Clinical diabetes research: methods and techniques
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Chichester
Wiley
2007
|
| Schlagworte: | |
| Online-Zugang: | Table of contents only Publisher description Inhaltsverzeichnis |
| Beschreibung: | 320 S. |
| ISBN: | 9780470017289 |
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| 245 | 1 | 0 | |a Clinical diabetes research |b methods and techniques |c ed. by Michael Roden |
| 264 | 1 | |a Chichester |b Wiley |c 2007 | |
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| 650 | 4 | |a Diabetes |x Research | |
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Datensatz im Suchindex
| _version_ | 1804137783416061952 |
|---|---|
| adam_text | Contents
List of Contributors
xi
1
Basics of Clinical Metabolic Research
1
Michael Roden
2
Methods for the Assessment of
ß-Cell
Function In Vivo
7
Andrea
Mari
and Giovanni Pacini
Introduction
7
Methods for insuLin secretion in vivo
7
ß-cell
response characteristics
9
ß-cell
function tests
12
Modelling methods
19
ß-cell
function and insulin sensitivity
20
Comparative evaluation of methods
21
Conclusion
24
3
Assessment of Insulin Sensitivity from Steady-State and Dynamic
Tests
27
Giovanni Pacini and Andrea Man
Introduction
27
Insulin sensitivity from steady-state tests
28
Insulin sensitivity from dynamic tests
31
Conclusion
37
4
Glucose Clamp Techniques
43
Attila
Brehm
and Michael
Roden
Introduction
43
Basic principles of the euglycaemic hyperinsulinaemic clamp technique
49
Methodology
57
Reproducibility of insulin sensitivity obtained from clamp tests
64
Safety considerations for hyperinsulinaemic euglycaemic clamp test
65
Modifications of the euglycaemic hyperinsulinaemic clamp test protocol
65
Conclusion
67
CONTENTS
Methods of Assessment of Counterregulation to Hypoglycaemia
77
Pratik Choudhary, Ming Ming Teh and Stephanie A Amiei
Introduction
77
Definitions
78
Pathophysiology
79
Documentation of hypoglycaemia experience
81
Investigating the pathogenesis of problematic hypoglycaemia
85
Hypoglycaemic stimuli for research
89
Measurement of physiological responses
93
Conclusion
97
6
Glucose Kinetics: Measurement of Flux Rates
105
Jerry
Radzi
и к
and Susan Pye
Introduction
105
Measurement of glucose production and uptake by the liver
-
tissue balance techniques
106
Properties of glucose tracers
107
Measurement of glucose production and uptake by the liver
-
systemic techniques 111
Conclusion
122
Acknowledgements
122
7
Xenobiotics as Probes of Carbohydrate Metabolism
125
Bernard Landau
Introduction
125
Glucuronidation
125
Glutamination 128
Ribosylation
130
Acetylation
131
Glycination
132
8
Tracing Hepatic Glucose and Glycogen Fluxes with 2H2O
139
John
G
Jones
Introduction
139
Methodology
140
Theoretical considerations
142
Quantifying hepatic glucose and glycogen metabolism
145
Conclusion
148
Lipid
Kinetics
John
M
Miles and Robert
H Nebon
Introduction
151
Tracers for the study of adipose tissue lipolysis
151
Tracers forthe study of triglyceride-rich lipoprotein kinetics
156
Conclusion ^g4
Acknowledgements
^g^
CONTENTS
vii
10 Protein
and Amino
Add
Kinetics
169
Stephen
F Previs, Danielie
A Gilge
and
Nadia
Rachdaoui
Introduction
169
Measuring
amino
add
turnover
170
Measuring protein turnover
175
Proteome dynamics
181
Urea kinetics
182
Determining the molecular control of protein dynamics
185
Conclusion
186
Acknowledgements
187
11
Assessment of Metabolic Fluxes by In Vivo MR Spectroscopy
193
Martin
Krššák
and Michael
Roden
Phenomena of nuclear magnetic resonance
-
imaging and spectroscopy
193
Skeletal muscle
198
Liver
207
Brain
213
Conclusion
214
12
Positron Emission Tomography in Metabolic Research
223
Pirjo
Nautila,
Patricia Iozzo and
Juhani Knuuti
Introduction
223
Tracers for metabolic imaging
224
Principles of modeling
225
Future perspectives
232
13
Assessment of Body Fat Content and Distribution
237
Martin
Krššák
Introduction
237
Measurement techniques
237
Body fat distribution and insulin resistance
247
14
Tissue Biopsies in Diabetes Research
265
Kurt Hejlund, Michael
Gaster
and
Henning
Beck-Nielsen
Introduction
265
Percutaneous needle biopsy of skeletal muscle
266
Biopsy procedure and sample handling
267
Discomfort and complications of needle biopsy
269
Advantages and limitations of needle biopsy
270
Application of muscle biopsy in diabetes
270
Morphology of skeletal muscle
273
Application of muscle morphology in type
2
diabetes
273
Human myotube cultures
276
The cell culture principle of human myotubes
277
Advantages of human myotubes
279
viii CONTENTS
Limitations
of human myotubes
279
Application of myotubes in diabetes research
281
Conclusion
282
15
Assessment of Vascular Function
289
Johannes
Pleiner
and Michael Wolzt
Basic theoretical concepts
289
The vascular endothelium
289
Strain gauge plethysmography
290
Flow Mediated Dilation (FMD) of the
brachial
artery
295
Intima
media thickness of the carotid artery
299
Assessment of arterial stiffness
303
16
Cardiovascular
Autonomie
Function Testing
311
Dan Ziegler
Introduction
311
Prognosis
312
Epidemiology
312
Clinical features
313
Diagnostic assessment
316
17
Nerve Function Testing
325
Hans
M
Rathur
and Andrew
J
M Boulton
Introduction
325
Clinical Assessment
325
Clinical screening devices (not requiring external power source)
328
Quantitative sensory testing
330
Electrophysiology
332
Other methods of assessment
334
Non-invasive assessment
335
Conclusion
336
18
Kidney Function
341
Sally
M
Marshall
Introduction
341
Glomerular function
341
Tubular function
345
Renal haemodynamics
346
Renal structure
347
Genetic studies
348
Provocation tests
34g
Functional magnetic resonance imaging and spectroscopy
349
Conclusion
350
CONTENTS ix
19
Techniques
for the Investigation of the Eye in Diabetes
357
Ayad Al-Bermani and Roy Taylor
Introduction
357
Visual acuity
357
FLuoresceinangiography of the
fundus
359
Optical coherence tomography
(OCT)
362
20
Basics of Molecular Genetics: Lessons from Type
2
Diabetes
367
Leif
Groop and Charlotte Ling
Introduction
367
Genetic risk
367
Genetic variability
368
Mapping genetic variability
369
Future directions
375
21
Good Clinical Practice: Friend or Foe?
377
Christian Joukhadar and
Markus
Müller
Introduction
377
Scientific misconduct
378
Publication bias
378
Institutional review board/independent ethics committee
379
Protocol and informed consent
380
Special populations
381
Serious adverse event reporting
382
Monitoring and inspection
383
Conclusion
384
22
Statistical Considerations in Diabetes Trials
387
Irene
M
Stratton and Carole A Cull
Introduction
387
Requirements
388
Study design and power calculations
388
Biochemical and clinical measurements
388
Demographics
389
Cross-over studies
390
Long term studies
390
Specialised trial designs
390
Reporting of study protocols
390
Identification and measurement of outcome measures and surrogate outcome measures
391
Adjudicated endpoints
391
Validation of data
391
Other sources of bias and error
391
Analysis
392
Index
395
|
| adam_txt |
Contents
List of Contributors
xi
1
Basics of Clinical Metabolic Research
1
Michael Roden
2
Methods for the Assessment of
ß-Cell
Function In Vivo
7
Andrea
Mari
and Giovanni Pacini
Introduction
7
Methods for insuLin secretion in vivo
7
ß-cell
response characteristics
9
ß-cell
function tests
12
Modelling methods
19
ß-cell
function and insulin sensitivity
20
Comparative evaluation of methods
21
Conclusion
24
3
Assessment of Insulin Sensitivity from Steady-State and Dynamic
Tests
27
Giovanni Pacini and Andrea Man
Introduction
27
Insulin sensitivity from steady-state tests
28
Insulin sensitivity from dynamic tests
31
Conclusion
37
4
Glucose Clamp Techniques
43
Attila
Brehm
and Michael
Roden
Introduction
43
Basic principles of the euglycaemic hyperinsulinaemic clamp technique
49
Methodology
57
Reproducibility of insulin sensitivity obtained from clamp tests
64
Safety considerations for hyperinsulinaemic euglycaemic clamp test
65
Modifications of the euglycaemic hyperinsulinaemic clamp test protocol
65
Conclusion
67
CONTENTS
Methods of Assessment of Counterregulation to Hypoglycaemia
77
Pratik Choudhary, Ming Ming Teh and Stephanie A Amiei
Introduction
77
Definitions
78
Pathophysiology
79
Documentation of hypoglycaemia experience
81
Investigating the pathogenesis of problematic hypoglycaemia
85
Hypoglycaemic stimuli for research
89
Measurement of physiological responses
93
Conclusion
97
6
Glucose Kinetics: Measurement of Flux Rates
105
Jerry
Radzi
и к
and Susan Pye
Introduction
105
Measurement of glucose production and uptake by the liver
-
tissue balance techniques
106
Properties of glucose tracers
107
Measurement of glucose production and uptake by the liver
-
systemic techniques 111
Conclusion
122
Acknowledgements
122
7
Xenobiotics as Probes of Carbohydrate Metabolism
125
Bernard Landau
Introduction
125
Glucuronidation
125
Glutamination 128
Ribosylation
130
Acetylation
131
Glycination
132
8
Tracing Hepatic Glucose and Glycogen Fluxes with 2H2O
139
John
G
Jones
Introduction
139
Methodology
140
Theoretical considerations
142
Quantifying hepatic glucose and glycogen metabolism
145
Conclusion
148
Lipid
Kinetics
John
M
Miles and Robert
H Nebon
Introduction
151
Tracers for the study of adipose tissue lipolysis
151
Tracers forthe study of triglyceride-rich lipoprotein kinetics
156
Conclusion ^g4
Acknowledgements
^g^
CONTENTS
vii
10 Protein
and Amino
Add
Kinetics
169
Stephen
F Previs, Danielie
A Gilge
and
Nadia
Rachdaoui
Introduction
169
Measuring
amino
add
turnover
170
Measuring protein turnover
175
Proteome dynamics
181
Urea kinetics
182
Determining the molecular control of protein dynamics
185
Conclusion
186
Acknowledgements
187
11
Assessment of Metabolic Fluxes by In Vivo MR Spectroscopy
193
Martin
Krššák
and Michael
Roden
Phenomena of nuclear magnetic resonance
-
imaging and spectroscopy
193
Skeletal muscle
198
Liver
207
Brain
213
Conclusion
214
12
Positron Emission Tomography in Metabolic Research
223
Pirjo
Nautila,
Patricia Iozzo and
Juhani Knuuti
Introduction
223
Tracers for metabolic imaging
224
Principles of modeling
225
Future perspectives
232
13
Assessment of Body Fat Content and Distribution
237
Martin
Krššák
Introduction
237
Measurement techniques
237
Body fat distribution and insulin resistance
247
14
Tissue Biopsies in Diabetes Research
265
Kurt Hejlund, Michael
Gaster
and
Henning
Beck-Nielsen
Introduction
265
Percutaneous needle biopsy of skeletal muscle
266
Biopsy procedure and sample handling
267
Discomfort and complications of needle biopsy
269
Advantages and limitations of needle biopsy
270
Application of muscle biopsy in diabetes
270
Morphology of skeletal muscle
273
Application of muscle morphology in type
2
diabetes
273
Human myotube cultures
276
The cell culture principle of human myotubes
277
Advantages of human myotubes
279
viii CONTENTS
Limitations
of human myotubes
279
Application of myotubes in diabetes research
281
Conclusion
282
15
Assessment of Vascular Function
289
Johannes
Pleiner
and Michael Wolzt
Basic theoretical concepts
289
The vascular endothelium
289
Strain gauge plethysmography
290
Flow Mediated Dilation (FMD) of the
brachial
artery
295
Intima
media thickness of the carotid artery
299
Assessment of arterial stiffness
303
16
Cardiovascular
Autonomie
Function Testing
311
Dan Ziegler
Introduction
311
Prognosis
312
Epidemiology
312
Clinical features
313
Diagnostic assessment
316
17
Nerve Function Testing
325
Hans
M
Rathur
and Andrew
J
M Boulton
Introduction
325
Clinical Assessment
325
Clinical screening devices (not requiring external power source)
328
Quantitative sensory testing
330
Electrophysiology
332
Other methods of assessment
334
Non-invasive assessment
335
Conclusion
336
18
Kidney Function
341
Sally
M
Marshall
Introduction
341
Glomerular function
341
Tubular function
345
Renal haemodynamics
346
Renal structure
347
Genetic studies
348
Provocation tests
34g
Functional magnetic resonance imaging and spectroscopy
349
Conclusion
350
CONTENTS ix
19
Techniques
for the Investigation of the Eye in Diabetes
357
Ayad Al-Bermani and Roy Taylor
Introduction
357
Visual acuity
357
FLuoresceinangiography of the
fundus
359
Optical coherence tomography
(OCT)
362
20
Basics of Molecular Genetics: Lessons from Type
2
Diabetes
367
Leif
Groop and Charlotte Ling
Introduction
367
Genetic risk
367
Genetic variability
368
Mapping genetic variability
369
Future directions
375
21
Good Clinical Practice: Friend or Foe?
377
Christian Joukhadar and
Markus
Müller
Introduction
377
Scientific misconduct
378
Publication bias
378
Institutional review board/independent ethics committee
379
Protocol and informed consent
380
Special populations
381
Serious adverse event reporting
382
Monitoring and inspection
383
Conclusion
384
22
Statistical Considerations in Diabetes Trials
387
Irene
M
Stratton and Carole A Cull
Introduction
387
Requirements
388
Study design and power calculations
388
Biochemical and clinical measurements
388
Demographics
389
Cross-over studies
390
Long term studies
390
Specialised trial designs
390
Reporting of study protocols
390
Identification and measurement of outcome measures and surrogate outcome measures
391
Adjudicated endpoints
391
Validation of data
391
Other sources of bias and error
391
Analysis
392
Index
395 |
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| index_date | 2024-07-02T21:23:38Z |
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| isbn | 9780470017289 |
| language | English |
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| spelling | Clinical diabetes research methods and techniques ed. by Michael Roden Chichester Wiley 2007 320 S. txt rdacontent n rdamedia nc rdacarrier Diabetes Diabetes Research Diabetes Mellitus Clinical Trials Diabetologie (DE-588)4659012-2 gnd rswk-swf Diabetologie (DE-588)4659012-2 s DE-604 Roden, Michael 1961- Sonstige (DE-588)130812773 oth http://www.loc.gov/catdir/toc/ecip0716/2007015950.html Table of contents only http://www.loc.gov/catdir/enhancements/fy0740/2007015950-d.html Publisher description Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=016583516&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Clinical diabetes research methods and techniques Diabetes Diabetes Research Diabetes Mellitus Clinical Trials Diabetologie (DE-588)4659012-2 gnd |
| subject_GND | (DE-588)4659012-2 |
| title | Clinical diabetes research methods and techniques |
| title_auth | Clinical diabetes research methods and techniques |
| title_exact_search | Clinical diabetes research methods and techniques |
| title_exact_search_txtP | Clinical diabetes research methods and techniques |
| title_full | Clinical diabetes research methods and techniques ed. by Michael Roden |
| title_fullStr | Clinical diabetes research methods and techniques ed. by Michael Roden |
| title_full_unstemmed | Clinical diabetes research methods and techniques ed. by Michael Roden |
| title_short | Clinical diabetes research |
| title_sort | clinical diabetes research methods and techniques |
| title_sub | methods and techniques |
| topic | Diabetes Diabetes Research Diabetes Mellitus Clinical Trials Diabetologie (DE-588)4659012-2 gnd |
| topic_facet | Diabetes Diabetes Research Diabetes Mellitus Clinical Trials Diabetologie |
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