Handbook of anticancer pharmacokinetics and pharmacodynamics:
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Totowa, NJ
Humana Press
2004
|
| Schriftenreihe: | Cancer drug discovery and development
|
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | XIV, 623 S. + CD-ROM-Beil. Ill., graph. Darst. |
| ISBN: | 1588291774 1592597343 |
Internformat
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| 245 | 1 | 0 | |a Handbook of anticancer pharmacokinetics and pharmacodynamics |c ed. by William D. Figg ... |
| 264 | 1 | |a Totowa, NJ |b Humana Press |c 2004 | |
| 300 | |a XIV, 623 S. + CD-ROM-Beil. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 0 | |a Cancer drug discovery and development | |
| 500 | |a Includes bibliographical references and index | ||
| 700 | 1 | |a Figg, William D. |0 (DE-588)135818621 |4 edt | |
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Datensatz im Suchindex
| _version_ | 1804145149453795328 |
|---|---|
| adam_text | Contents
Preface v
Contributors xi
Ebook/PDA xv
1 Molecular Targets
Udai Banerji, Ian Judson, and Paul Workman /
2 Preclinical Screening for New Anticancer Agents
Angelika M. Burger and Heinz-Herbert Fiebig 29
3 Mouse Models in Cancer Drug Discovery and Development
Edward A. Sausville and Melinda Hollingshead 45
4 Defining the Starting Dose:
Should It Be Based on mg/kg, mg/m , or Fixed?
Howard Gurney 57
5 Phase I Trials in Oncology: Design and Endpoints
James Cassidy 75
6 Analytical Methods: Development, Validation, and Clinical Applicability
Hans Ehrsson, Staffan Eksborg, and Jonas Bergh 81
7 Validation and Control of Bioanalytical Methods
in Clinical Drug Development
H. Thomas Karnes 91
8 Clinical Pharmacology Overview
Andrew P. Beelen and Lionel D. Lewis Ill
9 Pharmacokinetic Modeling
Sharyn D. Baker and Michelle A. Rudek 129
10 Pharmacodynamic Modeling
Kenneth S. Bauer and William P. Petros 139
11 Pharmacometric Knowledge-Based Oncology Drug Development
PaulJ. Williams, James A. Uchizono, and Ene I. Ette 149
12 Protein Binding of Anticancer Drugs
Alex Sparreboom and Walter J. Loos 169
13 Metabolism (Non-CYP Enzymes)
Sally A. Coulthard and Alan V. Boddy 189
14 Cytochrome P450 and Anticancer Drugs
YuichiAndo 215
15 Polymorphisms in Genes of Drug Targets and Metabolism
and in DNA Repair
Jan Stoehlmacher, Syma Iqbal, and Heinz-Josef Lenz 231
vii
viii Contents
16 Drug Interactions
Laurent P. Rivory 245
17 ABC Transporters: Involvement in Multidrug Resistance
and Drug Disposition
Susan E. Bates and Tito Fojo 267
18 Intrathecal Chemotherapy
Jeff Stone and Susan M. Blaney 289
19 Use of Microdialysis in Preclinical and Clinical Development
of Anticancer Agents
William C. Zamboni 307
20 Regional Therapy of Cancer Using Continuous Hyperthermic
Peritoneal Perfusion or Vascular Isolation and Perfusion Techniques
H. Richard Alexander, Maihgan A. Kavanagh, Steven K. Libutti,
and James F. Pingpank 327
21 Isolated Lung Perfusion for the Treatment of Inoperable
Pulmonary Malignancies
David S. Schrump 349
22 Pharmacokinetics of Isolated Lung Perfusion with Antitumor Agents
Suoping Zhai 363
23 Central Nervous System Malignancy and Clinical Pharmacology
Steve Y. Cho and Howard A. Fine 373
24 Pharmacokinetics of Anticancer Drugs in Children
Lisa C. Iacono, P. Kellie Turner, and Clinton F. Stewart 395
25 Clinical Pharmacokinetics in the Elderly
Patricia W. Slattum and Jtirgen Venitz 421
26 The Combination of Angiogenesis Inhibitors and Radiotherapy
for the Treatment of Primary Tumors
Kevin Camphausen and Cynthia Menard 431
27 Gene Therapy for the Treatment of Cancer
H. Trent Spencer and Jacques Galipeau 439
28 Vaccines for the Treatment of Cancer
Philip M. Arlen, James Gulley, Lauretta Odogwu,
and John L. Marshall 457
29 Pharmacokinetics of Antibodies and Immunotoxins in Mice and Humans
Victor Ghetie, E. Sally Ward, and Ellen S. Vitetta 475
30 Pharmacokinetics of Biologicals
Hdkan Mellstedt, Jan-Erik Frb din, and Anders Osterborg 499
31 Exposure-Response Relationship of Anticancer Agents: A Clinical
Pharmacology and Biopharmaceutics Regulatory Perspective
Atiqur Rahman 523
Contents ix
32 Identifying Agents to Test in Phase III Trials
Thomas G. Roberts Jr., Thomas J. Lynch Jr., and Bruce A. Chabner 539
33 Clinical Trial Designs for Approval of New Anticancer Agents:
A Clinical Science
Daniel D. Von Hoff 579
34 Pharmacogenetic Counseling
Jill M. Kolesar 593
Index 613
|
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| id | DE-604.BV026557978 |
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| indexdate | 2024-07-09T23:14:52Z |
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| isbn | 1588291774 1592597343 |
| language | English |
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| spelling | Handbook of anticancer pharmacokinetics and pharmacodynamics ed. by William D. Figg ... Totowa, NJ Humana Press 2004 XIV, 623 S. + CD-ROM-Beil. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Cancer drug discovery and development Includes bibliographical references and index Figg, William D. (DE-588)135818621 edt HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=022120073&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Handbook of anticancer pharmacokinetics and pharmacodynamics |
| title | Handbook of anticancer pharmacokinetics and pharmacodynamics |
| title_auth | Handbook of anticancer pharmacokinetics and pharmacodynamics |
| title_exact_search | Handbook of anticancer pharmacokinetics and pharmacodynamics |
| title_full | Handbook of anticancer pharmacokinetics and pharmacodynamics ed. by William D. Figg ... |
| title_fullStr | Handbook of anticancer pharmacokinetics and pharmacodynamics ed. by William D. Figg ... |
| title_full_unstemmed | Handbook of anticancer pharmacokinetics and pharmacodynamics ed. by William D. Figg ... |
| title_short | Handbook of anticancer pharmacokinetics and pharmacodynamics |
| title_sort | handbook of anticancer pharmacokinetics and pharmacodynamics |
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