Atherosclerosis: molecular and cellular mechanisms
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Weinheim
Wiley-VCH-Verl.
2010
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| Schlagworte: | |
| Online-Zugang: | Inhaltstext Inhaltsverzeichnis |
| Beschreibung: | Literaturangaben |
| Beschreibung: | XXI, 398 S. Ill., graph. Darst. |
| ISBN: | 9783527324484 |
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28 CONTENTS PREFACE XV LIST OF CONTRIBUTORS XVII PART I INTRODUCTION 7 1
PATHOGENESIS OF ATHEROSCLEROSIS 3 SARAH JANE GEORGE AND CRESSIDA LYON
1.1 EPIDEMIOLOGY OF CORONARY HEART DISEASE 3 1.2 RISK FACTORS 3 1.3
ATHEROSCLEROSIS 5 1.4 INITIATION OF PLAQUE FORMATION- ENDOTHELIAL
DYSFUNCTION 9 1.5 INFLAMMATION 10 1.6 FOAM CELL FORMATION 12 1.7
VASCULAR SMOOTH MUSCLE CELL MIGRATION AND PROLIFERATION 13 1.8 PLAQUE
RUPTURE AND THROMBUS FORMATION 14 REFERENCES 16 PART II PRO-LNFLAMMATORY
FACTORS 21 2 CHEMOKINES AND ATHEROSCLEROSIS: A CRITICAL ASSESSMENT OF
THERAPEUTIC TARGETS 23 GEMMA E. WHITE, KEITH M. CHANNON, AND DAVID R.
GREAVES 2.1 INTRODUCTION 23 2.1.1 CHEMOKINES 23 2.1.2 CHEMOKINE
RECEPTORS 24 2.1.3 CHEMOKINE FUNCTIONS 24 2.2 KEY CHEMOKINE FUNCTIONS IN
ATHEROGENESIS 25 2.3 EXPERIMENTAL EVIDENCE FOR THE ROLE OF CHEMOKINES IN
ATHEROSCLEROSIS 27 2.3.1 CCL2 ACTING VIA CCR2 BIBLIOGRAFISCHE
INFORMATIONEN HTTP://D-NB.INFO/996244891 DIGITALISIERT DURCH VI I
CONTENTS 2.3.2 CCL3, 4, 5 ACTING VIA CCR1 AND CCR5 28 2.3.3 CXCL9.10, 11
ACTING VIA CXCR3 29 2.3.4 CXCL1/CXCL8 ACTING VIA CXCR2 30 2.3.5 CX 3 CL1
ACTING VIA CX,CR1 30 2.4 STRATEGIES FOR TARGETING CHEMOKINES IN
ATHEROSCLEROSIS 31 2.4.1 NEUTRALIZING ANTIBODIES 31 2.4.2 SMALL MOLECULE
INHIBITORS 32 2.4.3 MUTANT CHEMOKINES 33 2.4.3.1 N-TERMINAL CHEMOKINE
MUTANTS 33 2.4.3.2 DISRUPTION OF OLIGOMERIZATION 34 2.4.4 BROAD-SPECTRUM
CHEMOKINE BLOCKADE 34 2.5 CONCLUSIONS AND FUTURE CLINICAL PROSPECTS FOR
CHEMOKINE TARGETING 35 REFERENCES 37 3 ADHESION MOLECULES AND
ATHEROSCLEROSIS 43 HUAN WANG AND YUQING HUO 3.1 THE LEUKOCYTE ADHESION
CASCADE IN ATHEROSCLEROSIS 43 3.2 BACKGROUND ON ADHESION MOLECULES 44
3.2.1 SELECTINS AND THEIR LIGANDS 44 3.2.2 IMMUNOGLOBULIN SUPERFAMILY
AND ITS COUNTERRECEPTORS 45 3.3 ADHESION MOLECULES AND RISK FACTORS OF
ATHEROSCLEROSIS 46 CONTENTS VII 4.5.9 TGFSS/IL-10 AND T REG -RELATED
CYTOKINES 76 4.6 CONCLUSION 77 REFERENCES 78 5 TOLL-LIKE RECEPTORS IN
ATHEROSCLEROSIS 85 ZHONG-QUN YAN, KRISTINA EDFELDT, AND ANNA M. LUNDBERG
5.1 INTRODUCTION 85 5.2 TOLL-LIKE RECEPTORS, MOLECULAR PATTERN
RECOGNITION, AND SIGNAL TRANSDUCTION PATHWAYS 85 5.3 TLR EXPRESSION
PATTERNS IN ATHEROSCLEROSIS 90 5.4 TLRS IN THE PATHOGENESIS OF
ATHEROSCLEROSIS 90 5A.I TLRS ON VASCULAR CELLS- IN VITRO STUDIES 90
5.4.2 GENETIC VARIANTS OF TLRS AND THEIR ASSOCIATION WITH CAD 91 5.4.3
THE ROLE OF TLRS IN ATHEROSCLEROSIS-EXPERIMENTAL MODELS 92 5.5 EXOGENOUS
TLR LIGANDS-INFECTIONS IN ATHEROSCLEROSIS 93 5.6 ENDOGENOUS TLR
LIGANDS-TRIGGERING INFLAMMATION IN THE ABSENCE OF EXOGENOUS INFECTIOUS
STIMULI 93 5.7 SUMMARY 94 ACKNOWLEDGMENTS 95 REFERENCES 95 6 PPAR-BASED
THERAPIES FOR THE MANAGEMENT OF ATHEROSCLEROSIS 705 FLORENCE VIII
CONTENTS 6.4.1 PPARY ACTIONS IN THE VASCULATURE 121 6.4.1.1 VASCULAR
ENDOTHELIUM 121 6.4.1.2 MONOCYTES/MACROPHAGES/T LYMPHOCYTES 122 6.4.1.3
SMCS 123 6.4.2 PPARY IN ANIMAL MODELS OF ATHEROSCLEROSIS AND ASSOCIATED
VASCULAR COMPLICATIONS 124 6.4.3 PPARY IN HUMAN CARDIOVASCULAR CLINICAL
DISEASES 125 6.5 PPARS: CONCLUSION AND PERSPECTIVES 127 ACKNOWLEDGMENT
128 REFERENCES 128 7 PENTRAXINS IN VASCULAR PATHOLOGY: THE ROLE OF PTX3
737 ALBERTO MANTOVANI, CECILIA GARLANDA, BARBARA BOTTAZZI, FABIOLA
MOLLA, AND ROBERTO LATINI 7.1 INTRODUCTION 137 7.2 THE PENTRAXIN
SUPERFAMILY 137 7.3 GENE AND PROTEIN PRODUCTION AND REGULATION 138 7.4
ROLE OF PTX3 IN INNATE IMMUNITY AND INFLAMMATION 141 7.5 PTX3 IN MODELS
OF VASCULAR PATHOLOGY 144 7.6 PTX3 AS MARKER OF VASCULAR PATHOLOGY 145
7.7 CONCLUDING REMARKS 148 ACKNOWLEDGMENT 148 REFERENCES 148 PART III
PROTEASES 755 8 CONTENTS IX 9.3 REGULATION 374 9.4 CATHEPSINS IN
(PATHO)PHYSIOLOGICAL TISSUE REMODELING 174 9.5 CATHEPSINS IN
ATHEROSCLEROSIS 175 9.5.1 EXPRESSION OF CATHEPSINS IN HUMAN
ATHEROSCLEROSIS 275 9.5.2 THE ROLE OF CATHEPSINS IN ATHEROGENESIS:
LESSONS LEARNED FROM ANIMAL MODELS 277 9.5.3 CATHEPSINS IN
ATHEROSCLEROSIS: POTENTIAL MECHANISMS 177 9.5.3.1 CATHEPSINS ARE
REGULATED BY SHEAR STRESS 177 9.5.3.2 CATHEPSINS MEDIATE LEUKOCYTE AND
SMC MIGRATION 178 9.5.3.3 CATHEPSIN-INDUCED ECM DEGRADATION IN
ATHEROSCLEROSIS 179 9.5.3.4 CATHEPSIN-MEDIATED NEOVASCULARIZATION 180
9.5.3.5 CATHEPSINS MEDIATE INFLAMMATION 180 9.5.3.6 APOPTOSIS 182
9.5.3.7 LIPID METABOLISM 182 9.5.3.8 THROMBUS FORMATION 183 9.5.4
CATHEPSINS IN PLAQUE INSTABILITY 184 9.6 THERAPEUTIC POTENTIAL 284 9.7
CONCLUSIONS 184 REFERENCES 185 10 THE PLASMIN SYSTEM AND ATHEROSCLEROSIS
793 CHRISTOPHER L JACKSON, AND KEVIN G.S. CARSON 10.1 INTRODUCTION 193
10.2 COMPONENTS OF THE PLASMIN SYSTEM 193 X CONTENTS 11 MAST CELL
PROTEASES AND ATHEROSCLEROSIS 207 PETRI T. KOVANEN 11.1 INTRODUCTION 207
11.2 MAST CELL PROGENITORS ENTER THE ARTERIAL INTIMA AND DIFFERENTIATE
INTO MATURE MAST CELLS FILLED WITH PROTEASE-CONTAINING CYTOPLASMIC
SECRETORY GRANULES 207 11.3 MAST CELLS IN FATTY STREAK LESIONS AND
MECHANISMS BY WHICH THEIR PROTEASES MAY CONTRIBUTE TO FOAM CELL
FORMATION 209 11.3.1 PROTEOLYTIC DEGRADATION OF LDL PARTICLES BY MAST
CELL CHYMASE 209 11.3.2 PROTEOLYTIC DEGRADATION OF HDL PARTICLES BY MAST
CELL CHYMASE AND TRYPTASE 212 11A MAST CELLS IN ADVANCED CORONARY
ATHEROSCLEROTIC PLAQUES, AND MECHANISMS BY WHICH THEY MAY PROMOTE PLAQUE
RUPTURE AND EROSION 225 11.4.1 POTENTIAL MECHANISMS BY WHICH MAST CELL
PROTEASES INDUCE LOSS OF EXTRACELLULAR MATRIX AND SMOOTH MUSCLE CELLS IN
ATHEROSCLEROTIC PLAQUES 226 11.4.2 POTENTIAL MECHANISMS BY WHICH MAST
CELL INDUCE DEATH OR DETACHMENT OF ENDOTHELIAL CELLS IN ATHEROSCLEROTIC
PLAQUES 238 11.5 MAST CELLS AROUND CORONARY PLAQUE NEOVESSELS
-ADDITIONAL MECHANISMS BY WHICH MAST CELL PROTEASES MAY PROMOTE PLAQUE
VULNERABILITY 220 11.6 GENETICALLY AND PHARMACOLOGICALLY MANIPULATED
MICE-AN OPPORTUNITY TO RIGOROUSLY TEST THE ROLE OF MAST CELL PROTEASES
IN ATHEROGENESI CONTENTS XI 12.2.5.3 NOVEL LIGANDS 239 12.2.5.4 OTHER
MECHANISMS OF SRS IN ATHEROSCLEROSIS 239 12.3 ENZYMATIC MODIFICATIONS OF
LDL LEADING TO FOAM CELL FORMATION 240 12.4 NATIVE LIPOPROTEIN RECEPTORS
AND FOAM CELL FORMATION 242 12.5 RECEPTOR-INDEPENDENT MACROPHAGE
CHOLESTEROL ACCUMULATION 243 12.6 MACROPHAGE CHOLESTEROL EFFLUX PATHWAYS
244 12.7 SUMMARY 245 REFERENCES 246 PART V OXIDATIVE STRESS 255 13 NADPH
OXIDASE AND ATHEROSCLEROSIS 257 JAMIE Y.JEREMY, SAIMA MUZAFFAR, CARINA
MILL AND NILIMA SHUKLA 13.1 INTRODUCTION 257 13.2 BIOLOGY OF NAPDH
OXIDASES 257 13.3 STUDIES IN HUMAN TISSUES AND KNOCKOUT MICE 259 13.4
APOPTOSIS 261 13.5 CELL PROLIFERATION AND MIGRATION 262 13.6 NITRIC
OXIDE 263 13.7 EICOSANOIDS 265 13.8 ANGIOGENESIS AND NEOVASCULARIZATION
268 13.9 MMPS, WNT-SS CATENIN AND FORKHEAD BOX (FOX) SIGNALING PATHWAY
269 13.10 THERAPEUTIC STRATEGIES INVOLVING INHIBITION OF NOX 270 13.11
CONCLUDING REMARKS 271 XII CONTENTS 14.3.3 THE RATIO OF REDUCED TO
OXIDIZED BIOPTERINS IN ENOS REGULATION 283 14.4 ENOS UNCOUPLING IN
EXPERIMENTAL DISEASE MODELS 283 14.4.1 DIABETES AND INSULIN RESISTANCE
286 14.4.2 HYPERTENSION 286 14.4.3 HYPERCHOLESTEROLEMIA 287 14.5 HUMAN
STUDIES 288 14.5.1 STUDIES OF ISOLATED BLOOD VESSELS 288 14.5.2 CLINICAL
STUDIES 289 14.6 CONCLUSION 291 ACKNOWLEDGMENTS 292 REFERENCES 292 15
HEME OXYGENASE-1 AND ATHEROSCLEROSIS 307 JUSTIN C. MASON AND FAISAL ALI
15.1 BACKGROUND 301 15.2 HEME OXYGENASES 301 15.3 EPIDEMIOLOGY 303
15.3.1 HO-1 PROMOTER POLYMORPHISMS 303 15.4 EXPRESSION OF HO-1 IN
ATHEROSCLEROTIC PLAQUES 304 15.5 GENETIC MODIFICATION OF HO-1 305 15.6
PROTECTION AGAINST ISCHEMIA-REPERFUSION INJURY 306 15.7 HOW DOES HO-1
EXERT ITS EFFECTS 307 15.7.1 CARBON MONOXIDE 307 15.7. CONTENTS XIII
16.2.1 MORPHOLOGICAL FEATURES 328 16.2.2 CYTOSKELETAL FEATURES 328 16.3
IN VITRO ESTABLISHMENT OF SMC PHENOTYPIC SWITCH 330 16.3.1
IDENTIFICATION OF SMC SUBPOPULATIONS IN ANIMAL MODELS 330 16.3.2
IDENTIFICATION OF SMC SUBPOPULATIONS IN HUMANS 333 16.3.3 BIOLOGICAL
FEATURES OF SMC SUBPOPULATIONS 332 16.3.3.1 PROLIFERATIVE ACTIVITY AND
APOPTOSIS 332 16.3.3.2 MIGRATORY AND PROTEOLYTIC ACTIVITIES 332 16.3.3.3
CYTOSKELETAL FEATURES 332 16.3.3.4 OTHER FEATURES 333 16.3.4 BIOMARKERS
OF SMC SUBPOPULATIONS 333 16.4 FACTORS INFLUENCING SMC PHENOTYPIC SWITCH
335 16.5 CONCLUSIONS AND PERSPECTIVES 336 ACKNOWLEDGMENTS 337 REFERENCES
337 17 PLATELETS: THEIR ROLE IN ATHEROGENESIS AND THROMBOSIS IN CORONARY
ARTERY DISEASE 343 MATTHEW T. HARPER, LUCY MACCARTHY-MORROGH, MATTHEW L.
JONES, OLGA KONOPATSKAYA, AND ALASTAIR W. POOLE XL.X INTRODUCTION 343
17.2 PLATELETS 343 XIV CONTENTS 17.4.1.7 ACTIVATED PLATELETS ENHANCE
TF-MEDIATED THROMBIN GENERATION 355 17.5 MECHANISMS OF PLATELET GRANULE
SECRETION 356 17.5.1 MOLECULAR REGULATION OF PLATELET EXOCYTOSIS 356
17.6 CONCLUSION 357 REFERENCES 358 18 MODULATORS OF MONOCYTE AND
MACROPHAGE PHENOTYPES IN ATHEROSCLEROSIS 365 JASON L JOHNSON AND
NICHOLAS P. JENKINS 18.1 INTRODUCTION 365 18.1.1 ORIGIN OF MONOCYTE AND
MACROPHAGE POPULATIONS 365 18.1.2 HUMAN MONOCYTE HETEROGENEITY 367
18.1.2.1 CDI47CDI6-MONOCYTES 367 18.1.2.2 CD14 + /CD16 + MONOCYTES 367
18.1.3 MOUSE MONOCYTE HETEROGENEITY 370 18.1.3.1 CD1157LY6C HIGH
MONOCYTES 370 18.1.3.2 CD1157LY6C LOW MONOCYTES 370 18.1.4 HUMAN
MACROPHAGE HETEROGENEITY 371 18.1.4.1 RECRUITED MACROPHAGES 372 18.1.4.2
RESIDENT MACROPHAGES 373 18.2 ROLE OF MONOCYTES/MACROPHAGES IN
ATHEROSCLEROSIS 375 |
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| publisher | Wiley-VCH-Verl. |
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| spelling | Atherosclerosis molecular and cellular mechanisms ed. by Sarah Jane George ... Weinheim Wiley-VCH-Verl. 2010 XXI, 398 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Literaturangaben Cytologie (DE-588)4070177-3 gnd rswk-swf Arteriosklerose (DE-588)4068866-5 gnd rswk-swf Molekularbiologie (DE-588)4039983-7 gnd rswk-swf Plaque Medizin (DE-588)4174819-0 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Arteriosklerose (DE-588)4068866-5 s Plaque Medizin (DE-588)4174819-0 s Molekularbiologie (DE-588)4039983-7 s Cytologie (DE-588)4070177-3 s DE-604 George, Sarah Jane edt text/html http://deposit.dnb.de/cgi-bin/dokserv?id=3348534&prov=M&dok_var=1&dok_ext=htm Inhaltstext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020201501&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Atherosclerosis molecular and cellular mechanisms Cytologie (DE-588)4070177-3 gnd Arteriosklerose (DE-588)4068866-5 gnd Molekularbiologie (DE-588)4039983-7 gnd Plaque Medizin (DE-588)4174819-0 gnd |
| subject_GND | (DE-588)4070177-3 (DE-588)4068866-5 (DE-588)4039983-7 (DE-588)4174819-0 (DE-588)4143413-4 |
| title | Atherosclerosis molecular and cellular mechanisms |
| title_auth | Atherosclerosis molecular and cellular mechanisms |
| title_exact_search | Atherosclerosis molecular and cellular mechanisms |
| title_full | Atherosclerosis molecular and cellular mechanisms ed. by Sarah Jane George ... |
| title_fullStr | Atherosclerosis molecular and cellular mechanisms ed. by Sarah Jane George ... |
| title_full_unstemmed | Atherosclerosis molecular and cellular mechanisms ed. by Sarah Jane George ... |
| title_short | Atherosclerosis |
| title_sort | atherosclerosis molecular and cellular mechanisms |
| title_sub | molecular and cellular mechanisms |
| topic | Cytologie (DE-588)4070177-3 gnd Arteriosklerose (DE-588)4068866-5 gnd Molekularbiologie (DE-588)4039983-7 gnd Plaque Medizin (DE-588)4174819-0 gnd |
| topic_facet | Cytologie Arteriosklerose Molekularbiologie Plaque Medizin Aufsatzsammlung |
| url | http://deposit.dnb.de/cgi-bin/dokserv?id=3348534&prov=M&dok_var=1&dok_ext=htm http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020201501&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT georgesarahjane atherosclerosismolecularandcellularmechanisms |