Long range control of gene expression:
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
Elsevier Acad. Press
2008
|
| Ausgabe: | 1. ed. |
| Schriftenreihe: | Advances in genetics
61 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Inhaltsverzeichnis |
| Beschreibung: | Einzelaufnahme eines Zeitschr.-Bd. |
| Beschreibung: | XV, 399 S. graph. Darst. |
| ISBN: | 9780123738813 |
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Datensatz im Suchindex
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| adam_text | LONG-RANGE CONTROL OF GENE EXPRESSION EDITED BY VERONICA VAN HEYNINGEN
MRC HUMAN GENETICS UNIT WESTERN GENERAL HOSPITAL EDINBURGH, UNITED
KINGDOM ROBERT E. HILL MRC HUMAN GENETICS UNIT WESTERN GENERAL HOSPITAL
EDINBURGH, UNITED KINGDOM UNIVERSITATS- UND LSNDCS- BIBLIOTHEK
DARRRTOTSDT BIBTIOTHEK BIOLOGIE AMSTERDAM * BOSTON * HEIDELBERG * LONDON
NEW YORK * OXFORD * PARIS * SAN DIEGO SAN FRANCISCO * SINGAPORE * SYDNEY
* TOKYO P.T ,SH. V I W,L^ ACADEMIC PRESS IS AN IMPRINT OF KLSEVIER
CONTENTS . CONTRIBUTORS XI PREFACE XIII 1 CHROMATIN STRUCTURE AND THE
REGULATION OF GENE EXPRESSION: THE LESSONS OF PEV IN DROSOPHILA 1 JACK
R. GIRTON AND KRISTEN M. JOHANSEN I. INTRODUCTION: POSITION EFFECT IN
DROSOPHILA 2 II. HISTORICAL BACKGROUND OF THE PEV PHENOTYPE 5 III. TYPES
OF PEV 8 IV. GENOME ORGANIZATION AND PEV 19 V. CONCLUDING REMARKS 29
REFERENCES 31 2 POLYCOMB GROUP PROTEINS AND LONG-RANGE GENE REGULATION
45 JULIO MATEOS-LANGERAK AND GIACOMO CAVALLI I. INTRODUCTION 46 II.
GENETIC AND BIOCHEMICAL CHARACTERIZATION OF PCG PROTEINS 48 III. PCG
MECHANISMS OF ACTION 49 IV. PCG PROTEINS AND LONG-RANGE GENE SILENCING
53 V. PCG AND VERY LONG-RANGE GENE SILENCING: TELEREGULATION OF GENE
EXPRESSION 57 VI. CONCLUSIONS AND PROSPECTS 61 REFERENCES 62 3 EVOLUTION
OF /S-REGULATORY SEQUENCES IN DROSOPHILA 67 PAT SIMPSON AND SAVITA
AYYAR I. INTRODUCTION 68 II. DEVELOPMENTAL HOMEOSTASIS, SEQUENCE
TURNOVER, AND STABILIZING SELECTION 72 III. ENHANCER EVOLUTION AND LOSS
OR GAIN OF TRAITS 84 VI CONTENTS IV. CIS-TRANS COEVOLUTION 91 V.
EVOLUTION OF NEW REGULATORY MODULES 95 VI. CONCLUSIONS 98 REFERENCES
99 4 /I-GLOBIN REGULATION AND LONG-RANGE INTERACTIONS 107 ROBERT-JAN
PALSTRA, WOUTER DE LAAT, AND FRANK GROSVELD I. INTRODUCTION 108 II. THE
/?-GLOBIN LOCUS 109 III. MODELS OF LONG-RANGE CONTROL OF GENE EXPRESSION
BY ENHANCERS 115 IV. LONG-RANGE ACTIVATION BY THE /3-GLOBIN LCR 117 V.
ENHANCEMENT OF TRANSCRIPTION BY THE /3-GLOBIN LCR: RATE-LIMITING STEPS
127 VI. THE CONCEPT OF AN ACTIVE CHROMATIN HUB 131 VII. FUTURE
DIRECTIONS 132 REFERENCES 133 5 LONG-RANGE REGULATION OF A-GLOBIN GENE
EXPRESSION 143 DOUGLAS R. HIGGS, DOUGLAS VERNIMMEN, AND BILL WOOD I.
INTRODUCTION 144 II. THE NORMAL STRUCTURE AND EVOLUTION OF THE A-GLOBIN
CLUSTER 146 III. FUNCTIONAL ANALYSIS OF THE A-GLOBIN REGULATORY DOMAIN
147 IV. STRUCTURE OF THE UPSTREAM REGULATORY ELEMENTS AND THE PROMOTERS
152 V. TRANSCRIPTION FACTORS INVOLVED IN ERYTHROPOIESIS 153 VI. CELLULAR
RESOURCES FOR STUDYING THE KEY STAGES OF HEMATOPOIESIS 157 VII.
TRANSCRIPTION FACTOR BINDING TO THE UPSTREAM REGULATORY ELEMENTS 158
VIII. TRANSCRIPTION FACTOR BINDING TO THE PROMOTER 159 IX. THE
RECRUITMENT OF RNA POLYMERASE AND GTFS TO THE A-GLOBIN CLUSTER 160 X.
WHAT ROLE DO THE REMOTE REGULATORY ELEMENTS PLAY ? 161 XI. HOW DO THE
UPSTREAM ELEMENTS INTERACT WITH THE PROMOTER? 162 CONTENTS VII XII.
SEQUENTIAL ACTIVATION OF THE A-GLOBIN GENE CLUSTER DURING
DIFFERENTIATION 165 XIII. CONCLUSIONS, SPECULATION, AND FUTURE
DIRECTIONS 166 REFERENCES 169 6 GLOBAL CONTROL REGIONS AND REGULATORY
LANDSCAPES IN VERTEBRATE DEVELOPMENT AND EVOLUTION 175 FRANCOIS SPITZ
AND DENIS DUBOULE I. INTRODUCTION 176 II. GLOBAL CONTROLS 178 III.
CO-EXPRESSION CHROMOSOMAL TERRITORIES, REGULATORY LANDSCAPES, AND GLOBAL
CONTROL REGIONS 185 IV. MECHANIMS OF UNDERLYING GLOBAL REGULATION 188 V.
CO-EXPRESSION CHROMOSOMAL TERRITORIES, REGULATORY LANDSCAPES: BYSTANDER
EFFECTS OR FUNCTIONAL OPERONS? 192 VI. EVOLUTIONARY IMPLICATIONS OF
GLOBAL GENE CONTROL 195 VII. GLOBAL REGULATION, CHROMOSOMAL
ARCHITECTURE, AND GENETIC DISORDERS 197 VIII. CONCLUDING REMARKS, 197
REFERENCES 198 7 REGULATION OF IMPRINTING IN CLUSTERS: NONCODING RNAS
VERSUS INSULATORS 207 LE-BEN WAN AND MARISAJS. BARTOLOMEI I.
INTRODUCTION 208 . X ~ II. INSULATOR MODEL OF REGULATION 209 III. THE
NCRNA MODEL OF REGULATION 212 IV. DLKL/GTL2 IMPRINTED CLUSTER: A BIT OF
EVERYTHING 215 V. CONCLUSIONS 218 REFERENCES 219 8 GENOMIC IMPRINTING
AND IMPRINTING DEFECTS IN HUMANS 225 BERNHARD HORSTHEMKE AND KARIN
BUITING I. INTRODUCTION 226 II. THE MECHANISMS OF GENOMIC IMPRINTING 226
III. IMPRINTING DEFECTS 230 IV. CONCLUSIONS 242 REFERENCES 243 VIII
CONTENTS 9 EPIGENETIC GENE REGULATION IN CANCER 247 ESTEBAN BALLESTAR
AND MANEL ESTELLER I. INTRODUCTION 248 II. CANCER CELLS SHOW A
DISRUPTION OF DNA METHYLATION PATTERNS . 250 III. DISRUPTION OF THE
HISTONE MODIFICATION PROFILE IN CANCER 253 IV. CASCADES OF EPIGENETIC
DEREGULATION IN CANCER 256 V. WHAT ARE THE MECHANISMS THAT LEAD TO
ABERRANT METHYLATION PATTERNS IN CANCER? 258 VI. EPIGENETIC THERAPY FOR
CANCER TREATMENT 261 REFERENCES 262 10 GENOMIC IDENTIFICATION OF
REGULATORY ELEMENTS BY EVOLUTIONARY SEQUENCE COMPARISON AND FUNCTIONAL
ANALYSIS 269 GABRIELA G. LOOTS I. INTRODUCTION 270 II. GENOMIC
ARCHITECTURE OF THE HUMAN GENOME 271 III. COMPUTATIONAL METHODS OF
PREDICTING REGULATORY ELEMENTS 276 IV. IN VIVO VALIDATION AND
CHARACTERIZATION OF TRANSCFIPTIONAL REGULATORY ELEMENTS 282 V.
CONCLUSIONS 286 REFERENCES 287 11 REGULATORY VARIATION AND EVOLUTION:
IMPLICATIONS FOR DISEASE 295 EMMANOUIL T. DERMITZAKIS I. INTRODUCTION
296 C II. EVOLUTION AND VARIATION OF NONCODING DNA 297 III. NATURAL
SELECTION IN NONCODING DNA 300 IV. GENE EXPRESSION STUDIES 301 V.
DISEASE IMPLICATIONS 302 VI. CONCLUSIONS 303 REFERENCES 304 CONTENTS 12
ORGANIZATION OF CONSERVED ELEMENTS NEAR KEY DEVELOPMENTAL REGULATORS IN
VERTEBRATE GENOMES 307 ADAM WOOLFE AND GREG ELGAR I. INTRODUCTION 308
II. GENE-REGULATORY NETWORKS IN DEVELOPMENT 309 III. IDENTIFICATION OF
EVOLUTIONARILY CONSTRAINED SEQUENCES USING PHYLOGENETIC FOOTPRINTING 310
IV. SEARCHES FOR REGULATORY ELEMENTS USING EVOLUTIONARY CONSERVATION 310
V. TAKIFUGU RUBRIPES: A COMPACT MODEL GENOME 312 VI. IDENTIFICATION OF
ENHANCER ELEMENTS THROUGH FISH-MAMMAL COMPARISONS 313 VII. FISH-MAMMAL
CONSERVED NONCODING ELEMENTS , ARE ASSOCIATED WITH VERTEBRATE
DEVELOPMENT 315 VIII. HIGH-RESOLUTION ANALYSIS OF THE ORGANIZATION OF
CNES AROUND KEY DEVELOPMENTAL REGULATORS 317 IX. GENERAL GENOMIC
ENVIRONMENT AROUND CNES 317 X. CNES PRESENT IN TRANSCRIPTS 319 XI. CNES
LOCATED WITHIN UTRS 321 XII. CNES ARE LOCATED LARGE DISTANCES AWAY FROM
THEIR PUTATIVE TARGET GENE 323 XIII. DISCUSSION 328 REFERENCES 333 13
LONG-RANGE GENE CONTROL AND GENETIC DISEASE 339 DIRK A. KLEINJAN AND
LAURA A. LETTICE I. FROM GENETIC DISEASE TO LONG-RANGE GENE REGULATION
340 II. POSITION EFFECT REVISITED - 342 III. LOSS OF A POSITIVE
REGULATOR 345 IV. TWIST, POU3F4, PITX2, SOX3, GLI3, AND FOXP2 346 V. THE
BYSTANDER -EFFECT 353 VI. MAF, SDC2, TGFB2, REEP3, AND PLP1 355 VII.
TWO POSITION EFFECTS*DIFFERENT OUTCOMES 357 VIII. PHENOTYPES RESULTING
FROM POSITION EFFECTS ON MORE THAN ONE GENE 362 IX. GLOBAL CONTROL
REGIONS; HOXD, GREMLIN, AND LIMB MALFORMATIONS 363 X. FOX GENES AND
POSITION EFFECTS 365 CONTENTS XI. SOX9 AND CAMPOMELIC DISPLASIA 366 XII.
FACIOSCAPULOHUMERAL DYSTROPHY 368 XIII. ABERRANT CREATION OF AN
ILLEGITIMATE SIRNA TARGET SITE 370 XIV. GENETIC DISEASE DUE TO ABERRANT
GENE TRANSCRIPTION CAN BE CAUSED BY MANY DIFFERENT MECHANISMS 371 XV.
CONCLUDING REMARKS 378 REFERENCES 379 INDEX 389
|
| adam_txt |
LONG-RANGE CONTROL OF GENE EXPRESSION EDITED BY VERONICA VAN HEYNINGEN
MRC HUMAN GENETICS UNIT WESTERN GENERAL HOSPITAL EDINBURGH, UNITED
KINGDOM ROBERT E. HILL MRC HUMAN GENETICS UNIT WESTERN GENERAL HOSPITAL
EDINBURGH, UNITED KINGDOM UNIVERSITATS- UND LSNDCS- BIBLIOTHEK
DARRRTOTSDT BIBTIOTHEK BIOLOGIE AMSTERDAM * BOSTON * HEIDELBERG * LONDON
NEW YORK * OXFORD * PARIS * SAN DIEGO SAN FRANCISCO * SINGAPORE * SYDNEY
* TOKYO P.T ,SH. V I W,L^ ACADEMIC PRESS IS AN IMPRINT OF KLSEVIER
CONTENTS . CONTRIBUTORS XI PREFACE XIII 1 CHROMATIN STRUCTURE AND THE
REGULATION OF GENE EXPRESSION: THE LESSONS OF PEV IN DROSOPHILA 1 JACK
R. GIRTON AND KRISTEN M. JOHANSEN I. INTRODUCTION: POSITION EFFECT IN
DROSOPHILA 2 II. HISTORICAL BACKGROUND OF THE PEV PHENOTYPE 5 III. TYPES
OF PEV 8 IV. GENOME ORGANIZATION AND PEV 19 V. CONCLUDING REMARKS 29
REFERENCES 31 2 POLYCOMB GROUP PROTEINS AND LONG-RANGE GENE REGULATION
45 JULIO MATEOS-LANGERAK AND GIACOMO CAVALLI I. INTRODUCTION 46 II.
GENETIC AND BIOCHEMICAL CHARACTERIZATION OF PCG PROTEINS 48 III. PCG
MECHANISMS OF ACTION 49 IV. PCG PROTEINS AND LONG-RANGE GENE SILENCING
53 V. PCG AND VERY LONG-RANGE GENE SILENCING: "TELEREGULATION" OF GENE
EXPRESSION 57 VI. CONCLUSIONS AND PROSPECTS 61 REFERENCES 62 3 EVOLUTION
OF /S-REGULATORY SEQUENCES IN DROSOPHILA 67 PAT SIMPSON AND SAVITA
AYYAR I. INTRODUCTION 68 II. DEVELOPMENTAL HOMEOSTASIS, SEQUENCE
TURNOVER, AND STABILIZING SELECTION 72 III. ENHANCER EVOLUTION AND LOSS
OR GAIN OF TRAITS 84 VI CONTENTS IV. CIS-TRANS COEVOLUTION 91 V.
EVOLUTION OF NEW REGULATORY MODULES 95 VI. CONCLUSIONS 98 REFERENCES
99 4 /I-GLOBIN REGULATION AND LONG-RANGE INTERACTIONS 107 ROBERT-JAN
PALSTRA, WOUTER DE LAAT, AND FRANK GROSVELD I. INTRODUCTION 108 II. THE
/?-GLOBIN LOCUS 109 III. MODELS OF LONG-RANGE CONTROL OF GENE EXPRESSION
BY ENHANCERS 115 IV. LONG-RANGE ACTIVATION BY THE /3-GLOBIN LCR 117 V.
ENHANCEMENT OF TRANSCRIPTION BY THE /3-GLOBIN LCR: RATE-LIMITING STEPS
127 VI. THE CONCEPT OF AN ACTIVE CHROMATIN HUB 131 VII. FUTURE
DIRECTIONS 132 REFERENCES 133 5 LONG-RANGE REGULATION OF A-GLOBIN GENE
EXPRESSION 143 DOUGLAS R. HIGGS, DOUGLAS VERNIMMEN, AND BILL WOOD I.
INTRODUCTION 144 II. THE NORMAL STRUCTURE AND EVOLUTION OF THE A-GLOBIN
CLUSTER 146 III. FUNCTIONAL ANALYSIS OF THE A-GLOBIN REGULATORY DOMAIN
147 IV. STRUCTURE OF THE UPSTREAM REGULATORY ELEMENTS AND THE PROMOTERS
152 V. TRANSCRIPTION FACTORS INVOLVED IN ERYTHROPOIESIS 153 VI. CELLULAR
RESOURCES FOR STUDYING THE KEY STAGES OF HEMATOPOIESIS 157 VII.
TRANSCRIPTION FACTOR BINDING TO THE UPSTREAM REGULATORY ELEMENTS 158
VIII. TRANSCRIPTION FACTOR BINDING TO THE PROMOTER 159 IX. THE
RECRUITMENT OF RNA POLYMERASE AND GTFS TO THE A-GLOBIN CLUSTER 160 X.
WHAT ROLE DO THE REMOTE REGULATORY ELEMENTS PLAY ? 161 XI. HOW DO THE
UPSTREAM ELEMENTS INTERACT WITH THE PROMOTER? 162 CONTENTS VII XII.
SEQUENTIAL ACTIVATION OF THE A-GLOBIN GENE CLUSTER DURING
DIFFERENTIATION 165 XIII. CONCLUSIONS, SPECULATION, AND FUTURE
DIRECTIONS 166 REFERENCES 169 6 GLOBAL CONTROL REGIONS AND REGULATORY
LANDSCAPES IN VERTEBRATE DEVELOPMENT AND EVOLUTION 175 FRANCOIS SPITZ
AND DENIS DUBOULE I. INTRODUCTION 176 II. GLOBAL CONTROLS 178 III.
CO-EXPRESSION CHROMOSOMAL TERRITORIES, REGULATORY LANDSCAPES, AND GLOBAL
CONTROL REGIONS 185 IV. MECHANIMS OF UNDERLYING GLOBAL REGULATION 188 V.
CO-EXPRESSION CHROMOSOMAL TERRITORIES, REGULATORY LANDSCAPES: BYSTANDER
EFFECTS OR FUNCTIONAL OPERONS? 192 VI. EVOLUTIONARY IMPLICATIONS OF
GLOBAL GENE CONTROL 195 VII. GLOBAL REGULATION, CHROMOSOMAL
ARCHITECTURE, AND GENETIC DISORDERS 197 VIII. CONCLUDING REMARKS, 197
REFERENCES 198 7 REGULATION OF IMPRINTING IN CLUSTERS: NONCODING RNAS
VERSUS INSULATORS 207 LE-BEN WAN AND MARISAJS. BARTOLOMEI I.
INTRODUCTION 208 . X ~ II. INSULATOR MODEL OF REGULATION 209 III. THE
NCRNA MODEL OF REGULATION 212 IV. DLKL/GTL2 IMPRINTED CLUSTER: A BIT OF
EVERYTHING 215 V. CONCLUSIONS 218 REFERENCES 219 8 GENOMIC IMPRINTING
AND IMPRINTING DEFECTS IN HUMANS 225 BERNHARD HORSTHEMKE AND KARIN
BUITING I. INTRODUCTION 226 II. THE MECHANISMS OF GENOMIC IMPRINTING 226
III. IMPRINTING DEFECTS 230 IV. CONCLUSIONS 242 REFERENCES 243 VIII
CONTENTS 9 EPIGENETIC GENE REGULATION IN CANCER 247 ESTEBAN BALLESTAR
AND MANEL ESTELLER I. INTRODUCTION 248 II. CANCER CELLS SHOW A
DISRUPTION OF DNA METHYLATION PATTERNS . 250 III. DISRUPTION OF THE
HISTONE MODIFICATION PROFILE IN CANCER 253 IV. CASCADES OF EPIGENETIC
DEREGULATION IN CANCER 256 V. WHAT ARE THE MECHANISMS THAT LEAD TO
ABERRANT METHYLATION PATTERNS IN CANCER? 258 VI. EPIGENETIC THERAPY FOR
CANCER TREATMENT 261 REFERENCES 262 10 GENOMIC IDENTIFICATION OF
REGULATORY ELEMENTS BY EVOLUTIONARY SEQUENCE COMPARISON AND FUNCTIONAL
ANALYSIS 269 GABRIELA G. LOOTS I. INTRODUCTION 270' II. GENOMIC
ARCHITECTURE OF THE HUMAN GENOME 271 III. COMPUTATIONAL METHODS OF
PREDICTING REGULATORY ELEMENTS 276 IV. IN VIVO VALIDATION AND
CHARACTERIZATION OF TRANSCFIPTIONAL REGULATORY ELEMENTS 282 V.
CONCLUSIONS 286 REFERENCES 287 11 REGULATORY VARIATION AND EVOLUTION:
IMPLICATIONS FOR DISEASE 295 EMMANOUIL T. DERMITZAKIS I. INTRODUCTION
296 C II. EVOLUTION AND VARIATION OF NONCODING DNA 297 III. NATURAL
SELECTION IN NONCODING DNA 300 IV. GENE EXPRESSION STUDIES 301 V.
DISEASE IMPLICATIONS 302 VI. CONCLUSIONS 303 REFERENCES 304 CONTENTS 12
ORGANIZATION OF CONSERVED ELEMENTS NEAR KEY DEVELOPMENTAL REGULATORS IN
VERTEBRATE GENOMES 307 ADAM WOOLFE AND GREG ELGAR I. INTRODUCTION 308
II. GENE-REGULATORY NETWORKS IN DEVELOPMENT 309 III. IDENTIFICATION OF
EVOLUTIONARILY CONSTRAINED SEQUENCES USING PHYLOGENETIC FOOTPRINTING 310
IV. SEARCHES FOR REGULATORY ELEMENTS USING EVOLUTIONARY CONSERVATION 310
V. TAKIFUGU RUBRIPES: A COMPACT MODEL GENOME 312 VI. IDENTIFICATION OF
ENHANCER ELEMENTS THROUGH FISH-MAMMAL COMPARISONS 313 VII. FISH-MAMMAL
CONSERVED NONCODING ELEMENTS , ARE ASSOCIATED WITH VERTEBRATE
DEVELOPMENT 315 VIII. HIGH-RESOLUTION ANALYSIS OF THE ORGANIZATION OF
CNES AROUND KEY DEVELOPMENTAL REGULATORS 317 IX. GENERAL GENOMIC
ENVIRONMENT AROUND CNES 317 X.' CNES PRESENT IN TRANSCRIPTS 319 XI. CNES
LOCATED WITHIN UTRS 321 XII. CNES ARE LOCATED LARGE DISTANCES AWAY FROM
THEIR PUTATIVE TARGET GENE 323 XIII. DISCUSSION 328 REFERENCES 333 13
LONG-RANGE GENE CONTROL AND GENETIC DISEASE 339 DIRK A. KLEINJAN AND
LAURA A. LETTICE I. FROM GENETIC DISEASE TO LONG-RANGE GENE REGULATION
340 II. POSITION EFFECT REVISITED - 342 III. LOSS OF A POSITIVE
REGULATOR 345 IV. TWIST, POU3F4, PITX2, SOX3, GLI3, AND FOXP2 346 V. THE
"BYSTANDER"-EFFECT 353 VI. MAF, SDC2, TGFB2, REEP3, AND PLP1 355 VII.
TWO POSITION EFFECTS*DIFFERENT OUTCOMES 357 VIII. PHENOTYPES RESULTING
FROM POSITION EFFECTS ON MORE THAN ONE GENE 362 IX. GLOBAL CONTROL
REGIONS; HOXD, GREMLIN, AND LIMB MALFORMATIONS 363 X. FOX GENES AND
POSITION EFFECTS 365 CONTENTS XI. SOX9 AND CAMPOMELIC DISPLASIA 366 XII.
FACIOSCAPULOHUMERAL DYSTROPHY 368 XIII. ABERRANT CREATION OF AN
ILLEGITIMATE SIRNA TARGET SITE 370 XIV. GENETIC DISEASE DUE TO ABERRANT
GENE TRANSCRIPTION CAN BE CAUSED BY MANY DIFFERENT MECHANISMS 371 XV.
CONCLUDING REMARKS 378 REFERENCES 379 INDEX 389 |
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| index_date | 2024-07-02T21:31:31Z |
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| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-016604981 |
| oclc_num | 184827813 |
| open_access_boolean | |
| owner | DE-703 |
| owner_facet | DE-703 |
| physical | XV, 399 S. graph. Darst. |
| publishDate | 2008 |
| publishDateSearch | 2008 |
| publishDateSort | 2008 |
| publisher | Elsevier Acad. Press |
| record_format | marc |
| series2 | Advances in genetics |
| spelling | Long range control of gene expression ed. by Veronica van Heyningen ... Long-range control of gene expression 1. ed. Amsterdam [u.a.] Elsevier Acad. Press 2008 XV, 399 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Advances in genetics 61 Einzelaufnahme eines Zeitschr.-Bd. Gene expression Genetic regulation Van Heyningen, Veronica edt http://digitool.hbz-nrw.de:1801/webclient/DeliveryManager?pid=2364946&custom_att_2=simple_viewer Long range control of gene expression Inhaltsverzeichnis HEBIS Datenaustausch Darmstadt application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016604981&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Long range control of gene expression Gene expression Genetic regulation |
| title | Long range control of gene expression |
| title_alt | Long-range control of gene expression |
| title_auth | Long range control of gene expression |
| title_exact_search | Long range control of gene expression |
| title_exact_search_txtP | Long range control of gene expression |
| title_full | Long range control of gene expression ed. by Veronica van Heyningen ... |
| title_fullStr | Long range control of gene expression ed. by Veronica van Heyningen ... |
| title_full_unstemmed | Long range control of gene expression ed. by Veronica van Heyningen ... |
| title_short | Long range control of gene expression |
| title_sort | long range control of gene expression |
| topic | Gene expression Genetic regulation |
| topic_facet | Gene expression Genetic regulation |
| url | http://digitool.hbz-nrw.de:1801/webclient/DeliveryManager?pid=2364946&custom_att_2=simple_viewer http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016604981&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT vanheyningenveronica longrangecontrolofgeneexpression |
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