Cancer chemotherapy: [basic science to the clinic]
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Chichester [u.a.]
Wiley-Blackwell
2009
|
| Ausgabe: | 1st publ. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Inhaltsverzeichnis |
| Beschreibung: | Literaturverz. S. [299]-330 |
| Beschreibung: | X, 341 S. Ill., graph. Darst. |
| ISBN: | 9780470092545 9780470092552 |
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| 250 | |a 1st publ. | ||
| 264 | 1 | |a Chichester [u.a.] |b Wiley-Blackwell |c 2009 | |
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Datensatz im Suchindex
| _version_ | 1804142788079517696 |
|---|---|
| adam_text | IMAGE 1
PREFACE
P. IX
CANCER EPIDEMIOLOGY
P. 1
CANCER INCIDENCE, PREVALENCE AND MORTALITY
P. 1
CHILDHOOD CANCERS
P. 3
GLOBAL EPIDEMIOLOGY
P. 6
HISTOPATHOLOGY OF CANCER
P. 11
INTRODUCTION
P. 11
MALIGNANT, BENIGN AND NORMAL (NON-MALIGNANT) TISSUE
P. 11
CELL DEATH
P. 12
CARCINOGENESIS, MALIGNANT TRANSFORMATION AND PROGRESSION
P. 19
INTRODUCTION
P. 19
CHEMICAL CARCINOGENESIS
P. 19
MOLECULAR BIOLOGY OF CANCER: ONCOGENES AND TUMOUR SUPPRESSOR GENES P. 23
INTRODUCTION
P. 23
ONCOGENESIS
P. 25
TUMOUR SUPPRESSOR GENES
P. 30
TUMOUR METASTASIS: A CONVERGENCE OF MANY THEORIES
P. 37
INTRODUCTION
P. 37
DETACHMENT AND MIGRATION FROM THE PRIMARY TUMOUR
P. 37
INTRAVASATION
P. 38
TRANSPORT
P. 42
EXTRAVASATION
P. 43
GROWTH OF THE METASTATIC TUMOUR MASS
P. 45
HEALTH PROFESSIONALS IN THE TREATMENT OF CANCER
P. 49
INTRODUCTION
P. 49
PATHOLOGY
P. 49
RADIOLOGY
P. 50
ROLE OF THE SURGICAL ONCOLOGIST
P. 51
ONCOLOGY PHARMACY
P. 52
ONCOLOGY NURSING
P. 53
THE NHS CANCER PLAN
P. 54
PRINCIPLES OF CANCER CHEMOTHERAPY
P. 55
INTRODUCTION
P. 55
TIMING OF CHEMOTHERAPY
P. 55
BIOMARKERS AND THEIR USES
P. 59
CLINICAL ASSESSMENT OF BIOMARKERS
P. 59
PHARMACOGENETICS AND PHARMACOGENOMICS OF CANCER CHEMOTHERAPY P. 64
CLASSICAL ANTICANCER AGENTS
P. 67
INTRODUCTION
P. 67
ALKYLATING AGENTS
P. 67
ANTIMETABOLITES
P. 71
IMAGE 2
AGENTS DERIVED FROM NATURAL OR SEMISYNTHETIC PRODUCTS
P. 77
HORMONAL ANTICANCER AGENTS
P. 106
CLINICALLY USED CHEMOTHERAPY REGIMENS
P. 111
THE PHILOSOPHY OF CANCER RESEARCH
P. 117
INTRODUCTION
P. 117
STRUCTURE OF CANCER RESEARCH ORGANIZATIONS IN THE UNITED KINGDOM P. 118
CANCER RESEARCH IN THE UNITED STATES
P. 120
NOVEL ANTICANCER AGENTS
P. 125
INTRODUCTION
P. 125
TARGET VALIDATION
P. 125
IDENTIFICATION AND OPTIMIZATION OF LEAD DRUGS
P. 146
PRECLINICAL PHARMACOLOGY
P. 148
CLINICAL TRIALS
P. 167
INTRODUCTION
P. 167
EVALUATION OF TREATMENT RESPONSE
P. 169
ASSESSMENT OF VASCULARITY AND ANGIOGENESIS BY NUCLEAR MEDICINE
TECHNOLOGY P. 173
TUMOUR HYPOXIA
P. 177
INTRODUCTION
P. 177
BIOREDUCTIVE DRUGS
P. 181
INHIBITORS OF HIF-1 AND HIF-1-REGULATED GENES
P. 187
ANTIANGIOGENIC AND ANTIVASCULAR AGENTS
P. 199
HISTORY OF ANGIOGENESIS AS A THERAPEUTIC TARGET
P. 199
ANTI-ANGIOGENIC DRUG TARGETS
P. 202
THE RETURN OF THALIDOMIDE
P. 209
MONOCLONAL ANTIBODIES AS ANTI-ANGIOGENIC AGENTS
P. 212
THE HOLLOW FIBRE ASSAY AS A DRUG SCREEN FOR ANTI-ANGIOGENIC DRUGS P. 213
VASCULAR DISRUPTING AGENTS
P. 215
TYROSINE KINASE INHIBITORS
P. 217
INTRODUCTION
P. 217
TYROSINE KINASE INHIBITORS TARGETING ANGIOGENESIS
P. 219
NON-RECEPTOR TYROSINE KINASE INHIBITORS
P. 221
RAS INHIBITORS
P. 225
INHIBITORS OF THE AKT/PKB PATHWAY
P. 229
TARGETING STRESS PROTEINS: HSP90 INHIBITORS
P. 233
THE PROTEASOME
P. 237
INTRODUCTION
P. 237
THE PROTEASOME AS A TARGET FOR NOVEL DRUG STRATEGIES
P. 239
UBIQUITYLATION AS A TARGET
P. 240
CHECKPOINT PROTEIN KINASES AS NOVEL TARGETS - MAMMALIAN TARGET OF
RAPAMYCIN (MTOR) P. 245
MAMMALIAN TARGET OF RAPAMYCIN
P. 245
STRUCTURE AND ACTIVATION OF MTOR
P. 246
IMAGE 3
NOVEL ANTICANCER AGENTS TARGETING MTOR
P. 248
TELOMERASE
P. 249
HISTONE DEACETYLASE: AN EPIGENETIC DRUG TARGET
P. 255
INTRODUCTION
P. 255
HDAC AND DNA PACKAGING
P. 255
HDAC INHIBITORS
P. 261
PHARMACEUTICAL PROBLEMS IN CANCER CHEMOTHERAPY
P. 265
MANIFESTATION OF TOXICITY
P. 265
REGIMEN-RELATED TOXICITY
P. 269
SECONDARY MALIGNANCIES
P. 270
DRUG RESISTANCE
P. 271
PHARMACEUTICAL COMPLICATIONS
P. 274
PHLEBITIS AND VENOUS IRRITATION
P. 279
HEALTH AND SAFETY
P. 279
NATIONAL GUIDANCE ON THE SAFE ADMINISTRATION OF INTRATHECAL CHEMOTHERAPY
P. 279
ONCOLOGY PHARMACY AT HOME AND ABROAD
P. 281
PRACTICE EXAM QUESTIONS
P. 283
BIBLIOGRAPHY AND FURTHER READING
P. 299
INDEX
P. 331
TABLE OF CONTENTS PROVIDED BY BLACKWELL S BOOK SERVICES AND R.R. BOWKER.
USED WITH PERMISSION.
|
| any_adam_object | 1 |
| author | Airley, Rachel |
| author_facet | Airley, Rachel |
| author_role | aut |
| author_sort | Airley, Rachel |
| author_variant | r a ra |
| building | Verbundindex |
| bvnumber | BV025603584 |
| classification_rvk | VS 9100 XI 7000 |
| ctrlnum | (OCoLC)637560407 (DE-599)BVBBV025603584 |
| dewey-full | 616.994061 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.994061 |
| dewey-search | 616.994061 |
| dewey-sort | 3616.994061 |
| dewey-tens | 610 - Medicine and health |
| discipline | Chemie / Pharmazie Medizin |
| edition | 1st publ. |
| format | Book |
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| id | DE-604.BV025603584 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T22:37:20Z |
| institution | BVB |
| isbn | 9780470092545 9780470092552 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-020198773 |
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| physical | X, 341 S. Ill., graph. Darst. |
| publishDate | 2009 |
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| spelling | Airley, Rachel Verfasser aut Cancer chemotherapy [basic science to the clinic] Rachel Airley 1st publ. Chichester [u.a.] Wiley-Blackwell 2009 X, 341 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Literaturverz. S. [299]-330 Chemotherapie (DE-588)4127083-6 gnd rswk-swf Krebs Medizin (DE-588)4073781-0 gnd rswk-swf Cytostatikum (DE-588)4068347-3 gnd rswk-swf Krebs Medizin (DE-588)4073781-0 s Chemotherapie (DE-588)4127083-6 s Cytostatikum (DE-588)4068347-3 s DE-604 DE-601 pdf/application http://www.gbv.de/dms/bowker/toc/9780470092552.pdf Inhaltsverzeichnis GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020198773&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Airley, Rachel Cancer chemotherapy [basic science to the clinic] Chemotherapie (DE-588)4127083-6 gnd Krebs Medizin (DE-588)4073781-0 gnd Cytostatikum (DE-588)4068347-3 gnd |
| subject_GND | (DE-588)4127083-6 (DE-588)4073781-0 (DE-588)4068347-3 |
| title | Cancer chemotherapy [basic science to the clinic] |
| title_auth | Cancer chemotherapy [basic science to the clinic] |
| title_exact_search | Cancer chemotherapy [basic science to the clinic] |
| title_full | Cancer chemotherapy [basic science to the clinic] Rachel Airley |
| title_fullStr | Cancer chemotherapy [basic science to the clinic] Rachel Airley |
| title_full_unstemmed | Cancer chemotherapy [basic science to the clinic] Rachel Airley |
| title_short | Cancer chemotherapy |
| title_sort | cancer chemotherapy basic science to the clinic |
| title_sub | [basic science to the clinic] |
| topic | Chemotherapie (DE-588)4127083-6 gnd Krebs Medizin (DE-588)4073781-0 gnd Cytostatikum (DE-588)4068347-3 gnd |
| topic_facet | Chemotherapie Krebs Medizin Cytostatikum |
| url | http://www.gbv.de/dms/bowker/toc/9780470092552.pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020198773&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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