Endocrinology:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Englewood Cliffs, NJ
Prentice Hall
1992
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| Ausgabe: | 3. ed. |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XXVI, 608 S. graph. Darst. |
| ISBN: | 013278243X |
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Datensatz im Suchindex
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| adam_text | Endocrinolog/
third edition
MAC E H/IDLEY
Department of Anatomy
University of Arizona
Tucson, Arizona
PRENTICE HALL
Englewood Cliffs, New Jersey 07632
Contents
Preface xxm
Introduction to Endocrinology
Historical Perspective 1
An Endocrine Chronology 1
The Discovery of Cyclic AMP 4
Neuropeptides and Nobel Prizes 5
The Science of Endocrinology 7
Comparative Endocrinology 7
Clinical Endocrinology 8
The Concept of Homeostasis 8
Feedback Systems 9
Hormones and Homeostasis 10
Glucose Homeostasis 10
Calcium Homeostasis 11
Sodium Homeostasis 12
Neuroendocrine Integration in Homeostasis 12
Control of Water Balance 13
Control of Body Temperature 13
Control of Feeding Behavior 14
Hormones, Growth Regulation, and Cancer 14
References 75
lhe /ertebrate Endocrine System 17
Endocrine Glands and Their Hormones 18
Hormones Defined 22
General Classes of Chemical Messengers 24
vii
viii Contents
Peptide Hormones 24
Thyroid Hormones 25
Steroid Hormones 25
Neurotransmitters 26
Neuropeptides 27
Other Chemical Messengers 27
Chalones 27
Peptide Growth-Stimulating Factors 27
Eicosanoids 28
Pheromones 28
Other Cellular Regulators 28
Hormone Synthesis 29
Peptide Hormones 29
Steroid Hormones 30
Thyroid Hormones 30
Neurotransmitters 30
Neuropeptides 30
Prohormones 31
Control of Hormone Secretion 32
Hormone Delivery 33
Hormone Circulation and Metabolism 34
Peptide Hormones 34
Steroid and Thyroid Hormones 34
Adrenal Catecholamines and Neurotransmitters 35
Physiological Roles of Hormones 36
General Mechanisms of Hormone Action 37
Endocrine Pathophysiology 37
Comparative Endocrinology 38
References 40
Endocrine /Methodologies 43
General Considerations 43
Histological-Cytological Studies 45
Immunocytochemistry 45
Surgical Methods 46
Hormone Replacement Therapy 47
Immunological Neutralization of Hormone Activity 47
Tissue Extracts and Purification 48
Chemical Identification and Synthesis 48
Bioassays 49
Structure-Activity Studies 50
Contents ix
Radioisotope Studies 51
Radioimmunoassays 57
Radioreceptor Assays 52
Enzyme Assays 52
Autoradiography 53
Electrophysiological Methods 55
Pharmacological Methods 55
Monoclonal Antibodies 58
Recombinant DNA Techniques 58
Genetic Engineering 59
Animal Models for Research 60
Cyclostomes 60
Cartilaginous Fishes 60
Bony Fishes 60
Amphibians 61 •
Reptiles 61
Birds 61
Nonprimate Mammals 61
Primates 62
Animal Welfare 62
Perspectives 62
Fetal Tissue Transplants 62
References 63
General /Mechanisms
of Hormone Action 65
Cellular Receptors and Hormone Action 65
Plasma Membrane Hormone Receptors 66
Regulation of Receptor Number 67
Hormone Intemalization and Hormone Action 68
Receptor Cooperativity and Hormone Action 68
Spare Receptors 69
Receptor Signal Transduction 69
G Proteins and Dual Control of Adenylate Cydase 70
Cyclic Nucleotides and Hormone Action 77
Separate Receptors for Hormone Action 76
Multiple Membrane Messengers 77
The Role of Protein Kinase C in Signal Transduction 78
Eicosanoids and Hormone Action 79
Prostaglandins 81
Prostacyclins 82
Contents
Thromboxanes 82
Leukotrienes 82
Cytosolic Hormone Receptors 83
Steroid Hormone Receptors 83
Thyroid Hormone Receptors 85
Permissive Action of Hormones 85
Stimulus Response Coupling 87
Calmodulin—An Intracellular Calcium Receptor 88
Phosphorylated Proteins as Physiological Effectors 91
Protein Phosphatases: Role in Cellular Regulation 92
Termination of Hormone Action 93
Pathophysiological Correlates of Hormone Action 94
Summary and Perspectives 94
References 95
Pituitary Hormones 98
Anatomy of the Pituitary Gland 99
Developmental Anatomy 99
Lobation, Vascularization, Innervation 707
Cytology 103
Hormones of the Pituitary 705
Families of Pituitary Hormones 705
Somatotropin and Prolactin 106
The Glyoprotein Hormones 777
Pro-opiomelanocortin: Corticotropin and Melanotropin 775
Neurohypophysial Hormones 778
Pituitary Pathophysiology 779
References 727
lhe Endocrine H/pothalamus 124
The Neurovascular Hypothesis 725
Structure-Function of the Endocrine Hypothalamus 725
The Hypophysiotropic Hormones 729
Thyrotropin-Releasing Hormone (TRH) 729
Somatostatin 131
Somatotropin-Releasing Hormone (Somatrocrinin) 133
Gonadotropin-Releasing Hormone (GnRH) 133
Corticotropin-Releasing Hormone (CRH) 735
Prolactin Release-Inhibiting Factor (PIF) 735
MSH Release-Inhibiting Factor (MIF) 136
Contents xi
Control of Hypothalamic-Hypophysial Hormone
Secretion 137
The Role of CNS Neurohormones 757
Neurohormonal Control of Hypophysiotropin Secretion 738
Feedback Mechanisms 140
Rhythms of Hypophysiotropin Secretion 143
Neuropharmacology 144
Mechanisms of Hypophysiotropin Action 144
Modulation of Pituitary Hormone Secretion by Thyroid and
Steroid Hormones 145
Pathophysiology of Hypothalamic Dysfunction 146
Conclusions and Speculations 148
References 750
NeurohKpoprysial Hormones 153
The Neurohypophysis 753
Synthesis and Chemistry 755
Control and Mechanisms of Release 758
Physiological Roles 759
Oxytocin 759
Vasopressin (AVP) 164
Vasotocin (AVT) 768
Metabolism 770
Mechanisms of Hormone Action 770
Oxytocin 770
Vasopressin 777
Pathophysiology 772
Evolution of the Neurohypophysial Hormones 774
Other Neurohypophysial Hormones 775
References 775
lhe /Melanotropic Hormones 179
The Pars Intermedia 780
Synthesis and Chemistry of Melanotropins 787
Control of MSH Secretion 184
Dopaminergic Control 184
Neuropeptide Y Control 786
Physiological Roles of MSH 787
Melanin Pigmentation of the Skin 787
Chromatophores and Color Changes 790
xii Contents
Other Putative Roles of Melanotropins 797
Mechanism of MSH Action 796
Melanosome Movements 796
Melanogenesis 798
Melanotropin Structure-Function Studies 200
Melanotropin Receptors 200
Pathophysiology 200
Melanin-Concentrating Hormone 207
References 204
Hormonal Control of Calcium
Homeostasis 208
Calcium and Bone Physiology 208
Parathormone 209
The Parathyroid Glands 209
Synthesis, Chemistry, and Metabolism 270
Control of Secretion 277
Physiological Roles 277
Calcitonin 273
The Parafollicular Cells 274
Synthesis, Chemistry, and Metabolism 274
Control of Secretion 275
Physiological Roles 276
Vitamin D 277
Source, Synthesis, Chemistry, and Metabolism 278
Regulation of Vitamin D Metabolism 220
Physiological Roles 227
Hormone Mechanisms of Action in Calcium
Homeostasis 225
Parathormone 225
Calcitonin 226
Vitamin D 227
Hormone Integration in Calcium Homeostasis 229
Comparative Endocrinology 230
Corpuscles of Stannius 230
Pathophysiology of Calcium Homeostasis 237
Hypoparathyroidism 237
Hyperparathyroidism 232
Pseudohypoparathyroidism 233
Osteomalacia 233
Paget s Disease 234
Osteoporosis 234
References 235
Contents xiii
Gastrointestinal Hormones 239
Gastrointestinal Tract Structure and Function 240
Source and Chemistry of the Gastrointestinal
Hormones 247
The Gastrin Family of Hormones 242
The Secretin Family of Hormones 244
Other Candidate Hormones 245
Physiological Roles of the Gastrointestinal Hormones 245
Gastrin 246
Secretin 248
Cholecystokinin (CCK) 249
Gastric Inhibitory Peptide (GIP) 257
Vasoactive Intestinal Peptide (VIP) 257
Substance P (SP) 252
Somatostatin 253
Gastrin-Releasing Peptide (GRP) 254
Motilin 255
Other Putative GI Hormones 256
Autonomic Nervous System Control of GI Function 260
Gastrointestinal Hormone Mechanisms of Action 267
Gastric Acid Secretion 267
Exocrine Pancreatic Secretion 267
Trophic Mechanisms 262
Summary of the Neuroendocrine Control of GI
Function 262
Evolutionary Relationships of the Gut Hormones 263
Pathophysiology 265
References 267
Pancreatic Hormones and
/Metabolic Regulation 270
The Endocrine Pancreas 277
Intermediary Metabolism 273
Insulin 276
Synthesis, Chemistry, and Metabolism 276
Physiological Roles 277
Mechanisms of Action 279
Glucagon 284
Synthesis, Chemistry, and Metabolism 284
Physiological Roles 284
Contents
Mechanisms of Action 285
Other Pancreatic Peptide Hormones 287
Somatostatin (SS) 287
Pancreatic Polypeptide (PP) 287
Control of Pancreatic Islet Function 288
Pancreatic Islet Pathophysiology 292
Islet Cell Tumors 296
Insulin Replacement Therapy 296
Comparative Endocrinology 297
References 298
Groi/tfh Hormones 302
Growth and Cellular Proliferation 302
Somatotropin and the Somatomedins 303
Insulin 370
Prolactin 372
Placental Lactogen 372
Neurotropic Growth Factors 374
Nerve Growth Factor 374
Other Neurotropic Factors 376
Other Peptide Growth Factors 377
Epidermal Growth Factor 377
Platelet-Derived Growth Factor 379
Angiogenic Factors 320
Hematopoietic Growth Factors 324
Erythropoietin 324
Thymic Hormones 325
Cytokines 328
Chalones 329
Growth Factors, Receptors, and Cancer 329
References 337
lh/roid Hormones 334
The Thyroid Gland 335
Synthesis and Chemistry 336
Contents xv
Thyrotropin Stimulation of Thyroid Hormone
Synthesis 337
Antithyroid Drugs 340
Thyroid Hormones or Thyroid Hormone? 347
Other lodothyronines in Biological Fluids 347
Control of Thyroid Hormone Secretion 342
Circulation and Metabolism 343
Physiological Roles 344
Growth and Development 344
Thermogenesis 345
Diet and Thyroid Hormone Function 346
Permissive Actions 346
Mechanisms of Action 346
Pathophysiology 349
Tests for Thyroid Function 353
Comparative Endocrinology 355
Role of the Thyroid in Other Vertebrates 358
References 359
Catecholamines and the
S/mpathoadrenal System 362
The Sympathoadrenal System 364
The Autonomic Nervous System 364
Adrenal Chromaffin Tissue 365
Nature and Nurture in ANS Development 368
Synthesis, Chemistry, and Metabolism of
Catecholamines 369
Sympathoadrenal System Receptors 377
Cholinergic Receptors 377
Adrenergic Receptors (Adrenoceptors) 372
Adrenoceptor Structure 376
)8-Adrenoceptors 376
Adrenoceptor Signal Transduction 378
Hormonal Modulation of Adrenoceptors 387
Sympathoadrenal Functions 382
Intermediary Metabolism 383
Thermogenesis 384
Cardiovascular System 385
Respiratory System 385
xvi
Sympathoadrenal Activity and Stress 386
Norepinephrine: Humoral Hormone and Neurotransr^
in Humans 386
Comparative Endocrinology 387
Sympathoadrenal Pathophysiology 387
References 390
Adrenal Steroid Hormones 391
The Adrenal Glands 392
Anatomy and Embryology 392
Histology 393
The Fetal Adrenal Cortex and the X Zone 394
Synthesis and Chemistry 395
Functional Zonation of the Adrenal Cortex 398
Control of Synthesis and Secretion 399
Glucocorticoids 400
Aldosterone 402
Renal Kallikrien-Kinin System 405
Atrial Natriuretic Factor (ANF) 406
Circulation and Metabolism 408
Physiological Roles 409
Glucocorticoids 409
Aldosterone 473
Adrenal Androgens 413
Mechanisms of Action 474
Glucocorticoids 474
Aldosterone 475
Pathophysiology 476
Disorders of Cortisol Secretion 477
Disorders of Aldosterone Secretion 420
Disorders Due to Adrenal Enzyme Deficiencies 427
Lipoprotein Receptors and Atherosclerosis 423
Adrenal Steroid Hormone Pharmacology 423
Comparative Endocrinology 424
Phylogenetic Relationships of Vertebrate Steroid
Hormones 424
Physiological Roles of Adrenal Steroid Hormones 425
References 427
Contents xvii
Endocrinology of Sex Differentiation
and Development 430
Sex Determination, Differentiation, and Development 437
Chromosomal (Genetic) Basis of Sex Determination 437
Gonadal Sex 432
Differentiation of the Genital Ducts 435
Differentiation of the External Genitalia 437
Gonadal Steroid Hormone Synthesis and Chemistry 437
Gonadal Steroids and Brain Differentiation 439
Organizational Roles 440
Activational Roles 442
Puberty 445
Precocious and Delayed Puberty 446
Hormonal Control of Puberty 446
Pathophysiology of Sex Differentiation and
Development 448
Hermaphroditism 448
Primary and Secondary Hypogonadism and
Hypergonadism 450
References 452
Hormones and /Male Reproductive
Physiology 455
Anatomy of the Male Reproductive System 455
The Testis 455
• Source, Synthesis, Chemistry, and Metabolism of
Androgens 456
Endocrine Control of Testicular Function 457
GnRH and Pituitary Gonadotropins 458
Inhibin 459
Prolactin 460
Physiological Roles of Androgens 460
Spermatogenesis 467
Nervous System 463
Anabolic Actions 464
Erythropoiesis 464
Secondary Sex Characteristics 465
Mechanisms of Androgen Action 467
xviii Contents
Antiandrogens 468
Control of Male Fertility 468
Pathophysiology 470
Pharmacological Considerations 472
References 473
Hormones and Female Reproductive
Physiology 476
Anatomy of the Female Reproductive System 476
Ovary 477
Fallopian Tubes 487
Uterus 487
Ovarian Steroid Hormones 487
Estrogen Biosynthesis 487
Progesterone Biosynthesis 483
Androgens 483
Somatomedin Regulation of Gonadal Steroidogenesis 484
Physiological Roles of Ovarian Steroid Hormones 484
Physiological Roles of Ovarian Steroid Hormones 484
Estrogens 485
Progesterone 485
Hormones and Sexual Desire in Women 485
Mechanisms of Action of Ovarian Steroid Hormones 487
Estrogens and Vitellogenesis 487
Progesterone and Egg Protein Synthesis 487
Nonsteroidal Estrogens and Antiestrogens 488
Neuroendocrine Control of Ovarian Function 488
Catecholestrogens 490
Intrafollicular Polypeptide Regulatory Factors 497
Mammalian Reproductive Cycles 493
Primate Menstrual Cycle 493
Induced and Spontaneous Ovulators 495
Delayed Implantation 496
Environment and Reproduction 498
Pathophysiology 500
Hyperestrogenemia, Diet, and Disorders of Western
Societies 503
References 503
Contents xix
Endocrinology of Pregnancy
Parturition, and Lactation 505
Pregnancy 505
Fertilization and Implantation 505
The Corpus Luteum 506
The Fetal-Placental Unit 508
Parturition 570
Neuroendocrine Control of Parturition 570
Parturition in Humans 576
Lactation 576
Hormonal Contraception 520
Menopause 523
Pathophysiology 525
Endocrine Dysfunctions 526
References 527
Endocrine Role of the Pineal Gland 531
Pineal Development and Morphology 537
The Melatonin Hypothesis 532
Historical Perspective 532
Animal Studies 533
Pineal Indoleamine Biosynthesis 535
Effect of Light on Pineal Indoleamine Biosynthesis 536
CNS Pathway in the Control of Pineal Indoleamine
Biosynthesis 536
Intracellular Control of Pineal Indoleamine
Biosynthesis 538
Melatonin Secretion and Circulation 539
Site of Action of Melatonin 540
Pineal Rhythms and Biological Clocks 547
Other Proposed Roles of the Pineal 543
Prolactin and Somatotropin Secretion 544
Ocular Melatonin 544
The Pineal and the Circadian System of Birds 545
Pineal-Melatonin Control of Chromatophores 546
The Photosensitive Pineal of Poikilotherms 547
Pineal Pathophysiology 548
Conclusions and Speculations 549
References 550
xx Contents
Neurohormones 553
The Endorphins 554
Source, Synthesis, Chemistry, and Metabolism 554
Physiological Roles 557
Mechanisms of Action 560
Pathophysiology 567
Substance P 562
Somatostatin 564
Human Bombesin and Nutrient Homeostasis 564
Neurotensin 566
Thyrotropin-Releasing Hormone 567
Cholecystokinin and Feeding Behavior 568
The Brain Renin-Angiotensin System 570
Brain Melanotropins and Behavior 570
Neurohypophysial Hormones and Behavior 573
Other Neurohormones 574
Corticotropin-Releasing Hormone 574
Gonadotropin-Releasing Hormone 575
Bradykinin 576
Insulin 576
Vasoactive Intestinal Peptide 577
Somatotropin and Prolactin 577
Brain Calcitonin 578
The Caudal Neurosecretory System (Urophysis) and the
Urotensins 579
Evolution of Neuropeptides 580
New Theory of Hormones 580
References 583
Appendix 587
Some Common Endocrine Abbreviations and
Terminology 587
Vertebrate Hormones 589
Contents xxi
Bibliography 591
Books and Monographs 597
Major Endocrinology Journals 592
Endocrinology-Related Journals 592
Serial Publications 593
Index 594
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| title | Endocrinology |
| title_auth | Endocrinology |
| title_exact_search | Endocrinology |
| title_full | Endocrinology Mac E. Hadley |
| title_fullStr | Endocrinology Mac E. Hadley |
| title_full_unstemmed | Endocrinology Mac E. Hadley |
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