Verfügbarkeit: Genome mapping and genomics in animal-associated microbes

Genome mapping and genomics in animal-associated microbes:

Gespeichert in:

Bibliographische Detailangaben
Weitere Verfasser:	Nene, Vishvanath (HerausgeberIn)
Format:	Buch
Sprache:	English
Veröffentlicht:	Berlin [u.a.] Springer 2009
Schlagworte:	gene mapping microbes genom analysis brucella mycobacterium avium subsp paratuberculosis anaplasma ehrlichia cryptosporidium theileria
Online-Zugang:	Inhaltsverzeichnis
Beschreibung:	XXI, 236 S. Ill., graph. Darst.
ISBN:	9783540740407

Internformat

MARC


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245	1	0	\|a Genome mapping and genomics in animal-associated microbes \|c Vishvanath Nene ... ed.
264		1	\|a Berlin [u.a.] \|b Springer \|c 2009
300			\|a XXI, 236 S. \|b Ill., graph. Darst.
336			\|b txt \|2 rdacontent
337			\|b n \|2 rdamedia
338			\|b nc \|2 rdacarrier
650		7	\|a gene mapping \|2 cabt
650		7	\|a microbes \|2 cabt
650		7	\|a genom analysis \|2 cabt
650		7	\|a brucella \|2 cabt
650		7	\|a mycobacterium avium subsp paratuberculosis \|2 cabt
650		7	\|a anaplasma \|2 cabt
650		7	\|a ehrlichia \|2 cabt
650		7	\|a cryptosporidium \|2 cabt
650		7	\|a theileria \|2 cabt
700	1		\|a Nene, Vishvanath \|4 edt
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999			\|a oai:aleph.bib-bvb.de:BVB01-020135155

Datensatz im Suchindex

_version_	1804142704129474560
adam_text	CONTENTS CONTRIBUTORS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . XIII ABBREVIATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . XVII 1 BRUCELLA NAMMALWAR SRIRANGANATHAN, MOHAMED N. SELEEM, STEVEN C. OLSEN, LUIS E. SAMARTINO, ADRIAN M. WHATMORE, BETSY BRICKER, DAVID OCALLAGHAN, BRUNO W. SOBRAL, ERIC E. SNYDER, KELLEY WILLIAMS, GONG-XI YU, THOMAS A. FICHT, C. MARTY ROOP II, PAUL DEFIGUEIREDO, STEPHEN M. BOYLE, OLIVER HE, AND RENE M. TSOLIS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 1.1.1 DISCOVERY OF THE BRUCELLAE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 1.1.2 SPECIES DISCOVERY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 1.1.3 ZOONOSES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 1.1.4 ERADICATION PROGRAM . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 1.1.5 VACCINATION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 1.1.6 MOLECULAR STUDY AND DIAGNOSES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 1.2 ECONOMIC AND ZOONOTIC IMPLICATIONS OF BRUCELLA . . . . . . . . . . . . . . . . . . . . . . 4 1.2.1 DISTRIBUTION OF BRUCELLA SPP. WORLDWIDE . . . . . . . . . . . . . . . . . . . . . . . 4 1.2.2 ZOONOTIC CHARACTERISTICS OF BRUCELLA SPP. . . . . . . . . . . . . . . . . . . . . . . 5 1.2.3 ECOMONIC LOSSES TO PRODUCERS AND COSTS FOR HUMAN CLINICAL CARE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 1.2.4 CONTROL PROGRAMS AND ASSOCIATED ECONOMIC COSTS . . . . . . . . . . . . . . 6 1.2.5 CONCLUSIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 1.3 BRUCELLA TAXONOMY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 1.3.1 MORPHOLOGY/LIFE CYCLE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 1.3.2 PHYLOGENETIC POSITION OF THE GENUS . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 1.3.3 BRUCELLA TAXONOMY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 1.4 MOLECULAR EPIDEMIOLOGY AND POPULATION DYNAMICS OF BRUCELLA . . . . . . . . . 10 1.4.1 TOOLS FOR MOLECULAR EPIDEMIOLOGY . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 1.4.2 POPULATION DYNAMICS AND HOW THEY CAN IMPACT MOLECULAR EPIDEMIOLOGY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 1.4.3 CONCLUSIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 1.5 PHYSICAL AND GENETIC MAP OF GENOMES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 1.5.1 BACTERIAL GENOMES AND THEIR ANALYSES . . . . . . . . . . . . . . . . . . . . . . . 13 1.5.3 THE BRUCELLA GENOME IS HIGHLY CONSERVED . . . . . . . . . . . . . . . . . . . . 14 1.5.4 THE BRUCELLA GENOME AND -PROTEOBACTERIA EVOLUTION . . . . . . . . . . 14 1.5.5 MULTIPLE GENOMES AND GENOME REARRANGEMENTS . . . . . . . . . . . . . . 14 1.5.6 MOBILE GENETIC ELEMENTS, REPEAT ELEMENTS AND GENOMIC REARRANGEMENTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 1.5.7 GENOMIC POLYMORPHISMS: TRANSPOSONS, PHAGE AND PLASMID ASSOCIATED SEQUENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . 16 1.5.8 GENETIC MAPS: SYNTENY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16 VIII CONTENTS 1.6 GENOME SEQUENCING AND BIOINFORMATICS RESOURCES . . . . . . . . . . . . . . . . . . . 16 1.6.1 INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16 1.6.2 GENOME SEQUENCING . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 1.6.3 HIGH-THROUGHPUT SEQUENCING TECHNOLOGIES . . . . . . . . . . . . . . . . . . . 17 1.6.4 BRUCELLA GENOME SEQUENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18 1.6.5 BIOINFORMATICS RESOURCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20 1.6.6 BIOLOGICAL DATA CURATION IN THE AGE OF HIGH-THROUGHPUT TECHNOLOGIES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21 1.6.7 BIOINFORMATICS RESOURCES FOR BRUCELLA . . . . . . . . . . . . . . . . . . . . . . . . 21 1.6.8 THE BRUCELLA BIOINFORMATICS PORTAL . . . . . . . . . . . . . . . . . . . . . . . . . . . 21 1.6.9 THE PATHOGEN PORTAL . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 23 1.6.10 THE PATHOSYSTEMS RESOURCE INTEGRATION CENTER . . . . . . . . . . . . . . . . 24 1.6.11 SUMMARY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26 1.7 COMPARATIVE GENOMICS OF BRUCELLA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26 1.7.1 INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26 1.7.2 COMPARATIVE ANALYSIS OF BRUCELLA AND RELATED SPECIES . . . . . . . . . . 27 1.7.3 COMPARATIVE GENOMIC ANALYSIS OF BRUCELLA . . . . . . . . . . . . . . . . . . . 29 1.7.4 SUMMARY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 35 1.8 FUNCTIONAL GENOMICS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 35 1.8.1 INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 35 1.8.2 GENOMICS: GLOBAL APPROACHES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 36 1.8.3 RATIONAL APPROACHES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 38 1.8.4 TRANSCRIPTOMICS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 40 1.8.5 BACTERIAL MICROARRAYS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 40 1.8.6 HOST CELL MICROARRAYS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41 1.8.7 PROTEOMICS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41 1.8.8 HIGHER ORDER (PROTEINPROTEIN) INTERACTIONS . . . . . . . . . . . . . . . . . . 42 1.8.9 CONCLUSIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 42 1.9 GENOME MAPPING AND MICROARRAY CONTRIBUTIONS TO UNDERSTANDING BRUCELLA PATHOBIOLOGY AND HOST RESPONSES TO BRUCELLA INFECTIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 43 1.9.1 INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 43 1.9.2 BIOLOGY OF A BRUCELLA INFECTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 43 1.9.3 GENOME MAPPING FOR UNDERSTANDING BRUCELLA PATHOBIOLOGY . . . . . 44 1.9.4 GENOME MAPPING FOR UNDERSTANDING HOST RESPONSE AGAINST BRUCELLA INFECTIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 47 1.10 FUTURE DIRECTIONS AND PROSPECTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51 REFERENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 52 2 MYCOBACTERIUM AVIUM SUBSPECIES PARATUBERCULOSIS LING-LING LI, SUSHMITA SINGH, JOHN BANNANTINE, SAGARIKA KANJILAL, AND VIVEK KAPUR . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 65 2.1 INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 65 2.1.1 THE PATHOGEN AND THE DISEASE IT CAUSES . . . . . . . . . . . . . . . . . . . . . . 65 2.1.2 MORPHOLOGY, TAXONOMIC POSITION, LIFE-CYCLE, AND HOST-RANGE OF MAP . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 67 2.2 THE GENOME SEQUENCE OF MAP . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 68 2.2.1 CHARACTERISTICS OF THE MAP K-10 GENOME . . . . . . . . . . . . . . . . . . . . . 68 2.2.2 REPETITIVE DNA IN MAP . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 68 2.2.3 PROTEIN ENCODING GENES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 69 2.2.4 UNIQUE REGIONS AND UNIQUE GENES . . . . . . . . . . . . . . . . . . . . . . . . . . . 69 CONTENTS IX 2.2.5 MYCOBACTIN SYNTHESIS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 70 2.2.6 INSIGHTS INTO VIRULENCE AND PATHOGENICITY GLEANED FROM THE MAP GENOME . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 70 2.2.7 DISTINGUISHING CHARACTERISTICS OF THE MAP GENOME . . . . . . . . . . . . 70 2.2.8 GENOMICS-BASED INSIGHTS INTO MAP METABOLISM . . . . . . . . . . . . . . . 71 2.3 POPULATION STUDIES OF MAP . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 72 2.3.1 MULTI-LOCUS ENZYME ELECTROPHORESIS (MLEE) . . . . . . . . . . . . . . . . . 73 2.3.2 DNA-BASED TOOLS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 73 2.3.3 MULTI-LOCUS SHORT SEQUENCE REPEATS (MLSSR) . . . . . . . . . . . . . . . . . 75 2.3.4 VARIABLE NUMBER OF TANDEM REPEATS (VNTR) . . . . . . . . . . . . . . . . . 77 2.4 CONCLUDING COMMENTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 78 REFERENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 79 3 ANAPLASMA KELLY A. BRAYTON, MICHAEL J. DARK, AND GUY H. PALMER . . . . . . . . . . . . . . . . . . . . . . . 85 3.1 INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 85 3.2 HISTORY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 85 3.3 IMPACT ON ANIMAL HEALTH . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 87 3.4 TAXONOMY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 87 3.5 STRAINS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 91 3.5.1 GENOTYPE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 91 3.5.2 STRAIN DIVERSITY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 91 3.6 POPULATION STUDIES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 93 3.7 GENOME SEQUENCE AND RESOURCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 94 3.7.1 GENOME ARCHITECTURE AND GENERAL FEATURES . . . . . . . . . . . . . . . . . . . 94 3.7.2 METABOLISM . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 96 3.7.3 CELL WALL BIOGENESIS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 98 3.7.4 TRANSPORTERS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 99 3.7.5 PARALOGOUS GENE FAMILIES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 102 3.8 COMPARATIVE GENOMICS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 105 3.9 FUTURE SCOPE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 108 REFERENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 110 4 EHRLICHIA BASIL A. ALLSOPP AND JERE W. MCBRIDE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 117 4.1 INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 117 4.1.1 HISTORY OF EHRLICHIA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 117 4.1.2 TAXONOMIC POSITION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 117 4.1.3 ULTRASTRUCTURE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 118 4.1.4 LIFE CYCLE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 119 4.1.5 ENTRY AND DEVELOPMENT IN HOST CELLS . . . . . . . . . . . . . . . . . . . . . . . 120 4.1.6 EPIDEMIOLOGY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 120 4.1.7 DISEASES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 121 4.1.8 ECONOMIC IMPORTANCE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 122 4.1.9 EHRLICHIA AS ZOONOTIC PATHOGENS . . . . . . . . . . . . . . . . . . . . . . . . . . . . 123 4.2 GENOMICS. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 123 4.2.1 GENETIC VARIABILITY OF EHRLICHIA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 124 4.2.2 GENOME SEQUENCING . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 128 4.2.3 GENOMIC INSIGHTS INTO THE BIOLOGY OF EHRLICHIA . . . . . . . . . . . . . . . 140 4.2.4 MOLECULAR DIAGNOSTICS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 148 X CONTENTS 4.2.5 VACCINE DEVELOPMENT . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 150 4.2.6 COMPARATIVE GENOMICS OF EHRLICHIA SPECIES . . . . . . . . . . . . . . . . . . 152 4.3 FUTURE SCOPE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 155 REFERENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 156 5 CRYPTOSPORIDIUM GUAN ZHU, SHINICHIRO ENOMOTO, JASON M. FRITZLER, MITCHELL S. ABRAHAMSEN, AND THOMAS J. TEMPLETON . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 165 5.1 CRYPTOSPORIDIUM AND CRYPTOSPORIDIOSIS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .165 5.1.1 INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 165 5.1.2 TAXONOMIC POSITION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 166 5.1.3 LIFE CYCLE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 167 5.1.4 CRYPTOSPORIDIUM GENOTYPES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 170 5.1.5 TREATMENT . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 170 5.2 GENOME SEQUENCING, MAPPING, AND RESOURCES . . . . . . . . . . . . . . . . . . . . . . . 172 5.2.1 HISTORY OF GENOME SEQUENCING PROJECTS . . . . . . . . . . . . . . . . . . . . . 172 5.2.2 GENERAL FEATURES OF CRYPTOSPORIDIUM GENOMES . . . . . . . . . . . . . . . 172 5.2.3 COMPARISON BETWEEN C. PARVUM AND C. HOMINIS GENOMES . . . . . 174 5.2.4 GENOME DATABASES AND RESOURCES . . . . . . . . . . . . . . . . . . . . . . . . . . 176 5.2.5 GENOME MAPS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 177 5.3 CRYPTOSPORIDIUM BIOLOGY: INSIGHTS FROM THE COMPLETE GENOME . . . . . . . . 178 5.3.1 STREAMLINED METABOLISM . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 178 5.3.2 EXPANDED FAMILIES OF TRANSPORTERS . . . . . . . . . . . . . . . . . . . . . . . . . 179 5.3.3 LINEAGE-SPECIFIC EXPANSION OF PROTEASES . . . . . . . . . . . . . . . . . . . . . 180 5.3.4 CRYPTOSPORIDIUM- SPECIFIC AMPLIFIED GENE FAMILIES . . . . . . . . . . . . 180 5.3.5 THE SURFACE PROTEIN REPERTOIRE OF CRYPTOSPORIDIUM . . . . . . . . . . . 180 5.3.6 MUCIN-LIKE PROTEINS. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 181 5.3.7 THE TRAP FAMILY OF MOTILITY AND INVASION PROTEINS . . . . . . . . . . . 181 5.3.8 THE LCCL DOMAIN FAMILY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 182 5.3.9 THE OOCYST WALL PROTEINS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 182 5.3.10 THE ROLE OF LATERAL GENE TRANSFER IN THE ORIGIN OF APICOMPLEXAN EXTRACELLULAR PROTEINS . . . . . . . . . . . . . . . . . . . . . . 182 5.4 PARASITE TARGETS FOR NEW THERAPEUTICS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 184 REFERENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 185 6 THEILERIA RICHARD P. BISHOP, DAVID O. ODONGO, DAVID J. MANN, TERRY W. PEARSON, CHIHIRO SUGIMOTO, LEE R. HAINES, ELIZABETH GLASS, KIRSTY JENSEN, ULRIKE SEITZER, JABBAR S. AHMED, SIMON P. GRAHAM, AND ETIENNE P. DE VILLIERS . . . . . . . . . . . . . . . 191 6.1 INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 191 6.1.1 THE GENUS THEILERIA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 191 6.1.2 ECONOMIC IMPORTANCE OF THEILERIA . . . . . . . . . . . . . . . . . . . . . . . . . . 192 6.1.3 THEILERIA TAXONOMY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 192 6.1.4 EPIDEMIOLOGY AND PATHOLOGY OF THEILERIA INFECTIONS . . . . . . . . . . . 193 6.1.5 THEILERIA LIFE CYCLE AND CELL BIOLOGY . . . . . . . . . . . . . . . . . . . . . . . . 194 6.2 PHYSICAL MAPPING OF THE T. PARVA GENOME . . . . . . . . . . . . . . . . . . . . . . . . . . 196 6.3 THE THEILERIA PARVA AND T. ANNULATA GENOME SEQUENCES . . . . . . . . . . . . . . 196 6.3.1 TELOMERE-ASSOCIATED SEQUENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . 198 6.3.2 COMPARATIVE GENOMICS OF T. PARVA AND T. ANNULATA . . . . . . . . . . . 200 6.3.3 CURRENT STATUS OF THE THEILERIA ORIENTALIS GENOME SEQUENCING PROJECT . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 201 CONTENTS XI 6.4 POPULATION GENETICS AND MOLECULAR EPIDEMIOLOGY OF T. PARVA AND T. ANNULATA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 202 6.5 GENETIC RECOMBINATION IN T. PARVA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 203 6.6 THE TRANSCRIPTOME OF THEILERIA PARVA SCHIZONTS AS REVEALED USING MPSS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 205 6.6.1 TRANSCRIPTION OF THE MULTICOPY TPR AND TAR LOCI . . . . . . . . . . . . . . 206 6.7 A SNAPSHOT OF THE T. PARVA PROTEOME . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 206 6.8 TRANSCRIPTIONAL ANALYSES OF HOSTPATHOGEN INTERACTIONS OF T. ANNULATA INFECTIONS IN BOVINE MACROPHAGES . . . . . . . . . . . . . . . . . . . 209 6.9 APPLICATION OF GENOMICS TO UNDERSTAND THE BIOLOGY OF THEILERIA *MAMMALIAN HOST CELL INTERACTION . . . . . . . . . . . . . . . . . . . . . 211 6.9.1 INSIGHTS INTO THE INTERACTION OF THEILERIA WITH BOVINE LEUKOCYTES DERIVED FROM ANALYSIS OF THE VIRTUAL PROTEOMES OF T. PARVA AND T. ANNULATA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 211 6.9.2 ANALYSIS OF THE T. PARVA PREDICTED PROTEOME IN RELATION TO CELL CYCLE REGULATION AND MODULATION OF MAMMALIAN HOST CELL FUNCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 213 6.9.3 PREDICTED CYCLIN-DEPENDENT KINASES IN THE T. PARVA GENOME . . . 213 6.9.4 PREDICTED CYCLINS IN THE T. PARVA GENOME . . . . . . . . . . . . . . . . . . . . 213 6.9.5 SEQUENCE HOMOLOGUES OF ADDITIONAL PARASITE-ENCODED CELL CYCLE REGULATORS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 219 6.9.6 POTENTIAL MODULATORS OF THE HOST CELL IDENTIFIED IN THE THEILERIA GENOMES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 219 6.10 APPLICATION OF GENOMICS TO THE DEVELOPMENT AND DEPLOYMENT OF VACCINES FOR THE CONTROL OF THEILERIA . . . . . . . . . . . . . . . . . . . . . . . . . . . . 221 6.10.1 MOLECULAR TOOLS TO SUPPORT LIVE VACCINATION AGAINST EAST COAST FEVER . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 221 6.10.2 LIVE ATTENUATED CELL CULTURE VACCINES FOR THE CONTROL OF T. ANNULATA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 221 6.10.3 APPLICATION OF GENOMICS TO DEVELOPMENT OF SUBUNIT VACCINES FOR CONTROL OF ECF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 222 6.11 INITIAL INVESTIGATION OF THEILERIA INTERACTION WITH IXODID TICK VECTORS USING EXPRESSED SEQUENCE TAGS DERIVED FROM R. APPENDICULATUS AND A. VARIEGATUM TICK SALIVARY GLAND TRANSCRIPTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 224 6.12 OPPORTUNITIES FOR FUTURE RESEARCH . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 224 REFERENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 225 INDEX . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 233
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spelling	Genome mapping and genomics in animal-associated microbes Vishvanath Nene ... ed. Berlin [u.a.] Springer 2009 XXI, 236 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier gene mapping cabt microbes cabt genom analysis cabt brucella cabt mycobacterium avium subsp paratuberculosis cabt anaplasma cabt ehrlichia cabt cryptosporidium cabt theileria cabt Nene, Vishvanath edt SWB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020135155&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle	Genome mapping and genomics in animal-associated microbes gene mapping cabt microbes cabt genom analysis cabt brucella cabt mycobacterium avium subsp paratuberculosis cabt anaplasma cabt ehrlichia cabt cryptosporidium cabt theileria cabt
title	Genome mapping and genomics in animal-associated microbes
title_auth	Genome mapping and genomics in animal-associated microbes
title_exact_search	Genome mapping and genomics in animal-associated microbes
title_full	Genome mapping and genomics in animal-associated microbes Vishvanath Nene ... ed.
title_fullStr	Genome mapping and genomics in animal-associated microbes Vishvanath Nene ... ed.
title_full_unstemmed	Genome mapping and genomics in animal-associated microbes Vishvanath Nene ... ed.
title_short	Genome mapping and genomics in animal-associated microbes
title_sort	genome mapping and genomics in animal associated microbes
topic	gene mapping cabt microbes cabt genom analysis cabt brucella cabt mycobacterium avium subsp paratuberculosis cabt anaplasma cabt ehrlichia cabt cryptosporidium cabt theileria cabt
topic_facet	gene mapping microbes genom analysis brucella mycobacterium avium subsp paratuberculosis anaplasma ehrlichia cryptosporidium theileria
url	http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020135155&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
work_keys_str_mv	AT nenevishvanath genomemappingandgenomicsinanimalassociatedmicrobes

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