Ultratrace analysis of pharmaceuticals and other compounds of interest:
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | Undetermined |
| Veröffentlicht: |
New York <<[u.a.]>>
Wiley
1986
|
| Schriftenreihe: | Chemical analysis
85 |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XVI, 384 S. graph. Darst. |
| ISBN: | 0471826731 |
Internformat
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| 245 | 1 | 0 | |a Ultratrace analysis of pharmaceuticals and other compounds of interest |c ed. by Satinder Ahuja |
| 264 | 1 | |a New York <<[u.a.]>> |b Wiley |c 1986 | |
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| 490 | 1 | |a Chemical analysis |v 85 | |
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Datensatz im Suchindex
| _version_ | 1804140305270702080 |
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| adam_text | ULTRATRACE ANALYSIS OF PHARMACEUTICALS AND OTHER COMPOUNDS OF INTEREST
EDITED BY SATINDER AHUJA DEVELOPMENT DEPARTMENT PHARMACEUTICALS DIVISION
CIBA-GEIGY CORPORATION SUFFERN, NEW YORK A WILEY-INTERSCIENCE
PUBLICATION JOHN WILEY & SONS NEW YORK / CHICHESTER / BRISBANE / TORONTO
/ SINGAPORE CONTENTS 1. THE SCOPE OF ULTRATRACE ANALYSIS OF
PHARMACEUTICALS AND OTHER COMPOUNDS OF INTEREST 1 SATINDER AHUJA 1.
SAMPLING AND SAMPLE PREPARATION 2 2. METHOD VALIDATION AND
INTERLABORATORY VARIATIONS 3 3. ANALYTICAL METHODOLOGIES AND
APPLICATIONS 4 3.1. ATOMIC SPECTROSCOPY 5 3.2. LIQUID CHROMATOGRAPHY 7
3.3. GAS CHROMATOGRAPHY 8 3.4. COMBINATION METHODS 11 3.4.1. LIQUID
CHROMATOGRAPHY-MASS SPECTROSCOPY (LC/MS) 12 3.4.2. GAS
CHROMATOGRAPHY-MASS SPECTROSCOPY (GC/MS) 13 2. DERIVATIZATION FOR GAS
AND LIQUID CHROMATOGRAPHY 19 SATINDER AHUJA 1. DERIVATIZATION IN GAS
CHROMATOGRAPHY 19 1.1. DERIVATIZATION METHODS 21 1.1.1. ON-COLUMN
REACTIONS 23 1.1.2. REACTIONS WITH DIAKYL ACETALS 24 1.1.3. SILYLATION
25 1.1.4. ESTERIFICATION . 26 1.1.5. ACETYLATION 28 1.1.6. HYDRAZONE
FORMATION 28 1.1.7. ION-PAIR FORMATION 28 1.1.8. DERIVATIZATION FOR
ELECTRON CAPTURE DETECTION 29 IX CONTENTS 1.2. CLASSES OF COMPOUNDS 32
1.2.1. ACIDS 33 1.2.2. ALKALOIDS 39 1.2.3. AMIDES, IMIDES, AND RELATED
COMPOUNDS 42 1.2.4. AMINES 44 1.2.5. ANTIBIOTICS 48 1.2.6. AZEPINES 50
1.2.7. BARBITURATES AND OTHER UREA DERIVATIVES 52 1.2.8. ESTERS 53
1.2.9. HYDROXY COMPOUNDS AND MERCAPTANS 54 1.2.10. STEROIDS 61 1.2.11.
VITAMINS 64 1.2.12. MISCELLANEOUS COMPOUNDS 66 2. DERIVATIZATION IN
LIQUID CHROMATOGRAPHY 68 2.1. DERIVATIZATION METHODS 68 2.1.1.
UV-ABSORBING DERIVATIVES 68 2.1.2. FLUORESCENT DERIVATIVES 69 2.2.
CLASSES OF COMPOUNDS 69 2.2.1. ACIDS 71 2.2.2. ALKALOIDS 73 2.2.3.
AMINES 74 2.2.4. ANTIBIOTICS 75 2.2.5. BARBITURATES AND RELATED
COMPOUNDS 75 2.2.6. CARBONYL COMPOUNDS 75 2.2.7. HYDROXY COMPOUNDS 76
2.2.8. STEROIDS AND OTHER HORMONES 77 2.2.9. MISCELLANEOUS 77 3.
SELECTED ION-MONITORING METHODS 91 W. J. A. VANDEN HEUVEL AND J. M.
LIESCH 1. PACKED-COLUMN GLC LOW-RESOLUTION SIM 94 2. CAPILLARY COLUMN
GLC LOW-RESOLUTION SIM 98 3. TECHNIQUES FOR ENHANCEMENT OF DETECTION
SELECTIVITY 101 4. IONIZATION METHODS FOR ENHANCEMENT OF SENSITIVITY AND
SPECIFICITY 104 CONTENTS XI 4. LIQUID CHROMATOGRAPHY AND LIQUID
CHROMATOGRAPHY-MASS SPECTROMETRY 109 L. R. SNYDER AND SATINDER AHUJA 1.
EQUIPMENT REQUIREMENTS 113 1.1. PUMPS 113 1.2. INJECTION SYSTEMS 114
1.3. DETECTORS 115 2. SEPARATION CONDITIONS 117 2.1. RESOLUTION 119 2.2.
DETECTOR RESPONSE 120 2.3. GRADIENT ELUTION 123 3. SAMPLE DERIVATIZATION
PROCEDURES 125 3.1. REACTION DETECTORS 126 4. SAMPLE CLEANUP AND
COLUMN-SWITCHING PROCEDURES 130 4.1. SAMPLE EXTRACTION 130 4.2. COLUMN
SWITCHING 131 4.3. AUTOMATION 136 5. LIQUID CHROMATOGRAPHY-MASS
SPECTROMETRY 138 5.1. TECHNIQUES 139 5.1.1. DIRECT LIQUID INTRODUCTION
(DLI) 139 5.1.2. JET EXPANSION 141 5.1.3. MECHANICAL TRANSFER 142 5.1.4.
MISCELLANEOUS TECHNIQUES 142 5.2. CLASSES OF COMPOUNDS 143 5. MODERN
THIN LAYER CHROMATOGRAPHY 149 JOSEPH C. TOUCHSTONE 1. SAMPLE PREPARATION
FOR ULTRATRACE ANALYSIS 151 2. CONVENTIONAL TLC 154 2.1. MATERIALS 155
2.2. EXTRACTION PROCEDURE FOR PLASMA 155 2.3. EXTRACTION PROCEDURE FOR
URINE 155 2.4. CHROMATOGRAPHY 155 2.5. FLUORESCENCE MEASUREMENT 15J XLL
CONTENTS 3. HIGH-PERFORMANCE THIN LAYER CHROMATOGRAPHY 3.1. SAMPLE
APPLICATION 3.2. DEVELOPMENT TECHNIQUES FOR HPTLC 3.2.1. LINEAR
DEVELOPMENT 3.2.2. CIRCULAR DEVELOPMENT 3.2.3. ANTICIRCULAR DEVELOPMENT
3.2.4. CONTINUOUS DEVELOPMENT 3.2.5. CONSIDERATIONS FOR DETECTION AND
DENSITOMETRY 3.3. CLASSES OF COMPOUNDS 3.3.1. PHENOTHIAZINES 3.3.2.
OTHER COMPOUNDS 4. REVERSED-PHASE THIN LAYER CHROMATOGRAPHY 4.1. TYPES
OF PLATES 4.2. THEORIES OF SEPARATION 4.3. SOURCES OF RPTLC LAYERS 4.4.
APPLICATION OF SAMPLES 4.5. MOBILE-PHASE SELECTION 4.6. DETECTION 4.7.
CLASSES OF COMPOUNDS 4.7.1. UBIQUINONES 4.7.2. OTHER COMPOUNDS 156 157
159 159 160 161 161 162 163 163 164 166 167 169 170 171 172 174 176 176
177 6. ATOMIC SPECTROMETRIC ANALYSIS 179 TERENCE H. RISBY 1. ATOM
RESERVOIRS 179 1.1. FLAME ATOMIZERS 179 1.2. NONFLAME ATOMIZERS 180
1.2.1. ELECTROTHERMAL ATOMIZERS 181 1.2.2. INDUCTIVELY COUPLED PLASMAS
181 2. ATOMIC EMISSION SPECTROMETRY 182 2.1. THEORY 182 2.2.
INSTRUMENTATION 183 2.3. GENERAL CONSIDERATIONS 184 CONTENTS XLLL 3.
ATOMIC ABSORPTION SPECTROMETRY 184 3.1. THEORY 184 3.2. INSTRUMENTATION
185 3.3. GENERAL CONSIDERATIONS 186 4. ATOMIC FLUORESCENCE SPECTROMETRY
186 4.1. THEORY 186 4.2. INSTRUMENTATION 187 4.3. GENERAL CONSIDERATIONS
187 5. METHODOLOGICAL CONSIDERATIONS 188 5.1. SAMPLE PREPARATION 188
5.2. SELECTION OF AN ANALYTICAL PROCEDURE 189 5.3. QUANTIFICATION 193
5.4. SPECIATION 193 7. IMPURITY ANALYSIS OF PHARMACEUTICAL COMPOUNDS 195
SATINDER AHUJA 1. METHOD DEVELOPMENT STRATEGIES 196 1.1. EXTRACTABLE
IMPURITIES 196 1.2. CHROMATOGRAPHABLE IMPURITIES 196 2. CLASSES OF
COMPOUNDS 197 2.1. ALKALOIDS 199 2.2. AMINES 200 2.3. AMINO ACIDS 201
2.4. ANALGESICS 202 2.5. ANTIBIOTICS 203 2.6. ANTIDEPRESSANTS AND
TRANQUILIZERS 206 2.7. ANTINEOPLASTIC AGENTS 208 2.8. LOCAL ANESTHETICS
209 2.9. PROSTAGLANDINS 209 2.10. STEROIDS 210 2.11. SULFONAMIDES 212
2.12. VITAMINS 212 2.13. MISCELLANEOUS 212 XIV CONTENTS 8. IMPURITY
ANALYSIS OF EXCIPIENTS 217 J. B. SMITH AND SATINDER AHUJA 1. ULTRATRACE
CONTAMINANTS 218 1.1. CATIONIC CONTAMINANTS OR METALS 219 1.1.1. ARSENIC
219 1.1.2. HEAVY METALS 225 1.1.3. IRON 228 1.2. ANIONIC CONTAMINANTS
228 1.2.1. CHLORIDE 229 1.2.2. SULFIDE 230 1.2.3. SULFITE 230 1.3.
GASEOUS CONTAMINANTS 230 1.3.1. AMMONIA 230 1.3.2. HYDROGEN SULFIDE 231
1.3.3. NITRIC OXIDE AND NITROUS DIOXIDE 231 1.4. ORGANIC CONTAMINANTS
231 1.4.1. CONTAMINANTS IN ALCOHOL 231 1.4.2. CONTAMINANTS IN CHLOROFORM
231 1.4.3. CONTAMINANTS IN SACCHARIN 232 1.5. MISCELLANEOUS CONTAMINANTS
232 9. ANALYSIS OF DRUGS AND THEIR METABOLITES 235 T. WALLE AND U. K.
WALLE 1. FLUOROMETRY 236 2. THIN LAYER CHROMATOGRAPHY 238 3.
HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY 239 4. GAS CHROMATOGRAPHY 247 5.
GAS CHROMATOGRAPHY-MASS SPECTROMETRY 254 6. RADIOIMMUNO- AND
RADIORECEPTOR ASSAYS 260 6.1. RIA 260 6.2. RRA 264 10. DRUG ANALYSIS IN
ANIMAL FEEDS 273 JAMES LUCH AND SATINDER AHUJA 1. ANALYSIS OF DRUGS IN
FEED TO SUPPORT TOXICOLOGICAL TESTING IN ANIMALS 277 1.1. LIQUID-LIQUID
PARTITION AND COLUMN CLEANUP 278 CONTENTS XV 1.2. LIQUID-LIQUID
PARTITION AND TLC CLEANUP 282 1.3. COLUMN CHROMATOGRAPHY CLEANUP 284
1.4. LIQUID-LIQUID PARTITION CLEANUP 288 2. MEDICATED FEEDS 289 2.1.
CLASSES OF COMPOUNDS 289 2.1.1. ANTIBACTERIALS 289 2.1.2. COCCIDIOSTATS
. 290 2.1.3. ANTIDYSENTERY COMPOUNDS 291 2.1.4. ANABOLIC AGENTS 291
11. REGULATORY ANALYSIS OF DRUG RESIDUES IN ANIMAL-DERIVED FOODS 295
ROBERT C. LIVINGSTON, C. J. BARNES, AND JOHN W. HOWARD 1. REGULATORY
BACKGROUND 296 1.1. FEDERAL FOOD, DRUG, AND COSMETIC ACT 296 1.2. SAFETY
ASSESSMENT OF ANIMAL DRUG RESIDUES 296 1.3. CRITERIA FOR METHODS OF
ANALYSIS 300 2. REGULATORY METHODS 301 2.1. MELENGESTROL ACETATE 302
2.2. LASALOCID 304 2.3. FENBENDAZOLE 305 2.4. IVERMECTIN 306 2.5.
CARBADOX 307 2.6. PYRANTEL AND MORANTEL TARTRATE 309 2.7. ARSENICALS 310
2.8. TIAMULIN 312 2.9. SULFONAMIDES 314 12. ULTRATRACE DRUG ANALYSIS
IN FORENSIC CHEMISTRY 319 IRA S. LURIE, JAMES M. MOORE, AND DONALD A.
COOPER 1. MS AND GC/MS APPLICATIONS 320 1.1. MODIFIED PROCEDURES FOR
FORENSIC DRUG ANALYSIS 321 1.2. INSTRUMENTAL METHODS 322 2. HPLC
APPLICATIONS 323 2.1. LSD . 323 2.2. MARIJUANA 325 XVI CONTENTS 2.3.
PSILOCYBIN AND PSILOCIN 328 2.4. MANUFACTURING BY-PRODUCTS 331 2.5.
GENERAL ANALYSIS 333 3. GC APPLICATIONS 338 3.1. GC-FID 338 3.2. GC-ECD
338 13. DRUG ANALYSIS IN POSTMORTEM TOXICOLOGY 353 J. C. GARRIOTT 1.
CIRCUMSTANCES AFFECTING POSTMORTEM DRUG ANALYSES 353 2. CHOICE OF
SPECIMENS 354 3. ANALYTICAL INSTRUMENTATION 355 4. ANALYTICAL PROCEDURES
356 4.1. EXTRACTION AND SEPARATION 356 4.2. ANALYSIS FOR DRUGS WITH
BASIC PROPERTIES 357 4.3. ANALYSIS FOR DRUGS WITH ACIDIC AND NEUTRAL
PROPERTIES 358 4.4. ALCOHOLS AND OTHER VOLATILE SUBSTANCES 359 5.
DETECTION OF ULTRATRACE CONCENTRATIONS OF DRUG AGENTS IN BIOLOGICAL
FLUIDS 360 5.1. OPIATE NARCOTICS 360 5.2. SYNTHETIC NARCOTICS 361 5.3.
BASIC DRUGS 362 5.4. CANNABINOIDS 363 6. OTHER POSTMORTEM ANALYSES
REQUIRING SPECIALIZED TECHNIQUES 364 7. SPECIAL PROBLEMS IN POSTMORTEM
SPECIMEN ANALYSIS 365 7.1. THE EXHUMED OR DECOMPOSED BODY 365 7.2.
STABILITY OF DRUGS 366 7.3. FINDINGS IN POSTMORTEM DRUG ANALYSIS 368
7.4. INTERPRETATION OF POSTMORTEM DRUG FINDINGS 370 INDEX 377
|
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| spelling | Ultratrace analysis of pharmaceuticals and other compounds of interest ed. by Satinder Ahuja New York <<[u.a.]>> Wiley 1986 XVI, 384 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Chemical analysis 85 A Wiley Interscience publication Ahuja, Satinder edt Chemical analysis 85 (DE-604)BV000008780 85 GBV Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=018334448&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Ultratrace analysis of pharmaceuticals and other compounds of interest Chemical analysis |
| title | Ultratrace analysis of pharmaceuticals and other compounds of interest |
| title_auth | Ultratrace analysis of pharmaceuticals and other compounds of interest |
| title_exact_search | Ultratrace analysis of pharmaceuticals and other compounds of interest |
| title_full | Ultratrace analysis of pharmaceuticals and other compounds of interest ed. by Satinder Ahuja |
| title_fullStr | Ultratrace analysis of pharmaceuticals and other compounds of interest ed. by Satinder Ahuja |
| title_full_unstemmed | Ultratrace analysis of pharmaceuticals and other compounds of interest ed. by Satinder Ahuja |
| title_short | Ultratrace analysis of pharmaceuticals and other compounds of interest |
| title_sort | ultratrace analysis of pharmaceuticals and other compounds of interest |
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