Ciliary function in mammalian development:
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
Elsevier [u.a.]
2008
|
| Ausgabe: | 1. ed. |
| Schriftenreihe: | Current topics in developmental biology
85 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIX, 464 S., [16] Bl. Ill., graph. Darst. |
| ISBN: | 9780123744531 |
Internformat
MARC
| LEADER | 00000nam a2200000 cb4500 | ||
|---|---|---|---|
| 001 | BV026678623 | ||
| 003 | DE-604 | ||
| 005 | 20110228 | ||
| 007 | t | ||
| 008 | 110326s2008 ad|| |||| 00||| eng d | ||
| 020 | |a 9780123744531 |9 978-0-12-374453-1 | ||
| 035 | |a (OCoLC)316279262 | ||
| 035 | |a (DE-599)BVBBV026678623 | ||
| 040 | |a DE-604 |b ger |e rakwb | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-188 |a DE-29T | ||
| 082 | 0 | |a 612.842 | |
| 245 | 1 | 0 | |a Ciliary function in mammalian development |c ed. by Bradley K. Yoder |
| 250 | |a 1. ed. | ||
| 264 | 1 | |a Amsterdam [u.a.] |b Elsevier [u.a.] |c 2008 | |
| 300 | |a XIX, 464 S., [16] Bl. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 0 | |a Current topics in developmental biology |v 85 | |
| 650 | 0 | 7 | |a Säugetiere |0 (DE-588)4051253-8 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Zilie |0 (DE-588)4190826-0 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Entwicklung |0 (DE-588)4113450-3 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4143413-4 |a Aufsatzsammlung |2 gnd-content | |
| 689 | 0 | 0 | |a Zilie |0 (DE-588)4190826-0 |D s |
| 689 | 0 | |5 DE-188 | |
| 689 | 1 | 0 | |a Säugetiere |0 (DE-588)4051253-8 |D s |
| 689 | 1 | 1 | |a Zilie |0 (DE-588)4190826-0 |D s |
| 689 | 1 | 2 | |a Entwicklung |0 (DE-588)4113450-3 |D s |
| 689 | 1 | |5 DE-188 | |
| 700 | 1 | |a Yoder, Bradley K. |4 edt | |
| 856 | 4 | 2 | |m HBZ Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=022223422&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-022223422 | ||
Datensatz im Suchindex
| _version_ | 1804145286611730432 |
|---|---|
| adam_text | Contents
Contributors xi
Preface xv
1. Basal Bodies: Platforms for Building Cilia 1
Wallace F. Marshall
1. Introduction 2
2. Basal Body Architecture and Assembly 3
3. Basal Body Functions in Ciliogenesis 7
4. Approaches to the Study of Basal Bodies 14
5. Conclusions 17
References 17
2. Intraflagellar Transport (IFT): Role in Ciliary Assembly,
Resorption and Signalling 23
Lotte B. Pedersen and Joel L. Rosenbaum
1. Introduction 24
2. Early Events in Ciliogenesis 28
3. General Description of Intraflagellar Transport 29
4. Discovery and Evolution of IFT 30
5. The Canonical Anterograde IFT Motor 32
6. Additional Kinesin Motors Involved in Ciliogenesis 35
7. The Retrograde IFT Motor 37
8. IFT Particle Polypeptides 38
9. Functional Analysis of IFT Particle Polypeptides:
Distinct Roles of IFT Complexes A and B 39
10. Regulation of IFT 41
11. Targeting of Proteins to the Ciliary Compartment:
Clues from Ciliary Disease Genes 43
12. IFT and Cilia-Mediated Signaling 47
13. Conclusions and Perspectives 49
Acknowledgments 50
References 50
v
vi Contents
3. How Did the Cilium Evolve? 63
Peter Satir, David R. Mitchell, and Gaspar Jekely
1. Introduction 64
2. The Link Between Ciliary Evolution and Eukaryotic Divergence 66
3. Hypotheses of the Origin of Cilia 67
4. The Viral Hypothesis of Ciliary Origin 68
5. The Autogenous Model for the Origin of Cilia 71
6. Origin of Intraflagellar Transport and the Sensory Function of Cilia 76
7. The Evolution of Ciliary Motility 78
Acknowledgments 79
References 79
4. Ciliary Tubulin and Its and Post-Translational Modifications 83
Jacek Gaertig and Dorota Wloga
1. Introduction 83
2. Production and Turnover of Ciliary Tubulin 84
3. Post-Translational Modifications of Tubulin 89
4. Conclusions 103
Acknowledgments 103
References 104
5. Targeting Proteins to the Ciliary Membrane 115
Gregory J. Pazour and Robert A. Bloodgood
1. Introduction 116
2. Structure of the Ciliary Membrane 118
3. Functions of the Ciliary Membrane 121
4. Protein Machinery Involved in Trafficking to the Ciliary Membrane 127
5. Ciliary Targeting Sequences 134
References 139
6. Cilia: Multifunctional Organelles at the Center of Vertebrate
Left-Right Asymmetry 151
Basudha Basu and Martina Brueckner
1. Introduction 152
2. Vertebrate LR Asymmetry is Chiral Asymmetry 154
3. The Structure and Distribution of Cilia in the Vertebrate Embryo 155
4. Motile Primary Cilia in LR Development 156
5. Mouse and Human Mutations Affecting Cilia Have a Wide-Ranging
Effect on Left-Right and Cardiac Development 158
Contents vii
6. A Structure with Prominent Primary Cilia is Essential to the
Development of LR Asymmetry in Most Vertebrates 160
7. Cilia at the LR Organizer Generate Directional Fluid Flow 162
8. A Conserved Asymmetric Calcium Signal Is Found at the
LR Organizer 164
9. Do Cilia Lie at the Root of All Vertebrate LR Asymmetry,
and What Leads from Asymmetric Calcium to Asymmetric
Organogenesis? 168
References 169
7. Ciliary Function and Wnt Signal Modulation 175
Jantje M. Gerdes and Nicholas Katsanis
1. Introduction 176
2. Overview of Wnt Signaling 176
3. Emerging Roles of the Primary Cilium and Basal Body
in Wnt Signaling Modulation 179
4. Wnt and Ciliogenesis 184
5. Wnt Dysfunction and Ciliopathy Phenotypes 185
6. What Drives the Phenotype: Gain of Canonical Wnt
Signaling or Loss of Noncanonical Wnt Signaling? 185
7. Other Phenotypes 187
8. Discussion 189
Acknowledgments 190
References 191
8. Primary Cilia in Planar Cell Polarity Regulation
of the Inner Ear 197
Chonnettia Jones and Ping Chen
1. Introduction 198
2. Planar Cell Polarity and Ciliogenesis of the Inner Ear Sensory Organs 200
3. Planar Cell Polarity Regulation for the Development of the Inner Ear 206
4. Cilia and PCP Regulation 209
5. Cilia and Determination of the Intrinsic Cellular
Polarity of Inner Ear Cells 214
6. Conclusions and Perspectives 217
References 219
viii Contents
9. The Primary Cilium: At the Crossroads of Mammalian
Hedgehog Signaling 225
Sunny Y. Wong and Jeremy F. Reiter
1. Hh Signals Pattern Diverse Developing Tissues 226
2. Hh Signal Transduction: Activating an Activator and
Repressing a Repressor 229
3. Functions of Gli Proteins in Development 233
4. Defective Intraflagellar Transport Disrupts Mammalian Hh Signaling 236
5. The Primary Cilium as a Cellular Signaling Center 239
6. Mammalian Smo Activates the Hh Pathway at the Primary Cilium 241
7. Proper Ciliary Function is Required for Processing of Gli Proteins 242
8. Additional Ciliary Components Function in Hh Signal Transduction 243
9. Are Cilia Involved in Hh Pathway-Mediated Tumorigenesis? 246
10. Lingering Questions 248
Acknowledgments 249
References 249
10. The Primary Cilium Coordinates Signaling Pathways in Cell Cycle
Control and Migration During Development and Tissue Repair 261
S0ren T. Christensen, Stine F. Pedersen, Peter Satir,
Iben R. Veland, and Linda Schneider
1. Introduction 262
2. Cell Cycle Entry Regulated by PDGFRaa Signaling in the
Primary Cilium 267
3. Directional Cell Migration is Regulated by PDGFRa in the
Primary Cilium 272
4. The Extracellular Matrix and the Primary Cilium 280
5. Polarization, Cell Migration, Cell Cycle Control and
Wnt Signaling in the Primary Cilium 282
6. Conclusions and Perspectives 286
Acknowledgments 288
References 288
11. Cilia Involvement in Patterning and Maintenance of the Skeleton 303
Courtney). Haycraft and Rosa Serra
1. Introduction 304
2. Cilia are Required for Anterior-Posterior Limb Patterning 305
3. A Role for IFT/Primary Cilia in Endochondral Bone Formation
and Development of the Postnatal Growth Plate 312
4. Primary Cilia in Articular Cartilage 318
Contents ix
5. A Role for Primary Cilia in the Development of the Bone Collar 319
6. Primary Cilia in the Maintenance of Bone 321
7. Primary Cilia in Craniofacial Development 323
8. Primary Cilia in Tooth Development 325
9. Summary 326
Acknowledgments 327
References 327
12. Olfactory Cilia: Our Direct Neuronal Connection to the
External World 333
Dyke P. McEwen, Paul M. Jenkins, and Jeffrey R. Martens
1. Olfaction as a Sensory Modality 334
2. Anatomy and Organization of the Olfactory Epithelium 335
3. Structure of Olfactory Cilia 338
4. Formation of Olfactory Cilia 344
5. Intraflagellar Transport 347
6. Ciliary Proteome 349
7. Olfactory Cilia and Disease 355
8. Summary 358
References 359
13. Ciliary Dysfunction in Developmental Abnormalities
and Diseases 371
Neeraj Sharma, Nicolas F. Berbari, and Bradley K. Yoder
1. Introduction 372
2. The Oak Ridge Polycystic Kidney (Orpk) Mouse: A Model
For Human Ciliopathies 374
3. Functions and Phenotypes Associated with Abnormal Motile Cilia 376
4. Functions and Diseases Associated with Immotile Cilium 383
5. Oligogenic Inheritance and Clinical Variability in the Ciliopathies 409
6. Cilia Proteome and Genome Databases and the
Identification of Human Ciliopathy Genes 410
Acknowledgments 412
References 413
Index 429
Contents of Previous Volumes 437
|
| any_adam_object | 1 |
| author2 | Yoder, Bradley K. |
| author2_role | edt |
| author2_variant | b k y bk bky |
| author_facet | Yoder, Bradley K. |
| building | Verbundindex |
| bvnumber | BV026678623 |
| ctrlnum | (OCoLC)316279262 (DE-599)BVBBV026678623 |
| dewey-full | 612.842 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 612 - Human physiology |
| dewey-raw | 612.842 |
| dewey-search | 612.842 |
| dewey-sort | 3612.842 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| edition | 1. ed. |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01583nam a2200421 cb4500</leader><controlfield tag="001">BV026678623</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20110228 </controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">110326s2008 ad|| |||| 00||| eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9780123744531</subfield><subfield code="9">978-0-12-374453-1</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)316279262</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV026678623</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-188</subfield><subfield code="a">DE-29T</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">612.842</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Ciliary function in mammalian development</subfield><subfield code="c">ed. by Bradley K. Yoder</subfield></datafield><datafield tag="250" ind1=" " ind2=" "><subfield code="a">1. ed.</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Amsterdam [u.a.]</subfield><subfield code="b">Elsevier [u.a.]</subfield><subfield code="c">2008</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">XIX, 464 S., [16] Bl.</subfield><subfield code="b">Ill., graph. Darst.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="0" ind2=" "><subfield code="a">Current topics in developmental biology</subfield><subfield code="v">85</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Säugetiere</subfield><subfield code="0">(DE-588)4051253-8</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Zilie</subfield><subfield code="0">(DE-588)4190826-0</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Entwicklung</subfield><subfield code="0">(DE-588)4113450-3</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="655" ind1=" " ind2="7"><subfield code="0">(DE-588)4143413-4</subfield><subfield code="a">Aufsatzsammlung</subfield><subfield code="2">gnd-content</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Zilie</subfield><subfield code="0">(DE-588)4190826-0</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-188</subfield></datafield><datafield tag="689" ind1="1" ind2="0"><subfield code="a">Säugetiere</subfield><subfield code="0">(DE-588)4051253-8</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="1" ind2="1"><subfield code="a">Zilie</subfield><subfield code="0">(DE-588)4190826-0</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="1" ind2="2"><subfield code="a">Entwicklung</subfield><subfield code="0">(DE-588)4113450-3</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="1" ind2=" "><subfield code="5">DE-188</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Yoder, Bradley K.</subfield><subfield code="4">edt</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">HBZ Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=022223422&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-022223422</subfield></datafield></record></collection> |
| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV026678623 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T23:17:02Z |
| institution | BVB |
| isbn | 9780123744531 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-022223422 |
| oclc_num | 316279262 |
| open_access_boolean | |
| owner | DE-188 DE-29T |
| owner_facet | DE-188 DE-29T |
| physical | XIX, 464 S., [16] Bl. Ill., graph. Darst. |
| publishDate | 2008 |
| publishDateSearch | 2008 |
| publishDateSort | 2008 |
| publisher | Elsevier [u.a.] |
| record_format | marc |
| series2 | Current topics in developmental biology |
| spelling | Ciliary function in mammalian development ed. by Bradley K. Yoder 1. ed. Amsterdam [u.a.] Elsevier [u.a.] 2008 XIX, 464 S., [16] Bl. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Current topics in developmental biology 85 Säugetiere (DE-588)4051253-8 gnd rswk-swf Zilie (DE-588)4190826-0 gnd rswk-swf Entwicklung (DE-588)4113450-3 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Zilie (DE-588)4190826-0 s DE-188 Säugetiere (DE-588)4051253-8 s Entwicklung (DE-588)4113450-3 s Yoder, Bradley K. edt HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=022223422&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Ciliary function in mammalian development Säugetiere (DE-588)4051253-8 gnd Zilie (DE-588)4190826-0 gnd Entwicklung (DE-588)4113450-3 gnd |
| subject_GND | (DE-588)4051253-8 (DE-588)4190826-0 (DE-588)4113450-3 (DE-588)4143413-4 |
| title | Ciliary function in mammalian development |
| title_auth | Ciliary function in mammalian development |
| title_exact_search | Ciliary function in mammalian development |
| title_full | Ciliary function in mammalian development ed. by Bradley K. Yoder |
| title_fullStr | Ciliary function in mammalian development ed. by Bradley K. Yoder |
| title_full_unstemmed | Ciliary function in mammalian development ed. by Bradley K. Yoder |
| title_short | Ciliary function in mammalian development |
| title_sort | ciliary function in mammalian development |
| topic | Säugetiere (DE-588)4051253-8 gnd Zilie (DE-588)4190826-0 gnd Entwicklung (DE-588)4113450-3 gnd |
| topic_facet | Säugetiere Zilie Entwicklung Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=022223422&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT yoderbradleyk ciliaryfunctioninmammaliandevelopment |