Solving problems in genetics:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
New York [u.a.]
Springer
2001
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XV, 479 S. graph. Darst. |
| ISBN: | 0387988408 |
Internformat
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Datensatz im Suchindex
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|---|---|
| adam_text | Richard Kowles
With 26 6 Figures
Springer
Preface vii
Mendelism 1
Introduction 1
Basic Probability: Methods for Analyzing Mendelian Genetics 2
Forked Line Method 6
Mendel s Data 8
Crosses Involving Three or More Gene Pairs 10
Goodness of Fit Testing 11
Subdividing Chi Square 15
Gene Interaction 15
Distinguishing Among Genetic Ratios 18
Double Fertilization in Plants 20
Additional Plant Genetics Considerations 22
XI
Contents
Problems 23
Solutions 28
Reference 38
Sex Determination and Sex Linkage 39
General Aspects of Mating Systems 39
XX/XY Chromosome System 40
Sex Ratios 40
Binomial Statistics 41
Haploid-Diploid Sex Determination 43
Sex Linkage 44
Pedigrees 47
Partial Sex-Linkage 51
Problems 52
Solutions 56
Chromosomes and Cell Division 65
Chromosomes 65
The Cell Cycle 66
Further Analysis of the Cell Cycle 68
Percent Labeled Mitoses Method 70
Mitosis 72
Meiosis 75
Genetic Diversity 79
C Values 80
Problems 81
Solutions 86
Linkage, Recombination, and Mapping 93
Exceptions to Independent Assortment 93
Recombination Values and Genetic Maps 97
Three-Point Tests 100
Mapping Concepts 107
Recombination Calculated with F2 Data 111
Haploid Genetics 114
Tetrad Analysis 115
Tetrad Analysis and Gene Mapping 119
Problems 121
Solutions 131
Reference 144
XII
Contents
Variations in Chromosome Number and Structure 145
Types of Chromosome Variation 145
Aneuploidy 146
Polyploidy 150
Deletions and Duplications 152
Inversions 156
Translocations 162
Other Aberrations 172
Problems 173
Solutions 179
Quantitative Inheritance 189
Continuous Variation 189
Polygenes 190
Estimating Number of Gene Pairs Involved in Quantitative Traits 193
Variance 195
Broad Sense Heritability 197
Narrow Sense Heritability 200
Heterosis 201
Thresholds 202
Mapping Quantitative Traits 204
Problems 206
Solutions 212
Reference 218
Population Genetics 119
Concept of Gene Pools 219
Gene and Genotype Frequencies 220
Hardy-Weinberg Principle 224
Hardy-Weinberg Equilibrium 226
Extensions of Hardy-Weinberg Relationships 228
Genetic Drift 231
Migration 232
Mutation 234
Selection 237
A Statistical Approach to Change in a Population 240
Nonrandom Mating 244
Problems 246
xm
Contents
Solutions 251
References 258
Gene Concepts 259
One-Gene One-Enzyme 259
Allelism 263
Bacterial Genetics 268
Bacteriophages 274
Complementation 275
Genetic Fine Structure Analysis in Bacteriophages 277
Genetic Fine Structure Analysis in Other Organisms 280
Problems 282
Solutions 291
References 297
Molecular Basis of Heredity 299
Nucleic Acids 299
Nearest Neighbor Frequency Analysis 303
Central Dogma 306
Semiconservative Mode of Replication 307
Replication Forks and Okazaki Fragments 312
Transcription 315
Proteins 318
Translation 320
Genetic Code 324
Regulation 330
Operon Systems 332
Mutation 338
Mutation Detection 345
Problems 351
Solutions 359
References 365
Non-Mendelian Inheritance 367
Cytoplasmic Inheritance 367
Male Sterility in Plants 370
Maternal Effects 373
Genomic Imprinting 374
DNA Trinucleotide Repeats 375
Meiotic Drive 376
xiv
Contents
B Chromosomes 378
Problems 380
Solutions 383
Human Genetics 389
Mendelian Inheritance in Humans 389
Bias of Ascertainment 392
Epidemiology and Pedigrees 396
Linkage Analysis—Classical Approaches 399
Physical Mapping 400
Human Genome Project 404
Population Genetics 404
Testing Inheritance of a Single Allelic Pair in a Population 405
Consanguinity 409
Methods of Studying the Genetic Basis of Behavior in Humans 415
Twin Studies and Concordance 415
Correlation 419
Heritability 421
Multiple Allelism 423
Disease Associations 425
Problems 427
Solutions 436
References 445
Additional Genetic Analysis Using Statistics 447
More Probability 447
Permutations and Combinations 449
The Binomial Distribution 451
Poisson Distribution 453
Contingency Tables—Test for Independence 456
Problems 459
Solutions 464
Index 473
xv
|
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| isbn | 0387988408 |
| language | English |
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| spelling | Kowles, Richard V. Verfasser aut Solving problems in genetics Richard Kowles New York [u.a.] Springer 2001 XV, 479 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Genetik (DE-588)4071711-2 gnd rswk-swf (DE-588)4123623-3 Lehrbuch gnd-content Genetik (DE-588)4071711-2 s DE-604 HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017428518&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
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| title | Solving problems in genetics |
| title_auth | Solving problems in genetics |
| title_exact_search | Solving problems in genetics |
| title_full | Solving problems in genetics Richard Kowles |
| title_fullStr | Solving problems in genetics Richard Kowles |
| title_full_unstemmed | Solving problems in genetics Richard Kowles |
| title_short | Solving problems in genetics |
| title_sort | solving problems in genetics |
| topic | Genetik (DE-588)4071711-2 gnd |
| topic_facet | Genetik Lehrbuch |
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