Genome mapping and genomics in animal-associated microbes:
Saved in:
| Other Authors: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Berlin [u.a.]
Springer
2009
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XXI, 236 S. Ill., graph. Darst. |
| ISBN: | 9783540740407 |
Staff View
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| 245 | 1 | 0 | |a Genome mapping and genomics in animal-associated microbes |c Vishvanath Nene ... ed. |
| 264 | 1 | |a Berlin [u.a.] |b Springer |c 2009 | |
| 300 | |a XXI, 236 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 7 | |a gene mapping |2 cabt | |
| 650 | 7 | |a microbes |2 cabt | |
| 650 | 7 | |a genom analysis |2 cabt | |
| 650 | 7 | |a brucella |2 cabt | |
| 650 | 7 | |a mycobacterium avium subsp paratuberculosis |2 cabt | |
| 650 | 7 | |a anaplasma |2 cabt | |
| 650 | 7 | |a ehrlichia |2 cabt | |
| 650 | 7 | |a cryptosporidium |2 cabt | |
| 650 | 7 | |a theileria |2 cabt | |
| 700 | 1 | |a Nene, Vishvanath |4 edt | |
| 856 | 4 | 2 | |m SWB Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020135155&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-020135155 | ||
Record in the Search Index
| _version_ | 1804142704129474560 |
|---|---|
| adam_text | CONTENTS CONTRIBUTORS . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . XIII
ABBREVIATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . XVII 1 BRUCELLA
NAMMALWAR SRIRANGANATHAN, MOHAMED N. SELEEM, STEVEN C. OLSEN, LUIS E.
SAMARTINO, ADRIAN M. WHATMORE, BETSY BRICKER, DAVID O*CALLAGHAN, BRUNO
W. SOBRAL, ERIC E. SNYDER, KELLEY WILLIAMS, GONG-XI YU, THOMAS A. FICHT,
C. MARTY ROOP II, PAUL DEFIGUEIREDO, STEPHEN M. BOYLE, OLIVER HE, AND
RENE M. TSOLIS . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 1.1.1
DISCOVERY OF THE BRUCELLAE . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . 1 1.1.2 SPECIES DISCOVERY . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 1.1.3
ZOONOSES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . 2 1.1.4 ERADICATION PROGRAM . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
3 1.1.5 VACCINATION . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . 3 1.1.6 MOLECULAR STUDY AND
DIAGNOSES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4
1.2 ECONOMIC AND ZOONOTIC IMPLICATIONS OF BRUCELLA . . . . . . . . . . .
. . . . . . . . . . . 4 1.2.1 DISTRIBUTION OF BRUCELLA SPP. WORLDWIDE .
. . . . . . . . . . . . . . . . . . . . . . 4 1.2.2 ZOONOTIC
CHARACTERISTICS OF BRUCELLA SPP. . . . . . . . . . . . . . . . . . . . .
. . 5 1.2.3 ECOMONIC LOSSES TO PRODUCERS AND COSTS FOR HUMAN CLINICAL
CARE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . 5 1.2.4 CONTROL PROGRAMS AND ASSOCIATED
ECONOMIC COSTS . . . . . . . . . . . . . . 6 1.2.5 CONCLUSIONS . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . 7 1.3 BRUCELLA TAXONOMY . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 1.3.1
MORPHOLOGY/LIFE CYCLE . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . 7 1.3.2 PHYLOGENETIC POSITION OF THE GENUS . .
. . . . . . . . . . . . . . . . . . . . . . . . . 7 1.3.3 BRUCELLA
TAXONOMY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . 9 1.4 MOLECULAR EPIDEMIOLOGY AND POPULATION DYNAMICS
OF BRUCELLA . . . . . . . . . 10 1.4.1 TOOLS FOR MOLECULAR EPIDEMIOLOGY
. . . . . . . . . . . . . . . . . . . . . . . . . . . 10 1.4.2
POPULATION DYNAMICS AND HOW THEY CAN IMPACT MOLECULAR EPIDEMIOLOGY . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11
1.4.3 CONCLUSIONS . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . 13 1.5 PHYSICAL AND GENETIC MAP
OF GENOMES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
13 1.5.1 BACTERIAL GENOMES AND THEIR ANALYSES . . . . . . . . . . . . .
. . . . . . . . . . 13 1.5.3 THE BRUCELLA GENOME IS HIGHLY CONSERVED . .
. . . . . . . . . . . . . . . . . . 14 1.5.4 THE BRUCELLA GENOME AND *
-PROTEOBACTERIA EVOLUTION . . . . . . . . . . 14 1.5.5 MULTIPLE GENOMES
AND GENOME REARRANGEMENTS . . . . . . . . . . . . . . 14 1.5.6 MOBILE
GENETIC ELEMENTS, REPEAT ELEMENTS AND GENOMIC REARRANGEMENTS . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . 15 1.5.7 GENOMIC
POLYMORPHISMS: TRANSPOSONS, PHAGE AND PLASMID ASSOCIATED SEQUENCES . . .
. . . . . . . . . . . . . . . . . . . . . . . . 16 1.5.8 GENETIC MAPS:
SYNTENY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . 16 VIII CONTENTS 1.6 GENOME SEQUENCING AND BIOINFORMATICS
RESOURCES . . . . . . . . . . . . . . . . . . . 16 1.6.1 INTRODUCTION .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . 16 1.6.2 GENOME SEQUENCING . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . 17 1.6.3
HIGH-THROUGHPUT SEQUENCING TECHNOLOGIES . . . . . . . . . . . . . . . .
. . . 17 1.6.4 BRUCELLA GENOME SEQUENCES . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . 18 1.6.5 BIOINFORMATICS RESOURCES . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20
1.6.6 BIOLOGICAL DATA CURATION IN THE AGE OF HIGH-THROUGHPUT
TECHNOLOGIES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . 21 1.6.7 BIOINFORMATICS RESOURCES FOR
BRUCELLA . . . . . . . . . . . . . . . . . . . . . . . . 21 1.6.8 THE
BRUCELLA BIOINFORMATICS PORTAL . . . . . . . . . . . . . . . . . . . . .
. . . . . . 21 1.6.9 THE PATHOGEN PORTAL . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . 23 1.6.10 THE PATHOSYSTEMS
RESOURCE INTEGRATION CENTER . . . . . . . . . . . . . . . . 24 1.6.11
SUMMARY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . 26 1.7 COMPARATIVE GENOMICS OF
BRUCELLA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. 26 1.7.1 INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . 26 1.7.2 COMPARATIVE
ANALYSIS OF BRUCELLA AND RELATED SPECIES . . . . . . . . . . 27 1.7.3
COMPARATIVE GENOMIC ANALYSIS OF BRUCELLA . . . . . . . . . . . . . . . .
. . . 29 1.7.4 SUMMARY . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . 35 1.8 FUNCTIONAL
GENOMICS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . 35 1.8.1 INTRODUCTION . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 35
1.8.2 GENOMICS: GLOBAL APPROACHES . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . 36 1.8.3 RATIONAL APPROACHES . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 38 1.8.4
TRANSCRIPTOMICS . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . 40 1.8.5 BACTERIAL MICROARRAYS . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 40 1.8.6
HOST CELL MICROARRAYS . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . 41 1.8.7 PROTEOMICS . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41
1.8.8 HIGHER ORDER (PROTEIN*PROTEIN) INTERACTIONS . . . . . . . . . . .
. . . . . . . 42 1.8.9 CONCLUSIONS . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . 42 1.9 GENOME
MAPPING AND MICROARRAY CONTRIBUTIONS TO UNDERSTANDING BRUCELLA
PATHOBIOLOGY AND HOST RESPONSES TO BRUCELLA INFECTIONS . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
43 1.9.1 INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . 43 1.9.2 BIOLOGY OF A BRUCELLA
INFECTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 43
1.9.3 GENOME MAPPING FOR UNDERSTANDING BRUCELLA PATHOBIOLOGY . . . . .
44 1.9.4 GENOME MAPPING FOR UNDERSTANDING HOST RESPONSE AGAINST
BRUCELLA INFECTIONS . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . 47 1.10 FUTURE DIRECTIONS AND PROSPECTS .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51
REFERENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 52 2
MYCOBACTERIUM AVIUM SUBSPECIES PARATUBERCULOSIS LING-LING LI, SUSHMITA
SINGH, JOHN BANNANTINE, SAGARIKA KANJILAL, AND VIVEK KAPUR . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . 65 2.1 INTRODUCTION . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . 65 2.1.1 THE PATHOGEN AND THE DISEASE IT CAUSES . . . . . . . . .
. . . . . . . . . . . . . 65 2.1.2 MORPHOLOGY, TAXONOMIC POSITION,
LIFE-CYCLE, AND HOST-RANGE OF MAP . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . 67 2.2 THE GENOME SEQUENCE OF MAP . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 68
2.2.1 CHARACTERISTICS OF THE MAP K-10 GENOME . . . . . . . . . . . . . .
. . . . . . . 68 2.2.2 REPETITIVE DNA IN MAP . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . 68 2.2.3 PROTEIN ENCODING
GENES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . 69 2.2.4 UNIQUE REGIONS AND UNIQUE GENES . . . . . . . . . . . . .
. . . . . . . . . . . . . . 69 CONTENTS IX 2.2.5 MYCOBACTIN SYNTHESIS .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. 70 2.2.6 INSIGHTS INTO VIRULENCE AND PATHOGENICITY GLEANED FROM THE
MAP GENOME . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . 70 2.2.7 DISTINGUISHING CHARACTERISTICS OF THE MAP GENOME .
. . . . . . . . . . . 70 2.2.8 GENOMICS-BASED INSIGHTS INTO MAP
METABOLISM . . . . . . . . . . . . . . . 71 2.3 POPULATION STUDIES OF
MAP . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . 72 2.3.1 MULTI-LOCUS ENZYME ELECTROPHORESIS (MLEE) . . . .
. . . . . . . . . . . . . 73 2.3.2 DNA-BASED TOOLS . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 73 2.3.3
MULTI-LOCUS SHORT SEQUENCE REPEATS (MLSSR) . . . . . . . . . . . . . . .
. . 75 2.3.4 VARIABLE NUMBER OF TANDEM REPEATS (VNTR) . . . . . . . . .
. . . . . . . . 77 2.4 CONCLUDING COMMENTS . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 78 REFERENCES
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . 79 3 ANAPLASMA KELLY A.
BRAYTON, MICHAEL J. DARK, AND GUY H. PALMER . . . . . . . . . . . . . .
. . . . . . . . . 85 3.1 INTRODUCTION . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
85 3.2 HISTORY . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 85 3.3 IMPACT
ON ANIMAL HEALTH . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . 87 3.4 TAXONOMY . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . 87 3.5 STRAINS . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 91
3.5.1 GENOTYPE . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . 91 3.5.2 STRAIN DIVERSITY . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . 91 3.6 POPULATION STUDIES . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 93 3.7
GENOME SEQUENCE AND RESOURCES . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . 94 3.7.1 GENOME ARCHITECTURE AND GENERAL
FEATURES . . . . . . . . . . . . . . . . . . . 94 3.7.2 METABOLISM . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . 96 3.7.3 CELL WALL BIOGENESIS . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . 98 3.7.4
TRANSPORTERS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . 99 3.7.5 PARALOGOUS GENE FAMILIES . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 102 3.8
COMPARATIVE GENOMICS . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . 105 3.9 FUTURE SCOPE . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . 108 REFERENCES . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. 110 4 EHRLICHIA BASIL A. ALLSOPP AND JERE W. MCBRIDE . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . 117 4.1
INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . 117 4.1.1 HISTORY OF
EHRLICHIA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . 117 4.1.2 TAXONOMIC POSITION . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . 117 4.1.3
ULTRASTRUCTURE . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . 118 4.1.4 LIFE CYCLE . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. 119 4.1.5 ENTRY AND DEVELOPMENT IN HOST CELLS . . . . . . . . . . . .
. . . . . . . . . . . 120 4.1.6 EPIDEMIOLOGY . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 120 4.1.7
DISEASES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . 121 4.1.8 ECONOMIC IMPORTANCE . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 122
4.1.9 EHRLICHIA AS ZOONOTIC PATHOGENS . . . . . . . . . . . . . . . . .
. . . . . . . . . . . 123 4.2 GENOMICS. . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . 123 4.2.1 GENETIC VARIABILITY OF EHRLICHIA . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . 124 4.2.2 GENOME SEQUENCING . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 128
4.2.3 GENOMIC INSIGHTS INTO THE BIOLOGY OF EHRLICHIA . . . . . . . . . .
. . . . . 140 4.2.4 MOLECULAR DIAGNOSTICS . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . 148 X CONTENTS 4.2.5
VACCINE DEVELOPMENT . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . 150 4.2.6 COMPARATIVE GENOMICS OF EHRLICHIA
SPECIES . . . . . . . . . . . . . . . . . . 152 4.3 FUTURE SCOPE . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . 155 REFERENCES . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . 156 5 CRYPTOSPORIDIUM GUAN ZHU, SHINICHIRO ENOMOTO, JASON M.
FRITZLER, MITCHELL S. ABRAHAMSEN, AND THOMAS J. TEMPLETON . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . 165 5.1 CRYPTOSPORIDIUM AND CRYPTOSPORIDIOSIS . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . .165 5.1.1 INTRODUCTION . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . 165 5.1.2 TAXONOMIC POSITION . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . 166 5.1.3 LIFE CYCLE . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . 167 5.1.4 CRYPTOSPORIDIUM GENOTYPES . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . 170 5.1.5 TREATMENT . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . 170 5.2 GENOME SEQUENCING, MAPPING, AND RESOURCES . .
. . . . . . . . . . . . . . . . . . . . . 172 5.2.1 HISTORY OF GENOME
SEQUENCING PROJECTS . . . . . . . . . . . . . . . . . . . . . 172 5.2.2
GENERAL FEATURES OF CRYPTOSPORIDIUM GENOMES . . . . . . . . . . . . . .
. 172 5.2.3 COMPARISON BETWEEN C. PARVUM AND C. HOMINIS GENOMES . . . .
. 174 5.2.4 GENOME DATABASES AND RESOURCES . . . . . . . . . . . . . . .
. . . . . . . . . . . 176 5.2.5 GENOME MAPS . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 177 5.3
CRYPTOSPORIDIUM BIOLOGY: INSIGHTS FROM THE COMPLETE GENOME . . . . . . .
. 178 5.3.1 STREAMLINED METABOLISM . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . 178 5.3.2 EXPANDED FAMILIES OF
TRANSPORTERS . . . . . . . . . . . . . . . . . . . . . . . . . 179 5.3.3
LINEAGE-SPECIFIC EXPANSION OF PROTEASES . . . . . . . . . . . . . . . .
. . . . . 180 5.3.4 CRYPTOSPORIDIUM- SPECIFIC AMPLIFIED GENE FAMILIES .
. . . . . . . . . . . 180 5.3.5 THE SURFACE PROTEIN REPERTOIRE OF
CRYPTOSPORIDIUM . . . . . . . . . . . 180 5.3.6 MUCIN-LIKE PROTEINS. . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
181 5.3.7 THE TRAP FAMILY OF MOTILITY AND INVASION PROTEINS . . . . . .
. . . . . 181 5.3.8 THE LCCL DOMAIN FAMILY . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . 182 5.3.9 THE OOCYST WALL PROTEINS .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 182
5.3.10 THE ROLE OF LATERAL GENE TRANSFER IN THE ORIGIN OF APICOMPLEXAN
EXTRACELLULAR PROTEINS . . . . . . . . . . . . . . . . . . . . . . 182
5.4 PARASITE TARGETS FOR NEW THERAPEUTICS . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . 184 REFERENCES . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . 185 6 THEILERIA RICHARD P. BISHOP, DAVID O. ODONGO,
DAVID J. MANN, TERRY W. PEARSON, CHIHIRO SUGIMOTO, LEE R. HAINES,
ELIZABETH GLASS, KIRSTY JENSEN, ULRIKE SEITZER, JABBAR S. AHMED, SIMON
P. GRAHAM, AND ETIENNE P. DE VILLIERS . . . . . . . . . . . . . . . 191
6.1 INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . 191 6.1.1 THE GENUS
THEILERIA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . 191 6.1.2 ECONOMIC IMPORTANCE OF THEILERIA . . . . . . . .
. . . . . . . . . . . . . . . . . . 192 6.1.3 THEILERIA TAXONOMY . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
192 6.1.4 EPIDEMIOLOGY AND PATHOLOGY OF THEILERIA INFECTIONS . . . . . .
. . . . . 193 6.1.5 THEILERIA LIFE CYCLE AND CELL BIOLOGY . . . . . . .
. . . . . . . . . . . . . . . . . 194 6.2 PHYSICAL MAPPING OF THE T.
PARVA GENOME . . . . . . . . . . . . . . . . . . . . . . . . . . 196 6.3
THE THEILERIA PARVA AND T. ANNULATA GENOME SEQUENCES . . . . . . . . . .
. . . . 196 6.3.1 TELOMERE-ASSOCIATED SEQUENCES . . . . . . . . . . . .
. . . . . . . . . . . . . . . . 198 6.3.2 COMPARATIVE GENOMICS OF T.
PARVA AND T. ANNULATA . . . . . . . . . . . 200 6.3.3 CURRENT STATUS OF
THE THEILERIA ORIENTALIS GENOME SEQUENCING PROJECT . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 201 CONTENTS
XI 6.4 POPULATION GENETICS AND MOLECULAR EPIDEMIOLOGY OF T. PARVA AND T.
ANNULATA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . 202 6.5 GENETIC RECOMBINATION IN T. PARVA . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . 203 6.6 THE
TRANSCRIPTOME OF THEILERIA PARVA SCHIZONTS AS REVEALED USING MPSS . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . 205 6.6.1 TRANSCRIPTION OF THE MULTICOPY TPR
AND TAR LOCI . . . . . . . . . . . . . . 206 6.7 A SNAPSHOT OF THE T.
PARVA PROTEOME . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . 206 6.8 TRANSCRIPTIONAL ANALYSES OF HOST*PATHOGEN INTERACTIONS OF T.
ANNULATA INFECTIONS IN BOVINE MACROPHAGES . . . . . . . . . . . . . . .
. . . . 209 6.9 APPLICATION OF GENOMICS TO UNDERSTAND THE BIOLOGY OF
THEILERIA *MAMMALIAN HOST CELL INTERACTION . . . . . . . . . . . . . . .
. . . . . . 211 6.9.1 INSIGHTS INTO THE INTERACTION OF THEILERIA WITH
BOVINE LEUKOCYTES DERIVED FROM ANALYSIS OF THE VIRTUAL PROTEOMES OF T.
PARVA AND T. ANNULATA . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . 211 6.9.2 ANALYSIS OF THE T. PARVA PREDICTED PROTEOME IN
RELATION TO CELL CYCLE REGULATION AND MODULATION OF MAMMALIAN HOST CELL
FUNCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . 213 6.9.3 PREDICTED CYCLIN-DEPENDENT KINASES IN THE T.
PARVA GENOME . . . 213 6.9.4 PREDICTED CYCLINS IN THE T. PARVA GENOME .
. . . . . . . . . . . . . . . . . . . 213 6.9.5 SEQUENCE HOMOLOGUES OF
ADDITIONAL PARASITE-ENCODED CELL CYCLE REGULATORS . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . 219 6.9.6
POTENTIAL MODULATORS OF THE HOST CELL IDENTIFIED IN THE THEILERIA
GENOMES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . 219 6.10 APPLICATION OF GENOMICS TO THE DEVELOPMENT AND DEPLOYMENT
OF VACCINES FOR THE CONTROL OF THEILERIA . . . . . . . . . . . . . . . .
. . . . . . . . . . . . 221 6.10.1 MOLECULAR TOOLS TO SUPPORT LIVE
VACCINATION AGAINST EAST COAST FEVER . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . 221 6.10.2 LIVE
ATTENUATED CELL CULTURE VACCINES FOR THE CONTROL OF T. ANNULATA . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . 221 6.10.3 APPLICATION OF GENOMICS TO DEVELOPMENT OF SUBUNIT
VACCINES FOR CONTROL OF ECF . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . 222 6.11 INITIAL INVESTIGATION OF THEILERIA
INTERACTION WITH IXODID TICK VECTORS USING EXPRESSED SEQUENCE TAGS
DERIVED FROM R. APPENDICULATUS AND A. VARIEGATUM TICK SALIVARY GLAND
TRANSCRIPTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . 224 6.12 OPPORTUNITIES FOR
FUTURE RESEARCH . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . 224 REFERENCES . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
225 INDEX . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 233
|
| any_adam_object | 1 |
| author2 | Nene, Vishvanath |
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| building | Verbundindex |
| bvnumber | BV025532126 |
| classification_rvk | WC 4460 |
| ctrlnum | (OCoLC)361709087 (DE-599)BVBBV025532126 |
| dewey-full | 636.08969 572.863329165 |
| dewey-hundreds | 600 - Technology (Applied sciences) 500 - Natural sciences and mathematics |
| dewey-ones | 636 - Animal husbandry 572 - Biochemistry |
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| dewey-tens | 630 - Agriculture and related technologies 570 - Biology |
| discipline | Biologie Agrar-/Forst-/Ernährungs-/Haushaltswissenschaft / Gartenbau |
| format | Book |
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| id | DE-604.BV025532126 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T22:36:00Z |
| institution | BVB |
| isbn | 9783540740407 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-020135155 |
| oclc_num | 361709087 |
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| owner | DE-11 DE-188 |
| owner_facet | DE-11 DE-188 |
| physical | XXI, 236 S. Ill., graph. Darst. |
| publishDate | 2009 |
| publishDateSearch | 2009 |
| publishDateSort | 2009 |
| publisher | Springer |
| record_format | marc |
| spelling | Genome mapping and genomics in animal-associated microbes Vishvanath Nene ... ed. Berlin [u.a.] Springer 2009 XXI, 236 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier gene mapping cabt microbes cabt genom analysis cabt brucella cabt mycobacterium avium subsp paratuberculosis cabt anaplasma cabt ehrlichia cabt cryptosporidium cabt theileria cabt Nene, Vishvanath edt SWB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020135155&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Genome mapping and genomics in animal-associated microbes gene mapping cabt microbes cabt genom analysis cabt brucella cabt mycobacterium avium subsp paratuberculosis cabt anaplasma cabt ehrlichia cabt cryptosporidium cabt theileria cabt |
| title | Genome mapping and genomics in animal-associated microbes |
| title_auth | Genome mapping and genomics in animal-associated microbes |
| title_exact_search | Genome mapping and genomics in animal-associated microbes |
| title_full | Genome mapping and genomics in animal-associated microbes Vishvanath Nene ... ed. |
| title_fullStr | Genome mapping and genomics in animal-associated microbes Vishvanath Nene ... ed. |
| title_full_unstemmed | Genome mapping and genomics in animal-associated microbes Vishvanath Nene ... ed. |
| title_short | Genome mapping and genomics in animal-associated microbes |
| title_sort | genome mapping and genomics in animal associated microbes |
| topic | gene mapping cabt microbes cabt genom analysis cabt brucella cabt mycobacterium avium subsp paratuberculosis cabt anaplasma cabt ehrlichia cabt cryptosporidium cabt theileria cabt |
| topic_facet | gene mapping microbes genom analysis brucella mycobacterium avium subsp paratuberculosis anaplasma ehrlichia cryptosporidium theileria |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020135155&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT nenevishvanath genomemappingandgenomicsinanimalassociatedmicrobes |