Chloride movements across cellular membranes:
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a]
Elsevier
2007
|
| Schriftenreihe: | Advances in molecular and cell biology
38 |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XI, 377 S. graph. Darst. |
| ISBN: | 0444528725 9780444528728 |
Internformat
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| 245 | 1 | 0 | |a Chloride movements across cellular membranes |c ed. Michael Pusch |
| 264 | 1 | |a Amsterdam [u.a] |b Elsevier |c 2007 | |
| 300 | |a XI, 377 S. |b graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
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| 490 | 1 | |a Advances in molecular and cell biology |v 38 | |
| 700 | 1 | |a Pusch, Michael |4 edt | |
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Datensatz im Suchindex
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|---|---|
| adam_text | Contents
Contributors ix
Preface xi
1. Chloride-Transporting Proteins in Mammalian Organisms:
An Overview
Michael Pusch
References 6
2. Physiological Functions of the CLC Chloride Transport Proteins
Tanja Maritzen, Judith Blanz, and Thomas Jentsch
I. Introduction 10
II. Physiological Function of CLC-0 and Mammalian CLC Proteins 15
III. CLC Proteins in Model Organisms 43
IV. Summary and Outlook 46
References 46
3. Structure and Function of CLC Chloride Channels and Transporters
Alessio Accardi
I. The Structure of CLC-ecl, a Bacterial CLC Transporter 60
II. Structural Conservation Among the CLCs 62
III. Ion Selectivity, Permeation and Binding 63
IV. A Multi-Ion Pore 64
V. Channels and Transporters: Where Is the Difference? 65
VI. Function of the CLC Transporters 66
VII. Speculative Modeling 68
VIII. CLC Channel Gating 69
IX. The Role of the C-Terminal Domain of CLC Channels:
Recent Developments 77
X. Conclusions and Outlook 78
References 79
4. Pharmacology of CLC Chloride Channels and Transporters
Michael Pusch, Antonella Liantonio, Annamaria De Luca,
and Diana Conte Camerino
I. Introduction 83
II. The Pharmacology of the Macroscopic Skeletal Muscle
C Conductance gCl 84
v
vi Contents
III. New Molecules Targeting C1C-1 Identified Using
Heterologous Expression 88
IV. Mechanism of Block of Muscle Type CLC Channels by Clofibric
Acid Derivatives 91
V. The Binding Site for 9-AC and CPA on C1C-1 and C1C-0 and
Use of CPA as a Tool to Explore the Mechanisms of Gating of C1C-0 96
VI. Pharmacology of CLC-K Channels 98
VII. Other CLC Channels and Other Blockers 101
VIII. Potential of Having Blockers of C1C-2, C1C-3, C1C-5,
C1C-7: Outlook 102
References 103
5. The Physiology and Pharmacology of the CFTR Cl Channel
Zhiwei Cai, Jeng-Haur Chen, Lauren K. Hughes, Hongyu Li,
and David N. Sheppard
I. Introduction 109
II. The Molecular Physiology of CFTR 110
III. The Cellular Physiology of CFTR 116
IV. The Role of CFTR in Epithelial Physiology 117
V. The Pathophysiology of CFTR 120
VI. The Pharmacology of CFTR 123
VII. Conclusions 137
References 137
6. Gating of Cystic Fibrosis Transmembrane Conductance
Regulator Chloride Channel
Zhen Zhou and Tzyh-Chang Hwang
I. CFTR Overview 145
II. Regulation of CFTR by Phosphorylation/Dephosphorylation 148
III. CFTR Is an ATPase 152
IV. Structural Biology of ABC Transporters 153
V. Methods Used to Study CFTR Gating 157
VI. CFTR Gating by ATP 160
VII. Unsettled Issues and Future Directions 169
References 172
7. Functional Properties of Ca2+-Dependent Cl Channels and
Bestrophins: Do They Correlate?
Jorge Arreóla and Patricia Pérez-Cornejo
I. Summary 181
II. Introduction 182
III. Functional Properties of CaCCs 182
IV. Molecular Candidates of CaCCs 187
Contents VÜ
V. Functional Properties of Bestrophins 188
VI. Concluding Remarks 191
References 193
8. Cell Volume Homeostasis: The Role of Volume-Sensitive
Chloride Channels
Alessandro Sordini
I. Introduction 199
II. Cell Volume Homeostasis 200
III. Volume-Sensitive Cl~ Channels 203
IV. Concluding Remarks 210
References 211
9. GABAergic Synaptic Transmission
Andreas Draguhn and Kristin Hartmann
I. Postsynaptic G AB A Responses 216
II. Molecular Composition and Function
of GABAergic/Glycinergic Synapses 221
III. Modulation of Synaptic Functions Through Endogenous
Substances and Drugs 228
IV. Perspective: Specificity of GABAergic and Glycinergic
Signaling in Defined Networks 232
References 233
10. Physiology of Cation-Chloride Cotransporters
Christian A. Hübner and Marco B. Rust
I. Introduction 241
II. The Cation-Chloride Cotransporter Family 243
III. Cation-Chloride Cotransporters in the Nervous System 250
IV. Cation-Chloride Cotransporters in the Inner Ear 256
V. Cation-Chloride Cotransporters in the Kidney 259
VI. Cation-Chloride Cotransporters in RBCs 262
VII. Cation-Chloride Cotransporter and Cancer 265
VIII. Cation-Chloride Cotransport and Hypertension 266
IX. Concluding Remarks 267
References 267
11. Plasma Membrane CP/HCO^ Exchange Proteins
Haley J. Shandro and Joseph R. Casey
I. Introduction 280
II. The Cr/HCO^ Exchangers 280
III. Disputed Cr/HCO^ Exchangers 300
viii Contents
IV. Structure 301
V. Regulation and Inhibition of CP/HCOf Exchange 303
VI. Pathophysiology 309
References 312
12. Orchestration of Vectorial Chloride Transport by Epithelia
Peying Fong and Michael A. Gray
I. Introduction 329
II. Epithelial Cell Structure and Organization 330
III. Junctional Proteins: An Overview 334
IV. Chloride Transporting Proteins in Epithelia: Channels, Transporters,
and All Things in Between 336
V. PDZ Proteins: What Are They? Where Are They? What Do They Do? 347
VI. Two Diseases Involving Epithelial Chloride Transport 351
VII. Summary 356
References 357
Index 369
|
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| indexdate | 2024-07-09T22:36:50Z |
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| isbn | 0444528725 9780444528728 |
| language | English |
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| physical | XI, 377 S. graph. Darst. |
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| series | Advances in molecular and cell biology |
| series2 | Advances in molecular and cell biology |
| spelling | Chloride movements across cellular membranes ed. Michael Pusch Amsterdam [u.a] Elsevier 2007 XI, 377 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Advances in molecular and cell biology 38 Pusch, Michael edt Advances in molecular and cell biology 38 (DE-604)BV006125762 38 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020176062&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Chloride movements across cellular membranes Advances in molecular and cell biology |
| title | Chloride movements across cellular membranes |
| title_auth | Chloride movements across cellular membranes |
| title_exact_search | Chloride movements across cellular membranes |
| title_full | Chloride movements across cellular membranes ed. Michael Pusch |
| title_fullStr | Chloride movements across cellular membranes ed. Michael Pusch |
| title_full_unstemmed | Chloride movements across cellular membranes ed. Michael Pusch |
| title_short | Chloride movements across cellular membranes |
| title_sort | chloride movements across cellular membranes |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020176062&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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