Perinatal stem cells:
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Hoboken, NJ
Wiley Blackwell
2009
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| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIV, 214 S. Ill. |
| ISBN: | 9780470420843 |
Internformat
MARC
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| 700 | 1 | |a Cetrulo, Curtis L. |4 edt | |
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Datensatz im Suchindex
| _version_ | 1804142790354927616 |
|---|---|
| adam_text | Titel: Perinatal stem cells
Autor: Cetrulo, Curtis L.
Jahr: 2009
CONTENTS
PREFACE xi
CONTRIBUTORS xiii
INTRODUCTION: PERINATAL STEM CELLS xv
1 CORD BLOOD TRANSPLANTS: PERINATAL STEM CELLS IN
CLINICAL PRACTICE 1
Richard L. Haspel and Karen K. Ballen
Introduction I
Hematopoietic Stem Cell Transplants: Adult Donor Collection I
Hematopoietic Stem Cell Transplants: Adult Donor Testing 2
Hematopoietic Stem Cell Transplants: Recipient Issues 3
Collection and Processing of Cord Blood Units 4
Bone Marrow versus Single Cord Blood: Pediatric 5
Bone Marrow versus Cord Blood: Adults 6
Cord Blood Transplant: Advantages and Disadvantages 7
Double Cord Blood Transplants: Ablative Regimens 8
Double Cord Blood Transplant: Non-Myeloablative Regimens 9
Chimerism 10
Predicting the Winner 12
Are Two Cords Better Than One? 13
Other Experimental Strategies 14
Summary 14
References 14
2 EXPANDING THE THERAPEUTIC POTENTIAL OF UMBILICAL
CORD BLOOD HEMATOPOIETIC STEM CELLS 21
Rouzbeh R. Taghizadeh and James L. Sherley
Introduction: Hematopoietic Stem Cells, the Therapeutic Distributed
Stem Cells in Umbilical Cord Blood 21
Biological Barriers to Hematopoietic Stem Cell Therapy 24
Umbilical Cord Blood: An Ideal Source of Therapeutic Hematopoietic
Stem Cells 27
v
CONTENTS
Shortcomings of Ex Vivo HSC Expansion Strategies 29
A Novel Strategy With Potential to Enable Ex Vivo Expansion of
Umbilical Cord Blood Hematopoietic Stem Cells 32
Acknowledgments 34
References 35
3 USE OF FETAL CELLS IN REGENERATIVE MEDICINE 41
Christian Breymann
Introduction 41
Principles of Tissue Engineering 42
Cell Sources for Tissue Engineering 43
Examples of Possible Use and Implications of Perinatal Stem Cells 43
Placental Derived Stem Cells (Chorionic, Amniotic Membranes) 44
Amniotic Derived Stem Cells QiAMSC/PlacentaV.) 44
Amniotic Fluid-Derived Stem Cells (NonplacentaK) 45
Conclusion 46
References 48
4 PERINATAL STEM CELL THERAPY 51
Daniel Surbek, Anna Wagner, and Andreina Schoeberlein
The Fetus as Recipient for Pre- and Perinatal Stem Cell Transplantation 5I
Prenatal Cell Transplantation: Current Experience 52
How Do We Improve the Success of Prenatal Stem Cell Transplantation? 53
Mesenchymal Stem Cells for Prenatal Transplantation 54
Fetal Gene Therapy as a New Strategy 54
Current Issues of Postnatal Gene Therapy 55
Prenatal Gene Therapy 5~l
Animal Models of Prenatal Gene Therapy 58
Fetal Gene Therapy Targeting Hematopoietic Stem Cells 58
Safety Aspects of Prenatal Gene Therapy 59
Ethical Considerations 60
References 60
5 UMBILICAL CORD MESENCHYMAL STEM CELLS 69
Laurent Boissel, Monica Betancur, Hans Klingemann,
and James Marchand
Preparation and Culture of UC-MSC 69
Characteristics-Properties and Bone Marrow Comparison 71
UC-MSC as Feeder Layer for Expansion of Human Cells 73
Clinical Indications for UC-MSC 75
References 75
CONTENTS Vii
6 WHARTON S JELLY-DERIVED MESENCHYMAL
STROMAL CELLS 79
Barbara Lutjemeier, Deryl L. Troyer, and Mark L. Weiss
Mesenchymal Stromal Cells 79
Immunophenotype of Mesenchymal Stromal Cells 81
MSCs are Multipotent Cells 81
MSC and Stromal Support of the Stem Cell Niche 81
Defining Primitive Stromal Cells: Differences between Fetal and
Adult MSCs 81
Umbilical Cord MSCs 82
Characterization of Wharton s Jelly Derived Cells 83
Other MSC-Like Cells from Umbilical Cord 83
Comparison of WJCs to Adult Derived MSCs 84
In Vitro Differentiation of WJCs 85
Comparison of WJCs to Fetal MSCs 86
Transplantation of WJCs 86
WJCs as Primitive Stromal Cells 89
Summary 90
Acknowledgments 90
References 90
7 PERINATAL ENDOTHELIAL PROGENITOR CELLS 95
Curtis L. Cetrulo, Jr. and Margaret J. Starnes
The Role of Vascular Stem Cells in Postnatal Blood Vessel Formation:
Endothelial Progenitor Cells and Postnatal Vasculogenesis 95
Sources of Endothelial Progenitor Cells 96
EPCs, Vasculogenesis and Angiogenesis 96
EPCs and Tissue Engineering 97
EPCs and Cardiovascular Tissue Engineering 98
The Future: Vascularized Engineered Tissue 99
References 99
8 UMBILICAL CORD DERIVED MAST CELLS AS MODELS
FOR THE STUDY OF INFLAMMATORY DISEASES 103
Taxiarchis Kourelis, Duraisamy Kempuraj, Akrivi Manola, and Theoharis
C- Thc oharides
Introduction 103
Mast Cell Triggers 106
Mast Cell Mediators 109
Selective Release of Mast Cell Mediators 111
Natural Mast Cell Secretion Inhibitors 112
Mast-T Cell Interaction 113
Inflarnrnatory Skin Diseases 113
CONTENTS
Fibromyalgia Syndrome 115
Asthma 117
Inflammatory Arthritis 119
Coronary Inflammation 120
Ocular Hypersensitivity Reactions 122
Conclusion 122
References 123
9 AMNIOTIC FLUID DERIVED STEM CELLS 147
Ming-Song Tsai
Introduction 147
Amniotic Fluid Cells 147
The Discovery of Stem Cells in Amniotic Fluid 149
Cultivation of Amniotic Fluid Derived Stem Cells 150
Characteristics of Amniotic Fluid Derived Stem Cells 150
Differentiation Potential of Amniotic Fluid Stem Cells 153
Amniotic Fluid as a Promising Alternative Source for
Neural Stem Cells 153
Current Applications of Amniotic Fluid Stem Cells in Therapy 155
Amniotic Fluid Stem Cells Banking 155
References 155
10 AMNIOTIC EPITHELIAL STEM CELLS IN REGENERATIVE MEDICINE 159
Fabio Marongiu, Roberto Gramignoli, Toshio Miki, Aarati Ranade,
Ewa C.S. Ellis, Kenneth Dorko, Stephen C. Strom, and Julio C. Davila
Introduction 159
Amnion and Its Properties 160
Isolation and Culture of hAE Cells 160
Stem Cell Characteristics of Amniotic Epithelium-Derived Cells 161
Differentiation of hAE Cells 162
Future Directions 163
Conclusions 164
Acknowledgment 165
References 165
11 HUMAN UMBILICAL VEIN ENDOTHEUAL CELLS AND HUMAN
DERMAL MICROVASCULAR ENDOTHEUAL CELLS OFFER NEW
INSIGHTS INTO THE RELATIONSHIP BETWEEN LIPID
METABOLISM, ANGIOGENESIS, AND ABDOMINAL
AORTIC ANEURYSM 169
Ho-Jin Park, Yali Zhang, Jack Naggar, Serban P. Georgescu,
Dequen Kong, and Jonas B. Galper
Human Umbilical Vein Endothelial Cells 169
CONTENTS JX
Role of Angiogenesis in the Pathophysiology of Disease 170
HMG-CoA Reductase Inhibitors have Therapeutic Effects that are
Both Dependent and Independent of Cholesterol Lowering 171
Studies of the Effects of Statins on Angiogenesis Using Both In Vivo
Models and In Vitro HUVEC and HDMEC Models for Angiogenesis 171
References 185
12 HEMATOPOIETIC STEM CELL DEVELOPMENT IN THE PLACENTA 189
Katrin E. Rhodes and Hanna K.A. Mikkola
Introduction 189
The Hematopoietic System 189
Historical Perspective on Placental Hematopoiesis 190
Development and Structure of the Mouse Placenta 192
Hematopoietic Activity in the Mouse Placenta 193
Phenotype of Placental HSCs 194
Origin and Localization of Placental HSCs 195
Summary and Future Directions 198
References 199
13 FETAL CELL MICROCHIMERISM, A LOW-GRADE NATURALLY
OCCURRING CELL THERAPY 203
Michele Leduc, Selim Aractingi, and Kiarash Khosrotehrani
Introduction 203
The Placenta is a Source of Stem Cells 203
Transfer of Fetal Progenitor Cells During Gestation 204
Fetal Progenitor Cells in Maternal Tissues 205
Future Therapies 206
References 207
INDEX 209
|
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