Pain in Research Animals:
General Principles and Considerations 11
Why Is It Important to Recognize and Alleviate Animal Pain?, 11
What Is Pain?, 13
Animal Pain: Do All Vertebrates Experience Pain?, 20
Causes of Pain in Research Animals, 24
Is Pain in Animals Ever Justifiable?, 26
Conclusions and Recommendations, 27
References, 27
2 Mechanisms of Pain 33
Nociception or Pain, 33
The Development of Persistent Pain, 38
xiii
xiv CONTENTS
Ontogeny of Pain, 40
Modulatory Influences on Pain: Anxiety, Fear, and Stress, 42
Conclusions and Recommendations, 43
References, 44
3 Recognition and Assessment of Pain 47
Introduction, 47
Pain Recognition: Clinical Signs and Behavior, 48
Pain Assessment Methods, 50
Pain Assessment: Species-specific Clinical Signs, 56
Conclusions and Recommendations, 63
References, 64
4 Effective Pain Management 71
Introduction, 71
Clinical Veterinary Pain Management, 72
Strategies for Managing Pain in Laboratory Animals, 73
Methods for the Prevention or Management of Pain, 79
Practical Applications and Considerations for Pain Management, 91
Analgesia in Selected Nonmammalian Species, 99
Limitations of Available Information, 104
Conclusions and Recommendations, 106
References, 106
5 Humane Endpoints for Animals in Pain 119
Guidelines and Reference Documents, 119
Pilot Studies, 124
International Regulations and Guidelines for Safety Assessment, 124
Humane Endpoints in Toxicology Studies, 126
Humane Endpoints in Infectious Disease Research, 128
Humane Endpoints in Vaccine Safety and Potency Testing, 129
Humane Endpoints in Cancer Research, 130
Humane Endpoints in Pain Research, 130
Euthanasia, 130
Conclusions and Recommendations, 131
Addendum, 133
References, 137
APPENDIXES
A Models of Pain 143
Introduction, 143
CONTENTS XV
Animal Models of Persistent Pain, 146
References, 154
B US Regulations and Guidelines Regarding Recognition and
Alleviation of Pain in Laboratory Animals 159
Legal Requirements and Agency Guidelines, 159
Other Relevant Guidelines and Statements, 164
References, 165
INDEX 167
|
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| isbn | 9780309128346 030912834X |
| language | English |
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| physical | 177 S. |
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| spelling | Recognition and alleviation of pain in laboratory animals Committee on Recognition and Alleviation of Pain in Laboratory Animals, Institute for Laboratory Animal Research, Division on Earth and Life Studies, National Research Council of the National Academies Washington, Wash. National Academy Press 2009 177 S. txt rdacontent n rdamedia nc rdacarrier laboratory animals cabt pain cabt animal welfare cabt analgesics cabt drug therapy cabt Tierversuch (DE-588)4060137-7 gnd rswk-swf Versuchstiere (DE-588)4078861-1 gnd rswk-swf Schmerz (DE-588)4052823-6 gnd rswk-swf Tierschutz (DE-588)4060131-6 gnd rswk-swf Versuchstiere (DE-588)4078861-1 s Schmerz (DE-588)4052823-6 s DE-604 Tierversuch (DE-588)4060137-7 s Tierschutz (DE-588)4060131-6 s Institute for Laboratory Animal Research (Washington, DC) Committee on Recognition and Alleviation of Pain in Laboratory Animals Sonstige (DE-588)16060333-X oth http://library.vetmed.fu-berlin.de/resources/global/contents/3529594/contents.pdf Inhalt HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=022236840&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Recognition and alleviation of pain in laboratory animals laboratory animals cabt pain cabt animal welfare cabt analgesics cabt drug therapy cabt Tierversuch (DE-588)4060137-7 gnd Versuchstiere (DE-588)4078861-1 gnd Schmerz (DE-588)4052823-6 gnd Tierschutz (DE-588)4060131-6 gnd |
| subject_GND | (DE-588)4060137-7 (DE-588)4078861-1 (DE-588)4052823-6 (DE-588)4060131-6 |
| title | Recognition and alleviation of pain in laboratory animals |
| title_auth | Recognition and alleviation of pain in laboratory animals |
| title_exact_search | Recognition and alleviation of pain in laboratory animals |
| title_full | Recognition and alleviation of pain in laboratory animals Committee on Recognition and Alleviation of Pain in Laboratory Animals, Institute for Laboratory Animal Research, Division on Earth and Life Studies, National Research Council of the National Academies |
| title_fullStr | Recognition and alleviation of pain in laboratory animals Committee on Recognition and Alleviation of Pain in Laboratory Animals, Institute for Laboratory Animal Research, Division on Earth and Life Studies, National Research Council of the National Academies |
| title_full_unstemmed | Recognition and alleviation of pain in laboratory animals Committee on Recognition and Alleviation of Pain in Laboratory Animals, Institute for Laboratory Animal Research, Division on Earth and Life Studies, National Research Council of the National Academies |
| title_short | Recognition and alleviation of pain in laboratory animals |
| title_sort | recognition and alleviation of pain in laboratory animals |
| topic | laboratory animals cabt pain cabt animal welfare cabt analgesics cabt drug therapy cabt Tierversuch (DE-588)4060137-7 gnd Versuchstiere (DE-588)4078861-1 gnd Schmerz (DE-588)4052823-6 gnd Tierschutz (DE-588)4060131-6 gnd |
| topic_facet | laboratory animals pain animal welfare analgesics drug therapy Tierversuch Versuchstiere Schmerz Tierschutz |
| url | http://library.vetmed.fu-berlin.de/resources/global/contents/3529594/contents.pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=022236840&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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