Microarray technology and its applications:
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | Undetermined |
| Veröffentlicht: |
Berlin [u.a.]
Springer
2005
|
| Schriftenreihe: | Biological and medical physics, biomedical engineering
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Literaturangaben |
| Beschreibung: | XXII, 379 S. Ill., graph. Darst. |
| ISBN: | 3540229310 |
Internformat
MARC
| LEADER | 00000nam a2200000zc 4500 | ||
|---|---|---|---|
| 001 | BV023744483 | ||
| 003 | DE-604 | ||
| 005 | 20100617 | ||
| 007 | t | ||
| 008 | 050303s2005 ad|| |||| 00||| und d | ||
| 020 | |a 3540229310 |9 3-540-22931-0 | ||
| 035 | |a (OCoLC)249426198 | ||
| 035 | |a (DE-599)BVBBV023744483 | ||
| 040 | |a DE-604 |b ger | ||
| 041 | |a und | ||
| 049 | |a DE-526 | ||
| 082 | 0 | |a 570 | |
| 084 | |a WC 4460 |0 (DE-625)148102: |2 rvk | ||
| 245 | 1 | 0 | |a Microarray technology and its applications |c U. R. Müller ... (Ed.) |
| 264 | 1 | |a Berlin [u.a.] |b Springer |c 2005 | |
| 300 | |a XXII, 379 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 0 | |a Biological and medical physics, biomedical engineering | |
| 500 | |a Literaturangaben | ||
| 650 | 0 | 7 | |a Microarray |0 (DE-588)4544227-7 |2 gnd |9 rswk-swf |
| 655 | 7 | |0 (DE-588)4143413-4 |a Aufsatzsammlung |2 gnd-content | |
| 689 | 0 | 0 | |a Microarray |0 (DE-588)4544227-7 |D s |
| 689 | 0 | |5 DE-604 | |
| 700 | 1 | |a Müller, Uwe R. |4 edt | |
| 856 | 4 | 2 | |m GBV Datenaustausch |q application/pdf |u http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=017293558&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |3 Inhaltsverzeichnis |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-017293558 | ||
Datensatz im Suchindex
| _version_ | 1804138794216062976 |
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| adam_text | IMAGE 1
CONTENTS
PART I GENERAL MICROARRAY TECHNOLOGIES
1 ARRAY FORMATS RALPH R. MARTEL, MATTHEW P. ROUNSEVILLE, IHAB W. BOTROS,
BRUCE E. SELIGMANN . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . 3
1.1 INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . 3
1.2 REASONS TO USE ARRAYS . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . 4
1.3 ARRAYS FOR NUCLEIC ACID ANALYSIS . . . . . . . . . . . . . . . . . .
. . . . . . . . 6
1.4 PROTEIN ARRAYS . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . 8
1.5 THE ARRAYPLATE TM . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . 9
1.6 CONCLUSION . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . 19
REFERENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . 20
2 BIOMOLECULES AND CELLS ON SURFACES - FUNDAMENTAL CONCEPTS KRISTI L.
HANSON, LUISA FILIPPONI, DAN V. NICOLAU . . . . . . . . . . . . . . . .
. . . 23
2.1 INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . 23
2.2 TYPES OF IMMOBILIZATION . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . 23
2.3 DNA IMMOBILIZATION ON SURFACES . . . . . . . . . . . . . . . . . . .
. . . . . . . 28
2.4 PROTEIN IMMOBILIZATION ON SURFACES . . . . . . . . . . . . . . . . .
. . . . . . . 32
2.5 CARBOHYDRATE IMMOBILIZATION . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . 36
2.6 IMMOBILIZATION OF CELLS ON SURFACES . . . . . . . . . . . . . . . .
. . . . . . . . 38
2.7 CONCLUSIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . 41
REFERENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . 42
3 SURFACES AND SUBSTRATES ALVARO CARRILLO, KUNAL V. GUJRATY, RAVI S.
KANE . . . . . . . . . . . . . . . . . . . . . 45
3.1 INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . 45
3.2 DNA MICROARRAYS . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . 46
3.3 PROTEIN MICROARRAYS . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . 50
IMAGE 2
XII CONTENTS
3.4 CONCLUSION . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . 55
REFERENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . 56
4 REAGENT JETTING BASED DEPOSITION TECHNOLOGIES FOR ARRAY CONSTRUCTION
MITCHEL J. DOKTYCZ . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . 63
4.1 INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . 63
4.2 REAGENT JETTING - TECHNOLOGY OVERVIEW . . . . . . . . . . . . . . .
. . . . . 63
4.3 THERMAL JET BASED DISPENSING . . . . . . . . . . . . . . . . . . . .
. . . . . . . . 65
4.4 PIEZO JET BASED DISPENSING . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . 67
4.5 SOLENOID JET BASED DISPENSING . . . . . . . . . . . . . . . . . . .
. . . . . . . . . 68
REFERENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . 71
5 MANUFACTURING OF 2-D ARRAYS BY PIN-PRINTING TECHNOLOGIES UWE R.
M¨ULLER, ROELAND PAPEN . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . 73
5.1 INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . 73
5.2 DEFINITION OF CONTACT PIN-PRINTING . . . . . . . . . . . . . . . .
. . . . . . . 73
5.3 OVERVIEW OF DIFFERENT PIN TECHNOLOGIES . . . . . . . . . . . . . . .
. . . . . 74
5.4 OTHER SYSTEM COMPONENTS AND ENVIRONMENTAL FACTORS . . . . . . 79 5.5
PIN PRINTING PROCESS . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . 81
5.6 EXAMPLE OF A HIGH THROUGHPUT PIN-PRINTING SYSTEM FOR MANUFACTURING
OF 2D ARRAYS - THE CORNING GENII SYSTEM . . . 84 5.7 CONCLUSION . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . 86
REFERENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . 87
6 NANOARRAYS DAN V. NICOLAU, LINNETTE DEMERS, DAVID S. GINGER . . . . .
. . . . . . . . . . . . . . 89
6.1 INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . 89
6.2 PASSIVE NANO-SCALE ARRAYS . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . 91
6.3 COMPUTATIONAL NANOARRAYS . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . 105
6.4 DYNAMIC NANOARRAYS . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . 109
6.5 CONCLUSION . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . 115
REFERENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . 115
7 THE USE OF MICROFLUIDIC TECHNIQUES IN MICROARRAY APPLICATIONS PIOTR
GRODZINSKI, ROBIN H. LIU, RALF LENIGK, YINGJIE LIU . . . . . . . . . . .
. . . 119
7.1 INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . 119
7.2 BIOCHANNEL HYBRIDIZATION ARRAYS . . . . . . . . . . . . . . . . . .
. . . . . . . . 120
7.3 CHIPS WITH CAVITATION MICROSTREAMING MIXERS - KINETICS STUDIES . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. 128
7.4 INTEGRATED MICROFLUIDIC REACTORS FOR DNA AMPLIFICATION AND
HYBRIDIZATION . . . . . . . . . . . . . . . . . . 135
7.5 SUMMARY AND CONCLUSIONS . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . 142
IMAGE 3
CONTENTS XIII
REFERENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . 142
8 LABELS AND DETECTION METHODS JAMES J. STORHOFF, SUDHAKAR S. MARLA,
VISWANADHAM GARIMELLA, CHAD A. MIRKIN . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 147
8.1 INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . 147
8.2 FLUOROPHORE LABELLING AND DETECTION METHODS . . . . . . . . . . . .
. . 148
8.3 ENHANCED FLUORESCENCE-BASED ASSAYS . . . . . . . . . . . . . . . . .
. . . . . 151
8.4 PHOSPHOR REPORTERS . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . 154
8.5 ELECTROCHEMICAL DETECTION . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . 156
8.6 METAL NANOPARTICLE LABELS AND METAL THIN FILMS FOR MICROARRAYS . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . 159
8.7 CONCLUSIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . 172
REFERENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . 174
9 MARKER-FREE DETECTION ON MICROARRAYS MATTHIAS VAUPEL, ANDREAS EING,
KARL-OTTO GREULICH, JAN ROEGENER, PETER SCHELLENBERG, HANS MARTIN.
STRIEBEL, HEINRICH F. ARLINGHAUS . . . . . . 181
9.1 INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . 181
9.2 IMAGING ELLIPSOMETRY AND IMAGING SURFACE PLASMON RESONANCE ON
BIOCHIPS . . . . . . . . 181 9.3 INTRINSIC UV FLUORESCENCE FOR CHIP
ANALYSIS OF RARE PROTEINS . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . 190
9.4 GENETIC DIAGNOSTICS WITH UNLABELLED DNA . . . . . . . . . . . . . .
. . . 197
REFERENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . 204
PART II DNA MICROARRAYS
10 ANALYSIS OF DNA SEQUENCE VARIATION IN THE MICROARRAY FORMAT ULRIKA
LILJEDAHL, MONA FREDRIKSSON, ANN-CHRISTINE SYV¨ ANEN . . . . . . . . . .
. 211
10.1 INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . 211
10.2 PRINCIPLES OF GENOTYPING . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . 213
10.3 PERFORMING THE ASSAYS IN PRACTICE . . . . . . . . . . . . . . . . .
. . . . . . . . 217
10.4 CONCLUSION . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . 222
REFERENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . 223
11 HIGH SENSITIVITY EXPRESSION PROFILING RAMESH RAMAKRISHNAN, PAUL BAO,
UWE R. M¨ ULLER . . . . . . . . . . . . . . . . . . . . 229
11.1 INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . 229
11.2 OLIGONUCLEOTIDE EXPRESSION ARRAYS . . . . . . . . . . . . . . . . .
. . . . . . . 230
11.3 CDNA-BASED EXPRESSION ARRAYS . . . . . . . . . . . . . . . . . . .
. . . . . . . . 239
11.4 APPENDIX . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . 244
IMAGE 4
XIV CONTENTS
REFERENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . 245
12 APPLICATIONS OF MATRIX-CGH (ARRAY-CGH) FOR GENOMIC RESEARCH AND
CLINICAL DIAGNOSTICS CARSTEN SCHWAENENA, MICHELLE NESSLINGA, BERNHARD
RADLWIMMERA, SWEN WESSENDORF, PETER LICHTERA . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . 251
12.1 INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . 251
12.2 TECHNICAL ASPECTS . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . 253
12.3 APPLICATIONS . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . 256
REFERENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . 260
13 ANALYSIS OF GENE REGULATORY CIRCUITS ZIRONG LI . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . 265
13.1 INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . 265
13.2 AN EXPERIMENTAL PROTOCOL FOR GENOME WIDE LOCATION ANALYSIS . . . .
. . . . . . . . . . . . . . . . . . . 268
13.3 EXAMPLE: IDENTIFYING THE TARGET GENES OF HUMAN E2F4 . . . . . . 273
13.4 SUMMARY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . 275
REFERENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . 275
PART III PROTEIN MICROARRAYS
14 PROTEIN, ANTIBODY AND SMALL MOLECULE MICROARRAYS HENDRIK WEINER, J¨
ORN GL¨ OKLER, CLAUS HULTSCHIG, KONRAD B¨ USSOW, GERALD WALTER . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . 279
14.1 INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . 279
14.2 PROTEIN MICROARRAYS . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . 280
14.3 ANTIBODY MICROARRAYS . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . 283
14.4 PEPTIDE AND OTHER SYNTHETIC ARRAYS . . . . . . . . . . . . . . . .
. . . . . . . 287
REFERENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . 290
15 PHOTOAPTAMER ARRAYS FOR PROTEOMICS APPLICATIONS DREW SMITH, CHAD
GREEF . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . 297
15.1 INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . 297
15.2 OVERVIEW OF PHOTOAPTAMER DISCOVERY AND HIGH THROUGHPUT PRODUCTION .
. . . . . . . . . . . . . . . . . . . . . . . . 298
15.3 USING PHOTOAPTAMER MICROARRAYS . . . . . . . . . . . . . . . . . .
. . . . . . . 301
15.4 DISCUSSION . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . 303
REFERENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . 305
16 BIOLOGICAL MEMBRANE MICROARRAYS YE FANG, ANTHONY G. FRUTOS, YULONG
HONG, JOYDEEP LAHIRI . . . . . . . . . . . . 309
16.1 INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . 309
IMAGE 5
CONTENTS XV
16.2 BIOSPECIFIC BINDING STUDIES USING MEMBRANE MICROARRAYS . . . . 313
16.3 CONCLUSIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . 318
REFERENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . 319
PART IV CELL & TISSUE MICROARRAYS
17 USE OF REPORTER SYSTEMS FOR REVERSE TRANSFECTION CELL ARRAYS BRIAN L.
WEBB . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . 323
17.1 INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . 323
17.2 REPORTER SYSTEMS FOR REVERSE TRANSFECTION . . . . . . . . . . . . .
. . . . 325
17.3 REAGENTS AND PROTOCOLS . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . 332
REFERENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . 333
18 WHOLE CELL MICROARRAYS RAVI KAPUR . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
335
18.1 INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . 335
18.2 THE NEED . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . 336
18.3 THE SOLUTION . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . 336
18.4 CHALLENGES AND OPPORTUNITIES FOR CELLULAR MICRROARRAYS . . . . . .
341 REFERENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . 343
19 TISSUE MICROARRAYS FOR MINIATURIZED HIGH-THROUGHPUT MOLECULAR
PROFILING OF TUMORS RONALD SIMON, MARTINA MIRLACHER, GUIDO SAUTER . . .
. . . . . . . . . . . . . . . . . . 345
19.1 INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . 345
19.2 THE TMA TECHNOLOGY . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . 346
19.3 THE REPRESENTATIVITY ISSUE . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . 346
19.4 TMA APPLICATIONS . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . 349
19.5 FUTURE DIRECTIONS . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . 351
19.6 PROTOCOL . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . 352
REFERENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . 354
20 APPLICATION OF MICROARRAY TECHNOLOGIES FOR TRANSLATIONAL GENOMICS
SPYRO MOUSSES, NATASHA CAPLEN, MARK BASIK, ANNE KALLIONIEMI, OLLI
KALLIONIEMI . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . 361
20.1 INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . 361
20.2 HIGH THROUGHPUT CLINICAL TARGET VALIDATION USING TISSUE MICROARRAYS
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . 363
20.3 EXAMPLES OF STUDIES INTEGRATING DNA AND TISSUE MICROARRAY
TECHNOLOGIES FOR THE RAPID CLINICAL TRANSLATION OF GENOMIC DISCOVERIES .
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 365
IMAGE 6
XVI CONTENTS
20.4 HIGH THROUGHPUT CHARACTERIZATION OF GENE FUNCTION USING LIVE CELL
MICROARRAYS . . . . . . . . . . . . . . 368
20.5 CONCLUSIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . 370
REFERENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . 372
INDEX . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . . . . 375
|
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