Enzyme inhibition in drug discovery and development: the good and the bad
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Hoboken, NJ
Wiley
2010
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | XIII, 854 S. Ill., graph. Darst. |
| ISBN: | 9780470281741 047028174X |
Internformat
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| 500 | |a Includes bibliographical references and index | ||
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Datensatz im Suchindex
| _version_ | 1804142788342710272 |
|---|---|
| adam_text | Titel: Enzyme inhibition in drug discovery and development
Autor: Lu, Chuang
Jahr: 2010
CONTENTS
PREFACE ix
CONTRIBUTORS xi
PART I. DRUG DISCOVERY APPROACHES AND
TECHNOLOGIES 1
1. The Drug Discovery Process 3
Gerald T. Miwa
2. Medicinal Chemistry of the Optimization of
Enzyme Inhibitors 15
Geraldine Harriman, Amy Elder, and Indranath Ghosh
3. Bioanalytical Technologies in Drug Discovery 43
Jing-Tao Wu
4. Safety Biomarkers in Drug Development: Emerging Trends
and Implications 71
Eric R. Fedyk
5. The Role of Drug Metabolism in Drug Discovery 91
Tonika Bohnert and Liang-Shang Gan
CONTENTS
6. Applied Pharmacokinetics in Drug Discovery and
Development 177
Hua Yang, Xingrong Liu, Anjaneya Chimalakonda, Zheng Lu,
Cuiping Chen, Frank Lee, and Wen Chyi Shyu
PART II. INHIBITION OF THE DRUG METABOLIZING
ENZYMES?THE UNDESIRABLE INHIBITION 241
7. Enzyme Inhibition and Inactivation: Cytochrome
P450 Enzymes 243
R. Scott Obach
8. Cytochrome P450 Induction 265
Edward L. LeCluyse, Michael W. Sinz, Nicola Hewitt,
Stephen S. Ferguson, and Jasminder Sahi
9. Inhibition of Drug-Metabolizing Enzymes in the
Gastrointestinal Tract and Its Influence on the Drug-Drug
Interaction Prediction 315
Aleksandra Galetin and J. Brian Houston
10. Enzyme Inhibition in Various In Vitro Systems 345
Ping Zhao
11. Cytochrome P450 Degradation and Its Clinical Relevance 363
Mingxiang Liao, Ping Kang, Bernard P. Murray,
and Maria Almira Correia
12. Complexities of Working with UDP-Glucuronosyltransferases
(UGTs): Focus on Enzyme Inhibition 407
Michael B. Fisher
13. Evaluation of Inhibitors of Drug Metabolism in Human
Hepatocytes 423
Albert P. Li and Chuang Lu
14. Grapefruit Juice and Its Constituents as New Esterase
Inhibitors 443
Suresh K. Balani
CONTENTS vii
15. Transporter-Xenobiotic Interactions: An Important Aspect
of Drug Development Studies 467
Gang Luo, Richard Ridgewell, and Thomas Guenthner
16. Polymorphisms of Drug Transporters and Their
Clinical Implications 503
Cindy Q. Xia and Johnny J. Yang
17. Clinical Drug Interactions Due to Metabolic Inhibition:
Prediction, Assessment, and Interpretation 533
Lisa L. von Moltke and David J. Greenblatt
18. Predicting Interindividual Variability of Metabolic Drug-Drug
Interactions: Identifying the Causes and Accounting for
Them Using a Systems Approach 549
Amin Rostami-Hodjegan
PART III. INHIBITION OF THE DRUG TARGET
ENZYMES?THE DESIRABLE INHIBITION 569
19. NF-kB: Mechanism, Tumor Biology, and Inhibitors 571
Lenny Dang
20. G-Protein-Coupled Receptors as Drug Targets 625
Wenyan Miao and Lijun Wu
21. Pharmacological Modulation of Ion Channels for the
Treatment of Chronic Pain 669
Yi Liu and Ning Qin
22. Targeting the mTOR Pathway for Tumor Therapeutics 719
Wei Chen
23. HTV-1 Protease Inhibitors as Antiretroviral Agents 749
Sergei V. Gulnik, Elena Afonina, and Michael Eissenstat
INDEX 811
|
| any_adam_object | 1 |
| author2 | Lu, Chuang |
| author2_role | edt |
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| author_facet | Lu, Chuang |
| building | Verbundindex |
| bvnumber | BV025603784 |
| classification_rvk | VS 5350 |
| ctrlnum | (OCoLC)603576457 (DE-599)BVBBV025603784 |
| discipline | Chemie / Pharmazie |
| format | Book |
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| illustrated | Illustrated |
| indexdate | 2024-07-09T22:37:20Z |
| institution | BVB |
| isbn | 9780470281741 047028174X |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-020198955 |
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| physical | XIII, 854 S. Ill., graph. Darst. |
| publishDate | 2010 |
| publishDateSearch | 2010 |
| publishDateSort | 2010 |
| publisher | Wiley |
| record_format | marc |
| spelling | Enzyme inhibition in drug discovery and development the good and the bad ed. by Chuang Lu ... Hoboken, NJ Wiley 2010 XIII, 854 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and index Enzyminhibitor (DE-588)4152479-2 gnd rswk-swf Arzneimittelentwicklung (DE-588)4143176-5 gnd rswk-swf Enzyminhibitor (DE-588)4152479-2 s Arzneimittelentwicklung (DE-588)4143176-5 s DE-604 Lu, Chuang edt HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020198955&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Enzyme inhibition in drug discovery and development the good and the bad Enzyminhibitor (DE-588)4152479-2 gnd Arzneimittelentwicklung (DE-588)4143176-5 gnd |
| subject_GND | (DE-588)4152479-2 (DE-588)4143176-5 |
| title | Enzyme inhibition in drug discovery and development the good and the bad |
| title_auth | Enzyme inhibition in drug discovery and development the good and the bad |
| title_exact_search | Enzyme inhibition in drug discovery and development the good and the bad |
| title_full | Enzyme inhibition in drug discovery and development the good and the bad ed. by Chuang Lu ... |
| title_fullStr | Enzyme inhibition in drug discovery and development the good and the bad ed. by Chuang Lu ... |
| title_full_unstemmed | Enzyme inhibition in drug discovery and development the good and the bad ed. by Chuang Lu ... |
| title_short | Enzyme inhibition in drug discovery and development |
| title_sort | enzyme inhibition in drug discovery and development the good and the bad |
| title_sub | the good and the bad |
| topic | Enzyminhibitor (DE-588)4152479-2 gnd Arzneimittelentwicklung (DE-588)4143176-5 gnd |
| topic_facet | Enzyminhibitor Arzneimittelentwicklung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020198955&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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