Angiogenesis assays: a critical appraisal of current techniques
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Chichester
Wiley
2006
|
| Schlagworte: | |
| Online-Zugang: | Table of contents only Contributor biographical information Publisher description Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | XX, 390 S. Ill., graph. Darst. |
| ISBN: | 9780470016008 0470016000 |
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| 245 | 1 | 0 | |a Angiogenesis assays |b a critical appraisal of current techniques |c [ed. by] Carolyn A. Staton ... |
| 264 | 1 | |a Chichester |b Wiley |c 2006 | |
| 300 | |a XX, 390 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 500 | |a Includes bibliographical references and index | ||
| 650 | 7 | |a Blood Vessels |2 cabt | |
| 650 | 7 | |a Angiogenesis |2 cabt | |
| 650 | 7 | |a Reviews |2 cabt | |
| 650 | 4 | |a Blood-vessels |x Growth | |
| 650 | 4 | |a Neovascularization | |
| 650 | 4 | |a Neovascularization, Pathologic |x physiopathology | |
| 650 | 4 | |a Biological Assay |x methods | |
| 650 | 4 | |a Models, Cardiovascular | |
| 650 | 4 | |a Neovascularization, Physiologic |x physiology | |
| 650 | 0 | 7 | |a Angiogenese |0 (DE-588)4142449-9 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Angiogenese |0 (DE-588)4142449-9 |D s |
| 689 | 0 | |C b |5 DE-604 | |
| 700 | 1 | |a Staton, Carolyn A. |e Sonstige |4 oth | |
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Datensatz im Suchindex
| _version_ | 1804137783703371776 |
|---|---|
| adam_text | Contents
Foreword xi
Preface xv
List of contributors xvii
1 Endothelial cell biology 1
Femke Hitten, Veerle Metotte, Judy R. van Beijnum and
Arjan W. Grijfioen
Abstract 1
1.1 Introduction 1
1.2 Morphology of the endothelium 2
1.3 Endothelial cell adhesion and interactions 4
1.4 Coagulation and haemostasis 11
1.5 Transport 13
1.6 Angiogenesis 14
1.7 Isolation and culture of endothelial cells 19
1.8 Endothelial cell heterogeneity and organ specificity 21
1.9 Gene expression in endothelial cells 23
1.10 Conclusions 28
References 28
2 Endothelial cell proliferation assays 39
Wen-Sen Lee
Abstract 39
2.1 Introduction 39
2.2 Cell proliferation 41
2.3 Cell proliferation assays 42
2.4 Conclusions 48
References 49
3 Endothelial cell migration assays 51
Christos Polytarchou, Maria Hatziapostobu and Evangelia Papadimitriou
Abstract 51
3.1 Introduction 51
3.2 Transfilter assay 52
3.3 Wound healing assay 55
3.4 Teflon fence assay 57
vi CONTENTS
3.5 Phagokinetic track assay 58
3.6 In/ex vivo approaches for studying endothelial cell migration 59
3.7 Conclusions 60
References 60
4 Tubule formation assays 65
Ewen J. Smith and Carolyn A. Staton
Abstract 65
4.1 Introduction 65
4.2 Endothelial cell sources 66
4.3 Endothelial cell morphology and tubule formation 67
4.4 Tubule assay matrices 68
4.5 2D assay protocols 69
4.6 Analysis of tubule formation in 2D assays 73
4.7 Recent developments in 2D assays 77
4.8 3D assays 78
4.9 Analysis of 3D assays 79
4.10 Co-culture assays 80
4.11 Conclusions 82
References 82
5 Modelling the effects of the haemodynamic environment
on endothelial cell responses relevant to angiogenesis 89
Gerard B. Nash and Stuart Egginton
Abstract 89
5.1 Introduction 89
5.2 Definitions 91
5.3 Experimental patterns of shear exposure and relevance to
angiogenesis assays 93
5.4 Methods for studying responses of endothelial cells exposed to shear stress 94
5.5 Readouts in flow cultures relevant to angiogenesis 98
5.6 Critical considerations and conclusions 99
References 101
6 Whole or partial vessel outgrowth assays 105
Cindy H. Chau and William D. Figg
Abstract 105
6.1 Introduction 105
6.2 Rat aortic ring assay 106
6.3 Mouse aorta models 108
6.4 Chick aortic arch assay 109
6.5 Porcine carotid artery assay 110
6.6 Human explant cultures 110
6.7 Recent developments 112
6.8 Quantification 113
6.9 Strengths and weaknesses of organ culture assays 115
6.10 Applications 117
6.11 Conclusions 118
References 118
CONTENTS vii
7 Assaying endothelial-mural cell interactions 123
Melissa K. Nix and Karen K. Hirschi
Abstract 123
7.1 2D models to study endothelial-mural cell interactions 123
7.2 3D models to study blood vessel assembly 128
7.3 Summary 134
References 135
8 Assays for membrane and intracellular signalling events 139
Vittorio Tomasi, Cristiana Griffoni, Spartaco Santi, Patrizia Lenaz,
Rosa Anna Ion o, Antonio Strillacci and Enzo Spisni
Abstract 139
8.1 Introduction 139
8.2 The endothelial caveolae as the organizers of efficient spatial
signal transduction mechanisms 140
8.3 The prostaglandins forming system: regulation of signal transduction
and angiogenesis 141
8.4 Use of antisense oligo and siRNA to evaluate the function of single
signalling molecules 143
8.5 Knocking down and knocking out Caveolin-1 gene 151
8.6 Analysing protein-protein interactions in signalling molecules
involved in angiogenesis 152
8.7 Final remarks 155
References 157
9 Implantation of sponges and polymers 167
Silvia P. Andrade, Monica A. N. D. Ferreira and Tai-Ping Fan
Abstract 167
9.1 Introduction 167
9.2 Materials used in implantation techniques 169
9.3 Implantation technique for assessment of inflammatory
processes 170
9.4 Implantation technique for assessment of systemic
pathological conditions 170
9.5 Implantation technique for assessment of tumour angiogenesis 171
9.6 Implantation technique for assessment of inflammatory angiogenesis
in genetically modified mice 172
9.7 Applications of cannulated sponge model for testing
angiogenesis modulators 172
9.8 Techniques for assessment of the vascularization in implants 172
9.9 Summary of cannulated sponge assay: advantages and
disadvantages 178
References 179
10 Angiogenesis assays in the chick 183
Andries Zijlstra, David Mikolon and Dwayne G. Stupack
Abstract 183
10.1 Introduction 183
10.2 Overview of the basic in shell CAM assay 186
viii CONTENTS
10.3 Variations on the CAM assay 189
10.4 Summary of the CAM assay: disadvantages and advantages 199
References 200
11 Corneal angiogenesis assay 203
Siqing Shan and Mark W. Dewhirst
Abstract 203
11.1 Introduction 203
11.2 Anatomy and histology 204
11.3 Brief history of CNV assays 205
11.4 The process of corneal neovascularization 206
11.5 Experimental induction of corneal neovascularization 208
11.6 Discussion and conclusions 220
References 222
12 Dorsal air sac model 229
Sei Yonezawa, Tomohiro Asai and Naoto Oku
Abstract 229
12.1 Introduction 229
12.2 Preparation of the DAS model 230
12.3 Evaluation of anti-angiogenic photodynamic therapy using
a DAS model 231
12.4 Determination of blood volume or blood flow in the
angiogenic site using the DAS model 232
12.5 Quantitative or semi-quantitative analysis of angiogenesis
in the DAS model 234
12.6 Isolation and application of neovessel-targeting probe
using DAS model 236
12.7 Conclusions 237
References 237
13 Chamber assays 239
Michael D. Menger, Matthias W. Laschke and
Brigitte Vollmar
Abstract 239
13.1 Introduction 239
13.2 In vivo imaging of angiogenesis and microcirculation 240
13.3 Chamber assays 241
13.4 Physiological angiogenesis 246
13.5 Tumour angiogenesis 248
13.6 Angiogenesis in endometriosis 249
13.7 Angiogenesis in wound and bone healing 250
13.8 Angiogenesis in ischaemia and hypoxia 252
13.9 Angiogenesis in transplantation 252
13.10 Angiogenesis in biomaterial incorporation 254
13.11 Angiogenesis in tissue engineering 255
13.12 Conclusions and perspectives 256
References 257
CONTENTS ix
14 Tumour models: analysis of angiogenesis in vivo 265
Sven A. Lang and Oliver Stoeltzing
Abstract 265
14.1 Introduction 265
14.2 Tumour microenvironment and angiogenesis 266
14.3 Tumour models 267
14.4 Subcutaneous tumour models 271
14.5 Orthotopic tumour models 272
14.6 Transgenic mouse models of tumour angiogenesis 277
14.7 Monitoring vascular permeability 279
14.8 Analysis of angiogenesis in tumours 280
14.9 Conclusions 283
References 283
15 Angiomouse: imageable models of angiogenesis 293
Robert M. Hoffman
Abstract 293
15.1 Introduction 293
15.2 Fluorescent proteins to image angiogenesis 294
15.3 Dual-colour tumour host models 297
15.4 ND-GFP mouse model 300
15.5 Methods of angiogenesis analysis in GFP models 306
15.6 Conclusions 307
References 308
16 Techniques and advances in vascular imaging in Danio rerio 311
Kenna R. Mills Shaw and Brant. M. Weinstein
Abstract 311
16.1 Introduction 311
16.2 Visualizing the developing vasculature 312
16.3 In situ hybridization reveals vascular specific expression 318
16.4 Vascular specific fluorescent reporter lines 320
16.5 Chemical mutagenesis screens reveal novel genes involved in
cardiovascular development 321
16.6 Conclusions 323
References 324
17 Biological and clinical implications of recruitment of
stem cells into angiogenesis 327
Gianluigi Castoldi, Antonio Cuneo and Gian Matteo Rigolin
Abstract 327
17.1 Introduction 327
17.2 Phenotypic and functional characterization of EPCS 328
17.3 Mobilization, homing and differentiation of EPCS 332
17.4 Ageing 335
17.5 Therapeutic applications 335
17.6 Conclusions 337
References 337
x CONTENTS
18 Methods for monitoring of the anti-angiogenic activity of
agents in patients: novel trial design 341
Shannon Smiley, Michael K. K. Wong and Shaker A. Mousa
Abstract 341
18.1 Introduction 341
18.2 Tumour micro-environmental factors 343
18.3 Possible mechanisms of acquired resistance to anti-angiogenic drugs 348
18.4 Standard chemotherapy versus angiogenesis inhibitors 348
18.5 Monitoring clinical trials 349
18.6 Tumour dormancy and tumour progression 350
18.7 Tumour markers 351
18.8 Microvessel density 351
18.9 Surrogate endpoints 352
18.10 Molecular imaging 354
18.11 New insights into trial design 354
18.12 Concluding remarks 355
References 355
19 An overview of current angiogenesis assays: Choice of
assay, precautions in interpretation, future requirements
and directions 361
Robert Auerbach
Abstract 361
19.1 Introduction 361
19.2 In vitro assays 362
19.3 In vivo assays 365
19.4 Clinical trials 370
19.5 Future directions 370
19.6 Concluding comments 371
References 372
Index 375
|
| adam_txt |
Contents
Foreword xi
Preface xv
List of contributors xvii
1 Endothelial cell biology 1
Femke Hitten, Veerle Metotte, Judy R. van Beijnum and
Arjan W. Grijfioen
Abstract 1
1.1 Introduction 1
1.2 Morphology of the endothelium 2
1.3 Endothelial cell adhesion and interactions 4
1.4 Coagulation and haemostasis 11
1.5 Transport 13
1.6 Angiogenesis 14
1.7 Isolation and culture of endothelial cells 19
1.8 Endothelial cell heterogeneity and organ specificity 21
1.9 Gene expression in endothelial cells 23
1.10 Conclusions 28
References 28
2 Endothelial cell proliferation assays 39
Wen-Sen Lee
Abstract 39
2.1 Introduction 39
2.2 Cell proliferation 41
2.3 Cell proliferation assays 42
2.4 Conclusions 48
References 49
3 Endothelial cell migration assays 51
Christos Polytarchou, Maria Hatziapostobu and Evangelia Papadimitriou
Abstract 51
3.1 Introduction 51
3.2 Transfilter assay 52
3.3 "Wound healing' assay 55
3.4 Teflon fence assay 57
vi CONTENTS
3.5 Phagokinetic track assay 58
3.6 In/ex vivo approaches for studying endothelial cell migration 59
3.7 Conclusions 60
References 60
4 Tubule formation assays 65
Ewen J. Smith and Carolyn A. Staton
Abstract 65
4.1 Introduction 65
4.2 Endothelial cell sources 66
4.3 Endothelial cell morphology and tubule formation 67
4.4 Tubule assay matrices 68
4.5 2D assay protocols 69
4.6 Analysis of tubule formation in 2D assays 73
4.7 Recent developments in 2D assays 77
4.8 3D assays 78
4.9 Analysis of 3D assays 79
4.10 Co-culture assays 80
4.11 Conclusions 82
References 82
5 Modelling the effects of the haemodynamic environment
on endothelial cell responses relevant to angiogenesis 89
Gerard B. Nash and Stuart Egginton
Abstract 89
5.1 Introduction 89
5.2 Definitions 91
5.3 Experimental patterns of shear exposure and relevance to
angiogenesis assays 93
5.4 Methods for studying responses of endothelial cells exposed to shear stress 94
5.5 Readouts in flow cultures relevant to angiogenesis 98
5.6 Critical considerations and conclusions 99
References 101
6 Whole or partial vessel outgrowth assays 105
Cindy H. Chau and William D. Figg
Abstract 105
6.1 Introduction 105
6.2 Rat aortic ring assay 106
6.3 Mouse aorta models 108
6.4 Chick aortic arch assay 109
6.5 Porcine carotid artery assay 110
6.6 Human explant cultures 110
6.7 Recent developments 112
6.8 Quantification 113
6.9 Strengths and weaknesses of organ culture assays 115
6.10 Applications 117
6.11 Conclusions 118
References 118
CONTENTS vii
7 Assaying endothelial-mural cell interactions 123
Melissa K. Nix and Karen K. Hirschi
Abstract 123
7.1 2D models to study endothelial-mural cell interactions 123
7.2 3D models to study blood vessel assembly 128
7.3 Summary 134
References 135
8 Assays for membrane and intracellular signalling events 139
Vittorio Tomasi, Cristiana Griffoni, Spartaco Santi, Patrizia Lenaz,
Rosa Anna Ion'o, Antonio Strillacci and Enzo Spisni
Abstract 139
8.1 Introduction 139
8.2 The endothelial caveolae as the organizers of efficient spatial
signal transduction mechanisms 140
8.3 The prostaglandins forming system: regulation of signal transduction
and angiogenesis 141
8.4 Use of antisense oligo and siRNA to evaluate the function of single
signalling molecules 143
8.5 Knocking down and knocking out Caveolin-1 gene 151
8.6 Analysing protein-protein interactions in signalling molecules
involved in angiogenesis 152
8.7 Final remarks 155
References 157
9 Implantation of sponges and polymers 167
Silvia P. Andrade, Monica A. N. D. Ferreira and Tai-Ping Fan
Abstract 167
9.1 Introduction 167
9.2 Materials used in implantation techniques 169
9.3 Implantation technique for assessment of inflammatory
processes 170
9.4 Implantation technique for assessment of systemic
pathological conditions 170
9.5 Implantation technique for assessment of tumour angiogenesis 171
9.6 Implantation technique for assessment of inflammatory angiogenesis
in genetically modified mice 172
9.7 Applications of cannulated sponge model for testing
angiogenesis modulators 172
9.8 Techniques for assessment of the vascularization in implants 172
9.9 Summary of cannulated sponge assay: advantages and
disadvantages 178
References 179
10 Angiogenesis assays in the chick 183
Andries Zijlstra, David Mikolon and Dwayne G. Stupack
Abstract 183
10.1 Introduction 183
10.2 Overview of the basic 'in shell' CAM assay 186
viii CONTENTS
10.3 Variations on the CAM assay 189
10.4 Summary of the CAM assay: disadvantages and advantages 199
References 200
11 Corneal angiogenesis assay 203
Siqing Shan and Mark W. Dewhirst
Abstract 203
11.1 Introduction 203
11.2 Anatomy and histology 204
11.3 Brief history of CNV assays 205
11.4 The process of corneal neovascularization 206
11.5 Experimental induction of corneal neovascularization 208
11.6 Discussion and conclusions 220
References 222
12 Dorsal air sac model 229
Sei Yonezawa, Tomohiro Asai and Naoto Oku
Abstract 229
12.1 Introduction 229
12.2 Preparation of the DAS model 230
12.3 Evaluation of anti-angiogenic photodynamic therapy using
a DAS model 231
12.4 Determination of blood volume or blood flow in the
angiogenic site using the DAS model 232
12.5 Quantitative or semi-quantitative analysis of angiogenesis
in the DAS model 234
12.6 Isolation and application of neovessel-targeting probe
using DAS model 236
12.7 Conclusions 237
References 237
13 Chamber assays 239
Michael D. Menger, Matthias W. Laschke and
Brigitte Vollmar
Abstract 239
13.1 Introduction 239
13.2 In vivo imaging of angiogenesis and microcirculation 240
13.3 Chamber assays 241
13.4 Physiological angiogenesis 246
13.5 Tumour angiogenesis 248
13.6 Angiogenesis in endometriosis 249
13.7 Angiogenesis in wound and bone healing 250
13.8 Angiogenesis in ischaemia and hypoxia 252
13.9 Angiogenesis in transplantation 252
13.10 Angiogenesis in biomaterial incorporation 254
13.11 Angiogenesis in tissue engineering 255
13.12 Conclusions and perspectives 256
References 257
CONTENTS ix
14 Tumour models: analysis of angiogenesis in vivo 265
Sven A. Lang and Oliver Stoeltzing
Abstract 265
14.1 Introduction 265
14.2 Tumour microenvironment and angiogenesis 266
14.3 Tumour models 267
14.4 Subcutaneous tumour models 271
14.5 Orthotopic tumour models 272
14.6 Transgenic mouse models of tumour angiogenesis 277
14.7 Monitoring vascular permeability 279
14.8 Analysis of angiogenesis in tumours 280
14.9 Conclusions 283
References 283
15 Angiomouse: imageable models of angiogenesis 293
Robert M. Hoffman
Abstract 293
15.1 Introduction 293
15.2 Fluorescent proteins to image angiogenesis 294
15.3 Dual-colour tumour host models 297
15.4 ND-GFP mouse model 300
15.5 Methods of angiogenesis analysis in GFP models 306
15.6 Conclusions 307
References 308
16 Techniques and advances in vascular imaging in Danio rerio 311
Kenna R. Mills Shaw and Brant. M. Weinstein
Abstract 311
16.1 Introduction 311
16.2 Visualizing the developing vasculature 312
16.3 In situ hybridization reveals vascular specific expression 318
16.4 Vascular specific fluorescent reporter lines 320
16.5 Chemical mutagenesis screens reveal novel genes involved in
cardiovascular development 321
16.6 Conclusions 323
References 324
17 Biological and clinical implications of recruitment of
stem cells into angiogenesis 327
Gianluigi Castoldi, Antonio Cuneo and Gian Matteo Rigolin
Abstract 327
17.1 Introduction 327
17.2 Phenotypic and functional characterization of EPCS 328
17.3 Mobilization, homing and differentiation of EPCS 332
17.4 Ageing 335
17.5 Therapeutic applications 335
17.6 Conclusions 337
References 337
x CONTENTS
18 Methods for monitoring of the anti-angiogenic activity of
agents in patients: novel trial design 341
Shannon Smiley, Michael K. K. Wong and Shaker A. Mousa
Abstract 341
18.1 Introduction 341
18.2 Tumour micro-environmental factors 343
18.3 Possible mechanisms of acquired resistance to anti-angiogenic drugs 348
18.4 Standard chemotherapy versus angiogenesis inhibitors 348
18.5 Monitoring clinical trials 349
18.6 Tumour dormancy and tumour progression 350
18.7 Tumour markers 351
18.8 Microvessel density 351
18.9 Surrogate endpoints 352
18.10 Molecular imaging 354
18.11 New insights into trial design 354
18.12 Concluding remarks 355
References 355
19 An overview of current angiogenesis assays: Choice of
assay, precautions in interpretation, future requirements
and directions 361
Robert Auerbach
Abstract 361
19.1 Introduction 361
19.2 In vitro assays 362
19.3 In vivo assays 365
19.4 Clinical trials 370
19.5 Future directions 370
19.6 Concluding comments 371
References 372
Index 375 |
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| id | DE-604.BV023400905 |
| illustrated | Illustrated |
| index_date | 2024-07-02T21:23:44Z |
| indexdate | 2024-07-09T21:17:47Z |
| institution | BVB |
| isbn | 9780470016008 0470016000 |
| language | English |
| lccn | 2006031246 |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-016583695 |
| oclc_num | 71466628 |
| open_access_boolean | |
| owner | DE-355 DE-BY-UBR DE-188 |
| owner_facet | DE-355 DE-BY-UBR DE-188 |
| physical | XX, 390 S. Ill., graph. Darst. |
| publishDate | 2006 |
| publishDateSearch | 2006 |
| publishDateSort | 2006 |
| publisher | Wiley |
| record_format | marc |
| spelling | Angiogenesis assays a critical appraisal of current techniques [ed. by] Carolyn A. Staton ... Chichester Wiley 2006 XX, 390 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and index Blood Vessels cabt Angiogenesis cabt Reviews cabt Blood-vessels Growth Neovascularization Neovascularization, Pathologic physiopathology Biological Assay methods Models, Cardiovascular Neovascularization, Physiologic physiology Angiogenese (DE-588)4142449-9 gnd rswk-swf Angiogenese (DE-588)4142449-9 s b DE-604 Staton, Carolyn A. Sonstige oth http://www.loc.gov/catdir/toc/ecip071/2006031246.html Table of contents only http://www.loc.gov/catdir/enhancements/fy0740/2006031246-b.html Contributor biographical information http://www.loc.gov/catdir/enhancements/fy0740/2006031246-d.html Publisher description HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016583695&sequence=000012&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Angiogenesis assays a critical appraisal of current techniques Blood Vessels cabt Angiogenesis cabt Reviews cabt Blood-vessels Growth Neovascularization Neovascularization, Pathologic physiopathology Biological Assay methods Models, Cardiovascular Neovascularization, Physiologic physiology Angiogenese (DE-588)4142449-9 gnd |
| subject_GND | (DE-588)4142449-9 |
| title | Angiogenesis assays a critical appraisal of current techniques |
| title_auth | Angiogenesis assays a critical appraisal of current techniques |
| title_exact_search | Angiogenesis assays a critical appraisal of current techniques |
| title_exact_search_txtP | Angiogenesis assays a critical appraisal of current techniques |
| title_full | Angiogenesis assays a critical appraisal of current techniques [ed. by] Carolyn A. Staton ... |
| title_fullStr | Angiogenesis assays a critical appraisal of current techniques [ed. by] Carolyn A. Staton ... |
| title_full_unstemmed | Angiogenesis assays a critical appraisal of current techniques [ed. by] Carolyn A. Staton ... |
| title_short | Angiogenesis assays |
| title_sort | angiogenesis assays a critical appraisal of current techniques |
| title_sub | a critical appraisal of current techniques |
| topic | Blood Vessels cabt Angiogenesis cabt Reviews cabt Blood-vessels Growth Neovascularization Neovascularization, Pathologic physiopathology Biological Assay methods Models, Cardiovascular Neovascularization, Physiologic physiology Angiogenese (DE-588)4142449-9 gnd |
| topic_facet | Blood Vessels Angiogenesis Reviews Blood-vessels Growth Neovascularization Neovascularization, Pathologic physiopathology Biological Assay methods Models, Cardiovascular Neovascularization, Physiologic physiology Angiogenese |
| url | http://www.loc.gov/catdir/toc/ecip071/2006031246.html http://www.loc.gov/catdir/enhancements/fy0740/2006031246-b.html http://www.loc.gov/catdir/enhancements/fy0740/2006031246-d.html http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016583695&sequence=000012&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT statoncarolyna angiogenesisassaysacriticalappraisalofcurrenttechniques |