Verfügbarkeit: Signal transduction

Signal transduction:

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Hauptverfasser:	Gomperts, Bastien D. (VerfasserIn), Kramer, Ijsbrand M. (VerfasserIn), Tatham, Peter E. R. (VerfasserIn)
Format:	Buch
Sprache:	English
Veröffentlicht:	Amsterdam [u.a.] Elsevier Acad. Press 2009
Ausgabe:	2. ed.
Schlagworte:	Zelle Signaltransduktion
Online-Zugang:	Inhaltsverzeichnis
Beschreibung:	XXVII, 810 S. graph. Darst., Ill.
ISBN:	9780123694416

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Datensatz im Suchindex

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adam_text	Titel: Signal transduction Autor: Gomperts, Bastien D Jahr: 2009 Contents Preface..........................................................................................................xix Notes............................................................................................................xxv Chapter 1: Prologue: Signal Transduction, Origins, and Ancestors..............1 Transduction, the word and its meaning: one dictionary, different points of view.....................................................................................................1 Hormones, evolution, and history................................................................................2 The plasma membrane barrier................................................................................2 Protohormones.............................................................................................................3 Protoendocrinologists................................................................................................5 Hormones: a definition..................................................................................................10 What s in a name?......................................................................................................11 Neurotransmitters...........................................................................................................12 Ergot...............................................................................................................................14 Receptors and ligands....................................................................................................16 References..........................................................................................................................17 Chapter 2: First Messengers.......................................................................21 Hormones...........................................................................................................................25 Growth factors............................................................................................................25 Cytokines......................................................................................................................26 Vasoactive agents......................................................................................................26 Neurotransmitters and neuropeptides.............................................................27 First messengers with intracellular receptors.................................................27 Common aspects.......................................................................................................28 Intracellular messengers...............................................................................................29 Binding of ligands to receptors............................................................................29 Binding heterogeneity............................................................................................30 Measurement of binding affinity.........................................................................30 KD and EC50: receptor binding and functional consequences...................31 Spare receptors..........................................................................................................32 Down-regulation of receptors..............................................................................33 Discovery of the first second messenger, cAMP.............................................34 References..........................................................................................................................35 Chapter 3: Receptors...................................................................................37 Adrenaline (again)...........................................................................................................37 a-and ^-adrenergic receptors.....................................................................................38 Adrenergic receptor agonists and antagonists..............................................38 Acetylcholine receptors.................................................................................................42 Acetylcholine..............................................................................................................42 Cholinergic receptor subtypes....................................................................................44 Nicotinic receptors....................................................................................................44 Muscarinic receptors................................................................................................45 Nicotinic receptors are ion channels..................................................................46 Architecture of the nicotinic receptor................................................................50 Other ligand-gated ion channels........................................................................54 The 7TM superfamily of G-protein-linked receptors...........................................55 Categories of 7TM receptor..........................................................................................58 Receptor diversity: variation and specialization............................................59 Binding of low-molecular-mass ligands............................................................61 Calcium sensors and metabotropic receptors................................................63 Proteinase-activated receptors (PARs)...............................................................65 The adhesion receptor subfamily........................................................................65 Frizzled..........................................................................................................................66 Receptor-ligand interaction and receptor activation........................................66 A two-state equilibrium description of receptor activation......................66 Receptor dimerization.............................................................................................69 Transmitting signals into cells.....................................................................................70 The receptor and the effector: one and the same or separate entities?.........................................................................................................................70 Mixing and matching receptors and effectors...............................................71 Intracellular 7TM receptor domains and signal transmission..........................73 Adrenaline (yet again)..............................................................................................73 References..........................................................................................................................73 Chapter 4: GTP-binding Proteins and Signal Transduction 81 Nucleotides as metabolic regulators........................................................................81 ATP is not quite what it seems..............................................................................82 GTP-binding proteins, G proteins, or GTPases................................................83 G proteins...........................................................................................................................83 The GTPase cycle: a monostable switch............................................................84 Switching off activity: switching on GTPase....................................................86 a-Subunits..........................................................................................................................88 a-Subunits determine G protein diversity.......................................................89 Sites on a-subunits that interact with the membrane and with other proteins...................................................................................................92 0 (-Subunits........................................................................................................................94 (3- and -^-subtypes......................................................................................................94 3~/-Subunits as signalling proteins......................................................................97 The G protein receptor kinase family........................................................................98 Receptor phosphorylation, down-regulation and pathway switching........98 Receptor mechanisms obviating G proteins........................................................100 Monomeric GTP-binding proteins...........................................................................101 Ras proteins discovered as oncogene products..........................................101 Subfamilies of Ras...................................................................................................101 Structure.....................................................................................................................102 Post-translational modifications........................................................................105 GTPases everywhere!.............................................................................................106 Mutations of Ras that promote cancer............................................................106 Functions of Ras.......................................................................................................107 RasGAPs.............................................................................................................................108 RasGAP........................................................................................................................108 Mechanism of GTPase activation.......................................................................110 Guanine nucleotide exchange factors (GEFs)...............................................111 Essay: Activation of G proteins without subunit unit dissociation..............111 Pheromone-induced mating response in yeast...........................................113 Monitoring subunit interactions in living cells by FRET............................114 Constructing the mammalian (3-adrenergic transduction system in insect cells..................................................................................................................117 References........................................................................................................................120 Chapter 5: Effector Enzymes Coupled to GTP Binding Proteins: Adenylyl Cyclase and Phospholipase C 131 Adeny lyl cyclase.............................................................................................................131 Cyclic AMP: the first second messenger..........................................................131 cAMP is formed from ATP.....................................................................................133 Adenylyl cyclase and its regulation..................................................................134 Structural organization of adenylyl cyclases.................................................134 Regulation of adenylyl cyclase...........................................................................136 ADP-ribosylation of (3-f-subunits.......................................................................146 Phospholipase C.............................................................................................................147 First hints of a signalling role for inositol phospholipids..........................147 The phospholipase family....................................................................................147 The isoenzymes of PLC..........................................................................................148 PLCS: a prototype....................................................................................................150 Regulation of PLC....................................................................................................151 References........................................................................................................................153 Chapter 6: The Regulation of Visual Transduction and Olfaction.........159 Phototransduction........................................................................................................159 Sensitivity of photoreceptors....................................................................................160 Photoreceptor mechanisms.......................................................................................161 Photoreceptor cells.................................................................................................163 Adaptation: calcium acts as a negative regulator..............................................167 Photo-excitation of rhodopsin..................................................................................170 Switching off the mechanism....................................................................................171 Retinal, an inverse agonist?.................................................................................172 Note on phototransduction in invertebrates......................................................174 Olfaction............................................................................................................................176 Olfactory receptor cells.........................................................................................177 Olfactory receptors.................................................................................................178 Transduction of olfactory signals......................................................................179 References........................................................................................................................181 Chapter 7: Intracellular Calcium...............................................................185 A new second messenger is discovered................................................................185 Calcium and evolution.................................................................................................187 Distinguishing Ca2+ and Mg2+.................................................................................188 Free, bound, and trapped Ca2+.................................................................................189 Cytosol Ca2+ is kept low..............................................................................................190 Extracellular calcium and activation.......................................................................191 Using Ca2+ ionophores to impose a rise in Ca2+.........................................191 Sensing changes in intracellular Ca2+ concentration.......................................191 Ca2+-sensitive photoproteins.............................................................................192 Fluorescent Ca2+ indicators.................................................................................192 Monitoring cytosol Ca2+ in individual cells...................................................194 Detecting and imaging subcellular Ca2+ changes......................................195 Mechanisms that elevate cytosol Ca2+ concentration.....................................198 Ca2+ release from intracellular stores, IP3 and ryanodine receptors.....200 Elevation of Ca2+ by cyclic ADP-ribose and NAADP...................................204 Elevation of Ca2+ by sphingosine-1-phosphate..........................................206 Ca2+ influx through plasma membrane channels......................................208 Replenishing depleted stores.............................................................................209 Ca2+ microdomains and global cellular signals..................................................214 Ca2+ signals in electrically excitable cells.......................................................214 Calcium signals in non-excitable cells.............................................................216 References........................................................................................................................216 Chapter 8: Calcium Effectors....................................................................221 Calcium-binding by proteins.....................................................................................221 Polypeptide modules that bind Ca2+..............................................................224 Decoding Ca2+ signals...........................................................................................224 Calmodulin and troponin C.................................................................................225 Kinases regulated by calmodulin......................................................................226 Other Ca2+-calmodulin dependent enzymes...............................................229 Calcium-dependent enzymes that are not regulated by calmodulin..233 Paradigms of calcium signalling...............................................................................236 Triggering neurotransmitter secretion............................................................236 Initiation of contraction in skeletal muscle....................................................237 Smooth muscle contraction................................................................................239 References........................................................................................................................239 Chapter 9: Phosphorylation and Dephosphorylation: Protein kinases A and C.............................................................................243 Protein phosphorylation as a switch in cellular functioning.........................243 Cyclic AMP and the amplification of signals........................................................245 Protein kinase A..............................................................................................................246 Protein kinase A and the regulation of transcription........................................248 Activation of the CREB transcription factor...................................................248 Attenuation of the cAMP response elements by dephosphorylation .250 Protein kinase A and the activation of ERK...........................................................250 Actions of cAMP not mediated by PKA..................................................................251 Epac, a guanine nucleotide exchange factor directly activated by cAMP..................................................................................................251 Protein kinase C..............................................................................................................253 Discovery of phosphorylating activity independent cAMP.....................253 The protein kinase C family........................................................................................254 Structural domains and activation of protein kinase C....................................255 The C1-C4 regions..................................................................................................255 Activation of protein kinase C...................................................................................259 Multiple sources of diacylglycerol and other lipids activate protein kinase C.......................................................................................................................259 Differential localization of PKC isoforms.........................................................260 Different types of PKC-binding proteins.........................................................261 Holding back the PKC response.........................................................................263 A matter of life or death: PKC signalling complexes in the evasion of the fly-swat...........................................................................................264 Phorbol ester and inflammation........................................................................265 References........................................................................................................................266 Chapter 10: Nuclear Receptors................................................................273 First steps in the isolation of steroid hormones..................................................273 Origins.........................................................................................................................273 Beginning again.......................................................................................................274 The discovery of intracellular hormone receptors.............................................274 Evidence for intracellular receptors..................................................................276 A superfamily of nuclear receptors.........................................................................277 Orphan receptors and evolution.......................................................................278 Nomenclature of nuclear receptors........................................................................281 Receptor structure and ligand binding.................................................................281 Ligand-binding domains are molecular switches.......................................281 Activation of cytosol-resident receptors.........................................................282 DNA binding....................................................................................................................284 Recognizing response elements........................................................................285 Activation and repression of transcription...........................................................287 Coactivators...............................................................................................................287 Corepressors..............................................................................................................288 Transrepression........................................................................................................289 Regulatory networks..............................................................................................289 Interaction with other signalling pathways.........................................................290 Phosphorylation......................................................................................................290 Phosphorylation may up- or down-regulate transcription......................291 Ligand-independent activation.........................................................................291 Non-transcriptional actions of nuclear receptors and their ligands...........292 References........................................................................................................................293 Chapter 11: Growth Factors: Setting the Framework............................297 Viruses and tumours.....................................................................................................298 The discovery of NGF ... and EGF............................................................................299 Platelet-derived growth factor (PDGF)...................................................................303 Transforming growth factors (TGFa and TGF0)...................................................304 Problems with nomenclature....................................................................................305 Essay: Cancer and transformation...........................................................................306 Definitions..................................................................................................................306 The essence of cancer............................................................................................307 Alterations dictating malignancy......................................................................307 Genetic alterations at the basis of malignancy............................................308 Constructing cancer in a dish.............................................................................309 References........................................................................................................................311 Chapter 12: Signalling Pathways Operated by Receptor Protein Tyrosine Kinases...........................................................................315 Introduction.....................................................................................................................315 Spotting phosphotyrosine...................................................................................316 v-Src and other protein tyrosine kinases........................................................317 Processes mediated through tyrosine phosphorylation...........................317 Tyrosine kinase-containing receptors....................................................................318 The ErbB receptor family and their ligands....................................................318 Cross-linking of receptors causes activation.................................................318 Assembly of receptor signalling complexes-------------------------.........323 Protein domains that bind phosphotyrosines and the assembly of signalling complexes..............................................................................................324 Branching of the signalling pathway......................................................................325 The PLC~f-PKC signal transduction pathway.................................................326 The Ras signalling pathway.................................................................................327 From Ras to MAP kinase and the activation of transcription..................334 Raf genes....................................................................................................................335 Beyond ERK......................................................................................................................337 Docking sites and a MAP kinase phosphorylation motif..........................337 Activation of protein kinases by ERKs 1 and 2..............................................337 Activation of early response genes...................................................................342 Regulation of the cell cycle..................................................................................343 Fine tuning the Ras-MAP kinase pathway: scaffold proteins..................344 MAP kinase scaffold proteins discovered in yeast.......................................344 KSR, a mammalian scaffold protein that regulates MAP kinase signalling............................................................................................345 Other proteins that regulate MAP kinase pathways...................................348 Why are the signalling pathways so complicated?............................................348 Termination of the ERK response.......................................................................349 The Ca2+-calmodulin pathway..........................................................................353 Activation of PI3-kinase.........................................................................................353 Direct phosphorylation of STAT transcription factors................................353 A switch in receptor signalling: activation of ERK by 7TM receptors..........354 Pathway switching mediated by receptor phosphorylation...................354 Pathway switching by transactivation.............................................................356 Pathway switching, transactivation, and metastatic progression of colorectal cancer......................................................................................................357 References........................................................................................................................362 Chapter 13: Signal Transduction to and from Adhesion Molecules..................................................................................375 Adhesion molecules.....................................................................................................376 Naming names.........................................................................................................378 Immunoglobulin superfamily.............................................................................378 ICAM.............................................................................................................................379 SIGLEC..........................................................................................................................380 Junctional adhesion molecules (JAMs)...........................................................382 Claudins......................................................................................................................382 Occludin......................................................................................................................383 Integrins......................................................................................................................383 Inactive to primed...................................................................................................384 Primed to active.......................................................................................................387 Cadherins...................................................................................................................387 Selectins......................................................................................................................392 Cartilage link proteins............................................................................................395 Integrins, cell survival, and cell proliferation.......................................................397 Inside-out signalling and the formation of integrin adhesion complexes..................................................................................................................397 Outside-in signalling from integrin adhesion complexes........................398 Integrins and cell survival.....................................................................................400 Integrins and cell proliferation...........................................................................403 References........................................................................................................................409 Chapter 14: Adhesion Molecules in the Regulation of Cell Differentiation: Mainly About Wnt...................................................417 Destabilization of adherens junctions causes cellular de-differentiation...........................................................................................417 Signalling through the canonical WNT pathway.........................................419 Adenomatous polyposis coli (APC) and the localization of P-catenin....................................................................................................................424 Take your partner: which way [3-catenin?.......................................................426 The O-catenin-dependent) canonical Wnt pathway.................................426 Wnt organizes the villous epithelium of the small intestine...................434 Mutations of (3-catenin, Axin, and APC in human cancers.......................437 Non-canonical signal transduction pathways..............................................438 A role for cadherin in contact inhibition.........................................................438 Other examples of signalling through adhesion molecules..........................439 Cadherin in the central nervous system.........................................................439 JAM and the regulation of differentiation......................................................439 Occludin interacts with theTGF(3 type I receptor........................................439 Occludin prevents Raf-1-mediated cell transformation............................440 References........................................................................................................................442 Chapter 15: Activation of the Innate Immune System: the Toll-like Receptor 4 and Signalling through Ubiquitylation......?........ 451 Sensing the microbial universe..........................................................................452 The toll receptor in Drosophila..........................................................................453 Signalling through the TLR4 receptor..............................................................458 The TIRAP/MyD88 pathway.................................................................................460 From TRAF6 to activation of NF-K.B...................................................................460 From TRAF6 to activation of IRF-3.....................................................................464 The IRF family of transcription factors.............................................................464 Some consequences of TLR4-induced gene transcription.......................466 Essay: Ubiquitylation and SUMOylation................................................................467 Ubiquitylation...........................................................................................................467 Ubiquitylation: a process involving three activities (but not necessarily three proteins)..................................................................467 63K or 48K conjugation.........................................................................................468 Two classes of E3-ubiquitin ligases...................................................................469 Ubiquitin-binding proteins..................................................................................470 SUMO and sumoylation........................................................................................470 Essay: The proteasome complex..............................................................................471 The proteasome.......................................................................................................472 20S particle................................................................................................................472 Proteasome activator (PA) subunits..................................................................474 References........................................................................................................................477 Chapter 16: Traffic of White Blood Cells.................................................483 Inflammation and leukocytes....................................................................................483 Inflammatory mediators.......................................................................................483 Tumour necrosis factor-ot, potential anti-tumour agent or inflammatory cytokine?...................................................................................486 The family of TNF proteins and receptors.......................................................489 TNF-a. and regulation of adhesion molecule expression in endothelial cells..................................................................................................489 Signalling via NF-kB...............................................................................................493 Chemokines and activation of integrins on leukocytes............................494 The three-step process of leukocyte adhesion to endothelial cells......501 References........................................................................................................................505 Chapter 17: Tyrosine Protein Kinases and Adaptive Immunity: TCR, BCR, Soluble Tyrosine Kinases and NFAT........................................513 The family of non-receptor protein tyrosine kinases........................................513 T-cell receptor signalling.............................................................................................515 More than one lymphocyte receptor must be engaged to ensure activation....................................................................................................................515 PLC~ 1 to NFAT..........................................................................................................519 The PLO-fl to NF-kB pathway.............................................................................521 Down-regulation of theTCR response.............................................................521 Signalling through interferon receptors...............................................................523 Interferon-ot receptor and STAT proteins.......................................................525 Alternative signalling pathways.........................................................................526 Down-regulation of the JAK-STAT pathway...................................................527 Oncogenes, malignancy, and signal transduction............................................530 Viral oncogenes........................................................................................................530 Non-viral oncogenes..............................................................................................531 Essay: Non-receptor protein tyrosine kinases and their regulation............532 References........................................................................................................................538 Chapter 18: Phosphoinositide 3-Kinases, Protein Kinase B, and Signalling through the Insulin Receptor..........................................543 Insulin receptor signalling; it took a little time to work out the details.................................................................................................................543 Signalling through phosphoinositides..................................................................545 PI 3-kinase, PI(3,4)P2 and PI(3,4,5)P3........................................................................546 A family of PI 3-kinases..........................................................................................547 Studying the role of PI 3-kinase.........................................................................549 Protein kinase B and activation through PI(3,4,5)P2...................................550 Insulin: the role of IRS, PI 3-kinase, and PKB in the regulation of glycogen synthesis...................................................................................................554 From the insulin receptor to PKB.......................................................................554 From PKB to glycogen synthase.........................................................................557 The role of PI 3-kinase in activation of protein synthesis..........................559 Other processes mediated by the 3-phosphorylated inositol phospholipids.................................................................................................566 So, who did discover insulin?..............................................................................567 References........................................................................................................................569 Chapter 19: Protein Kinase C Revisited.................?.......?.................. 577 PKC in cell transformation..........................................................................................577 The search for transcription factors that mediate phorbol ester effects..............................................................................................578 Regulation of cell polarity...........................................................................................585 Role of atypical PKC................................................................................................585 References........................................................................................................................594 Chapter 20: Signalling Through Receptor Serine/ Threonine Kinases.....................................................................................599 TheTGFp family of growth factors...........................................................................599 TGF(3 receptors, type I and type II......................................................................600 TGF(3-mediated receptor activation..................................................................603 Accessory and pseudo receptors: betaglycan, endoglin, cripto, and BAMBI................................................................................605 Downstream signalling: Drosophila, Caenorhabitidis, and Smad.................607 Smad proteins have multiple roles in signal transduction.......................608 Hetero-oligomeric complex formation...........................................................611 Nuclear import and export..................................................................................612 Holding the TGF(3 pathway in check.................................................................620 TGF3: tumour suppressor and metastatic promoter?................................623 References........................................................................................................................632 Chapter 21: Protein Dephosphorylation and Protein Phosphorylation........................................................................................641 Protein tyrosine phosphatases.................................................................................642 Cytosolic PTPs...........................................................................................................644 Transmembrane receptor-like PTPs..................................................................645 Tyrosine specificity and catalytic mechanism...............................................645 PTPs in signal transduction........................................................................................646 PTP1B, diabetes, and obesity..............................................................................647 Redox regulation of PTP1B: reactive oxygen species as second messengers...........................................................................................650 SHP-1 andSHP-2......................................................................................................653 CD45 and the regulation of immune cell function.....................................658 Regulating receptor PTPs.....................................................................................660 Dual specificity phosphatases...................................................................................661 Regulation of MAP kinases by dual-specificity protein phosphatases (DS-MKP)........................................................................................662 Physiological role of the dual-specificity MAP kinase phosphatases ...665 PTEN, a dual-specificity phosphatase for phosphatidyl inositol lipids 668 Serine/threonine phosphatases...............................................................................671 Classification of the serine/threonine phosphatases.................................672 Regulation of PPPs..................................................................................................675 PP1 in the regulation of glycogen metabolism............................................679 PP2B (calcineurin)....................................................................................................682 Dephosphorylation of NFAT: immunophilins show the way...................683 References........................................................................................................................689 Chapter 22: Notch.....................................................................................699 Notched wings, Morgan, and the gene theory...................................................699 One gene, many alleles.........................................................................................702 Membrane components of the Notch pathway.................................................703 Notch ligands (DSL proteins)..............................................................................703 Notch receptors.......................................................................................................703 Glycosylation of ligands and receptor.............................................................706 Activation of Notch.................................................................................................707 Both receptor and ligand trafficking are essential for Notch signalling.......................................................................................................712 Notch and sensory progenitor cells of Drosophila; the importance ofendocytosis.................................................................................................................716 Development of mechanoreceptors on thorax and wing........................717 Notch and the development of the bristle-containing sensory organ...........................................................................................................720 Notch in the maintenance of an intestinal stem cell compartment.....722 Cross-talk with other signal transduction pathways..................................722 References........................................................................................................................730 Chapter 23: Targeting Transduction Pathways for Research and Medical Intervention.........................................................................735 Chemotherapy................................................................................................................736 Cytotoxic antibiotics and antimetabolites.....................................................737 The purine pathway to chemotherapy............................................................739 Good drugs and bad..............................................................................................739 Combination chemotherapy...............................................................................740 Alternative targets for cancer therapy: towards a scientific rationale........742 Inhibiting the EGF family of receptor kinases......................................................743 The antibody approach: trastuzumab.............................................................743 The tyrosine kinase inhibitor approach...........................................................745 Other signal transduction components targeted for therapeutic intervention.............................................................................................754 Towards a different approach in testing cancer drugs?...................................754 References........................................................................................................................758 Chapter 24: Protein Domains and Signal Transduction........................763 Modular structure of proteins...................................................................................763 Structural domains........................................................................................................763 The evolution and shuffling of domains................................................................764 Sequence homology and the acquisition of function......................................765 Domain function......................................................................................................766 The inventory of domains...........................................................................................767 Detection....................................................................................................................767 Classification.............................................................................................................767 Examples of domains with roles in signalling.....................................................768 Domains that bind oligopeptide motifs................................................:........768 Phosphoinositide-binding domains.................................................................774 Polypeptide modules that bind Ca2+...............................................................779 Zinc finger domains................................................................................................781 Protein kinase domains.........................................................................................782 References........................................................................................................................787 Index............................................................................................................791
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illustrated	Illustrated
indexdate	2024-07-09T22:36:48Z
institution	BVB
isbn	9780123694416
language	English
oai_aleph_id	oai:aleph.bib-bvb.de:BVB01-020173961
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owner	DE-11 DE-703
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physical	XXVII, 810 S. graph. Darst., Ill.
publishDate	2009
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publisher	Elsevier Acad. Press
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spelling	Gomperts, Bastien D. Verfasser aut Signal transduction Bastien D. Gomperts ; Ijsbrand M. Kramer ; Peter E. R. Tatham 2. ed. Amsterdam [u.a.] Elsevier Acad. Press 2009 XXVII, 810 S. graph. Darst., Ill. txt rdacontent n rdamedia nc rdacarrier Zelle (DE-588)4067537-3 gnd rswk-swf Signaltransduktion (DE-588)4318717-1 gnd rswk-swf Zelle (DE-588)4067537-3 s Signaltransduktion (DE-588)4318717-1 s 1\p DE-604 Kramer, Ijsbrand M. Verfasser aut Tatham, Peter E. R. Verfasser aut HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020173961&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk
spellingShingle	Gomperts, Bastien D. Kramer, Ijsbrand M. Tatham, Peter E. R. Signal transduction Zelle (DE-588)4067537-3 gnd Signaltransduktion (DE-588)4318717-1 gnd
subject_GND	(DE-588)4067537-3 (DE-588)4318717-1
title	Signal transduction
title_auth	Signal transduction
title_exact_search	Signal transduction
title_full	Signal transduction Bastien D. Gomperts ; Ijsbrand M. Kramer ; Peter E. R. Tatham
title_fullStr	Signal transduction Bastien D. Gomperts ; Ijsbrand M. Kramer ; Peter E. R. Tatham
title_full_unstemmed	Signal transduction Bastien D. Gomperts ; Ijsbrand M. Kramer ; Peter E. R. Tatham
title_short	Signal transduction
title_sort	signal transduction
topic	Zelle (DE-588)4067537-3 gnd Signaltransduktion (DE-588)4318717-1 gnd
topic_facet	Zelle Signaltransduktion
url	http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020173961&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
work_keys_str_mv	AT gompertsbastiend signaltransduction AT kramerijsbrandm signaltransduction AT tathampeterer signaltransduction

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