Approaches to high throughput toxicity screening:
Gespeichert in:
| Weitere Verfasser: | |
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| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
London
Taylor and Francis
1999
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | X, 184 S. |
| ISBN: | 0748407529 |
Internformat
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Datensatz im Suchindex
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| adam_text | APPROACHES TO HIGH THROUGHPUT TOXICITY SCREENING EDITED BY C.K.
ATTERWILL P. GOLDFARB AND W. PURCELL CONTENTS PREFACE IX CHAPTER I
INTRODUCTION C.K. ATTERWILL, P. GOLDFARB AND W. PURCELL CHAPTER 2
AUTOMATION AND TECHNOLOGY FOR HTS IN DRUG DEVELOPMENT M. BANKS 2.1
INTRODUCTION 2.2 HIGH THROUGHPUT SCREENING 2.3 AUTOMATION OF THE
BIOLOGICAL ASSAY 2.4 MINIATURIZATION TRENDS IN HIGH THROUGHPUT SCREENING
2.5 CONCLUSIONS 1 9 9 9 13 17 27 CHAPTER 3 CYTOTOXICITY AND MECHANISTIC
STUDIES IN HIGH THROUGHPUT TOXICITY SCREENING 31 JEFFREY R. FRY 3.1
INTRODUCTION 31 3.2 BASAL CYTOTOXICITY SCREENS 32 3.3 SELECTIVE
CYTOTOXICITY 34 3.4 MECHANISTICALLY-BASED TESTS FOR TOXICITY 35 3.5
CONCLUSIONS 39 CHAPTER 4 GENE EXPRESSION AND ITS APPLICATIONS TO HIGH
THROUGHPUT SCREENS AND MOLECULAR TOXICOLOGY 43 ROBERT H. BURNS, ROBERT
T. DUNN II AND SPENSER B. FARR 4.1 INTRODUCTION 43 4.2 THE NEED FOR HIGH
THROUGHPUT TOXICITY SCREENS 43 4.3 THE ADVENT OF GENE MICROARRAYS AND
THEIR IMPACT ON TOXICOLOGY 44 4.4 DEVELOPING HIGH THROUGHPUT GENE
EXPRESSION TOXICITY SCREENS 46 4.5 FINDING TOXICOLOGICALLY RELEVANT
GENES 46 APPROACHES TO HIGH THROUGHPUT TOXICITY SCREENING 4.6
DIFFERENTIAL DISPLAY 47 4.7 SAGE 48 4.8 AFLP 49 4.9 MEASURING
TOXICOLOGICALLY RELEVANT GENES WITH MICROARRAYS 51 4.10 DEVISING
STRATEGIES FOR DERIVING TOXICITY RULES 52 4.11 DERIVING GENE
EXPRESSION/TOXICITY RULES 53 4.12 HIGH THROUGHPUT GENE EXPRESSION
SYSTEMS 54 4.13 REPORTER CONSTRUCTS 57 4.14 VALIDATING GENE
EXPRESSION/TOXICITY RULES 59 4.15 RANKING COMPOUNDS FOR GENOTOXICITY 59
4.16 CONCLUSIONS 61 NOTE IN PROOF - CURAGEN 66 DR R. SAVORY CHAPTER 5
EARLY TOXIC STRESSOR GENES - MODULATION AND SCREENING TECHNOLOGIES 69 C.
KIND AND T. HAMMOND 5.1 THE STRESS RESPONSE - A UNIVERSAL BUT ADAPTED
SYSTEM OF CELL DEFENCE 69 5.2 FACTORS THAT DETERMINE THE STRESS GENE
RESPONSE 75 5.3 THE UTILITY OF STRESS GENES AS MARKERS OF CELL TOXICITY
78 5.4 DETECTION METHODS AND SCREENING FOR STRESS GENE EXPRESSION 79
CHAPTER 6 THE UTILITY OF BRANCHED DNA (BDNA) ASSAYS IN HIGH THROUGHPUT
TOXICITY SCREENING 91 MARQUE D. TODD ET AL. 6.1 INTRODUCTION 91 6.2
CELL-BASED BDNA ASSAY 92 6.3 BDNA ASSAYS FOR TOXICITY SCREENING 95 6.4
BDNA ASSAY PERFORMANCE 97 6.5 AUTOMATABILITY OF BDNA SCREENING ASSAYS
102 6.6 DISCUSSION 103 CHAPTER 7 METHODS FOR ASSESSING APOPTOSIS 107
GEORGE E.N. KASS AND RICHARD A. JONES 7.1 INTRODUCTION 107 7.2
APOPTOSIS: MORPHOLOGICAL FEATURES 109 7.3 APOPTOSIS: BIOCHEMICAL
FEATURES 111 7.4 APOPTOSIS: A NEW CHALLENGE FOR TOXICOLOGISTS 115 7.5
MORPHOLOGICAL ANALYSIS OF APOPTOTIC CELLS 118 CONTENTS 7.6 BIOCHEMICAL
ANALYSIS OF APOPTOSIS 119 7.7 CHOICE OF METHODS TO STUDY DRUG-INDUCED
APOPTOSIS 129 7.8 CONCLUSIONS 130 CHAPTER 8 GENETICALLY MODIFIED CELLS
TO ACCESS DRUG METABOLISM IN VITRO 139 MIKAEL OSCARSON AND MAGNUS
INGELMAN-SUNDBERG 8.1 INTRODUCTION 139 8.2 IN VITRO METHODS FOR THE
PREDICTION OF HUMAN DRUG METABOLISM 148 8.3 HETEROLOGOUS EXPRESSION
SYSTEMS FOR DRUG METABOLIZING ENZYMES 150 CHAPTER 9 THE FUTURE OF HIGH
THROUGHPUT SCREENING AND PHARMACOTOXICOLOGY 171 MICHAEL BALLS 9.1
INTRODUCTION 171 9.2 HIGH THROUGHPUT SCREENING 171 9.3 THE VALIDATION OF
HTS SYSTEMS 174 INDEX 179
|
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| spelling | Approaches to high throughput toxicity screening ed. by C.K. Atterwill ... London Taylor and Francis 1999 X, 184 S. txt rdacontent n rdamedia nc rdacarrier Toxikologische Analyse (DE-588)4078371-6 gnd rswk-swf Toxikologische Analyse (DE-588)4078371-6 s DE-604 Atterwill, C. K. edt GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=019806572&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Approaches to high throughput toxicity screening Toxikologische Analyse (DE-588)4078371-6 gnd |
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| title | Approaches to high throughput toxicity screening |
| title_auth | Approaches to high throughput toxicity screening |
| title_exact_search | Approaches to high throughput toxicity screening |
| title_full | Approaches to high throughput toxicity screening ed. by C.K. Atterwill ... |
| title_fullStr | Approaches to high throughput toxicity screening ed. by C.K. Atterwill ... |
| title_full_unstemmed | Approaches to high throughput toxicity screening ed. by C.K. Atterwill ... |
| title_short | Approaches to high throughput toxicity screening |
| title_sort | approaches to high throughput toxicity screening |
| topic | Toxikologische Analyse (DE-588)4078371-6 gnd |
| topic_facet | Toxikologische Analyse |
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