Penem antibiotics: FCE 22101 and its orally absorbed ester FCE 22891 ; with 13 tables
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| Weitere Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Tokyo
Japan Scientific Societies Pr.
1991
Berlin <<[u.a.]>> Springer |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | X, 130 S. zahlr. graph. Darst. |
| ISBN: | 476224645X 3540531424 0387531424 |
Internformat
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| 245 | 1 | 0 | |a Penem antibiotics |b FCE 22101 and its orally absorbed ester FCE 22891 ; with 13 tables |c ed. by Susumu Mitsuhashi ... |
| 264 | 1 | |a Tokyo |b Japan Scientific Societies Pr. |c 1991 | |
| 264 | 1 | |a Berlin <<[u.a.]>> |b Springer | |
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| 700 | 1 | |a Mitsuhashi, Susumu |4 edt | |
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Datensatz im Suchindex
| _version_ | 1808769874493702144 |
|---|---|
| adam_text |
IMAGE 1
PENE
ANTIBIOTICS FCE 22101 AND ITS ORALLY ABSORBED ESTER FCE 22891 EDITED BY
SUSUMU MITSUHASHI AND G. FRANCESCHI WITH 47 FIGURES AND 13 TABLES JAPAN
SCIENTIFIC SOCIETIES PRESS TOKYO
SPRINGER-VERLAG BERLIN HEIDELBERG NEW YORK LONDON PARIS TOKYO HONG KONG
BARCELONA BUDAPEST
IMAGE 2
CONTENTS
PREFACE
SYNTHESIS OF FCE 22101 AND ITS ORAL ESTER PRODRUG FCE 22891 G.
FRANCESCHI, E. PERRONE, M. ALPEGIANI, A. BEDESCHI, AND F. ZARINI 3
CHEMISTRY 4
SUMMARY 7
IN VITRO ANTIBACTERIAL ACTIVITY OF FCE 22101 AND ITS STABILITY TO
/J-LACTAMASES S. MITSUHASHI AND S. TAKAGI 13 1. PENAMS 13
A) CLASSICAL PENICILLINS 13
B) PENICILLINASE-RESISTANT PENICILLINS 14
C) BROAD SPECTRUM PENICILLIN 14
D) ANTIPSEUDOMONAL PENICILLINS 15
2. CEPHEMS 16
A) FIRST GENERATION CEPHEMS 16
VII
IMAGE 3
VLLL
B) SECOND GENERATION CEPHEMS 16
C) THIRD GENERATION CEPHEMS 16
3. NONCLASSICAL /J-LACTAMS 16
A) MONOBACTAMS 17
B) CARBAPENEMS 17
C) PENEMS 17
4. ANTIBACTERIAL ACTIVITY OF FCE 22101 23
5. STABILITY OF /?-LACTAMASES 29
6. CONCLUSION 37
SUMMARY 37
MODE OF ACTIN OF PENEM ANTIBIOTICS AND THEIR CLINI- CAL SIGNIFICANCE T.
YOKOTA 43
1. MUREIN TRANSPEPTIDASES AND PENICILLIN-BINDING PROTEINS 44
2. ELECTROPHORETIC PATTERNS OF PBPS IN VARIOUS BACTERIA . 46 3. SPECIFIC
BINDING AFFINITY TO A FRACTION OF PBPS BY FAMILIES OF /?-LACTAM
ANTIBIOTICS 47
4. BINDING AFFINITY OF FCE 22101, THE FIRST PENEM ANTIBIOTIC, TO
BACTERIAL PBPS 47
5. INACTIVATIN OF /?-LACTAMASES BY FCE 22101 50
6. SYNERGY OF BACTERIAL EFFECT BETWEEN FCE 22101 AND MOUSE CULTURED
MACROPHAGES 55
7. STABILITY OF FCE 22101 AGAINST MAMMALIAN DEHYDROPEPTIDASE I
(DIPEPTIDASE) 55
SUMMARY 60
IN VIVO ANTIMICROBIAL ACTIVITY OF FCE 22891 5". GOTO AND S. MIYAZAKI 65
1. ANTIMICROBIAL ACTIVITY AGAINT CLINICALLY ISOLATED STRAINS 66
2. STABILITY TO /?-LACTAMASE 69
3. ANTIMICROBIAL ACTIVITY IN VIVO 69
4. SERUM CONCENTRATION IN MICE 73
IMAGE 4
CONTENTS IX
5. CONCLUSION 74
SUMMARY 75
MORPHOLOGICAL ALTERATION OF GRAM-NEGATIVE BACTE- RIA EXPOSED TO PENEM
ANTIBIOTICS AND ITS MODE OF ACTION T. NISHINO, M. TANAKA, S. NAGATSUJI,
AND M. OTSUKI 79
1. CELL WALLS OF GRAM-POSITIVE AND GRAM-NEGATIVE BACTERIA 80
2. STRUCTURE OF PEPTIDOGLYCAN AND ACTION OF /?-LACTAM ANTIBIOTICS 81
3. PENICILLIN BINDING PROTEINS AND /3-LACTAM ANTIBIOTICS 83
4. ANTIBACTERIAL POTENCY OF FCE 22101 IN VITRO . . . 55
5. BACTERICIDAL ACTION OF FCE 22101 86
6. OBSERVATION OF THE MORPHOLOGICAL CHANGES BY PHASE- CONTRAST
MICROSCOPY 87
7. OBSERVATION OF MORPHOLOGICAL CHANGES BY SCANNING AND TRANSMISSION
ELECTRON MICROSCOPY 90
8. AFFINITY OF E. COLI TO PBPS 95
SUMMARY . . * 96
IN VITRO ACTIVITY OF FCE 22101 AGAINST CLINICAL ISO- LATES OF
STAPHYLOCOCCI AND ULTRASTRUCTURE OF FCE 22101 TREATED METHICILLIN
RESISTANT STAPHYLOCOCCUS AUREUS (MRSA)
A. NAGAYAMA, K. YASUNAKA, AND K. MURATA 101
1. ACTIVITY OF F CE 22101 AGAINST STAPHYLOCOCCI . . . 102
2. ULTRASTRUCTURE OF F CE 22101 TREATED M R SA 104
FCE 22101 TREATED MRSA 145 106
SUMMARY ILL
MECHANISM OF ACTION OF FCE 22101 AND EFFECT OF SIMULATED HUMAN
PHARMACOKINETICS D. JABES AND C. DELIA BRUNA 117
IMAGE 5
1. IN VITRO MODELS 118
2. IN VIVO MODELS 120
3. MECHANISM OF ACTION 122
4. FCE 22101 AND NEW MECHANISMS OF RESISTANCE . . . 126 SUMMARY 126
SUBJECT INDEX 129 |
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| illustrated | Illustrated |
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| isbn | 476224645X 3540531424 0387531424 |
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| spelling | Penem antibiotics FCE 22101 and its orally absorbed ester FCE 22891 ; with 13 tables ed. by Susumu Mitsuhashi ... Tokyo Japan Scientific Societies Pr. 1991 Berlin <<[u.a.]>> Springer X, 130 S. zahlr. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Penemantibiotikum (DE-588)4289672-1 gnd rswk-swf Penemantibiotikum (DE-588)4289672-1 s DE-188 Mitsuhashi, Susumu edt GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=021685559&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Penem antibiotics FCE 22101 and its orally absorbed ester FCE 22891 ; with 13 tables Penemantibiotikum (DE-588)4289672-1 gnd |
| subject_GND | (DE-588)4289672-1 |
| title | Penem antibiotics FCE 22101 and its orally absorbed ester FCE 22891 ; with 13 tables |
| title_auth | Penem antibiotics FCE 22101 and its orally absorbed ester FCE 22891 ; with 13 tables |
| title_exact_search | Penem antibiotics FCE 22101 and its orally absorbed ester FCE 22891 ; with 13 tables |
| title_full | Penem antibiotics FCE 22101 and its orally absorbed ester FCE 22891 ; with 13 tables ed. by Susumu Mitsuhashi ... |
| title_fullStr | Penem antibiotics FCE 22101 and its orally absorbed ester FCE 22891 ; with 13 tables ed. by Susumu Mitsuhashi ... |
| title_full_unstemmed | Penem antibiotics FCE 22101 and its orally absorbed ester FCE 22891 ; with 13 tables ed. by Susumu Mitsuhashi ... |
| title_short | Penem antibiotics |
| title_sort | penem antibiotics fce 22101 and its orally absorbed ester fce 22891 with 13 tables |
| title_sub | FCE 22101 and its orally absorbed ester FCE 22891 ; with 13 tables |
| topic | Penemantibiotikum (DE-588)4289672-1 gnd |
| topic_facet | Penemantibiotikum |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=021685559&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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