Mammalian alkaline phosphatases: from biology to applications in medicine and biotechnology
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Weinheim
Wiley-Vch
2006
|
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XV, 322 S. graph. Darst., Ill. |
| ISBN: | 3527310797 |
Internformat
MARC
| LEADER | 00000nam a2200000 c 4500 | ||
|---|---|---|---|
| 001 | BV025374819 | ||
| 003 | DE-604 | ||
| 005 | 00000000000000.0 | ||
| 007 | t | ||
| 008 | 100417s2006 ad|| |||| 00||| eng d | ||
| 020 | |a 3527310797 |9 3-527-31079-7 | ||
| 035 | |a (OCoLC)255183732 | ||
| 035 | |a (DE-599)BVBBV025374819 | ||
| 040 | |a DE-604 |b ger |e rakwb | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-11 | ||
| 082 | 0 | |a 572.7553 | |
| 084 | |a WC 4350 |0 (DE-625)148095: |2 rvk | ||
| 084 | |a WD 5050 |0 (DE-625)148185: |2 rvk | ||
| 100 | 1 | |a Millán, José Luis |e Verfasser |0 (DE-588)131691554 |4 aut | |
| 245 | 1 | 0 | |a Mammalian alkaline phosphatases |b from biology to applications in medicine and biotechnology |c José Luis Millán |
| 264 | 1 | |a Weinheim |b Wiley-Vch |c 2006 | |
| 300 | |a XV, 322 S. |b graph. Darst., Ill. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 856 | 4 | 2 | |m HBZ Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020000285&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-020000285 | ||
Datensatz im Suchindex
| _version_ | 1804142519817076736 |
|---|---|
| adam_text | |v
Contents
Preface IX
Abbreviations XI
Glossary XV
Introduction 1
Part I Gene and Protein Structure 3
1 Gene Structure 5
1.1 Genomic Organization and Complexity 5
1.2 Restriction Fragment Length Polymorphisms 11
2 Developmental Expression 13
2.1 The TNAP Gene 13
2.2 The TSAP Genes 15
3 Gene Regulation 19
3.1 The TNAP Gene 19
3.2 The TSAP Genes 22
4 Protein Structure and Functional Domains 25
4.1 The Three-dimensional Structure of PLAP 25
4.1.1 Overview of the Structure 25
4.1.2 The Active Site 28
4.1.3 The Calcium Site 36
4.1.4 The Disulfide Bonds 38
4.1.5 The N-terminal Arm 38
4.1.6 The Crown Domain 41
4.1.7 The Monomer-Monomer Interface 46
4.1.8 The Noncatalytic Peripheral Binding Site 46
4.2 Genetic Polymorphism and Protein Variability 49
Mammalian Alkaline Phosphatases: From Biology to Applications in Medicine and Biotechnology. J. L. Millan
Copyright © 2006 WILEY-VCH Verlag GmbH Co. KGaA, Weinheim
ISBN: 3-527-31079-7
VI I Contents
4.3 Post-translational Modifications 54
4.3.1 Glycosylation Sites 54
4.3.2 Ectoplasmic Localization of APs via a GPI Anchor 56
4.3.3 Nonenzymatic Glycation of APs 61
4.3.4 Quaternary Structure of APs 62
4.3.5 Subcellular Localization of APs 63
5 Enzymatic Properties 67
5.1 Catalytic Inhibition 67
5.1.1 Competitive and Noncompetitive Inhibitors of APs 69
5.1.2 Uncompetitive Inhibition 71
5.1.2.1 Mechanism of Inhibition in PLAP/GCAP 71
5.1.2.2 Inhibitor Binding in TNAP 76
5.2 Allosteric Behavior 80
5.3 Catalytic Efficiency of Mammalian APs 83
5.4 Substrate Specificities 85
5.5 APs as Members of a Superfamily of Enzymes 88
6 Epitope Maps 91
6.1 Epitopes in PLAP and GCAP 91
6.2 Epitopes in IAP 98
6.3 Discrimination Between Bone and Liver TNAP 99
Part II In Vivo Functions 105
7 The In Vivo Role of TNAP 107
7.1 Function of TNAP in Bone 107
7.1.1 Hypophosphatasia 107
7.1.2 Hypophosphatasia Mutations 109
7.1.3 Variable Penetrance and Expressivity 123
7.2 Role of TNAP in Nonskeletal Tissues 124
7.3 Proposed Biological Functions of TSAPs 126
7.3.1 Proposed Functions of IAP 126
7.3.2 Putative Functions of GCAP and PLAP 128
8 Knockout Mouse Models 131
8.1 Phenotypic Abnormalities in AkpT1 mice 131
8.1.1 Developmental and Skeletal Defects 131
8.1.2 Dental Abnormalities in Akp2~!~ Mice 136
8.1.3 Deficient Mineralization by AkpTh Osteoblasts In Vitro 136
8.1.4 Metabolic Pathways Affected in AkpTh Mice 139
8.1.4.1 Neuro-physiological Abnormalities 139
8.1.4.2 The Function of TNAP in Bone Mineralization 141
8.1.4.3 Co-expression of TNAP and Fibrillar Collagens Restricts Calcification
to Skeletal Tissues 148
Contents IVII
8.1.4.4 Other Organs Affected in AkpTh Mice 152
8.2 Phenotypic Abnormalities in AkpT1 Mice 154
8.3 Phenotypic Abnormalities in AkpT1 Mice 160
Part III AP Expression in Health and Disease 165
9 APs as Physiological and Disease Markers 167
9.1 Clinical Usefulness of TNAP 167
9.1.1 TNAP as a Marker of Bone Formation 167
9.1.2 TNAP and Bone Cancer or Bone Metastasis 173
9.1.3 TNAP Expression in Cholestasis 175
9.1.4 TNAP in Other Conditions 178
9.2 Clinical Usefulness of PLAP in Normal and Complicated
Pregnancies 180
9.3 IAP Expression in Relation to ABO Status, Fat Feeding and Other
Pathologies 182
9.4 Complexes of APs and Immunoglobulins 184
9.5 Hyperphosphatasia 185
10 Neoplastic Expression of PLAP, CCAP, IAP (Regan, Nagao, Kasahara)
and TNAP Isozymes 187
10.1 Some History 187
10.2 GCAP as Marker for Testicular Cancer 189
10.3 Usefulness ofPLAP/GCAP in Ovarian Cancer 194
10.4 Other Tumors 196
10.5 Immunolocalization and Immunotherapy of Tumors
Using PLAP/GCAP as Targets 197
10.6 Tumoral Expression of IAP 204
Part IV Uses of APs in Industry and Biotechnology 207
11 Applications of Recombinant APs 209
11.1 Expression of Recombinant APs 209
11.2 APs as In Vitro and In Vivo Reporters 213
11.3 APs as Molecular Biology and Diagnostic Reagents 218
12 Use of APs in Prodrug Converting Strategies 223
13 APs as Therapeutic Agents 227
13.1 In the Treatment of Hypophosphatasia 227
13.2 In the Treatment of CPPD Disease 231
13.3 Endotoxin Treatment 231
13.4 TNAP as Therapeutic Target for the Management of
Ectopic Calcification 234
VIII I Contents
14 APs in the Food Industry 237
15 Veterinary Uses of AP Determinations 239
16 Methodologies 241
16.1 Amperometric, Spectrophotometric and Potentiometric Assays 241
16.2 Using Inhibitors and Heat Inactivation 244
16.3 Electrophoretic Methods 245
16.4 Lectin-based Assays 245
16.5 High-performance Liquid Chromatographic Methods 247
16.6 Specific Immunoassays with Polyclonal and MAbs 249
16.7 mRNA-based Assays 253
16.8 Histochemical and Immunohistochemical Detection 254
References 257
Index 315
|
| any_adam_object | 1 |
| author | Millán, José Luis |
| author_GND | (DE-588)131691554 |
| author_facet | Millán, José Luis |
| author_role | aut |
| author_sort | Millán, José Luis |
| author_variant | j l m jl jlm |
| building | Verbundindex |
| bvnumber | BV025374819 |
| classification_rvk | WC 4350 WD 5050 |
| ctrlnum | (OCoLC)255183732 (DE-599)BVBBV025374819 |
| dewey-full | 572.7553 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 572 - Biochemistry |
| dewey-raw | 572.7553 |
| dewey-search | 572.7553 |
| dewey-sort | 3572.7553 |
| dewey-tens | 570 - Biology |
| discipline | Biologie |
| format | Book |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01151nam a2200301 c 4500</leader><controlfield tag="001">BV025374819</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">00000000000000.0</controlfield><controlfield tag="007">t</controlfield><controlfield tag="008">100417s2006 ad|| |||| 00||| eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">3527310797</subfield><subfield code="9">3-527-31079-7</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)255183732</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV025374819</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-11</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">572.7553</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">WC 4350</subfield><subfield code="0">(DE-625)148095:</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">WD 5050</subfield><subfield code="0">(DE-625)148185:</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Millán, José Luis</subfield><subfield code="e">Verfasser</subfield><subfield code="0">(DE-588)131691554</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Mammalian alkaline phosphatases</subfield><subfield code="b">from biology to applications in medicine and biotechnology</subfield><subfield code="c">José Luis Millán</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Weinheim</subfield><subfield code="b">Wiley-Vch</subfield><subfield code="c">2006</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">XV, 322 S.</subfield><subfield code="b">graph. Darst., Ill.</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">n</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">nc</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="856" ind1="4" ind2="2"><subfield code="m">HBZ Datenaustausch</subfield><subfield code="q">application/pdf</subfield><subfield code="u">http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020000285&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA</subfield><subfield code="3">Inhaltsverzeichnis</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-020000285</subfield></datafield></record></collection> |
| id | DE-604.BV025374819 |
| illustrated | Illustrated |
| indexdate | 2024-07-09T22:33:04Z |
| institution | BVB |
| isbn | 3527310797 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-020000285 |
| oclc_num | 255183732 |
| open_access_boolean | |
| owner | DE-11 |
| owner_facet | DE-11 |
| physical | XV, 322 S. graph. Darst., Ill. |
| publishDate | 2006 |
| publishDateSearch | 2006 |
| publishDateSort | 2006 |
| publisher | Wiley-Vch |
| record_format | marc |
| spelling | Millán, José Luis Verfasser (DE-588)131691554 aut Mammalian alkaline phosphatases from biology to applications in medicine and biotechnology José Luis Millán Weinheim Wiley-Vch 2006 XV, 322 S. graph. Darst., Ill. txt rdacontent n rdamedia nc rdacarrier HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020000285&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Millán, José Luis Mammalian alkaline phosphatases from biology to applications in medicine and biotechnology |
| title | Mammalian alkaline phosphatases from biology to applications in medicine and biotechnology |
| title_auth | Mammalian alkaline phosphatases from biology to applications in medicine and biotechnology |
| title_exact_search | Mammalian alkaline phosphatases from biology to applications in medicine and biotechnology |
| title_full | Mammalian alkaline phosphatases from biology to applications in medicine and biotechnology José Luis Millán |
| title_fullStr | Mammalian alkaline phosphatases from biology to applications in medicine and biotechnology José Luis Millán |
| title_full_unstemmed | Mammalian alkaline phosphatases from biology to applications in medicine and biotechnology José Luis Millán |
| title_short | Mammalian alkaline phosphatases |
| title_sort | mammalian alkaline phosphatases from biology to applications in medicine and biotechnology |
| title_sub | from biology to applications in medicine and biotechnology |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=020000285&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT millanjoseluis mammalianalkalinephosphatasesfrombiologytoapplicationsinmedicineandbiotechnology |