Apoptotic chromatin changes:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
[Dordrecht]
Springer
2009
|
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XII, 412 S. Ill., graph. Darst. 1 DVD, 1 3D-Brille |
| ISBN: | 9781402095603 |
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Datensatz im Suchindex
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|---|---|
| adam_text | GASPAR BANFALVI APOPTOTIC CHROMATIN CHANGES 4U SPRINGER CONTENTS 1 DNA
EMPIRE 1 SUMMARY 1 HISTORICAL EVENTS LEADING TO THE RECOGNITION OF CORE
PROCESSES OF GENETIC INFORMATION 1 JACOB, THE FIRST GENETICIST 1
MENDEL, THE FATHER OF MODERN GENETICS 2 DARWIN, THE MOST DANGEROUS
MAN 2 SCHLEIDEN AND SCHWANN: LIVING UNITS ARE CELLS 3 WHY ARE CELLS SO
SMALL? 4 IS LIFE ON EARTH POSSIBLE WITHOUT CELLS? 7 WHY IS IT DIFFICULT
TO IMAGINE CELLULAR AND SUBCELLULAR PROPORTIONS? .... 7 RNA WORLD 8
PRE-RNA WORLD 9 ADDITIONAL ARGUMENTS SUPPORTING RNA WORLD HYPOTHESIS 9
BASIC PRINCIPLES OF THE TRANSFER OF GENETIC INFORMATION 12 CORE
INFORMATION PROCESSES BELONGING TO THE DNA EMPIRE 16 WHEN DID DNA
EVOLVE? 16 MOLECULAR OXYGEN SERVING THE GRADUAL TRANSITION FROM RNA
WORLD TO DNA EMPIRE 19 SATURATION OF SEAWATER WITH OXYGEN AND
DEVELOPMENT OF OXYGEN ATMOSPHERE 19 ADVANTAGE OF OXYGEN PRODUCTION 20
OXYGEN THE JANUS FACED MOLECULE 20 PROTECTION OF ANAEROBES FROM OXYGEN
TOXICITY 22 FREE RADICAL FORMATION DURING THE SYNTHESIS OF
DEOXYRIBONUCLEOTIDES .. 22 CELLULAR RESPONSES TO DNA DAMAGES 24
CONCEPTUAL CHANGES IN GENE STABILITY 24 PRIMARY INFORMATION ON
CYTOTOXICITY CAN BE OBTAINED AT DNA LEVEL ... 24 DETECTION OF GENOTOXIC
CHANGES AT THE STRUCTURAL LEVEL OF DNA 25 CONCLUSIONS 26 REFERENCES 27
VIII CONTENTS 2 STRUCTURAL ORGANIZATION OF DNA 31 SUMMARY 31 BUILDING
BLOCKS OF NUCLEIC ACIDS 31 STRUCTURE OF NUCLEOTIDES 31 NUCLEIC ACID
BASES 32 SUGAR COMPONENT OF NUCLEOTIDES 39 PHOSPHATE AS NUCLEOTIDE
COMPONENT 49 BOND TYPES IN NUCLEOTIDES 49 NOMENCLATURE OF BASES,
NUCLEOSIDES AND NUCLEOTIDES 50 METABOLISM OF NUCLEOTIDES 50 REGULATION
OF NUCLEOTIDE BIOSYNTHESIS 57 DEGRADATION OF NUCLEOTIDES 57 BIOSYNTHESIS
OF COENZYMES 57 TISSUE SPECIFIC PURINE SYNTHESIS 59 FUNCTIONS OF
NUCLEOTIDES 59 DNA STRUCTURE 62 STRUCTURAL LEVELS OF DNA 63 PRIMARY
STRUCTURE 63 SECONDARY DNA STRUCTURES 63 TERTIARY STRUCTURE OF DNA
(TOPOLOGY) 77 THERMODINAMIC ASPECTS OF SUPERCOILING 79 TOPOISOMERASES 80
MODELS OF GYRASE ACTION 82 TOPOLOGY OF EUKARYOTIC DNA 85
SUPRANUCLEOSOMAL (CHROMOSOMAL) ORGANIZATION OF DNA 87 EARLY CHROMATIN
MODELS 87 SOLENOID VERSUS ZIG-ZAG MODEL 88 CHROMOSOMES OF ANIMAL CELLS
93 TEMPORAL AND SPATIAL ORDER OF GENE REPLICATION 112 DNA IS REPLICATED
AND REPAIRED IN SEVERAL SUBPHASES IN S-PHASE 113 REFERENCES 114 3
CHROMATIN CONDENSATION 125 SUMMARY 125 IMPORTANCE OF CHROMATIN
CONDENSATION 125 ACTIVE AND INACTIVE CHROMATIN 126 EUCHROMATIN AND
HETEROCHROMATIN 127 HISTONE CODE HYPOTHESIS 127 CHROMOSOME ARRANGEMENT
IN THE NUCLEUS 129 MODELS OF CHROMOSOME CONDENSATION 129 CHROMATIN
FOLDING IN THE INTERPHASE NUCLEUS IS POORLY UNDERSTOOD 135 CHROMATIN
MODELS 136 REVIEW OF METHODOLOGIES TO FOLLOW CHROMOSOME DYNAMICS 136
METHODS TO MONITOR CHROMOSOME CONDENSATION DURING THE CELL CYCLE ... 139
CONTENTS IX CENTRIFUGAL ELUTRIATION 139 PERMEABLE CELLS 140 TECHNICAL
LIMITATIONS TO VISUALIZE LARGE SCALE CHROMATIN STRUCTURES ... 141
REVERSIBLE PERMEABILIZATION 141 ISOLATION OF INTERPHASE CHROMOSOMES:
VISUALISING BABIES BEFORE BIRTH 142 VISUALIZATION OF INTERMEDIATES OF
CHROMATIN CONDENSATION IN CHO CELLS .. 142 BIOTINYLATION INTERPHERES
WITH CHROMATIN FOLDING 142 DECONDENSED CHROMATIN STRUCTURES AFTER
BIOTINYLATION 144 GLOBULAR, SUPERCOILED, FIBROUS, RIBBONED STRUCTURES
UPON DNA BIOTINYLATION 146 CHROMATIN CONDENSATION OF NON-BIOTINYLATED
DNA STUDIED IN SYNCHRONIZED CELLS 148 DECONDENSED CHROMATIN STRUCTURES
IN CELLS SYNCHRONIZED IN EARLY S PHASE (2.0 - 2.5 C) 149 TRANSITION FROM
VEILED TO RIBBONED STRUCTURES IN CELLS SYNCHRONIZED IN EARLY MID S PHASE
(2.5-3.0 C) 150 LINEAR CONNECTION OF CHROMOSOMES IN CONDENSING
INTERPHASE CHROMATIN IN CELLS SYNCHRONIZED AT LATE MID S PHASE (3.0-3.5
C) ... 151 DISTINCT FORMS OF EARLY CHROMOSOMES IN CELLS SYNCHRONIZED AT
THE END OF S PHASE (3.5-4.0 C) 153 CHROMATIN IMAGE ANALYSIS 153 LINEAR
CONNECTION OF CONDENSING CHROMOSOMES IN NUCLEI DURING CELL CYCLE 155
LINEAR CONNECTION OF ISOLATED CHROMOSOMES 155 LINEAR CONNECTION OF
CHROMOSOMES INSIDE THE NUCLEUS 157 COMMON PATHWAY OF CHROMATIN
CONDENSATION IN MAMMALIAN CELL LINES .. 158 DECONDENSED CHROMATIN
STRUCTURES AT THE UNSET OF S PHASE (2.0-2.25 C VALUE) 161 SUPERCOILED
CHROMATIN IN EARLY S (2.25-2.5 C) 161 FROM VEILED TO FIBROUS STRUCTURES
LATER IN EARLY S PHASE (2.5-2.75 C) 161 TRANSITION TO RIBBONED CHROMATIN
STRUCTURES IN EARLY MID S PHASE (2.75-3.0 C) 161 CHROMATIN BODIES AFTER
THE MID S PHASE PAUSE (3.0-3.25 C) 162 EARLY CHROMOSOMES LATER IN MID S
PHASE (3.25-3.5 C) 162 EARLY ELONGATED FORMS OF CHROMOSOMES (3.5-3.75 C)
162 FINAL STAGE OF CHROMOSOME CONDENSATION (3.75^.0 C) 162 CHROMATIN
CONDENSATION IN RESTING CELLS AND CHEMICALLY INDUCED TUMOURS OF RAT
HEPATOCYTES 164 TRANSMISSION OF HEPATOCELLULAR TUMOUR WITH THE HEDE CELL
LINE 164 DECONDENSED CHROMATIN STRUCTURES IN RESTING HEPATOCYTES 165
TRANSITION FROM ROUND CHROMATIN BODIES TO LINEAR CHROMOSOMES IN MURINE
PREB AND CHO CELLS 166 CYTOMETRIC ANALYSIS OF SYNCHRONIZED PREB CELL
POPULATIONS 168 CONTENTS CHROMATIN STRUCTURES EXCLUDED FROM NUCLEI OF
PREB CELLS 169 CONDENSATION OF ROUND SHAPED INTERPHASE CHROMOSOMES IN
PREB CELLS . 170 KARYOTYPE OF EARLY INTERPHASE CHROMOSOMES 170 LINEAR
CONNECTION OF CHROMOSOMES EXCLUDED FROM NUCLEI OF CHO CELLS 175
CONDENSATION OF INTERPHASE CHROMOSOMES IN CHO CELLS 176 STRUCTURE OF
INTERPHASE CHROMOSOMES IN DROSOPHILA CELLS 180 SYNCHRONIZATION OF
DROSOPHILA CELLS AT LOW RESOLUTION OF ELUTRIATION... 180 CYTOMETRIC
ANALYSIS OF DROSOPHILA CELLS SYNCHRONIZED AT LOW RESOLUTION OF
ELUTRIATION 181 CHROMATIN CONDENSATION IN SYNCHRONIZED DROSOPHILA CELLS
182 CHROMATIN RODLETS IN NUCLEI OF DROSOPHILA CELLS 184 LINEAR
ARRANGEMENT OF DROSOPHILA CHROMOSOMES 185 INTERPHASE CHROMOSOMAL FORMS
IN NUCLEI OF DROSOPHILA CELLS 185 INTERMEDIATES OF CHROMATIN
CONDENSATION IN DROSOPHILA CELLS AT HIGH RESOLUTION OF SYNCHRONIZATION
187 HIGH RESOLUTION OF SYNCHRONY OF ELUTRIATED FRACTIONS AND DNA
SYNTHESIS IN SYNCHRONIZED CELLS 188 MAJOR STEPS AND STRUCTURES OF
CHROMATIN CONDENSATION IN DROSOPHILA CELLS 189 BUILDING UNITS OF
DROSOPHILA CHROMOSOMES 191 FOLDING OF NUCLEOSOMAL CHROMATIN STRING IN
DROSOPHILA CELLS 192 PLECTONEMIC MODEL OF CHROMATIN CONDENSATION IN
DROSOPHILA CELLS .... 193 REFERENCES 196 4 APOPTOSIS 203 SUMMARY 203
HISTORY 203 INCREASED SCIENTIFIC INTEREST TO UNDERSTAND APOPTOSIS 206
RELATIONSHIP OF APOPTOSIS TO GENETIC COMMUNICATION 208 DESTRUCTION OF
BIOLOGICAL INFORMATION 208 HAVE YOU EVER SEEN APOPTOSIS? 209 WHAT
TRIGGERS APOPTOSIS? 211 APOPTOSIS (TYPE I PROGRAMMED CELL DEATH) AND
NECROSIS 212 CHARACTERIZATION OF APOPTOSIS 212 NECROSIS 218 INDUCTION OF
APOPTOSIS 220 APOPTOSIS INDUCING SIGNALS 229 CHEMICAL INDUCERS OF
APOPTOSIS 229 APOPTOTIC PATHWAYS 237 IRRADIATION AND STRESS-INDUCED
APOPTOSIS 238 INDUCTION OF NUCLEASES 240 DEVELOPMENTAL^ INDUCED CELL
DEATH 241 GRANZYME MEDIATED APOPTOSIS 241 CONTENTS INDUCTION OF
APOPTOSIS THROUGH DEATH RECEPTORS 243 CASPASE-DEPENDENT INITIATION OF
APOPTOSIS AND NECROSIS 248 P53 IN NORMAL AND DEREGULATED CANCER CELLS
251 APOPTOSIS TRIGGERED BY CHEMICAL DNA DAMAGE 258 RETINOIDS AS
APOPTOTIC AGENTS 259 TROMBOSPONDIN INDUCED APOPTOSIS IN ANGIOGENESIS 259
ANTIAPOPTOTIC PATHWAYS 260 REVERSE EFFECTS OF APOPTOSIS-INDUCING FACTOR
(AIF) IN APOPTOSIS AND IN CELL SURVIVAL 260 AKT PATHWAY PROMOTES CELL
SURVIVAL 261 INACTIVATION OF P53 IN MALIGNANT TRANSFORMATION OF CELLS
261 VIRAL ONCOPROTEINS INACTIVATE P53 262 WILD-TYPE LEVEL AND
OVEREXPRESSION OF P53 *. 263 ANTITAPOPTOTIC PATHWAYS BY GROWTH FACTOR
ACTIVATION 264 STRESS INDUCTION OF HEAT SHOCK PROTEIN REGULATION 264
ALTERNATIVE MECHANISMS TO SUPPRESS APOPTOSIS BY CYTOKINES 265 NICOTINIC
ACETYLCHOLINE RECEPTORS AGAINST APOPTOSIS 267 TREFOIL FACTORS FOR
MUCOSAL HEALING 267 TRANSGENIC MICE FOR APOPTOTIC RESEARCH 268 APOPTOSIS
PROTOCOLS 269 STAINING DEAD CELLS 269 TUNEL ASSAY 269 ISEL (IN SITU EN D
LABELING) (LEP) 270 DNA LADDERING 270 IMMUNOLOGICAL DETECTION OF LOW
MOLECULAR WEIGHT DNA V .. .. 270 ANNEXIN V ANALYSIS 270
FLUORESCENCE-ACTIVATED CELL SORTING (FACS) 271 LIGHT SCATTERING FLOW
CYTOMETRY 271 COMET ASSAY 271 APOPTOSIS PROTEINS 272 DETECTION OF MONO-
AND OLIGONUCLEOSOMES 272 ANTI-FAS MAB 272 P53 PROTEIN ANALYSIS 272
CASPASE STAINING KITS 273 REFERENCES 273 5 APOPTOTIC CHROMATIN CHANGES
293 SUMMARY 293 GENOTOXIC AGENTS 293 CHANGES IN DNA STRUCTURE CAUSED BY
GENOTOXIC AGENTS 294 CHROMATIN CHANGES UPON GENOTOXIC TREATMENT 297
CHEMICALLY INDUCED CHROMATIN CHANGES 297 HEAVY METAL INDUCED
CYTOTOXICITY 301 XII CONTENTS RELATIONSHIP BETWEEN REPLICATIVE AND
REPAIR DNA SYNTHESIS IN UNDAMAGED CELLS DURING THE CELL CYCLE 301
CADMIUM AS A GENOTOXIC AND CARCINOGENIC AGENT 302 EFFECT OF IONIZING
RADIATION ON CHROMATIN STRUCTURE 326 GAMMA IRRADIATION-INDUCED APOPTOSIS
IN MURINE PREB CELLS 326 GAMMA IRRADIATION-INDUCED APOPTOSIS IN
RADIATION RESISTANT HUMAN ERYTHROLEUKEMIA K562 CELLS 334 PREAPOPTOTIC
CHROMATIN CHANGES INDUCED BY ULTRAVIOLET B IRRADIATION IN HUMAN
ERYTHROLEUKEMIA K562 CELLS 346 SUMMARIZING THE APOPTOTIC CHANGES OF
GENOTOXIC TREATMENTS 356 REFERENCES 358 ABBREVIATIONS 365 GLOSSARY 379
INDEX 411
|
| any_adam_object | 1 |
| author | Bánfalvi, Gáspár |
| author_facet | Bánfalvi, Gáspár |
| author_role | aut |
| author_sort | Bánfalvi, Gáspár |
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| building | Verbundindex |
| bvnumber | BV025543052 |
| classification_rvk | WE 4500 |
| ctrlnum | (OCoLC)890620206 (DE-599)BVBBV025543052 |
| discipline | Biologie |
| format | Book |
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| illustrated | Illustrated |
| indexdate | 2024-07-09T22:36:11Z |
| institution | BVB |
| isbn | 9781402095603 |
| language | English |
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| physical | XII, 412 S. Ill., graph. Darst. 1 DVD, 1 3D-Brille |
| publishDate | 2009 |
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| spelling | Bánfalvi, Gáspár Verfasser aut Apoptotic chromatin changes Gáspár Bánfalvi [Dordrecht] Springer 2009 XII, 412 S. Ill., graph. Darst. 1 DVD, 1 3D-Brille txt rdacontent n rdamedia nc rdacarrier HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020144478&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Bánfalvi, Gáspár Apoptotic chromatin changes |
| title | Apoptotic chromatin changes |
| title_auth | Apoptotic chromatin changes |
| title_exact_search | Apoptotic chromatin changes |
| title_full | Apoptotic chromatin changes Gáspár Bánfalvi |
| title_fullStr | Apoptotic chromatin changes Gáspár Bánfalvi |
| title_full_unstemmed | Apoptotic chromatin changes Gáspár Bánfalvi |
| title_short | Apoptotic chromatin changes |
| title_sort | apoptotic chromatin changes |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020144478&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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