The coiled spring: how life begins
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Cold Spring Harbor, NY
Cold Spring Harbor Laboratory Press
2000
|
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XV, 252 S. Ill., graph. Darst. |
| ISBN: | 0879695625 0879695633 |
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CONTENTS
PREFACE, XI FOREWORD, XIII INTRODUCTION, 1
1 THE CENTRAL DOGMA OF BIOLOGY, 7 THE CENTRAL DOGMA -THAT DNA, THE
HERITABLE GENETIC MATERIAL, IS COPIED INTO RNA, WHICH DIRECTS THE
SYNTHESIS OF PROTEIN-IS A BASIC TENET OF LIFE. HOW THIS IDEA GUIDED
IMPORTANT DISCOVERIES IN DEVEL-
OPMENTAL BIOLOGY IS DESCRIBED USING EXAMPLES OF THE GURDON EX- PERIMENT,
WHICH PROVED THAT ALL CELLS IN A FROG CONTAIN THE SAME GE- NETIC
INFORMATION; THE NATURE OF HERITABLE MUTATIONS; AND THE MANGOLD-SPEMANN
EXPERIMENT, WHICH SHOWED THAT A SPECIALIZED
REGION OF THE FROG EMBRYO DIRECTS THE FORMATION OF THE NERVOUS SYSTEM.
2 MOLECULAR METHODS FOR ANALYZING DEVELOPMENT, 35 TECHNIQUES DEVELOPED
DURING THE PAST 30 YEARS HAVE PROVIDED POW- ERFUL TOOLS FOR ANALYZING
DEVELOPMENT. THE MOST IMPORTANT OF THESE-GENE CLONING, METHODS FOR
SHOWING GENE ACTIVITY IN DEVEL- OPING EMBRYOS, AND METHODS FOR ANALYZING
AND MANIPULATING GENE ACTIVITY-ARE DESCRIBED.
3 ESTABLISHING THE PRIMARY AXES OF FRUIT FLY EMBRYOS, 49 ESTABLISHING A
PLAN OR PATTERN FOR DEVELOPMENT OF THE FERTILIZED EGG IS THE KEY EVENT
IN PRODUCING A DIFFERENTIATED EMBRYO WITH DIFFER- ENT TISSUE TYPES. THIS
PROCESS IN THE FRUIT FLY IS DESCRIBED USING THE GROUND-BREAKING WORK OF
ERIC WIESCHAUS, GHRISTIANE NIISSLEIN-
VOLHARD, GERD JURGENS, AND ED LEWIS, WHO FOUND THE GENES THAT ARE
REQUIRED FOR NORMAL DEVELOPMENT BY LOOKING FOR MUTANTS IN WHICH
DEVELOPMENT WAS ABNORMAL.
IVLL
IMAGE 2
VIII * CONTENTS
4 PATTERNING FLY APPENDAGES AND EYES, 87 ASSEMBLY OF THE ADULT FRUIT FLY
DURING METAMORPHOSIS IS THE FOCUS HERE, PARTICULARLY THE DEVELOPMENT OF
FLY WINGS, LEGS, AND EYES. THESE PROCESSES ARC EXPLAINED BY DESCRIBING
THE SMALL SET OF GENES
THAT DEFINE THE PRIMARY AXES OF THE WING, LINKING THE FORMATION OF AN
ADULT STRUCTURE TO EARLIER EVENTS IN EMBRYONIC DEVELOPMENT, AND
DISCUSSING THE QUESTION OF WHETHER OR NOT THERE ARE MASTER GENES THAT
DIRECT THE FORMATION OF EYES.
5 ESTABLISHING THE PRIMARY AXES OF VERTEBRATE EMBRYOS, 113 ALTHOUGH
HIGHER ON THE EVOLUTIONARY SCALE THAN FLIES, VERTEBRATE EMBRYOS USE MANY
OF THE SAME GENES AS THE FLY EMBRYO TO SET UP THE PRIMARY BODY AXES AND
TISSUE TYPES. EVEN MORE REMARKABLE IS
THE FACT THAT VERTEBRATE GENES INVOLVED IN EARLY EMBRYONIC DEVEL- OPMENT
CAN REPLACE THEIR FRUIT FLY COUNTERPARTS IN DEVELOPING FLIES AND VICE
VERSA. THE EXPERIMENTS THAT REVEALED THESE ASTONISHING FACTS AND THEIR
IMPLICATIONS ARE DISCUSSED.
6 PATTERNING VERTEBRATE APPENDAGES AND EYES, 135 HERE AGAIN IS THE
UNEXPECTED FINDING THAT GENES INVOLVED IN DEFIN- ING ADULT STRUCTURES
SUCH AS APPENDAGES AND EYES ARE THE SAME IN VERTEBRATES AND FLIES. THE
EVOLUTIONARY IMPLICATIONS OF THE SIMILAR-
ITIES OF FLY AND VERTEBRATE DEVELOPMENT ARE DISCUSSED, AND THE MOST
RECENT COMMON ANCESTOR OF FLIES AND VERTEBRATES IS RECONSTRUCTED.
7 ESTABLISHING THE PRIMARY AXES OF PLANT EMBRYOS, 159 USING THE MUSTARD
PLANT EMBRYO AS AN EXAMPLE, IMPORTANT DIFFER- ENCES BETWEEN PLANT AND
ANIMAL DEVELOPMENT ARE ILLUSTRATED. THE POLARIZATION OF THE PLANT EMBRYO
ALONG THE SHOOT-TO-ROOT AXIS, AS WELL AS RADIAL ORGANIZATION, IS SHOWN
USING ANALYSIS OF MUTANT PLANTS THAT GENERATE ABNORMAL EMBRYOS.
SIMILARITIES BETWEEN PLANT AND ANIMAL DEVELOPMENT ARE ALSO DISCUSSED.
8 PATTERNING PLANT APPENDAGES, 177 THE FORMATION OF THE PLANT EQUIVALENT
OF APPENDAGES-FLOWERS, FRUITS, AND LEAVES-IS DESCRIBED. TOPICS INCLUDE
HOW FLOWER BUDS DEVELOP INTO FOUR BASIC ORGAN TYPES, GOETHE S INFERENCE
THAT ALL OR- GANS OF THE FLOWER ARE MODIFIED FORMS OF LEAVES (HE WAS
RIGHT!), AND
THE FINDING THAT ALTHOUGH VERY DIFFERENT GENES IN PLANTS AND ANIMALS
CONTROL FORMATION OF FLAT STRUCTURES SUCH AS LEAVES OR WINGS, THESE
GENES WORK BY SURPRISINGLY SIMILAR MECHANISMS.
9 THE FUTURE OF BIOLOGY AND MAN, 199 WE ARE VERY RAPIDLY MAKING PROGRESS
IN UNDERSTANDING HOW GENES CONTROL DEVELOPMENT AND OTHER HUMAN
CHARACTERISTICS. THE SOCIAL
IMAGE 3
CONTENTS M IX
IMPLICATIONS OF THESE DISCOVERIES-HOW WE THINK OF OURSELVES AS HU- MANS
AND HOW THESE DISCOVERIES CAN CHANGE OUR NATURE-ARE CON- SIDERED USING
TOPICS SUCH AS THE HUMAN GENOME PROJECT, WHICH IS DETERMINING THE
COMPLETE GENETIC BLUEPRINT OF HUMANS; THE IMPLI- CATIONS OF OUR NEWFOUND
KNOWLEDGE OF THE GENETICS OF HUMAN DIS- EASE AND HEALTH; AND GENETIC
ENGINEERING OF PLANTS AND ANIMALS. HOW THE WORLD OF SCIENCE FICTION
VIEWS THESE TOPICS IS ALSO CONSID- ERED.
COLOR PLATE SECTION, FOLLOWING PAGE 112 GLOSSARY, 217 REFERENCES AND
ADDITIONAL READING, 233 CREDITS, 241 INDEX, 245
BIOBOXES LANDMARK PROGRESS IN SCIENCE IS MADE BY PIONEERING INDIVIDUALS.
THOSE RESPONSIBLE FOR SOME OF THE KEY DISCOVERIES IN DEVELOPMEN- TAL
BIOLOGY ARE HIGHLIGHTED IN BIOBOXES THAT APPEAR THROUGHOUT THE TEXT.
THESE SCIENTISTS REPRESENT THE HVIMAN SIDE OF THE WONDER- FUL
DISCOVERIES DESCRIBED IN THIS BOOK.
JOHN GURDON HILDE MANGOLD JOHANN WOLFGANG VON GOETHE GHRISTIANE
NIISSLEIN-VOLHARD
ERIC WIESCHAUS ED LEWIS MIKE LEVINE SEAN CARROLL
GARY STRUHL ANTONIO GAREIA-BELLIDO WILLIAM MCGINNIS MATTHEW SCOTT
CLIFF TABIN GERD JIIRGENS ENRICO COEN ELLIOTT MEYEROWITZ MARTY YANOFSKY
P. 10 P. 32 P. 44 P. 61 P. 62 P. 66 P. 83
P. 91 P. 95 P. 98 P. 122 P. 125 P. 142 P. 168
P. 183 P. 184 P. 190
|
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| author | Bier, Ethan |
| author_facet | Bier, Ethan |
| author_role | aut |
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| building | Verbundindex |
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| ctrlnum | (OCoLC)248672255 (DE-599)BVBBV025255444 |
| dewey-full | 571.85 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 571 - Physiology & related subjects |
| dewey-raw | 571.85 |
| dewey-search | 571.85 |
| dewey-sort | 3571.85 |
| dewey-tens | 570 - Biology |
| discipline | Biologie |
| format | Book |
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| indexdate | 2024-07-09T22:29:48Z |
| institution | BVB |
| isbn | 0879695625 0879695633 |
| language | English |
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| physical | XV, 252 S. Ill., graph. Darst. |
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| spelling | Bier, Ethan Verfasser aut The coiled spring how life begins Ethan Bier Cold Spring Harbor, NY Cold Spring Harbor Laboratory Press 2000 XV, 252 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier SWB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=019892098&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Bier, Ethan The coiled spring how life begins |
| title | The coiled spring how life begins |
| title_auth | The coiled spring how life begins |
| title_exact_search | The coiled spring how life begins |
| title_full | The coiled spring how life begins Ethan Bier |
| title_fullStr | The coiled spring how life begins Ethan Bier |
| title_full_unstemmed | The coiled spring how life begins Ethan Bier |
| title_short | The coiled spring |
| title_sort | the coiled spring how life begins |
| title_sub | how life begins |
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