Short and long term influences of Chlamydia trachomatis infection on host cell cycle, apoptosis and senescence programs:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
Berlin
Mensch und Buch Verl.
2009
|
| Schriftenreihe: | Biological science
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | dt. Zusammenfassung |
| Beschreibung: | 133 S. Ill., graph. Darst. |
| ISBN: | 9783866647183 |
Internformat
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Datensatz im Suchindex
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| adam_text | TABLE OF CONTENT 1 TABLE OF CONTENT TABLE OF CONTENT 1 TABLE OF CONTENT
2 2 ABBREVIATIONS 5 3 DEUTSCHE ZUSAMMENFASSUNG 7 4 ABSTRACT 9 5
INTRODUCTION 11 5.1 SIGNALING NETWORK IN SENESCENCE 11 5.1.1 SENESCENCE
11 5.1.2 TELOMERE DYSFUNCTION AND THE P53 RESPONSE 12 5.1.3 IMPORTANCE
OF P53 AS A TUMOR SUPPRESSOR 13 5.2 P53 TUMOR SUPPRESSOR SIGNALING AND
REGULATION 14 5.2.1 OVERVIEW OF P53 FUNCTIONS 14 5.2.2 P53 STRUCTURE 15
5.2.3 P53 POSTTRANSLATTONAI MODIFICATIONS 15 5.2.4 TARGET PROMOTER
SELECTIVITY OF P53 16 5.2.5 MOUSE MODELS OF P53 REGULATION 17 5.2.6
MDM2, MDM4, ARF AND P53 REGULATION 18 5.3 TRANSCRIPTIONAL TARGETS OF P53
20 5.3.1 HTERT ACTIVITY AND TRANSCRIPTIONAL REGULATION 20 5.3.2 P21
ACTIVITY AND TRANSCRIPTIONS! REGULATION 25 5.4 REGULATION OF P53
ACTIVITY BY HTTRT 27 5.5 SUMMARY OF INTERACTIONS IN THE P53, HTERT P21
NETWORK 28 5.6 EPIGENETICS 29 5.6.1 DEFINITION OF EPIGENETIC CHANGES 29
5-6.2 DNA METHYLATION 29 5.6.3 EPIGENETIC COMPONENTS OF HTERT, P21 AND
P53 REGULATION 31 5.7 CHLAMYDIA 33 5.7.1 CHIAMYDIA CLASSIFICATION 33
5.7.2 CNONRYDTO FIFE EYEFE 33 5.7.3 INFLUENCES OF CNAMYDFA ONTO HOST
CELT »GNAT TRANSDUCTION. 34 5-7. BIBLIOGRAFISCHE INFORMATIONEN
HTTP://D-NB.INFO/1000287254 DIGITALISIERT DURCH TABLE OF CONTENT 5.7.5
CHLOMYDIA AND APOPTOSIS 35 5.7.6 CHLOMYDIA AND THE HOST CELL CYCLE 36
5.7.7 DISEASES RESULTING FROM CHLAMYDIAL INFECTION 37 5.7.8 CHLAMYDIAL
PERSISTENCE AND CO-CULTURE 37 5.8 IMR90E1A CELL LINE 38 5.8.1 IMR90
CELLS 38 5.8.2 ADENOVIRUS 39 5.8.3 E1A 39 5.8.4 P53 AND E1A 42 5.9
OBJECTIVE OF THIS WORK 43 6 MATERIAL AND METHODS 44 6.1 MATERIAL 44
6.1.1 BACTERIA AND CELL LINES 44 6.1.2 CELL MEDIA AND SOLUTIONS 44 6.1.3
CHEMICALS, ENZYMES AND CONSUMABLES 44 6.1.4 REALTIME PCR-PRIMER *6 6.1.5
PRIMER FOR CHIP 46 6.1.6 SIRNA OLIGINUCLEOTIDES 47 6.1.7 BIOTINYLATED
EMSA PROBES 47 6.1.8 VECTORS 47 6.1.9 KITS 47 6.1.10 SOLUTIONS AND
BUFFERS 48 6.1.11 ANTIBODIES 51 61.12 EQUIPMENT 52 6.1.13 SOFTWARE 52
6.2 METHODS 53 6.2.1 CELL CULTURE 53 6.2.2 CHLAMYDIA 56 6.2.3
IMMUNOSTAINING 58 6.2.4 PROTEINS 58 6.2.5 NUCLEIC ACIDS 61 6.2.6
ENZYMATIC ACTIVITY ASSAY IHTERT) 63 6.2.7 CBEMILUMINESCENT LUCIFERAS
ASSAY JP53 64 TABLE OF CONTENT 6.2.8 FLOW CYTOMETRY 65 6.2.9 CFSE
PROLIFERATION ASSAY 65 7 RESULTS 66 7.1 HTERT REGULATION AFTER
CHLAMYDIAL INFECTION 66 7.2 CHANGES IN THE BINDING OF TRANSCRIPTION
FACTORS ONTO THE HTERT PROMOTER 71 7.3 P21 EXPRESSION AFTER CHLAMYDIAL
INFECTION 74 7.4 P53 BINDING TO THE P21 PROMOTER IS REDUCED AT TEN DAYS
POST INFECTION 79 7.5 LONG TERM INFECTED CEILS DISPLAY AN INCREASED CELL
DIVISION RATE 81 7.6 P53 ACTIVITY IS REDUCED IN INFECTED IMR90E1A CELLS
82 7.7 EXPRESSION OF THE P53 TARGET GADD45A IS REDUCED TEN DAYS POST
INFECTION 85 7.8 APOPTOSIS OF INFECTED CELLS AFTER METHYLATION INHIBITOR
TREATMENT 86 8 DISCUSSION 89 8.1 REGULATION OF P53 ACTIVITY 89 8.1.1
POSTTRANSLATIONAL MODIFICATIONS OF P53 89 8.1.2 P53 REGULATORS INVOLVED
IN THE CONTROL OF PS3 ACTIVITY 90 8.1.3 INFLUENCES OF POSTTRANSLATIONAL
MODIFICATIONS OF P53 ONTO PROMOTER SELECTION 92 8.1.4 SUMMARY 95 8.2
CHROMOSOMAL STABILITY AND CYTOKINESIS 96 8.3 DIFFERENCES N HTERT AND
P21 REGUIATION AFTER CHLAMYDIAL INFECTION 97 8.4 OTHER FACTORS
POTENTIALLY INVOLVED IN HTERT REGULATION 101 8.5 BIOLOGICAL SIGNIFICANCE
OF CHANGES IN P53, HTERT AND P21 ACTIVITY 103 8.$ EPIGENETIC COMPONENT
IN GENE REGULATION PATTERNS 105 8.7 APOPTOSIS INHIBITION AFTER LONG TERM
INFECTION 106 8.8 OUTLOOK 107 9 REFERENCES 109 10 APPENDIX 130 10.1
CURRICULUM VITAE 130 10.2 MANUSCRIPTS AND POSTER 131 10.3
ACKNOWLEDGEMENTS 132 10.
|
| any_adam_object | 1 |
| author | Padberg, Inken |
| author_GND | (DE-588)1244957895 |
| author_facet | Padberg, Inken |
| author_role | aut |
| author_sort | Padberg, Inken |
| author_variant | i p ip |
| building | Verbundindex |
| bvnumber | BV025599227 |
| classification_rvk | WF 6000 |
| ctrlnum | (OCoLC)608746538 (DE-599)BVBBV025599227 |
| dewey-full | 616.9235027 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 616 - Diseases |
| dewey-raw | 616.9235027 |
| dewey-search | 616.9235027 |
| dewey-sort | 3616.9235027 |
| dewey-tens | 610 - Medicine and health |
| discipline | Biologie Medizin |
| format | Thesis Book |
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| isbn | 9783866647183 |
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| spelling | Padberg, Inken Verfasser (DE-588)1244957895 aut Short and long term influences of Chlamydia trachomatis infection on host cell cycle, apoptosis and senescence programs Inken Padberg Berlin Mensch und Buch Verl. 2009 133 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Biological science dt. Zusammenfassung Zugl.: Berlin, Humboldt-Univ., Diss., 2009 Apoptosis (DE-588)4291096-1 gnd rswk-swf Wirtszelle (DE-588)4232591-2 gnd rswk-swf Altern (DE-588)4068596-2 gnd rswk-swf Zellzyklus (DE-588)4129960-7 gnd rswk-swf Chlamydia-trachomatis-Infektion (DE-588)4192859-3 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Chlamydia-trachomatis-Infektion (DE-588)4192859-3 s Wirtszelle (DE-588)4232591-2 s Zellzyklus (DE-588)4129960-7 s Apoptosis (DE-588)4291096-1 s Altern (DE-588)4068596-2 s DE-604 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020194843&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Padberg, Inken Short and long term influences of Chlamydia trachomatis infection on host cell cycle, apoptosis and senescence programs Apoptosis (DE-588)4291096-1 gnd Wirtszelle (DE-588)4232591-2 gnd Altern (DE-588)4068596-2 gnd Zellzyklus (DE-588)4129960-7 gnd Chlamydia-trachomatis-Infektion (DE-588)4192859-3 gnd |
| subject_GND | (DE-588)4291096-1 (DE-588)4232591-2 (DE-588)4068596-2 (DE-588)4129960-7 (DE-588)4192859-3 (DE-588)4113937-9 |
| title | Short and long term influences of Chlamydia trachomatis infection on host cell cycle, apoptosis and senescence programs |
| title_auth | Short and long term influences of Chlamydia trachomatis infection on host cell cycle, apoptosis and senescence programs |
| title_exact_search | Short and long term influences of Chlamydia trachomatis infection on host cell cycle, apoptosis and senescence programs |
| title_full | Short and long term influences of Chlamydia trachomatis infection on host cell cycle, apoptosis and senescence programs Inken Padberg |
| title_fullStr | Short and long term influences of Chlamydia trachomatis infection on host cell cycle, apoptosis and senescence programs Inken Padberg |
| title_full_unstemmed | Short and long term influences of Chlamydia trachomatis infection on host cell cycle, apoptosis and senescence programs Inken Padberg |
| title_short | Short and long term influences of Chlamydia trachomatis infection on host cell cycle, apoptosis and senescence programs |
| title_sort | short and long term influences of chlamydia trachomatis infection on host cell cycle apoptosis and senescence programs |
| topic | Apoptosis (DE-588)4291096-1 gnd Wirtszelle (DE-588)4232591-2 gnd Altern (DE-588)4068596-2 gnd Zellzyklus (DE-588)4129960-7 gnd Chlamydia-trachomatis-Infektion (DE-588)4192859-3 gnd |
| topic_facet | Apoptosis Wirtszelle Altern Zellzyklus Chlamydia-trachomatis-Infektion Hochschulschrift |
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